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  1. Resistance towards known antimalarial drugs poses a significant problem, urging for novel drugs that target vital proteins in the malaria parasite Plasmodium falciparum. However, recombinant production of malaria...

    Authors: Karen Molbaek, Maria Tejada, Christina Hoeier Ricke, Peter Scharff-Poulsen, Peter Ellekvist, Claus Helix-Nielsen, Nirbhay Kumar, Dan A. Klaerke and Per Amstrup Pedersen

    Citation: Microbial Cell Factories 2020 19:183

    Content type: Research

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  2. FODMAPs (Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) intake is associated with the onset of irritable bowel syndrome symptoms. FODMAPs in wheat-derived baked goods may be reduced...

    Authors: Marta Acín Albiac, Raffaella Di Cagno, Pasquale Filannino, Vincenzo Cantatore and Marco Gobbetti

    Citation: Microbial Cell Factories 2020 19:182

    Content type: Research

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  3. Chitinase and chitin-oligosaccaride can be used in multiple field, so it is important to develop a high-yield chitinase producing strain. Here, a recombinant Pichia pastoris with 4 copies of ChiA gene from Bacill...

    Authors: Wen Song, Nuo Zhang, Mo Yang, Yuling Zhou, Nisha He and Guimin Zhang

    Citation: Microbial Cell Factories 2020 19:181

    Content type: Research

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  4. Epothilone B is a natural product that stabilizes microtubules, similar to paclitaxel (Taxol); therefore, epothilone B and several derivatives have shown obvious antitumour activities. Some of these products a...

    Authors: Junheng Liang, Huimin Wang, Xiaoying Bian, Youming Zhang, Guoping Zhao and Xiaoming Ding

    Citation: Microbial Cell Factories 2020 19:180

    Content type: Research

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  5. Sugars and triglycerides are common carbon sources for microorganisms. Nonetheless, a systematic comparative interpretation of metabolic changes upon vegetable oil or glucose as sole carbon source is still lac...

    Authors: Arief Izzairy Zamani, Susann Barig, Sarah Ibrahim, Hirzun Mohd. Yusof, Julia Ibrahim, Jaime Yoke Sum Low, Shwu Fun Kua, Syarul Nataqain Baharum, Klaus-Peter Stahmann and Chyan Leong Ng

    Citation: Microbial Cell Factories 2020 19:179

    Content type: Research

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  6. Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclod...

    Authors: Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, Nicolas Canu, Muriel Gondry, Olivier Lequin and Pascal Belin

    Citation: Microbial Cell Factories 2020 19:178

    Content type: Research

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yunchang Xie, Jiawen Chen, Bo Wang, Tai Chen, Junyu Chen, Yuan Zhang, Xiaoying Liu and Qi Chen

    Citation: Microbial Cell Factories 2020 19:177

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2020 19:159

  8. Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape and function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de...

    Authors: Jorge Royes, Valérie Biou, Nathalie Dautin, Christophe Tribet and Bruno Miroux

    Citation: Microbial Cell Factories 2020 19:176

    Content type: Review

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  9. Inclusion bodies (IBs) are biologically active protein aggregates forming natural nanoparticles with a high stability and a slow-release behavior. Because of their nature, IBs have been explored to be used as ...

    Authors: Ramon Roca-Pinilla, Sara Fortuna, Antonino Natalello, Alejandro Sánchez-Chardi, Diletta Ami, Anna Arís and Elena Garcia-Fruitós

    Citation: Microbial Cell Factories 2020 19:175

    Content type: Research

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  10. One major mission of microbial breeding is high-level production of desired metabolites. Overproduction of intermediate metabolites in core pathways is challenging as it may impair cell growth and viability.

    Authors: Qingyang Li, Peng Zhao, Hang Yin, Zhaonan Liu, Haifeng Zhao and Pingfang Tian

    Citation: Microbial Cell Factories 2020 19:174

    Content type: Research

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  13. Although recent studies have indicated that intestinal microbiota dweller are involved in the pathogenesis of allergy rhinitis (AR), the influence of gut microbiota on AR adult has not been fully elucidated ye...

    Authors: Libing Zhu, Feng Xu, Wenrong Wan, Bin Yu, Lin Tang, Yiming Yang, Yanling Du, Zhangran Chen and Hongzhu Xu

    Citation: Microbial Cell Factories 2020 19:171

    Content type: Research

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  14. Miniaturization of biochemical reaction volumes within artificial microcompartments has been the key driver for directed evolution of several catalysts in the past two decades. Typically, single cells are co-c...

    Authors: Salvatore Di Girolamo, Chasper Puorger and Georg Lipps

    Citation: Microbial Cell Factories 2020 19:170

    Content type: Technical notes

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  16. Probiotics have several health benefits by modulating gut microbiome; however, techno-functional limitations such as viability controls have hampered their full potential applications in the food and pharmaceu...

    Authors: Basavaprabhu H. Nataraj, Syed Azmal Ali, Pradip V. Behare and Hariom Yadav

    Citation: Microbial Cell Factories 2020 19:168

    Content type: Review

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  17. Despite the latest advancements in metabolic engineering for genome editing and characterization of host performance, the successful development of robust cell factories used for industrial bioprocesses and ac...

    Authors: Maren Wehrs, Mitchell G. Thompson, Deepanwita Banerjee, Jan-Philip Prahl, Norma M. Morella, Carolina A. Barcelos, Jadie Moon, Zak Costello, Jay D. Keasling, Patrick M. Shih, Deepti Tanjore and Aindrila Mukhopadhyay

    Citation: Microbial Cell Factories 2020 19:167

    Content type: Research

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  18. The biotechnology production of enzymes is often troubled by the toxicity of the recombinant products of cloned and expressed genes, which interferes with the recombinant hosts’ metabolism. Various approaches ...

    Authors: Natalia Krawczun, Marta Bielawa, Kasjan Szemiako, Beata Łubkowska, Ireneusz Sobolewski, Agnieszka Zylicz-Stachula and Piotr M. Skowron

    Citation: Microbial Cell Factories 2020 19:166

    Content type: Research

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  19. l-malate is one of the most important platform chemicals widely used in food, metal cleaning, textile finishing, pharmaceuticals, and synthesis of various fine chemicals. Recently, the development of biotechnol.....

    Authors: Youming Jiang, Tianwen Zheng, Xiaohan Ye, Fengxue Xin, Wenming Zhang, Weiliang Dong, Jiangfeng Ma and Min Jiang

    Citation: Microbial Cell Factories 2020 19:165

    Content type: Research

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  20. Ergothioneine (EGT) has a unique antioxidant ability and diverse beneficial effects on human health. But the content of EGT is very low in its natural producing organisms such as Mycobacterium smegmatis and mushr...

    Authors: Ying-Hao Yu, Hong-Yu Pan, Li-Qiong Guo, Jun-Fang Lin, Han-Lu Liao and Hao-Ying Li

    Citation: Microbial Cell Factories 2020 19:164

    Content type: Research

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  21. Cinnamyl alcohol is not only a kind of flavoring agent and fragrance, but also a versatile chemical applied in the production of various compounds. At present, the preparation of cinnamyl alcohol depends on pl...

    Authors: Chen Zhang, Qian Xu, Hongliang Hou, Jiawei Wu, Zhaojuan Zheng and Jia Ouyang

    Citation: Microbial Cell Factories 2020 19:163

    Content type: Research

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  22. Whey is a major pollutant generated by the dairy industry. To decrease environmental pollution caused by the industrial release of whey, new prospects for its utilization need to be urgently explored. Here, we...

    Authors: Wensi Meng, Yongjia Zhang, Menghao Cao, Wen Zhang, Chuanjuan Lü, Chunyu Yang, Chao Gao, Ping Xu and Cuiqing Ma

    Citation: Microbial Cell Factories 2020 19:162

    Content type: Research

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  23. In Lactobacillus plantarum, fructooligosaccharides (FOS) metabolism is controlled by both global and local regulatory mechanisms. Although catabolite control protein A has been identified as a global regulator of...

    Authors: Chen Chen, Linlin Wang, Haiyan Yu and Huaixiang Tian

    Citation: Microbial Cell Factories 2020 19:161

    Content type: Research

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  24. Thioesters of coenzyme A participate in 5% of all enzymatic reactions. In microbial cell factories, they function as building blocks for products of recognized commercial value, including natural products such...

    Authors: Lars Gläser, Martin Kuhl, Sofija Jovanovic, Michel Fritz, Bastian Vögeli, Tobias J. Erb, Judith Becker and Christoph Wittmann

    Citation: Microbial Cell Factories 2020 19:160

    Content type: Research

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  25. Activation of silent biosynthetic gene clusters (BGCs) in marine-derived actinomycete strains is a feasible strategy to discover bioactive natural products. Actinoalloteichus sp. AHMU CJ021, isolated from the sea...

    Authors: Yunchang Xie, Jiawen Chen, Bo Wang, Tai Chen, Junyu Chen, Yuan Zhang, Xiaoying Liu and Qi Chen

    Citation: Microbial Cell Factories 2020 19:159

    Content type: Research

    Published on:

    The Correction to this article has been published in Microbial Cell Factories 2020 19:177

  26. The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis.

    Authors: Jiajia Wang, Guannan Zhu, Cheng Sun, Kangwei Xiong, Tingting Yao, Yuan Su and Haiming Fang

    Citation: Microbial Cell Factories 2020 19:158

    Content type: Research

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  27. Maltoheptaose as malto-oligosaccharides with specific degree of polymerization, has wide applications in food, medicine and cosmetics industries. Currently, cyclodextrinase have been applied as prepared enzyme...

    Authors: Lei Wang, Quan Wu, Kang Zhang, Sheng Chen, Zhengfei Yan and Jing Wu

    Citation: Microbial Cell Factories 2020 19:157

    Content type: Research

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  28. Two marine fungi, a Trichoderma sp. and a Coniochaeta sp., which can grow on d-galacturonic acid and pectin, were selected as hosts to engineer for mucic acid production, assessing the suitability of marine fungi...

    Authors: Virve Vidgren, Satu Halinen, Anu Tamminen, Susanna Olenius and Marilyn G. Wiebe

    Citation: Microbial Cell Factories 2020 19:156

    Content type: Research

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  29. Filamentous fungi have long been used as hosts for the production of proteins, enzymes and valuable products in various biotechnological applications. However, recombinant proteins are expressed with highly se...

    Authors: Changyu Pi, Zhe Zhang, Boyu Xiang, Hongwei Tian, Qinzhen Liao, Yu Chen, Liqiu Xia, Yibo Hu and Shengbiao Hu

    Citation: Microbial Cell Factories 2020 19:155

    Content type: Research

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  30. Bacillus subtilis is widely used for the industrial production of recombinant proteins, mainly due to its high secretion capacity, but higher production yields can be achieved only if bottlenecks are removed. To ...

    Authors: Kristina Volkenborn, Laura Kuschmierz, Nuka Benz, Patrick Lenz, Andreas Knapp and Karl-Erich Jaeger

    Citation: Microbial Cell Factories 2020 19:154

    Content type: Research

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  31. Furfural and 5-hydroxymethyl furfural (5-HMF) are key furan inhibitors that are generated due to breakdown of lignocellulosic sugars at high temperature and acidic treatment conditions. Both furfural and 5-HMF...

    Authors: Syed Bilal Jilani, Chandra Dev, Danish Eqbal, Kamran Jawed, Rajendra Prasad and Syed Shams Yazdani

    Citation: Microbial Cell Factories 2020 19:153

    Content type: Research

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  32. Accumulating evidence infer that gut microbiome-host relations are key mediators or modulators driving the observed sexual dimorphism in some disease onset and progression. To date, the sex-differences of gut ...

    Authors: Xin Yuan, Ruimin Chen, Ying Zhang, Xiangquan Lin and Xiaohong Yang

    Citation: Microbial Cell Factories 2020 19:152

    Content type: Research

    Published on:

  33. The suitability of bacteria as microbial cell factories is dependent on several factors such as price of feedstock, product range, production yield and ease of downstream processing. The facultative methylotroph

    Authors: Marta Irla, Eivind B. Drejer, Trygve Brautaset and Sigrid Hakvåg

    Citation: Microbial Cell Factories 2020 19:151

    Content type: Research

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  34. Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. Howeve...

    Authors: William B. Black, Derek Aspacio, Danielle Bever, Edward King, Linyue Zhang and Han Li

    Citation: Microbial Cell Factories 2020 19:150

    Content type: Research

    Published on:

  35. Enzymatic hydrolysis is a key step in the conversion of lignocellulosic polysaccharides to fermentable sugars for the production of biofuels and high-value chemicals. However, current enzyme preparations from ...

    Authors: Ning Zhu, Hongmei Jin, Xiangping Kong, Yanyun Zhu, Xiaomei Ye, Yonglan Xi, Jing Du, Bingqing Li, Menghan Lou and Ghulam Mustafa Shah

    Citation: Microbial Cell Factories 2020 19:149

    Content type: Research

    Published on:

  36. The expression of recombinant proteins triggers a stress response which downregulates key metabolic pathway genes leading to a decline in cellular health and feedback inhibition of both growth and protein expr...

    Authors: Ashish K. Sharma, Esha Shukla, Deepak S. Janoti, Krishna J. Mukherjee and Joseph Shiloach

    Citation: Microbial Cell Factories 2020 19:148

    Content type: Research

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  38. With the development of engineering the microbial cell factories, biosensors have been used widely for regulation of cellular metabolism and high-throughput screening. However, most of the biosensors construct...

    Authors: Chenxi Qiu, Xiaoxu Chen, Reheman Rexida, Yu Shen, Qingsheng Qi, Xiaoming Bao and Jin Hou

    Citation: Microbial Cell Factories 2020 19:146

    Content type: Research

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  39. Biosurfactants, being highly biodegradable, ecofriendly and multifunctional compounds have wide applications in various industrial sectors including environmental bioremediation. Surfactin, a member of lipopep...

    Authors: Irfan Ali Phulpoto, Zhisheng Yu, Bowen Hu, Yanfen Wang, Fabrice Ndayisenga, Jinmei Li, Hongxia Liang and Muneer Ahmed Qazi

    Citation: Microbial Cell Factories 2020 19:145

    Content type: Research

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  41. Resveratrol is a plant secondary metabolite with diverse, potential health-promoting benefits. Due to its nutraceutical merit, bioproduction of resveratrol via microbial engineering has gained increasing atten...

    Authors: Shuo-Fu Yuan, Xiunan Yi, Trevor G. Johnston and Hal S. Alper

    Citation: Microbial Cell Factories 2020 19:143

    Content type: Research

    Published on:

  42. β-mannanase can hydrolyze β-1,4 glycosidic bond of mannan by the manner of endoglycosidase to generate mannan-oligosaccharides. Currently, β-mannanase has been widely applied in food, medicine, textile, paper ...

    Authors: Siyu Liu, Tangbing Cui and Yan Song

    Citation: Microbial Cell Factories 2020 19:142

    Content type: Research

    Published on:

  43. Carotenoids are natural tetraterpene pigments widely utilized in the food, pharmaceutical and cosmetic industries. Currently, chemical synthesis of these compounds outperforms their production in Escherichia coli

    Authors: Anna Maj, Lukasz Dziewit, Lukasz Drewniak, Maciej Garstka, Tomasz Krucon, Katarzyna Piatkowska, Katarzyna Gieczewska, Jakub Czarnecki, Ewa Furmanczyk, Robert Lasek, Jadwiga Baj and Dariusz Bartosik

    Citation: Microbial Cell Factories 2020 19:141

    Content type: Research

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  44. α-Glucosidases are widely distributed enzymes with a varied substrate specificity that are traditionally used in biotechnological industries based on oligo- and polysaccharides as starting materials. According...

    Authors: Martin Garcia-Gonzalez, Marina Minguet-Lobato, Francisco J. Plou and Maria Fernandez-Lobato

    Citation: Microbial Cell Factories 2020 19:140

    Content type: Research

    Published on:

  47. Zoonotic hepatitis E virus (HEV) infection emerged as a serious threat in the industrialized countries. The aim of this study is exploring a new approach for the control of zoonotic HEV in its main host (swine...

    Authors: Nouredine Behloul, Sarra Baha, Zhenzhen Liu, Wenjuan Wei, Yuanyuan Zhu, Yuliang Rao, Ruihua Shi and Jihong Meng

    Citation: Microbial Cell Factories 2020 19:137

    Content type: Research

    Published on:

  48. Escherichia coli BL21 is arguably the most popular host for industrial production of proteins, and industrial fermentations are often plagued by phage infections. The CRISPR/Cas system is guided by a gRNA to clea...

    Authors: Li Liu, Dongdong Zhao, Lijun Ye, Tao Zhan, Bin Xiong, Muzi Hu, Changhao Bi and Xueli Zhang

    Citation: Microbial Cell Factories 2020 19:136

    Content type: Research

    Published on:

  49. A neutral, heat-sensitive serine protease (NHSSP) originating from the feather-degrading fungus Onygena corvina (O. corvina) was described and defined as an alkaline serine protease of the subtilisin type S8 fami...

    Authors: Piotr M. Skowron, Daria Krefft, Robert Brodzik, Paulina Kasperkiewicz, Marcin Drag and Klaus-Peter Koller

    Citation: Microbial Cell Factories 2020 19:135

    Content type: Research

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  50. The Saccharomyces cerevisiae Snf1 complex is a member of the AMP-activated protein kinase family and plays an important role in response to environmental stress. The α catalytic subunit Snf1 regulates the activit...

    Authors: Lu Meng, Hui-Ling Liu, Xue Lin, Xiao-Ping Hu, Kun-Ru Teng and Si-Xin Liu

    Citation: Microbial Cell Factories 2020 19:134

    Content type: Research

    Published on:

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