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  1. Omics approaches are widely applied in the field of biology for the discovery of potential CAZymes including whole genome sequencing. The aim of this study was to identify protein encoding genes including CAZy...

    Authors: Rihab Ameri, José Luis García, Amel Bouanane Derenfed, Nathalie Pradel, Sawssan Neifar, Sonia Mhiri, Monia Mezghanni, Nadia Zaraî Jaouadi, Jorge Barriuso and Samir Bejar
    Citation: Microbial Cell Factories 2022 21:91
  2. A total of 11 β-glucosidases are predicted in the genome of Trichoderma reesei, which are of great importance for regulating cellulase biosynthesis. Nevertheless, the relevant function and regulation mechanism of...

    Authors: Ai-Ping Pang, Yongsheng Luo, Xin Hu, Funing Zhang, Haiyan Wang, Yichen Gao, Samran Durrani, Chengcheng Li, Xiaotong Shi, Fu-Gen Wu, Bing-Zhi Li, Zuhong Lu and Fengming Lin
    Citation: Microbial Cell Factories 2022 21:90
  3. The sesquiterpene germacrene D is a highly promising product due to its wide variety of insecticidal activities and ability to serve as a precursor for many other sesquiterpenes. Biosynthesis of high value com...

    Authors: Jiajia Liu, Chang Chen, Xiukun Wan, Ge Yao, Shaoheng Bao, Fuli Wang, Kang Wang, Tianyu Song, Penggang Han and Hui Jiang
    Citation: Microbial Cell Factories 2022 21:89
  4. The extracellular vesicles (EVs) traffic constitutes an essential pathway of cellular communication. And the molecules in EVs produced by procaryotes help in maintaining homeostasis, addressing microbial imbal...

    Authors: Liping Liang, Chenghai Yang, Le Liu, Genghui Mai, Haolin Li, Lele Wu, Ming Jin and Ye Chen
    Citation: Microbial Cell Factories 2022 21:88
  5. Microbial strain information databases provide valuable data for microbial basic research and applications. However, they rarely contain information on the genetic operating system of microbial strains.

    Authors: Pengli Cai, Mengying Han, Rui Zhang, Shaozhen Ding, Dachuan Zhang, Dongliang Liu, Sheng Liu and Qian-Nan Hu
    Citation: Microbial Cell Factories 2022 21:87
  6. Eriodictyol is a bioactive flavonoid compound that shows potential applications in medicine development and food processing. Microbial synthesis of eriodictyol has been attracting increasing attention due to s...

    Authors: Xia Wu, Jingyi Liu, Dan Liu, Miaomiao Yuwen, Mattheos A. G. Koffas and Jian Zha
    Citation: Microbial Cell Factories 2022 21:86
  7. Polyhydroxyalkanoates (PHAs) are microbial polyesters synthesized by PHA synthases. Naturally occurring PHA copolymers possess a random monomer sequence. The development of PhaCAR, a unique sequence-regulating PH...

    Authors: Keigo Satoh, Tomoya Kawakami, Nagi Isobe, Loïc Pasquier, Hiroya Tomita, Manfred Zinn and Ken’ichiro Matsumoto
    Citation: Microbial Cell Factories 2022 21:84
  8. Butenyl-spinosyn produced by Saccharopolyspora pogona exhibits strong insecticidal activity and a broad pesticidal spectrum. Currently, important functional genes involve in butenyl-spinosyn biosynthesis remain u...

    Authors: Jie Rang, Ziyuan Xia, Ling Shuai, Li Cao, Yang Liu, Xiaomin Li, Jiao Xie, Yunlong Li, Shengbiao Hu, Qingji Xie and Liqiu Xia
    Citation: Microbial Cell Factories 2022 21:83
  9. The production of bioelectricity via the anaerobic oxidation of organic matter by microorganisms is recently receiving much interest and is considered one of the future alternative technologies. In this study,...

    Authors: Ghada E. Hegazy, Tarek H. Taha and Yasser R. Abdel-Fattah
    Citation: Microbial Cell Factories 2022 21:82
  10. Aromatic compounds, such as p-coumaric acid (p-CA) and caffeic acid, are secondary metabolites of various plants, and are widely used in diet and industry for their biological activities. In addition to expensive...

    Authors: Miao Cai, Jiayu Liu, Xiaofei Song, Hang Qi, Yuanzi Li, Zhenzhou Wu, Haijin Xu and Mingqiang Qiao
    Citation: Microbial Cell Factories 2022 21:81
  11. Due to their huge biodiversity and the capability to produce a wide range of secondary metabolites, lichens have a great potential in biotechnological applications. They have, however, hardly been used as cell...

    Authors: Zakieh Zakeri, Stefan Junne, Fabia Jäger, Marcel Dostert, Volker Otte and Peter Neubauer
    Citation: Microbial Cell Factories 2022 21:80
  12. Currently, the generation of genetic diversity for microbial cell factories outpaces the screening of strain variants with omics-based phenotyping methods. Especially isotopic labeling experiments, which const...

    Authors: Jochen Nießer, Moritz Fabian Müller, Jannick Kappelmann, Wolfgang Wiechert and Stephan Noack
    Citation: Microbial Cell Factories 2022 21:78
  13. The growing emergence of microorganisms resistant to antibiotics has prompted the development of alternative antimicrobial therapies. Among them, the antimicrobial peptides produced by innate immunity, which a...

    Authors: Adrià López-Cano, Marc Martínez-Miguel, Judith Guasch, Imma Ratera, Anna Arís and Elena Garcia-Fruitós
    Citation: Microbial Cell Factories 2022 21:77
  14. Ergothioneine (ERG) is a potent histidine-derived antioxidant that confers health-promoting effects. Only certain bacteria and fungi can biosynthesize ERG, but the ERG productivity in natural producers is low....

    Authors: Zhihui Chen, Yongzhi He, Xinyu Wu, Li Wang, Zhiyang Dong and Xiuzhen Chen
    Citation: Microbial Cell Factories 2022 21:76
  15. Melanins are a heterologous group of biopolymeric pigments synthesized by diverse prokaryotes and eukaryotes and are widely utilized as bioactive materials and functional polymers in the biotechnology industry...

    Authors: Han Sae Lee, Jun Young Choi, Soon Jae Kwon, Eun Seo Park, Byeong M. Oh, Jong H. Kim and Pyung Cheon Lee
    Citation: Microbial Cell Factories 2022 21:75
  16. Streptomyces mobaraenesis transglutaminase (smTG) is widely used to generate protein crosslinking or attachment of small molecules. However, the low thermostability is a main obstacle for smTG application. In add...

    Authors: Xinglong Wang, Beichen Zhao, Jianhui Du, Yameng Xu, Xuewen Zhu, Jingwen Zhou, Shengqi Rao, Guocheng Du, Jian Chen and Song Liu
    Citation: Microbial Cell Factories 2022 21:74
  17. The construction of protein expression systems is mainly focused on carbon catabolite repression and quorum-sensing systems. However, each of these regulatory modes has an inherent flaw, which is difficult to ...

    Authors: Qin Yan, Laichuang Han, Xinyue Liu, Cuiping You, Shengmin Zhou and Zhemin Zhou
    Citation: Microbial Cell Factories 2022 21:73
  18. Engineered probiotics are a kind of new microorganisms produced by modifying original probiotics through gene editing. With the continuous development of tools and technology progresses, engineering renovation...

    Authors: Junheng Ma, Yuhong Lyu, Xin Liu, Xu Jia, Fangyun Cui, Xiaoheng Wu, Shanshan Deng and Changwu Yue
    Citation: Microbial Cell Factories 2022 21:72
  19. The bifunctional enzyme β-carotene hydroxylase (CrtZ) catalyzes the hydroxylation of carotenoid β-ionone rings at the 3, 3’ position regardless of the presence of keto group at 4, 4’ position, which is an impo...

    Authors: Meng Zhang, Zhongkuo Gong, Jinlei Tang, Fuping Lu, QingYan Li and XueLi Zhang
    Citation: Microbial Cell Factories 2022 21:71
  20. The yeast genus Komagataella currently consists of seven methylotrophic species isolated from tree environments. Well-characterized strains of K. phaffii and K. pastoris are important hosts for biotechnological a...

    Authors: Lina Heistinger, Juliane C. Dohm, Barbara G. Paes, Daniel Koizar, Christina Troyer, Özge Ata, Teresa Steininger-Mairinger and Diethard Mattanovich
    Citation: Microbial Cell Factories 2022 21:70
  21. Cyanobacteria receive huge interest as green catalysts. While exploiting energy from sunlight, they co-utilize sugar and CO2. This photomixotrophic mode enables fast growth and high cell densities, opening perspe...

    Authors: Dennis Schulze, Michael Kohlstedt, Judith Becker, Edern Cahoreau, Lindsay Peyriga, Alexander Makowka, Sarah Hildebrandt, Kirstin Gutekunst, Jean-Charles Portais and Christoph Wittmann
    Citation: Microbial Cell Factories 2022 21:69
  22. During fermentation, industrial microorganisms encounter multiple stresses that inhibit cell growth and decrease fermentation yields, in particular acid stress, which is due to the accumulation of acidic metab...

    Authors: Xurong Yao, Peng Liu, Bo Chen, Xiaoyan Wang, Fei Tao, Zhanglin Lin and Xiaofeng Yang
    Citation: Microbial Cell Factories 2022 21:68
  23. Escherichia coli adapted to carbon-limiting conditions is generally geared for energy-efficient carbon utilization. This includes also the efficient utilization of glucose, which serves as a source for cellular b...

    Authors: Zhaopeng Li, Markus Nees, Katja Bettenbrock and Ursula Rinas
    Citation: Microbial Cell Factories 2022 21:67
  24. Glycoengineering, in the biotechnology workhorse bacterium, Escherichia coli, is a rapidly evolving field, particularly for the production of glycoconjugate vaccine candidates (bioconjugation). Efficient producti...

    Authors: Emily J. Kay, Marta Mauri, Sam J. Willcocks, Timothy A. Scott, Jon Cuccui and Brendan W. Wren
    Citation: Microbial Cell Factories 2022 21:66
  25. Lactiplantibacillus plantarum has various healthcare functions including the regulation of immunity and inflammation, reduction of serum cholesterol levels, anti-tumor activity, and maintenance of the balance of ...

    Authors: Xin-Xin Liu, Lei Liu, Xin Song, Guang-Qiang Wang, Zhi-Qiang Xiong, Yong-Jun Xia and Lian-Zhong Ai
    Citation: Microbial Cell Factories 2022 21:65
  26. Terpene synthases are versatile catalysts in all domains of life, catalyzing the formation of an enormous variety of different terpenoid secondary metabolites. Due to their diverse bioactive properties, terpen...

    Authors: Marion Ringel, Nicole Dimos, Stephanie Himpich, Martina Haack, Claudia Huber, Wolfgang Eisenreich, Gerhard Schenk, Bernhard Loll and Thomas Brück
    Citation: Microbial Cell Factories 2022 21:64
  27. D-allulose, a hexulose monosaccharide with low calorie content and high sweetness, is commonly used as a functional sugar in food and nutrition. However, enzyme preparation of D-allulose from D-frutose was sev...

    Authors: Mengkai Hu, Yuxia Wei, Rongzhen Zhang, Minglong Shao, Taowei Yang, Meijuan Xu, Xian Zhang and Zhiming Rao
    Citation: Microbial Cell Factories 2022 21:63
  28. Hemicellulose is one of the copious polymer in lignocellulosic biomass (LCB). It is primarily composed of xylan linked by β-1,4 glycosidic bonds. Xylanase preferentially cleaves the β-1,4-glycosidic bonds in t...

    Authors: Johnson Beslin Joshi, R. Priyadharshini and Sivakumar Uthandi
    Citation: Microbial Cell Factories 2022 21:62
  29. Soluble cello-oligosaccharides (COS, β‐1,4‐D‐gluco‐oligosaccharides with degree of polymerization DP 2–6) have been receiving increased attention in different industrial sectors, from food and feed to cosmetics. ...

    Authors: Katharina N. Schwaiger, Alena Voit, Birgit Wiltschi and Bernd Nidetzky
    Citation: Microbial Cell Factories 2022 21:61
  30. AdpA is a global regulator of morphological differentiation and secondary metabolism in Streptomyces, but the regulatory roles of the Streptomyces AdpA family on the biosynthesis of the natural product ε-poly-l-l...

    Authors: Rui Huang, Honglu Liu, Wanwan Zhao, Siqi Wang, Shufang Wang, Jun Cai and Chao Yang
    Citation: Microbial Cell Factories 2022 21:60
  31. -hydroxylated steroids (7β-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics. However, the production of 7β-OHSt is still a challe....

    Authors: Yun-Qiu Zhao, Yong-Jun Liu, Wei-Ting Ji, Kun Liu, Bei Gao, Xin-Yi Tao, Ming Zhao, Feng-Qing Wang and Dong-Zhi Wei
    Citation: Microbial Cell Factories 2022 21:59
  32. Fatty acid hydratases are unique to microorganisms. Their native function is the oxidation of unsaturated C–C bonds to enable detoxification of environmental toxins. Within this enzyme family, the oleate hydra...

    Authors: Sophia Prem, Carl P. O. Helmer, Nicole Dimos, Stephanie Himpich, Thomas Brück, Daniel Garbe and Bernhard Loll
    Citation: Microbial Cell Factories 2022 21:58
  33. Subtilin is a peptide antibiotic (lantibiotic) natively produced by Bacillus subtilis ATCC6633. It is encoded in a gene cluster spaBTCSIFEGRK (spa-locus) consisting of four transcriptional units: spaS (subtilin p...

    Authors: Qian Zhang, Carolin M. Kobras, Susanne Gebhard, Thorsten Mascher and Diana Wolf
    Citation: Microbial Cell Factories 2022 21:57
  34. In vivo biosensors have a wide range of applications, ranging from the detection of metabolites to the regulation of metabolic networks, providing versatile tools for synthetic biology and metabolic engineerin...

    Authors: Kun-Qiang Hong, Jing Zhang, Biao Jin, Tao Chen and Zhi-Wen Wang
    Citation: Microbial Cell Factories 2022 21:56
  35. The gut microbiota play an important role in maintaining host metabolism, the immune system and health, while sex, genotype, diet and health have specific effects on the composition of the gut microbiota. Ther...

    Authors: Xinyu Guo, Yuzhu Sha, Weibing Lv, Xiaoning Pu, Xiu Liu, Yuzhu Luo, Jiang Hu, Jiqing Wang, Shaobin Li and Zhidong Zhao
    Citation: Microbial Cell Factories 2022 21:55
  36. Proteins are used as reagents in a broad range of scientific fields. The reliability and reproducibility of experimental data will largely depend on the quality of the (recombinant) proteins and, consequently,...

    Authors: Kim Remans, Mario Lebendiker, Celeste Abreu, Mariano Maffei, Shaila Sellathurai, Marina M. May, Ondřej Vaněk and Ario de Marco
    Citation: Microbial Cell Factories 2022 21:52
  37. Reactive oxygen species (ROS) trigger different morphogenic processes in filamentous fungi and have been shown to play a role in the regulation of the biosynthesis of some secondary metabolites. Some bZIP tran...

    Authors: W. D. Pérez-Pérez, U. Carrasco-Navarro, C. García‑Estrada, K. Kosalková, M. C. Gutiérrez-Ruíz, J. Barrios-González and F. Fierro
    Citation: Microbial Cell Factories 2022 21:50
  38. The rapidly expanding synthetic biology toolbox allows engineers to develop smarter strategies to tackle the optimization of complex biosynthetic pathways. In such a strategy, multi-gene pathways are subdivide...

    Authors: Maarten Van Brempt, Andries Ivo Peeters, Dries Duchi, Lien De Wannemaeker, Jo Maertens, Brecht De Paepe and Marjan De Mey
    Citation: Microbial Cell Factories 2022 21:49
  39. Sunflower seeds (Helianthus annuus) display an attractive source for the rapidly increasing market of plant-based human nutrition. Of particular interest are press cakes of the seeds, cheap residuals from sunflow...

    Authors: Muzi Tangyu, Michel Fritz, Lijuan Ye, Rosa Aragão Börner, Delphine Morin-Rivron, Esther Campos-Giménez, Christoph J. Bolten, Biljana Bogicevic and Christoph Wittmann
    Citation: Microbial Cell Factories 2022 21:48
  40. l-Tryptophan (l-Trp) derivatives such as 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT), N-Acetyl-5-hydroxytryptamine and melatonin are important molecules with pharmaceutical interest. Among, 5-HT is...

    Authors: Yingying Wang, Xueman Chen, Qiaoyu Chen, Ning Zhou, Xin Wang, Alei Zhang, Kequan Chen and Pingkai Ouyang
    Citation: Microbial Cell Factories 2022 21:47
  41. Human gut microbiota is individually unique that hints the microbiota in fecal traces left in the crime scene could act as a potential biomarker for forensic personal identification. Next-generation DNA sequen...

    Authors: Shuangshuang Wang, Feng Song, Haoyu Gu, Zhilong Shu, Xiaowen Wei, Ke Zhang, Yuxiang Zhou, Lanrui Jiang, Zefei Wang, Jienan Li, Haibo Luo and Weibo Liang
    Citation: Microbial Cell Factories 2022 21:46
  42. The nitrogen containing aromatic compound indole is known for its floral odor typical of jasmine blossoms. Due to its characteristic scent, it is frequently used in dairy products, tea drinks and fine fragranc...

    Authors: Melanie Mindt, Arman Beyraghdar Kashkooli, Maria Suarez-Diez, Lenny Ferrer, Tatjana Jilg, Dirk Bosch, Vitor Martins dos Santos, Volker F. Wendisch and Katarina Cankar
    Citation: Microbial Cell Factories 2022 21:45
  43. The genus Planococcus is comprised of halophilic bacteria generally reported for the production of carotenoid pigments and biosurfactants. In previous work, we showed that the culturing of the orange-pigmented Pl...

    Authors: Anesu Conrad Moyo, Laurent Dufossé, Daniele Giuffrida, Leonardo Joaquim van Zyl and Marla Trindade
    Citation: Microbial Cell Factories 2022 21:43
  44. Lipoxygenase (LOX) is a non-heme iron containing dioxygenase that is widely used to improve food quality and produce active drug intermediates and biodiesel. Escherichia coli is one of the most widely used host m...

    Authors: Cuiping Pang, Song Liu, Guoqiang Zhang, Jingwen Zhou, Guocheng Du and Jianghua Li
    Citation: Microbial Cell Factories 2022 21:42

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