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  1. The use of biocatalysts has become an increasingly attractive alternative to traditional chemical methods, due to the high selectivity, mild reaction conditions and environmentally-friendly processes in nonaqu...

    Authors: Meiyan Yang, Hui Wu, Yan Lian, Xiaofeng Li, Yao Ren, Furao Lai and Guanglei Zhao
    Citation: Microbial Cell Factories 2014 13:143
    Content type: Research Published on:

  2. The rapid increase in the number of diabetic patients globally and exploration of alternate insulin delivery methods such as inhalation or oral route that rely on higher doses, is bound to escalate the demand ...

    Authors: Nabih A Baeshen, Mohammed N Baeshen, Abdullah Sheikh, Roop S Bora, Mohamed Morsi M Ahmed, Hassan A I Ramadan, Kulvinder Singh Saini and Elrashdy M Redwan
    Citation: Microbial Cell Factories 2014 13:141
    Content type: Review Published on:

  4. Cyanobacteria are increasingly recognized as promising cell factories for the production of renewable biofuels and chemical feedstocks from sunlight, CO2, and water. However, most biotechnological applications...

    Authors: Philipp Erdrich, Henning Knoop, Ralf Steuer and Steffen Klamt
    Citation: Microbial Cell Factories 2014 13:128
    Content type: Research Published on:

  5. Clostridium acetobutylicum fermentations are promising for production of commodity chemicals from heterogeneous biomass due to the wide range of substrates the organism can metabolize. Much work has been done to...

    Authors: Matthew D Servinsky, Sanchao Liu, Elliot S Gerlach, Katherine L Germane and Christian J Sund
    Citation: Microbial Cell Factories 2014 13:139
    Content type: Research Published on:

  6. The isolation of recombinant antibody fragments from displayed libraries represents a powerful alternative to the generation of IgGs using hybridoma technology. The selected antibody fragments can then be easi...

    Authors: Selma Djender, Aurelie Schneider, Anne Beugnet, Ronan Crepin, Klervi Even Desrumeaux, Chiara Romani, Sandrine Moutel, Franck Perez and Ario de Marco
    Citation: Microbial Cell Factories 2014 13:140
    Content type: Research Published on:

  7. Over the last few years High-Throughput Protein Production (HTPP) has played a crucial role for functional proteomics. High-quality, high yield and fast recombinant protein production are critical for new HTPP...

    Authors: Cecilia Deantonio, Valentina Sedini, Patrizia Cesaro, Fabio Quasso, Diego Cotella, Francesca Persichetti, Claudio Santoro and Daniele Sblattero
    Citation: Microbial Cell Factories 2014 13:132
    Content type: Research Published on:

  8. Inclusion bodies (IBs) are aggregated proteins that form clusters when protein is overexpressed in heterologous expression systems. IBs have been considered as non-usable proteins, but recently they are being ...

    Authors: Andrea Castellanos-Mendoza, Ricardo M Castro-Acosta, Alejandro Olvera, Guadalupe Zavala, Miguel Mendoza-Vera, Enrique García-Hernández, Alejandro Alagón, Mauricio A Trujillo-Roldán and Norma A Valdez-Cruz
    Citation: Microbial Cell Factories 2014 13:137
    Content type: Research Published on:

  9. Isopentenols, such as prenol and isoprenol, are promising advanced biofuels because of their higher energy densities and better combustion efficiencies compared with ethanol. Microbial production of isopenteno...

    Authors: Huaiwei Liu, Yang Wang, Qiang Tang, Wentao Kong, Wook-Jin Chung and Ting Lu
    Citation: Microbial Cell Factories 2014 13:135
    Content type: Research Published on:

  10. α-2,6-sialyltransferase catalyzes the terminal step of complex N-glycan biosynthesis on human glycoproteins, attaching sialic acid to outermost galactosyl residues on otherwise fully assembled branched glycans. T...

    Authors: Doris Ribitsch, Sabine Zitzenbacher, Peter Augustin, Katharina Schmölzer, Tibor Czabany, Christiane Luley-Goedl, Marco Thomann, Christine Jung, Harald Sobek, Rainer Müller, Bernd Nidetzky and Helmut Schwab
    Citation: Microbial Cell Factories 2014 13:138
    Content type: Research Published on:

  11. Fungal production of polyunsaturated fatty acids (PUFAs) is a highly potential approach in biotechnology. Currently the main focus is directed towards screening of hundreds strains in order to select of few po...

    Authors: Volha Shapaval, Nils Kristian Afseth, Gjermund Vogt and Achim Kohler
    Citation: Microbial Cell Factories 2014 13:86
    Content type: Research Published on:

  12. Norovirus virus-like particles (NoV VLPs) have recently been explored as potential vaccine platforms due to their ability to produce an effective immune response. Expression of the main structural protein, VP1, l...

    Authors: Jaime Tomé-Amat, Lauren Fleischer, Stephanie A Parker, Cameron L Bardliving and Carl A Batt
    Citation: Microbial Cell Factories 2014 13:134
    Content type: Research Published on:

  14. The gene encoding the putative reductase component (KshB) of 3-ketosteroid 9α-hydroxylase was cloned from Rhodococcus equi USA-18, a cholesterol oxidase-producing strain formerly named Arthrobacter simplex USA-18...

    Authors: Chin-Hsing Yeh, Yung-Shun Kuo, Che-Ming Chang, Wen-Hsiung Liu, Meei-Ling Sheu and Menghsiao Meng
    Citation: Microbial Cell Factories 2014 13:130
    Content type: Research Published on:

  15. The production of aromatic amino acids using fermentation processes with recombinant microorganisms can be an advantageous approach to reach their global demands. In addition, a large array of compounds with a...

    Authors: Alberto Rodriguez, Juan A Martnez, Noem Flores, Adelfo Escalante, Guillermo Gosset and Francisco Bolivar
    Citation: Microbial Cell Factories 2014 13:126
    Content type: Review Published on:

  16. Pichia pastoris is a widely-used host for recombinant protein production; expression is typically driven by methanol-inducible alcohol oxidase (AOX) promoters. Recently this system has become an important source...

    Authors: Zharain Bawa, Sarah J Routledge, Mohammed Jamshad, Michelle Clare, Debasmita Sarkar, Ian Dickerson, Markus Ganzlin, David R Poyner and Roslyn M Bill
    Citation: Microbial Cell Factories 2014 13:127
    Content type: Research Published on:

  17. The methylotrophic yeast Pichia pastoris is frequently used for the production of recombinant proteins. However, expression levels can vary depending on the target protein. Allowing for simultaneous regulation of...

    Authors: Claudia Ruth, Markus Buchetics, Viktorija Vidimce, Daniela Kotz, Stefan Naschberger, Diethard Mattanovich, Harald Pichler and Brigitte Gasser
    Citation: Microbial Cell Factories 2014 13:120
    Content type: Research Published on:

  18. The most successful polyhydroxyalkanoate (PHA) in medical applications is poly(4-hydroxybutyrate) (P4HB), which is due to its biodegradability, biocompatibility and mechanical properties. One of the major obst...

    Authors: Sylvaine Le Meur, Manfred Zinn, Thomas Egli, Linda Thöny-Meyer and Qun Ren
    Citation: Microbial Cell Factories 2014 13:131
    Content type: Research Published on:

  19. Bacillus subtilis is widely used in agriculture and industrial biotechnology; however, cell autolysis significantly decreases its yield in liquid cultures. Numerous factors mediate the lysis of B. subtilis, such...

    Authors: Yi Wang, Zhenmin Chen, Ruili Zhao, Tingting Jin, Xiaoming Zhang and Xiangdong Chen
    Citation: Microbial Cell Factories 2014 13:129
    Content type: Research Published on:

  20. Especially in western civilizations, immune diseases that are driven by innocuous (auto- or allo-) antigens are gradually evolving to become pandemic threats. A particularly poignant example is type 1 diabetes...

    Authors: Sofie Robert and Lothar Steidler
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S11
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  21. Innovative new genome engineering technologies for manipulating chromosomes have appeared in the last decade. One of these technologies, recombination mediated genetic engineering (recombineering) allows for p...

    Authors: Jan Peter van Pijkeren and Robert A Britton
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S10
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  22. The cell wall of Gram-positive bacteria is a complex assemblage of glycopolymers and proteins. It consists of a thick peptidoglycan sacculus that surrounds the cytoplasmic membrane and that is decorated with t...

    Authors: Marie-Pierre Chapot-Chartier and Saulius Kulakauskas
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S9
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  23. Genome analysis using next generation sequencing technologies has revolutionized the characterization of lactic acid bacteria and complete genomes of all major groups are now available. Comparative genomics ha...

    Authors: François P Douillard and Willem M de Vos
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  24. Lactobacillus rhamnosus GG (LGG) is one of the most widely used probiotic strains. Various health effects are well documented including the prevention and treatment of gastro-intestinal infections and diarrhea, a...

    Authors: Marijke E Segers and Sarah Lebeer
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  25. Metazoans establish with microorganisms complex interactions for their mutual benefits. Drosophila, which has already proven useful host model to study several aspects of innate immunity and host-bacteria pathoge...

    Authors: Renata C Matos and François Leulier
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S6
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  26. The food industry is constantly striving to develop new products to fulfil the ever changing demands of consumers and the strict requirements of regulatory agencies. For foods based on microbial fermentation, ...

    Authors: Patrick MF Derkx, Thomas Janzen, Kim I Sørensen, Jeffrey E Christensen, Birgitte Stuer-Lauridsen and Eric Johansen
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S5
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  27. The human gastrointestinal tract represents an environment which is a densely populated home for a microbiota that has evolved to positively contribute to host health. At birth the essentially sterile gastroin...

    Authors: Francesca Bottacini, Marco Ventura, Douwe van Sinderen and Mary O'Connell Motherway
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S4
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  28. Bacteriocins are heat-stable ribosomally synthesized antimicrobial peptides produced by various bacteria, including food-grade lactic acid bacteria (LAB). These antimicrobial peptides have huge potential as bo...

    Authors: Rodney H Perez, Takeshi Zendo and Kenji Sonomoto
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S3
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  29. This review describes the recent advances made in the studies of the microbial community of complex and undefined cheese starter cultures. We report on work related to the composition of the cultures at the le...

    Authors: Eddy J Smid, Oylum Erkus, Maciej Spus, Judith CM Wolkers-Rooijackers, Svetlana Alexeeva and Michiel Kleerebezem
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S2
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  30. Research on lactic acid bacteria (LAB) has advanced significantly over the past number of decades and these developments have been driven by the parallel advances in technologies such as genomics, bioinformati...

    Authors: Jennifer Mahony, Francesca Bottacini, Douwe van Sinderen and Gerald F Fitzgerald
    Citation: Microbial Cell Factories 2014 13(Suppl 1):S1
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  32. Budding yeasts are often used to secrete foreign proteins, but the efficiency is variable. To identify roadblocks in the yeast secretory pathway, we used a monomeric superfolder GFP (msGFP) as a visual tracer in

    Authors: Ivy Fitzgerald and Benjamin S Glick
    Citation: Microbial Cell Factories 2014 13:125
    Content type: Research Published on:

  33. Recent advances in synthesizing valuable chemicals such as organic acids from low-cost renewable biomass through microbial fermentation have attracted great attention. However, the toxicity of organic acids pr...

    Authors: Han Xiao, Zengyi Shao, Yu Jiang, Sudhanshu Dole and Huimin Zhao
    Citation: Microbial Cell Factories 2014 13:121
    Content type: Research Published on:

  34. Numerous bacterial human growth hormone (hGH) expression methods under conventional fermentation and induction conditions have been described. Despite significant progress made in this area over the past sever...

    Authors: Anna Wojtowicz-Krawiec, Iwona Sokolowska, Maria Smorawinska, Luiza Chojnacka-Puchta, Diana Mikiewicz, Natalia Lukasiewicz, Alina Marciniak-Rusek, Renata Wolinowska, Anna Bierczynska-Krzysik, Anna Joanna Porebska, Jolanta Kuthan-Styczen, Lidia Gurba, Piotr Borowicz, Anna Mazurkiewicz, Grazyna Plucienniczak and Andrzej Plucienniczak
    Citation: Microbial Cell Factories 2014 13:113
    Content type: Research Published on:

  35. Polyketides, such as spinosad, are mainly synthesized in the stationary phase of the fermentation. The synthesis of these compounds requires many primary metabolites, such as acetyl-CoA, propinyl-CoA, NADPH, a...

    Authors: Xiangmei Zhang, Chaoyou Xue, Fanglong Zhao, Dashuai Li, Jing Yin, Chuanbo Zhang, Qinggele Caiyin and Wenyu Lu
    Citation: Microbial Cell Factories 2014 13:98
    Content type: Research Published on:

  36. Styrene is an important building-block petrochemical and monomer used to produce numerous plastics. Whereas styrene bioproduction by Escherichia coli was previously reported, the long-term potential of ...

    Authors: Rebekah McKenna, Brian Thompson, Shawn Pugh and David R Nielsen
    Citation: Microbial Cell Factories 2014 13:123
    Content type: Research Published on:

  37. The methylotrophic yeast, Hansenula polymorpha is an industrially important microorganism, and belongs to the best studied yeast species with well-developed tools for ...

    Authors: Olena O Kurylenko, Justyna Ruchala, Orest B Hryniv, Charles A Abbas, Kostyantyn V Dmytruk and Andriy A Sibirny
    Citation: Microbial Cell Factories 2014 13:122
    Content type: Research Published on:

  38. Succinic acid is well established as bio-based platform chemical with production quantities expecting to increase exponentially within the next decade. Actinobacillus succinogenes is by far the most studied wild ...

    Authors: Hendrik Gideon Brink and Willie Nicol
    Citation: Microbial Cell Factories 2014 13:111
    Content type: Research Published on:

  39. Under N-limiting conditions, Saccharomyces cerevisiae strains display a substantial variability in their biomass yield from consumed nitrogen -in particular wine yeasts exhibit high growth abilities- that is corr...

    Authors: Lucie Crépin, Isabelle Sanchez, Thibault Nidelet, Sylvie Dequin and Carole Camarasa
    Citation: Microbial Cell Factories 2014 13:109
    Content type: Research Published on:

  40. Peptides are increasingly used in industry as highly functional materials. Bacterial production of recombinant peptides has the potential to provide large amounts of renewable and low cost peptides, however, a...

    Authors: Michele Bruschi, Jens O Krömer, Jennifer A Steen and Lars K Nielsen
    Citation: Microbial Cell Factories 2014 13:99
    Content type: Research Published on:

  41. Itaconic acid is on the DOE (Department of Energy) top 12 list of biotechnologically produced building block chemicals and is produced commercially by Aspergillus terreus. However, the production cost of itaconic...

    Authors: Xuenian Huang, Mei Chen, Xuefeng Lu, Yueming Li, Xia Li and Jian-Jun Li
    Citation: Microbial Cell Factories 2014 13:108
    Content type: Research Published on:

  42. Vibrio pathogens are causative agents of mid-culture outbreaks, and early mortality syndrome and secondary aetiology of most dreadful viral outbreaks in shrimp aquaculture. Among the pathogenic vibrios group, Vib...

    Authors: George Seghal Kiran, Anuj Nishanth Lipton, Sethu Priyadharshini, Kumar Anitha, Lucia Elizabeth Cruz Suárez, Mariadhas Valan Arasu, Ki Choon Choi, Joseph Selvin and Naif Abdullah Al-Dhabi
    Citation: Microbial Cell Factories 2014 13:114
    Content type: Research Published on:

    The Correction to this article has been published in Microbial Cell Factories 2021 20:21

  43. One-pot multi-step biocatalysis is advantageous over step-by-step synthesis as it reduces the number of process operation units, leading to significant process intensification. Whole-cell biocatalysis with met...

    Authors: Nora Weber, Marie Gorwa-Grauslund and Magnus Carlquist
    Citation: Microbial Cell Factories 2014 13:118
    Content type: Research Published on:

  44. Recombinant antibodies are highly successful in many different pathological conditions and currently enjoy overwhelming recognition of their potential. There are a wide variety of protein expression systems av...

    Authors: Ana Blanco-Toribio, Javier Lacadena, Natalia Nuñez-Prado, Ana Álvarez-Cienfuegos, Maider Villate, Marta Compte, Laura Sanz, Francisco J Blanco and Luis Álvarez-Vallina
    Citation: Microbial Cell Factories 2014 13:116
    Content type: Research Published on:

  45. Development of mucosal vaccines strongly relies on an efficient delivery system and, over the years, a variety of approaches based on phages, bacteria or synthetic nanoparticles have been proposed to display a...

    Authors: Ezio Ricca, Loredana Baccigalupi, Giuseppina Cangiano, Maurilio De Felice and Rachele Isticato
    Citation: Microbial Cell Factories 2014 13:115
    Content type: Review Published on:

  47. Ergot alkaloids are a group of highly bioactive molecules produced by a number of filamentous fungi. These compounds have been intensely studied for decades, mainly due to their deleterious effects in contamin...

    Authors: Curt AF Nielsen, Christophe Folly, Anaëlle Hatsch, Andrea Molt, Hartwig Schröder, Sarah E O’Connor and Michael Naesby
    Citation: Microbial Cell Factories 2014 13:95
    Content type: Research Published on:

  48. Itaconic acid, which has been declared to be one of the most promising and flexible building blocks, is currently used as monomer or co-monomer in the polymer industry, and produced commercially by Aspergillus te...

    Authors: Xuenian Huang, Xuefeng Lu, Yueming Li, Xia Li and Jian-Jun Li
    Citation: Microbial Cell Factories 2014 13:119
    Content type: Research Published on:

  49. A previously discovered mutant of Saccharomyces cerevisiae alcohol dehydrogenase 1 (Adh1p) was shown to enable a unique NADH-dependent reduction of 5-hydroxymethylfurfural (HMF), a well-known inhibitor of yeast f...

    Authors: Boaz Laadan, Valeria Wallace-Salinas, Åsa Janfalk Carlsson, João RM Almeida, Peter Rådström and Marie F Gorwa-Grauslund
    Citation: Microbial Cell Factories 2014 13:112
    Content type: Research Published on:

  50. Microalgae have been an emerging biofuel resource; however, the germplasm improvement has been slow due to the lack of molecular tools. Pyruvate dehydrogenase kinase (PDK) deactivates the pyruvate dehydrogenas...

    Authors: Yu-Han Ma, Xiang Wang, Ying-Fang Niu, Zhi-Kai Yang, Meng-Han Zhang, Zhong-Ming Wang, Wei-Dong Yang, Jie-Sheng Liu and Hong-Ye Li
    Citation: Microbial Cell Factories 2014 13:100
    Content type: Research Published on:
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Microbial Cell Factories is a companion journal to:

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Microbial Cell Factories

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