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    CRISPR-Cas9 mediated gene deletions in lager yeast Saccharomyces pastorianus

    The ease of use of CRISPR-Cas9 reprogramming, its high efficacy, and its multiplexing capabilities have brought this technology at the forefront of genome editing techniques. Saccharomyces pastorianus is an aneup...

    Arthur R. Gorter de Vries, Philip A. de Groot, Marcel van den Broek and Jean-Marc G. Daran

    Microbial Cell Factories 2017 16:222

    Published on: 5 December 2017

  2. Research

    Severe inhibition of lipooligosaccharide synthesis induces TLR2-dependent elimination of Mycobacterium marinum from THP1-derived macrophages

    Although mycobacterial glycolipids are among the first-line molecules involved in host–pathogen interactions, their contribution in virulence remains incomplete. Mycobacterium marinum is a waterborne pathogen of ...

    Izabela Szulc-Kielbik, Jakub Pawelczyk, Michal Kielbik, Laurent Kremer, Jaroslaw Dziadek and Magdalena Klink

    Microbial Cell Factories 2017 16:217

    Published on: 28 November 2017

  3. Research

    Ochrobactrum sp. MPV1 from a dump of roasted pyrites can be exploited as bacterial catalyst for the biogenesis of selenium and tellurium nanoparticles

    Bacteria have developed different mechanisms for the transformation of metalloid oxyanions to non-toxic chemical forms. A number of bacterial isolates so far obtained in axenic culture has shown the ability to...

    Emanuele Zonaro, Elena Piacenza, Alessandro Presentato, Francesca Monti, Rossana Dell’Anna, Silvia Lampis and Giovanni Vallini

    Microbial Cell Factories 2017 16:215

    Published on: 28 November 2017


    Bacterial magnetosomes as an efficient gene delivery platform for cancer theranostics

    Gene therapy has gained an increasing interest in its anti-tumor efficiency. However, numerous efforts are required to promote them to clinics. In this study, a novel and efficient delivery platform based on b...

    Qinglei Dai, Ruimin Long, Shibin Wang, Ranjith Kumar Kankala, Jiaojiao Wang, Wei Jiang and Yuangang Liu

    Microbial Cell Factories 2017 16:216

    Published on: 28 November 2017


    Surface display of ACC deaminase on endophytic Enterobacteriaceae strains to increase saline resistance of host rice sprouts by regulating plant ethylene synthesis

    Most endophytic bacteria in consortia, which provide robust and broad metabolic capacity, are attractive for applications in plant metabolic engineering. The aim of this study was to investigate the effects of...

    Yupei Liu, Lixiang Cao, Hongming Tan and Renduo Zhang

    Microbial Cell Factories 2017 16:214

    Published on: 28 November 2017


    Conversion of xylan by recyclable spores of Bacillus subtilis displaying thermophilic enzymes

    The Bacillus subtilis spore has long been used to display antigens and enzymes. Spore display can be accomplished by a recombinant and a non-recombinant approach, with the latter proved more efficient than the re...

    Rosanna Mattossovich, Roberta Iacono, Giuseppina Cangiano, Beatrice Cobucci-Ponzano, Rachele Isticato, Marco Moracci and Ezio Ricca

    Microbial Cell Factories 2017 16:218

    Published on: 28 November 2017

  7. Research

    Non-sterilized fermentation of high optically pure d-lactic acid by a genetically modified thermophilic Bacillus coagulans strain

    Optically pure d-lactic acid (≥ 99%) is an important precursor of polylactic acid. However, there are relatively few studies on d-lactic acid fermentation compared with the extensive investigation of l-lactic aci...

    Caili Zhang, Cheng Zhou, Nilnate Assavasirijinda, Bo Yu, Limin Wang and Yanhe Ma

    Microbial Cell Factories 2017 16:213

    Published on: 25 November 2017

  8. Research

    Metabolic engineering of Synechococcus elongatus PCC 7942 for improvement of 1,3-propanediol and glycerol production based on in silico simulation of metabolic flux distribution

    Production directly from carbon dioxide by engineered cyanobacteria is one of the promising technologies for sustainable future. Previously, we have successfully achieved 1,3-propanediol (1,3-PDO) production u...

    Yasutaka Hirokawa, Shingo Matsuo, Hiroyuki Hamada, Fumio Matsuda and Taizo Hanai

    Microbial Cell Factories 2017 16:212

    Published on: 25 November 2017

  9. Research

    Production of highly efficient cellulase mixtures by genetically exploiting the potentials of Trichoderma reesei endogenous cellulases for hydrolysis of corncob residues

    Trichoderma reesei is one of the most important fungi utilized for cellulase production. However, its cellulase system has been proven to be present in suboptimal ratio for deconstruct...

    Yuanchao Qian, Lixia Zhong, Jia Gao, Ningning Sun, Yifan Wang, Guoyong Sun, Yinbo Qu and Yaohua Zhong

    Microbial Cell Factories 2017 16:207

    Published on: 21 November 2017

  10. Research

    Production of d-lactate from glucose using Klebsiella pneumoniae mutants

    d-Lactate is a valued chemical which can be produced by some bacteria including Klebsiella pneumoniae. However, only a few studies have focused on K. pneumoniae for d-lactate productio...

    Xinjun Feng, Liqun Jiang, Xiaojuan Han, Xiutao Liu, Zhiqiang Zhao, Huizhou Liu, Mo Xian and Guang Zhao

    Microbial Cell Factories 2017 16:209

    Published on: 21 November 2017

  11. Research

    Metabolism of aromatics by Trichosporon oleaginosus while remaining oleaginous

    The oleaginous yeast, Trichosporon oleaginosus, has been extensively studied for its ability to metabolize non-conventional feedstocks. These include phenol-containing waste streams, such as distillery wastewater...

    Allison Yaguchi, Alana Robinson, Erin Mihealsick and Mark Blenner

    Microbial Cell Factories 2017 16:206

    Published on: 17 November 2017

  12. Research

    Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution

    There is a need to replace petroleum-derived with sustainable feedstocks for chemical production. Certain biomass feedstocks can meet this need as abundant, diverse, and renewable resources. Specific ionic liq...

    Elsayed T. Mohamed, Shizeng Wang, Rebecca M. Lennen, Markus J. Herrgård, Blake A. Simmons, Steven W. Singer and Adam M. Feist

    Microbial Cell Factories 2017 16:204

    Published on: 16 November 2017

  13. Research

    Regulation of antimicrobial activity and xenocoumacins biosynthesis by pH in Xenorhabdus nematophila

    Xenocoumacin 1 (Xcn1) and Xenocoumacin 2 (Xcn2) are the main antimicrobial compounds produced by Xenorhabdus nematophila. Culture conditions, including pH, had remarkably distinct effects on the antimicrobial act...

    Shuqi Guo, Shujing Zhang, Xiangling Fang, Qi Liu, Jiangtao Gao, Muhammad Bilal, Yonghong Wang and Xing Zhang

    Microbial Cell Factories 2017 16:203

    Published on: 15 November 2017

  14. Research

    Profiling of Saccharomyces cerevisiae transcription factors for engineering the resistance of yeast to lignocellulose-derived inhibitors in biomass conversion

    Yeast transcription factors (TFs) involved in the regulation of multidrug resistance (MDR) were investigated in experiments with deletion mutants, transformants overexpressing synthetic genes encoding TFs, and...

    Guochao Wu, Zixiang Xu and Leif J. Jönsson

    Microbial Cell Factories 2017 16:199

    Published on: 14 November 2017

  15. Commentary

    Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase

    Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions. PEGylation has become a sophis...

    Yanying Xu, Yueyuan Shi, Jianzhong Zhou, Wei Yang, Lei Bai, Shilei Wang, Xin Jin, Qiangsi Niu, Ailong Huang and Deqiang Wang

    Microbial Cell Factories 2017 16:197

    Published on: 14 November 2017

  16. Research

    LesR is a novel upstream regulator that controls downstream Clp expression to modulate antibiotic HSAF biosynthesis and cell aggregation in Lysobacter enzymogenes OH11

    Heat-stable antifungal factor (HSAF) is a polycyclic tetramate macrolactam secondary metabolite that exhibits broad-spectrum inhibitory activities against filamentous fungal pathogens. The native yield of this...

    Huiyong Xu, Ruping Wang, Yangyang Zhao, Zheng Qing Fu, Guoliang Qian and Fengquan Liu

    Microbial Cell Factories 2017 16:202

    Published on: 14 November 2017

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