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Research
γ-Linolenic acid (GLA) is important because of its nutritional value and medicinal applications. Although the biosynthetic pathways of some plant and microbial GLA have been deciphered, current understanding o...
Microbial Cell Factories 2017 16:113
Published on: 21 June 2017
Research
Citramalate, a chemical precursor to the industrially important methacrylic acid (MAA), can be synthesized using Escherichia coli overexpressing citramalate synthase (cimA gene). Deletion of gltA encoding citrate...
Microbial Cell Factories 2017 16:114
Published on: 21 June 2017
Research
Lactofen, a member of the diphenylether herbicides, has high activity and is commonly used to control broadleaf weeds. As a post-emergent herbicide, it is directly released to the environment, and easily cause...
Microbial Cell Factories 2017 16:112
Published on: 19 June 2017
Research
The production of recombinant proteins containing disulfide bonds in Escherichia coli is challenging. In most cases the protein of interest needs to be either targeted to the oxidizing periplasm or expressed in t...
Microbial Cell Factories 2017 16:108
Published on: 15 June 2017
Research
The expression of the Gloeobacter rhodopsin (GR) in a chemotrophic Escherichia coli enables the light-driven phototrophic energy generation. Adaptive laboratory evolution has been used for acquiring desired pheno...
Microbial Cell Factories 2017 16:111
Published on: 15 June 2017
Research
Phaseolamin or α-amylase inhibitor 1 (αAI) is a glycoprotein from common beans (Phaseolus vulgaris L.) that inhibits some insect and mammalian α-amylases. Several clinical studies support the beneficial use of be...
Microbial Cell Factories 2017 16:110
Published on: 15 June 2017
Research
Acetic acid bacteria (AAB) are widely applied in food, bioengineering and medicine fields. However, the acid stress at low pH conditions limits acetic acid fermentation efficiency and high concentration of vin...
Microbial Cell Factories 2017 16:109
Published on: 15 June 2017
Erratum
Microbial Cell Factories 2017 16:107
Published on: 14 June 2017
The original article was published in Microbial Cell Factories 2015 14:170
Research
21-deoxycortisol (21-DF) is the key intermediate to manufacture pharmaceutical glucocorticoids. Recently, a Japan patent has realized 21-DF production via biotransformation of 17-hydroxyprogesterone (17-OHP) b...
Microbial Cell Factories 2017 16:105
Published on: 13 June 2017
Review
Whole-cell biocatalysts provide unique advantages and have been widely used for the efficient biosynthesis of value-added fine and bulk chemicals, as well as pharmaceutically active ingredients. What is more, ...
Microbial Cell Factories 2017 16:106
Published on: 13 June 2017
Erratum
Microbial Cell Factories 2017 16:102
Published on: 12 June 2017
The original article was published in Microbial Cell Factories 2017 16:69
Research
4-Hydroxycinnamyl alcohols are a class of natural plant secondary metabolites that include p-coumaryl alcohol, caffeyl alcohol, coniferyl alcohol and sinapyl alcohol, and have physiological, ecological and biomed...
Microbial Cell Factories 2017 16:104
Published on: 12 June 2017
Research
Genome mining facilitated by heterologous systems is an emerging approach to access the chemical diversity encoded in basidiomycete genomes. In this study, three sesquiterpene synthase genes, GME3634, GME3638,...
Microbial Cell Factories 2017 16:103
Published on: 12 June 2017
Research
Nocamycins I and II, produced by the rare actinomycete Saccharothrix syringae, belong to the tetramic acid family natural products. Nocamycins show potent antimicrobial activity and they hold great potential for ...
Microbial Cell Factories 2017 16:100
Published on: 9 June 2017
Research
Oleaginous fungi can accumulate lipids by utilizing a wide range of waste substrates. They are an important source for the industrial production of omega-6 polyunsaturated fatty acids (gamma-linolenic and arac...
Microbial Cell Factories 2017 16:101
Published on: 9 June 2017
Technical notes
A commonly used approach to improve recombinant protein production is to increase the levels of expression by providing extra-copies of a heterologous gene. In Komagataella phaffii (Pichia pastoris) this is usual...
Microbial Cell Factories 2017 16:99
Published on: 8 June 2017
Research
Sucrose is an naturally abundant and easily fermentable feedstock for various biochemical production processes. By now, several sucrose utilization pathways have been identified and characterized. Among them, ...
Microbial Cell Factories 2017 16:98
Published on: 6 June 2017
Research
Heterologous expression of biosynthetic gene clusters of natural microbial products has become an essential strategy for titer improvement and pathway engineering of various potentially-valuable natural produc...
Microbial Cell Factories 2017 16:96
Published on: 31 May 2017
Research
The sexual stages of Plasmodium falciparum are responsible for the spread of the parasite in malaria endemic areas. The cysteine-rich Pfs48/45 protein, exposed on the surface of sexual stages, is one of the most ...
Microbial Cell Factories 2017 16:97
Published on: 31 May 2017
Research
Sophorolipids are one of the most promising glycolipid biosurfactants and have been successfully employed in bioremediation and various other industrial sectors. They have also been described to exhibit antimi...
Microbial Cell Factories 2017 16:95
Published on: 30 May 2017
Research
The biosynthesis pathway of benzoxazole compounds caboxamycin and nataxazole have been recently elucidated. Both compounds share one of their precursors, 3-hydroxyanthranilate (two units in the case of nataxaz...
Microbial Cell Factories 2017 16:93
Published on: 25 May 2017
Research
Clostridium perfringens is an important animal and human pathogen that can produce more than 16 different major and minor toxins. The beta-2 minor toxin (CPB2), comprising atypical and...
Microbial Cell Factories 2017 16:94
Published on: 25 May 2017
Research
Microbial secondary metabolism is regulated by a complex and mostly-unknown network of global and pathway-specific regulators. A dozen biosynthetic gene clusters for secondary metabolites have been reported in...
Microbial Cell Factories 2017 16:92
Published on: 23 May 2017
Research
Levan has been traditionally produced from microorganism. However, there is a continuous effort in looking for new strains that improve levan production yield and uses alternative sugar sources for growth. Des...
Microbial Cell Factories 2017 16:91
Published on: 23 May 2017
Research
The metabolic engineering of Saccharomyces cerevisiae for the production of succinic acid has progressed dramatically, and a series of high-producing hosts are available. At low cultivation pH and high titers, th...
Microbial Cell Factories 2017 16:90
Published on: 23 May 2017
