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  1. Benzylisoquinoline alkaloids (BIAs) are a type of secondary metabolite with clinical application value. (S)-stylopine is a special BIA which contains methylenedioxy bridge structures. CYP719As could catalyze the ...

    Authors: Xiuyu Liu, Xiang Jiao, Yatian Cheng, Ying Ma, Junling Bu, Baolong Jin, Qishuang Li, Zhimin Hu, Jinfu Tang, Changjiangsheng Lai, Jian Wang, Guanghong Cui, Yun Chen, Juan Guo and Luqi Huang
    Citation: Microbial Cell Factories 2023 22:23
  2. Pseudomonas putida DOT-T1E is a highly solvent tolerant strain for which many genetic tools have been developed. The strain represents a promising candidate host for the synthesis of aromatic compounds—opening a ...

    Authors: Ana García-Franco, Patricia Godoy, Estrella Duque and Juan Luis Ramos
    Citation: Microbial Cell Factories 2023 22:22
  3. Despite recent advances in genetic engineering tools for effectively regulating and manipulating genes, efficient simultaneous multigene insertion methods have not been established in Bacillus subtilis. To date, ...

    Authors: Jordi Ferrando, Oriana Filluelo, Daniel R. Zeigler and Pere Picart
    Citation: Microbial Cell Factories 2023 22:21
  4. 4-Androstene-3,17-dione (4-AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (BA) are the most important and representative C19- and C22-steroidal materials. The optimalization of sterol production with mycobact...

    Authors: Shikui Song, Jianxin He, Meng Gao, Yongqi Huang, Xiyao Cheng and Zhengding Su
    Citation: Microbial Cell Factories 2023 22:19
  5. Although Levan-type fructooligosaccharides (L-FOS) have been shown to exhibit prebiotic properties, no efficient methods for their large-scale production have been proposed. One alternative relies on the simul...

    Authors: Ángela Ávila-Fernández, Silvia Montiel, María Elena Rodríguez-Alegría, Luis Caspeta and Agustín López Munguía
    Citation: Microbial Cell Factories 2023 22:18
  6. The tobacco leaf–derived cembratriene-ol exhibits anti-insect effects, but its content in plants is scarce. Cembratriene-ol is difficult and inefficiently chemically synthesised due to its complex structure. M...

    Authors: Haiquan Yang, Kunjie Zhang, Wei Shen, Lei Chen, Yuanyuan Xia, Wei Zou, Yu Cao and Xianzhong Chen
    Citation: Microbial Cell Factories 2023 22:17
  7. The large application potential of microbiomes has led to a great need for mixed culture methods. However, microbial interactions can compromise the maintenance of biodiversity during cultivation in a reactor....

    Authors: Alexis Dijamentiuk, Cécile Mangavel, Annelore Elfassy, Florentin Michaux, Jennifer Burgain, Emmanuel Rondags, Stéphane Delaunay, Sandie Ferrigno, Anne-Marie Revol-Junelles and Frédéric Borges
    Citation: Microbial Cell Factories 2023 22:16
  8. Spinosad is a macrolide insecticide with the tetracyclic lactone backbone to which forosamine and tri-o-methylrhamnose are attached. Both the sugar moieties are essential for its insecticidal activity. In biosynt...

    Authors: Xiaochen Li, Ruofei Guo, Ji Luan, Jun Fu, Youming Zhang and Hailong Wang
    Citation: Microbial Cell Factories 2023 22:15
  9. Pseudomonas putida has received increasing interest as a cell factory due to its remarkable features such as fast growth, a versatile and robust metabolism, an extensive genetic toolbox and its high tolerance to ...

    Authors: Lyon Bruinsma, Maria Martin-Pascual, Kesi Kurnia, Marieken Tack, Simon Hendriks, Richard van Kranenburg and Vitor A. P. Martins dos Santos
    Citation: Microbial Cell Factories 2023 22:14
  10. Gene expression data of cell cultures is commonly measured in biological and medical studies to understand cellular decision-making in various conditions. Metabolism, affected but not solely determined by the ...

    Authors: Haoyang Yao, Sanjeev Dahal and Laurence Yang
    Citation: Microbial Cell Factories 2023 22:13
  11. Microalgae are considered a suitable production platform for high-value lipids and oleochemicals. Several species including Nannochloropsis oceanica produce large amounts of essential ...

    Authors: Christian Südfeld, Aamna Kiyani, Katrin Wefelmeier, René H. Wijffels, Maria J. Barbosa and Sarah D’Adamo
    Citation: Microbial Cell Factories 2023 22:12
  12. L-cysteine is an essential chemical building block in the pharmaceutical-, cosmetic-, food and agricultural sector. Conventionally, L-cysteine production relies on the conversion of keratinous biomass mediated...

    Authors: Kevin Heieck, Nathanael David Arnold and Thomas Bartholomäus Brück
    Citation: Microbial Cell Factories 2023 22:10
  13. A number of antimicrobial peptides (AMPs) hold promise as new drugs owing to their potent bactericidal activity and because they are often refractory to the development of drug resistance. Cryptdins (Crps) are...

    Authors: Yuchi Song, Yi Wang, Shaonan Yan, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe and Tomoyasu Aizawa
    Citation: Microbial Cell Factories 2023 22:9
  14. Purification of L-methionine γ-lyase (MGL) from A. fumigatus was sequentially conducted using heat treatment and gel filtration, resulting in 3.04 of purification fold and 73.9% of enzymatic recovery. The molecul...

    Authors: Mahmoud H. Hendy, Amr H. Hashem, Waleed B. Sulieman, Mahmoud H. Sultan and Mohamed Abdelraof
    Citation: Microbial Cell Factories 2023 22:8
  15. The oleaginous yeast Yarrowia lipolytica is increasingly used as a chassis strain for generating bioproducts. Several hybrid promoters with different strengths have been developed by combining multiple copies of ...

    Authors: Lea Vidal, Esteban Lebrun, Young-Kyoung Park, Guillaume Mottet and Jean-Marc Nicaud
    Citation: Microbial Cell Factories 2023 22:7
  16. Phaeodactylum tricornutum (Pt) is a critical microbial cell factory to produce a wide spectrum of marketable products including recombinant biopharmaceutical N-glycoproteins. N-glycosylation modification of prote...

    Authors: Xihui Xie, Jianchao Yang, Hong Du, Jichen Chen, Edmond Sanganyado, Yangmin Gong, Hua Du, Weizhou Chen, Zhengyi Liu and Xiaojuan Liu
    Citation: Microbial Cell Factories 2023 22:6
  17. New antibiotics are urgently needed in clinical treatment of superdrug-resistant bacteria. Nonribosomal peptides (NRPs) are a major source of antibiotics because they exhibit structural diversity, and unique a...

    Authors: Kan Jiang, Ximing Chen, Wei Zhang, Yehong Guo and Guangxiu Liu
    Citation: Microbial Cell Factories 2023 22:5
  18. The metabolic potency of fungi as camptothecin producer elevates their prospective use as an industrial platform for commercial production, however, the loss of camptothecin productivity by fungi with the stor...

    Authors: Ashraf S. A. El-Sayed, Nelly M. George, Amira Abou-Elnour, Rasha M. El-Mekkawy and Marwa M. El-Demerdash
    Citation: Microbial Cell Factories 2023 22:4
  19. Corynebacterium glutamicum has industrial track records for producing a variety of valuable products such as amino acids. Although CRISPR-based genome editing technologies have undergone immense developments in r...

    Authors: Rui Su, Ting Wang, Taidong Bo, Ningyun Cai, Meng Yuan, Chen Wu, Hao Jiang, Huadong Peng, Ning Chen and Yanjun Li
    Citation: Microbial Cell Factories 2023 22:3
  20. Two laccase isoenzymes (LacA and LacB) were isolated from a novel Trichoderma harzianum S7113 isolate employing ammonium sulfate precipitation, Sephadex G100, and DEAE Sepharose ion exchange chromatography. The m...

    Authors: Alshaimaa M. Elsayed, Mohamed Mahmoud, Ghada S. A. Abdel Karim, Mohamed Abdelraof and Abdelmageed M. Othman
    Citation: Microbial Cell Factories 2023 22:1
  21. Over the 70 years since the introduction of plastic into everyday items, plastic waste has become an increasing problem. With over 360 million tonnes of plastics produced every year, solutions for plastic recy...

    Authors: Raphael Loll-Krippleber, Victoria A. Sajtovich, Michael W. Ferguson, Brandon Ho, Andrew R. Burns, Brandon J. Payliss, Joseph Bellissimo, Sydney Peters, Peter J. Roy, Haley D. M. Wyatt and Grant W. Brown
    Citation: Microbial Cell Factories 2022 21:280
  22. Melanin is a natural pigment that can be applied in different fields such as medicine, environment, pharmaceutical, and nanotechnology. Studies carried out previously showed that the melanin produced by the mel1 ...

    Authors: William Bartolomeu Medeiros, Kelly Johana Dussán Medina and Sandra Regina Pombeiro Sponchiado
    Citation: Microbial Cell Factories 2022 21:278
  23. The biosynthesis of silver nanoparticles (AgNPs) is an area of interest for researchers due to its eco-friendly approach. The use of biological approaches provides a clean and promising alternative process for...

    Authors: Hany M. Abdelmoneim, Tarek H. Taha, Mohamed S. Elnouby and Hala Mohamed AbuShady
    Citation: Microbial Cell Factories 2022 21:277
  24. Poly γ-glutamic acid (γ-PGA) is a promising biopolymer for various applications. For glutamic acid-independent strains, the titer of γ-PGA is too low to meet the industrial demand. In this study, we isolated a...

    Authors: Dexin Wang, Xiaoping Fu, Dasen Zhou, Jiaqi Gao and Wenqin Bai
    Citation: Microbial Cell Factories 2022 21:276
  25. Itaconic acid, an unsaturated C5 dicarbonic acid, has significant market demand and prospects. It has numerous biological functions, such as anti-cancer, anti-inflammatory, and anti-oxidative in medicine, and ...

    Authors: Jiao Feng, Chunqiu Li, Hao He, Sheng Xu, Xin Wang and Kequan Chen
    Citation: Microbial Cell Factories 2022 21:275
  26. Extremolytes enable microbes to withstand even the most extreme conditions in nature. Due to their unique protective properties, the small organic molecules, more and more, become high-value active ingredients...

    Authors: Lukas Jungmann, Sarah Lisa Hoffmann, Caroline Lang, Raphaela De Agazio, Judith Becker, Michael Kohlstedt and Christoph Wittmann
    Citation: Microbial Cell Factories 2022 21:274
  27. Clostridium thermocellum is a promising candidate for consolidated bioprocessing of lignocellulosic biomass to ethanol. The low ethanol tolerance of this microorganism is one of the remaining obstacles to industr...

    Authors: Teun Kuil, Johannes Yayo, Johanna Pechan, Jan Küchler and Antonius J. A. van Maris
    Citation: Microbial Cell Factories 2022 21:273
  28. Raw starch-degrading enzyme (RSDE) is applied in biorefining of starch to produce biofuels efficiently and economically. At present, RSDE is obtained via secretion by filamentous fungi such as Penicillium oxalicu...

    Authors: Shuai Zhao, Ming-Zhu Tan, Rui-Xian Wang, Fa-Ting Ye, Yuan-Peng Chen, Xue-Mei Luo and Jia-Xun Feng
    Citation: Microbial Cell Factories 2022 21:272
  29. α-Humulene is an important biologically active sesquiterpene, whose heterologous production in microorganisms is a promising alternative biotechnological process to plant extraction and chemical synthesis. In ...

    Authors: Qi Guo, Qian-Qian Peng, Ying-Ying Chen, Ping Song, Xiao-Jun Ji, He Huang and Tian-Qiong Shi
    Citation: Microbial Cell Factories 2022 21:271
  30. Resveratrol is a plant-derived phenylpropanoid with diverse biological activities and pharmacological applications. Plant-based extraction could not satisfy ever-increasing market demand, while chemical synthe...

    Authors: Mengyao Zhang, Qidou Gao, Yijuan Liu, Zhumei Fang, Zhiwei Gong, Zongbao K. Zhao and Xiaobing Yang
    Citation: Microbial Cell Factories 2022 21:270
  31. 2-Phenylethanol (2-PE), a higher alcohol with a rose-like odor, inhibits growth of the producer strains. However, the limited knowledge regarding 2-PE tolerance mechanisms renders our current knowledge base in...

    Authors: Huili Xia, Yue Kang, Zilin Ma, Cuiyu Hu, Qiao Yang, Xiaoling Zhang, Shihui Yang, Jun Dai and Xiong Chen
    Citation: Microbial Cell Factories 2022 21:269
  32. The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that ...

    Authors: Ramon Roca-Pinilla, Leszek Lisowski, Anna Arís and Elena Garcia-Fruitós
    Citation: Microbial Cell Factories 2022 21:267
  33. Genetic modifications in Bacillus subtilis have allowed the conversion of myo-inositol into scyllo-inositol, which is proposed as a therapeutic agent for Alzheimer’s disease. This conversion comprises two reactio...

    Authors: Yuzheng Wu, Honami Kawabata, Kyosuke Kita, Shu Ishikawa, Kan Tanaka and Ken-ichi Yoshida
    Citation: Microbial Cell Factories 2022 21:266
  34. Continuous processing with enzyme reuse is a well-known engineering strategy to enhance the efficiency of biocatalytic transformations for chemical synthesis. In one-pot multistep reactions, continuous process...

    Authors: Katharina N. Schwaiger and Bernd Nidetzky
    Citation: Microbial Cell Factories 2022 21:265
  35. The immobilized technology for microbial or cells has the advantages of high microbial activity, high microbial density per unit space, good tolerance, strong shock, load resistance, high processing efficiency...

    Authors: Zhi-Hao Zhong and Yu-Qing Zhang
    Citation: Microbial Cell Factories 2022 21:264
  36. Phospholipase D (PLD) is highly valuable in the food and medicine industries, where it is used to convert low-cost phosphatidylcholine into high-value phospholipids (PLs). Despite being overexpressed in Streptomy...

    Authors: Juntan Wang, Haihua Zhu, Huiyi Shang, Bishan Guo, Mengxue Zhang, Fayun Wang, Lipan Zhang, Jun Xu and Hui Wang
    Citation: Microbial Cell Factories 2022 21:263
  37. Pyocyanin, a specific extracellular secondary metabolite pigment produced by Pseudomonas aeruginosa, exhibits redox activity and has toxic effects on mammalian cells, making it a new and potent alternative for tr...

    Authors: Ahmed A. Abdelaziz, Amal M. Abo Kamer, Khaled B. Al-Monofy and Lamiaa A. Al-Madboly
    Citation: Microbial Cell Factories 2022 21:262
  38. Antarctica has one of the most extreme environments in the world. This region is inhabited by specifically adapted microorganisms that produce various unique secondary metabolites (e.g. pigments) enabling thei...

    Authors: Michal Styczynski, Agata Rogowska, Christine Nyabayo, Przemyslaw Decewicz, Filip Romaniuk, Cezary Pączkowski, Anna Szakiel, Roderich Suessmuth and Lukasz Dziewit
    Citation: Microbial Cell Factories 2022 21:261
  39. Membrane proteins (MPs) are an important class of molecules with a wide array of cellular functions and are part of many metabolic pathways. Despite their great potential—as therapeutic drug targets or in micr...

    Authors: Chiara Guidi, Lien De Wannemaeker, Jasmine De Baets, Wouter Demeester, Jo Maertens, Brecht De Paepe and Marjan De Mey
    Citation: Microbial Cell Factories 2022 21:260
  40. Owing to CRISPR-Cas9 and derivative technologies, genetic studies on microorganisms have dramatically increased. However, the CRISPR-Cas9 system is still difficult to utilize in many wild-type Bacillus strains ow...

    Authors: Man Su Kim, Da-Eun Jeong and Soo-Keun Choi
    Citation: Microbial Cell Factories 2022 21:259
  41. Expression of affinity-tagged recombinant proteins for crystallography, protein–protein interaction, antibody generation, therapeutic applications, etc. mandates the generation of high-yield soluble proteins. ...

    Authors: Amruta A. Shendge and Jacinta S. D’Souza
    Citation: Microbial Cell Factories 2022 21:258
  42. Spray drying is the most cost-effective production method for lactic acid bacteria starters, but heat and oxidative stresses result in low survival rates. The heat stress and oxidative stress tolerance of Lactica...

    Authors: Chenchen Zhang, Haohao Cheng, Yuemei Han, Yunchao Wa, Dawei Chen, Chengran Guan, Yujun Huang and Ruixia Gu
    Citation: Microbial Cell Factories 2022 21:257
  43. The global market for sweeteners is increasing, and the food industry is constantly looking for new low-caloric sweeteners. The natural sweetener 5-keto-d-fructose is one such candidate. 5-Keto-d-fructose has a s...

    Authors: Svenja Battling, Tobias Engel, Elena Herweg, Paul-Joachim Niehoff, Matthias Pesch, Theresa Scholand, Marie Schöpping, Nina Sonntag and Jochen Büchs
    Citation: Microbial Cell Factories 2022 21:255
  44. Rhodosporidium toruloides is capable of co-utilization of complex carbon sources and robust growth from lignocellulosic hydrolysates. This oleaginous yeast is therefore an attractive host for heterologous produc...

    Authors: Peter B. Otoupal, Gina M. Geiselman, Asun M. Oka, Carolina A. Barcelos, Hemant Choudhary, Duy Dinh, Wenqing Zhong, HeeJin Hwang, Jay D. Keasling, Aindrila Mukhopadhyay, Eric Sundstrom, Robert W. Haushalter, Ning Sun, Blake A. Simmons and John M. Gladden
    Citation: Microbial Cell Factories 2022 21:254

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