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  1. Content type: Research

    Saccharomyces cerevisiae is a suitable host for the industrial production of pyruvate-derived chemicals such as ethanol and 2,3-butanediol (23BD). For the improvement of the productivity of these chemicals, it is...

    Authors: Keisuke Morita, Fumio Matsuda, Koji Okamoto, Jun Ishii, Akihiko Kondo and Hiroshi Shimizu

    Citation: Microbial Cell Factories 2019 18:177

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  2. Content type: Research

    Yarrowia lipolytica is an unconventional yeast with a huge industrial potential. Despite many advantages for biotechnological applications, it possesses enormous demand for oxygen, which is a bottleneck in large ...

    Authors: Aleksandra M. Mirończuk, Katarzyna E. Kosiorowska, Anna Biegalska, Magdalena Rakicka-Pustułka, Mateusz Szczepańczyk and Adam Dobrowolski

    Citation: Microbial Cell Factories 2019 18:176

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  3. Content type: Research

    Herbicidin F has an undecose tricyclic furano-pyrano-pyran structure with post-decorations. It was detected from Streptomyces mobaraensis US-43 fermentation broth as a trace component by HPLC–MS analysis. As herb...

    Authors: Yuanyuan Shi, Renjie Gu, Yihong Li, Xinwei Wang, Weicong Ren, Xingxing Li, Lifei Wang, Yunying Xie and Bin Hong

    Citation: Microbial Cell Factories 2019 18:175

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  4. Content type: Research

    Currently, industrial societies are seeking for green alternatives to conventional chemical synthesis. This demand has merged with the efforts to convert lignocellulosic biomass into value-added products. In t...

    Authors: Manuel Nieto-Domínguez, José Alberto Martínez-Fernández, Beatriz Fernández de Toro, Juan A. Méndez-Líter, Francisco Javier Cañada, Alicia Prieto, Laura I. de Eugenio and María Jesús Martínez

    Citation: Microbial Cell Factories 2019 18:174

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  5. Content type: Research

    Bioemulsifiers are surface-active compounds, which exhibit advantages including low toxicity, higher biodegradability and biocompatibility over synthetic chemical surfactants. Despite their potential benefits,...

    Authors: Weiyi Tao, Junzhang Lin, Weidong Wang, He Huang and Shuang Li

    Citation: Microbial Cell Factories 2019 18:173

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  6. Content type: Research

    α-Galactosidases are enzymes that act on galactosides present in many vegetables, mainly legumes and cereals, have growing importance with respect to our diet. For this reason, the use of their catalytic activ...

    Authors: María-Efigenia Álvarez-Cao, María-Esperanza Cerdán, María-Isabel González-Siso and Manuel Becerra

    Citation: Microbial Cell Factories 2019 18:172

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  7. Content type: Research

    The biological degradation of plastics is a promising method to counter the increasing pollution of our planet with artificial polymers and to develop eco-friendly recycling strategies. Polyethylene terephthal...

    Authors: Daniel Moog, Johanna Schmitt, Jana Senger, Jan Zarzycki, Karl-Heinz Rexer, Uwe Linne, Tobias Erb and Uwe G. Maier

    Citation: Microbial Cell Factories 2019 18:171

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  8. Content type: Research

    Most microorganisms have evolved to maximize growth rate, with rapid consumption of carbon sources from the surroundings. However, fast growing phenotypes usually feature secretion of organic compounds. For ex...

    Authors: Hwi-Min Jung, Dae-Kyun Im, Jae Hyung Lim, Gyoo Yeol Jung and Min-Kyu Oh

    Citation: Microbial Cell Factories 2019 18:170

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  9. Content type: Research

    With a variety of physiological and pharmacological functions, menaquinone is an essential prenylated product that can be endogenously converted from phylloquinone (VK1) or menadione (VK3) via the expression of H...

    Authors: Xiaowen Sun, Hui Liu, Peng Wang, Li wang, Wenfeng Ni, Qiang Yang, Han Wang, Hengfang Tang, Genhai Zhao and Zhiming Zheng

    Citation: Microbial Cell Factories 2019 18:169

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  10. Content type: Research

    Bioethanol is one of the most representative eco-friendly fuels developed to replace the non-renewable fossil fuels and is the most successful commercially available bio-conversion technology till date. With t...

    Authors: Jeongmo Yang, Ji Hee Son, Hyeonsoo Kim, Sukhyeong Cho, Jeong-geol Na, Young Joo Yeon and Jinwon Lee

    Citation: Microbial Cell Factories 2019 18:168

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  11. Content type: Research

    The oleaginous yeast Yarrowia lipolytica is increasingly used as an alternative cell factory for the production of recombinant proteins. Recently, regulated promoters from genes EYK1 and EYD1, encoding an erythru...

    Authors: Young-Kyoung Park, Marie Vandermies, Paul Soudier, Samuel Telek, Stéphane Thomas, Jean-Marc Nicaud and Patrick Fickers

    Citation: Microbial Cell Factories 2019 18:167

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  12. Content type: Research

    Polyhydroxyalkanoate (PHA) are nano-granules naturally produced by bacteria. Two types of proteins, PHA synthase (PhaC) and phasins (PhaPs), are attached to the PHA surface by covalent and hydrophobic interact...

    Authors: Ru Li, Jian Yang, Yunzhu Xiao and Lijuan Long

    Citation: Microbial Cell Factories 2019 18:166

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  13. Content type: Research

    In comparison to synthetically derived surfactants, biosurfactants produced from microbial culture are generally regarded by industry as being more sustainable and possess lower toxicity. One major class of bi...

    Authors: Lakshmi Tripathi, Matthew S. Twigg, Aikaterini Zompra, Karina Salek, Victor U. Irorere, Tony Gutierrez, Georgios A. Spyroulias, Roger Marchant and Ibrahim M. Banat

    Citation: Microbial Cell Factories 2019 18:164

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  14. Content type: Research

    Sustainable production of microbial fatty acids derivatives has the potential to replace petroleum based equivalents in the chemical, cosmetic and pharmaceutical industry. Most fatty acid sources for productio...

    Authors: Elias Kassab, Monika Fuchs, Martina Haack, Norbert Mehlmer and Thomas B. Brueck

    Citation: Microbial Cell Factories 2019 18:163

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  15. Content type: Research

    Efficient and convenient genome-editing toolkits can expedite genomic research and strain improvement for desirable phenotypes. Zymomonas mobilis is a highly efficient ethanol-producing bacterium with a small gen...

    Authors: Wei Shen, Jun Zhang, Binan Geng, Mengyue Qiu, Mimi Hu, Qing Yang, Weiwei Bao, Yubei Xiao, Yanli Zheng, Wenfang Peng, Guimin Zhang, Lixin Ma and Shihui Yang

    Citation: Microbial Cell Factories 2019 18:162

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  16. Content type: Research

    Numerous studies have shown that stress induction and genetic engineering can effectively increase lipid accumulation, but lead to a decrease of growth in the majority of microalgae. We previously found that e...

    Authors: Songcui Wu, Wenhui Gu, Aiyou Huang, Yuanxiang Li, Manoj Kumar, Phaik Eem Lim, Li Huan, Shan Gao and Guangce Wang

    Citation: Microbial Cell Factories 2019 18:161

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  17. Content type: Research

    Xylanases randomly cleave the internal β-1,4-glycosidic bonds in the xylan backbone and are grouped into different families in the carbohydrate-active enzyme (CAZy) database. Although multiple xylanases are de...

    Authors: Yi Yang, Jinshui Yang, Ruonan Wang, Jiawen Liu, Yu Zhang, Liang Liu, Fengqin Wang and Hongli Yuan

    Citation: Microbial Cell Factories 2019 18:159

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  18. Content type: Research

    PrsA is an extracytoplasmic folding catalyst essential in Bacillus subtilis. Overexpression of the native PrsA from B. subtilis has repeatedly lead to increased amylase yields. Nevertheless, little is known about...

    Authors: Ane Quesada-Ganuza, Minia Antelo-Varela, Jeppe C. Mouritzen, Jürgen Bartel, Dörte Becher, Morten Gjermansen, Peter F. Hallin, Karen F. Appel, Mogens Kilstrup, Michael D. Rasmussen and Allan K. Nielsen

    Citation: Microbial Cell Factories 2019 18:158

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  19. Content type: Research

    Bifidobacterium inhabiting the human and animal intestinal tract is known for its health-promoting effect. Tolerance to acid stress is crucial for bifidobacteria to survive and then exert their beneficial effects...

    Authors: Yanxia Wei, Jing Gao, Dianbin Liu, Yang Li and Wenli Liu

    Citation: Microbial Cell Factories 2019 18:156

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  20. Content type: Research

    A microorganism engineered for non-native tasks may suffer stresses it never met before. Therefore, we examined whether a Kluyveromyces marxianus strain engineered with a carotenoid biosynthesis pathway can serve...

    Authors: Hsien-Lin Liu, Jui-Jen Chang, Caroline Thia, Yu-Ju Lin, Shou-Chen Lo, Chieh-Chen Huang and Wen-Hsiung Li

    Citation: Microbial Cell Factories 2019 18:155

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  21. Content type: Research

    Mitochondrial and cytoplasmic malate transporter proteins are responsible for transmembrane transport of malate, thereby linking malate metabolism in various subcellular regions of the cell. These transporters...

    Authors: Lu Wang, Huaiyuan Zhang, Yao Zhang and Yuanda Song

    Citation: Microbial Cell Factories 2019 18:154

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  22. Content type: Research

    Dextransucrases are extracellular enzymes, which catalyze the formation of α-1→6-linked glucose polymers from sucrose. These enzymes are exclusively expressed by lactic acid bacteria, which commonly acidify th...

    Authors: Jonas Schmid, Julia Bechtner, Rudi F. Vogel and Frank Jakob

    Citation: Microbial Cell Factories 2019 18:153

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  23. Content type: Research

    The soil bacterium Pseudomonas putida is a promising platform for the production of industrially valuable natural compounds. In the case of isoprenoids, the availability of biosynthetic precursors is a major limi...

    Authors: Sofía Hernandez-Arranz, Jordi Perez-Gil, Dominic Marshall-Sabey and Manuel Rodriguez-Concepcion

    Citation: Microbial Cell Factories 2019 18:152

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  24. Content type: Research

    Escherichia coli (E. coli) is a bacteria that is widely employed in many industries for the production of high interest bio-products such as recombinant proteins. Nevertheless, the use of E. coli for recombinant ...

    Authors: Gema Lozano Terol, Julia Gallego-Jara, Rosa Alba Sola Martínez, Manuel Cánovas Díaz and Teresa de Diego Puente

    Citation: Microbial Cell Factories 2019 18:151

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  25. Content type: Research

    Fine-tuning the aeration for cultivations when oxygen-limited conditions are demanded (such as the production of vaccines, isobutanol, 2–3 butanediol, acetone, and bioethanol) is still a challenge in the area ...

    Authors: Thiago José Barbosa Mesquita, Cíntia Regina Sargo, José Roberto Fuzer Neto, Sheyla Alexandra Hidalgo Paredes, Roberto de Campos Giordano, Antonio Carlos Luperni Horta and Teresa Cristina Zangirolami

    Citation: Microbial Cell Factories 2019 18:150

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  26. Content type: Research

    Polyol esters of fatty acids (PEFA) are a kind of promising biosurfactants and mainly secreted by Rhodotorula strains. In addition, some strains of Rhodotorula are reliable producers of microbial lipid. Therefore...

    Authors: Mengqi Wang, Weian Mao, Xiaoxiang Wang, Fengyi Li, Jiming Wang, Zhe Chi, Zhenming Chi and Guanglei Liu

    Citation: Microbial Cell Factories 2019 18:149

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  27. Content type: Research

    Colonization of Trichoderma spp. is essential for exerting their beneficial functions on the plant. However, the interactions between Trichoderma spp. and plant roots are still not completely understood. The aim ...

    Authors: Xiaohui Meng, Youzhi Miao, Qiumei Liu, Lei Ma, Kai Guo, Dongyang Liu, Wei Ran and Qirong Shen

    Citation: Microbial Cell Factories 2019 18:148

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  28. Content type: Research

    Poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) [P(3HB-co-3HHx)] is a bacterial polyester with high biodegradability, even in marine environments. Ralstonia eutropha has been engineered for the biosynthesis...

    Authors: Mengxiao Zhang, Shunsuke Kurita, Izumi Orita, Satoshi Nakamura and Toshiaki Fukui

    Citation: Microbial Cell Factories 2019 18:147

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  29. Content type: Research

    Roseoflavin, a promising broad-spectrum antibiotic, is naturally produced by the bacteria Streptomyces davaonensis and Streptomyces cinnabarinus. The key enzymes responsible for roseoflavin biosynthesis and the c...

    Authors: Rodrigo Mora-Lugo, Julian Stegmüller and Matthias Mack

    Citation: Microbial Cell Factories 2019 18:146

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  30. Content type: Research

    Simultaneous co-fermentation of mixed sugars is an important feature to consider in the production of ethanol from lignocellulosic biomass hydrolysates because it enhances the overall ethanol yield and volumet...

    Authors: Marco T. Fernández-Sandoval, Juvencio Galíndez-Mayer, Francisco Bolívar, Guillermo Gosset, Octavio T. Ramírez and Alfredo Martinez

    Citation: Microbial Cell Factories 2019 18:145

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  31. Content type: Research

    Pichia pastoris (syn. Komagataella phaffii) is a widely used generally recognized as safe host for heterologous expression of proteins in both industry and academia. Recently, it has been shown to be a potentiall...

    Authors: Qi Liu, Xiaona Shi, Lili Song, Haifeng Liu, Xiangshan Zhou, Qiyao Wang, Yuanxing Zhang and Menghao Cai

    Citation: Microbial Cell Factories 2019 18:144

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  32. Content type: Research

    In most microbial cultivations d-glucose is the main carbon and energy source. However, quantification of d-glucose especially in small scale is still challenging. Therefore, we developed a FRET-based glucose bio...

    Authors: Julia Otten, Niklas Tenhaef, Roman P. Jansen, Johannes Döbber, Lisa Jungbluth, Stephan Noack, Marco Oldiges, Wolfgang Wiechert and Martina Pohl

    Citation: Microbial Cell Factories 2019 18:143

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  33. Content type: Research

    Hirame novirhabdovirus (HIRRV) can infect a wide range of marine and freshwater fish, causing huge economic losses to aquaculture industry. Vaccine development, especially oral vaccine, has become an effective...

    Authors: Lining Zhao, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing and Wenbin Zhan

    Citation: Microbial Cell Factories 2019 18:142

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  34. Content type: Research

    Bacillus subtilis 916 has been identified as an effective biocontrol agent against Rhizoctonia solani, the causal pathogen of rice sheath blight, under greenhouse and field conditions. HPLC analysis showed that s...

    Authors: Xiaoyu Wang, Zhiyi Chen, Hui Feng, Xi Chen and Lihui Wei

    Citation: Microbial Cell Factories 2019 18:141

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  35. Content type: Research

    S-Formylglutathione is hydrolyzed to glutathione and formate by an S-formylglutathione hydrolase (SFGH) ( This thiol esterase belongs to the esterase family and is also known as esterase D. SFGHs contai...

    Authors: Chang Woo Lee, Wanki Yoo, Sun-Ha Park, Ly Thi Huong Luu Le, Chang-Sook Jeong, Bum Han Ryu, Seung Chul Shin, Han-Woo Kim, Hyun Park, Kyeong Kyu Kim, T. Doohun Kim and Jun Hyuck Lee

    Citation: Microbial Cell Factories 2019 18:140

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  36. Content type: Research

    Acrylic acid (AA) is a widely used commodity chemical derived from non-renewable fossil fuel sources. Alternative microbial-based production methodologies are being developed with the aim of providing “green” ...

    Authors: Sarada S. Raghavan, Sharon Chee, Juntao Li, Jeremie Poschmann, Niranjan Nagarajan, Siau Jia Wei, Chandra S. Verma and Farid J. Ghadessy

    Citation: Microbial Cell Factories 2019 18:139

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  37. Content type: Research

    The development of sustainable technologies for plant cell wall degradation greatly depends on enzymes with hydrolytic activities against carbohydrates. The waste by-products of agricultural cereals are import...

    Authors: Tao Tu, Xiaoli Li, Kun Meng, Yingguo Bai, Yuan Wang, Zhenxing Wang, Bin Yao and Huiying Luo

    Citation: Microbial Cell Factories 2019 18:138

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  38. Content type: Research

    Microbial cell factories are widely used in the production of acidic products such as organic acids and amino acids. However, the metabolic activity of microbial cells and their production efficiency are sever...

    Authors: Zhengming Zhu, Jinhua Yang, Peishan Yang, Zhimeng Wu, Juan Zhang and Guocheng Du

    Citation: Microbial Cell Factories 2019 18:136

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  39. Content type: Research

    Medium-chain-length polyhydroxyalkanoates (mcl-PHAs) containing various chain length monomers from C6 to C14 have more applications besides sustainable and environmental-friendly biomaterials owing to their su...

    Authors: Qianqian Zhuang and Qingsheng Qi

    Citation: Microbial Cell Factories 2019 18:135

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  40. Content type: Research

    The halophilic bacterium Chromohalobacter salexigens metabolizes glucose exclusively through the Entner–Doudoroff (ED) pathway, an adaptation which results in inefficient growth, with significant carbon overflow,...

    Authors: José M. Pastor, Nuno Borges, Juan P. Pagán, Sara Castaño-Cerezo, Laszlo N. Csonka, Bradley W. Goodner, Kathryn A. Reynolds, Luís G. Gonçalves, Montserrat Argandoña, Joaquín J. Nieto, Carmen Vargas, Vicente Bernal and Manuel Cánovas

    Citation: Microbial Cell Factories 2019 18:134

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  41. Content type: Research

    Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting materia...

    Authors: Asher Williams, Kamil S. Gedeon, Deepika Vaidyanathan, Yanlei Yu, Cynthia H. Collins, Jonathan S. Dordick, Robert J. Linhardt and Mattheos A. G. Koffas

    Citation: Microbial Cell Factories 2019 18:132

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  42. Content type: Research

    The overexpression and purification of membrane proteins is a bottleneck in biotechnology and structural biology. E. coli remains the host of choice for membrane protein production. To date, most of the efforts h...

    Authors: Kerstin Kanonenberg, Jorge Royes, Alexej Kedrov, Gereon Poschmann, Federica Angius, Audrey Solgadi, Olivia Spitz, Diana Kleinschrodt, Kai Stühler, Bruno Miroux and Lutz Schmitt

    Citation: Microbial Cell Factories 2019 18:131

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  43. Content type: Research

    Acetyl-CoA is an important metabolic intermediate and serves as an acetylation precursor for the biosynthesis of various value-added acetyl-chemicals. Acetyl-CoA can be produced from glucose, acetate, or fatty...

    Authors: Shasha Zhang, Wei Yang, Hao Chen, Bo Liu, Baixue Lin and Yong Tao

    Citation: Microbial Cell Factories 2019 18:130

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  44. Content type: Research

    Vitamin K2 (menaquinone, MK-n) is a lipid-soluble vitamin that functions as a carboxylase co-factor for maturation of proteins involved in many vital physiological processes in humans. Notably, long-chain vita...

    Authors: Yue Liu, Eric O. van Bennekom, Yu Zhang, Tjakko Abee and Eddy J. Smid

    Citation: Microbial Cell Factories 2019 18:129

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  45. Content type: Research

    Acetoin (AC) and 2,3-butanediol (2,3-BD) as highly promising bio-based platform chemicals have received more attentions due to their wide range of applications. However, the non-efficient substrate conversion ...

    Authors: Xian Zhang, Rumeng Han, Teng Bao, Xiaojing Zhao, Xiangfei Li, Manchi Zhu, Taowei Yang, Meijuan Xu, Minglong Shao, Youxi Zhao and Zhiming Rao

    Citation: Microbial Cell Factories 2019 18:128

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