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  1. Exocrine pancreatic insufficiency (EPI) is characterized by the loss of active pancreatic enzymes and a resulting severely reduced food digestion. EPI therapy requires orally applied pancreatic enzyme replacem...

    Authors: Sabrina Ritz, Daniela Hahn, Haleluya T. Wami, Karin Tegelkamp, Ulrich Dobrindt and Juergen Schnekenburger

    Citation: Microbial Cell Factories 2020 19:221

    Content type: Research

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  2. Zeaxanthin, a major xanthophyll pigment, has a significant role as a retinal pigment and antioxidant. Because zeaxanthin helps to prevent age-related macular degeneration, its commercial use in personalized nu...

    Authors: Inhwa Song, Jongrae Kim, Kwangryul Baek, Young Choi, ByongCheol Shin and EonSeon Jin

    Citation: Microbial Cell Factories 2020 19:220

    Content type: Research

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  3. Diet, loss of aryl hydrocarbon receptor (AhR) expression and their modification of the gut microbiota community composition and its metabolites affect the development of colorectal cancer (CRC). However, the c...

    Authors: Fang Yang, Jennifer A. A. DeLuca, Rani Menon, Erika Garcia-Vilarato, Evelyn Callaway, Kerstin K. Landrock, Kyongbum Lee, Stephen H. Safe, Robert S. Chapkin, Clinton D. Allred and Arul Jayaraman

    Citation: Microbial Cell Factories 2020 19:219

    Content type: Research

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  4. All of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular eukaryotes like helminths, and v...

    Authors: Taha Baghbani, Hossein Nikzad, Javid Azadbakht, Fatemeh Izadpanah and Hamed Haddad Kashani

    Citation: Microbial Cell Factories 2020 19:217

    Content type: Review

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  5. Gut microbiota in humans and animals play an important role in health, aiding in digestion, regulation of the immune system and protection against pathogens. Changes or imbalances in the gut microbiota (dysbio...

    Authors: Walter H. Gunzburg, Myo Myint Aung, Pauline Toa, Shirelle Ng, Eliot Read, Wee Jin Tan, Eva Maria Brandtner, John Dangerfield and Brian Salmons

    Citation: Microbial Cell Factories 2020 19:216

    Content type: Research

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  6. T helper (Th)17 and regulatory T (Treg) cells with toll-like receptor (TLR)-2 have been acknowledged to play a critical role in chronic rhinosinusitis with nasal polyposis (CRSwNP). However, its pathogenesis h...

    Authors: Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Sajad Ahmad Dar, Shafiul Haque, Neelima Gupta, Sonal Sharma, Vishnampettai Ganapathysubramanian Ramachandran, Sanskriti Sharma, Charu Jain and Shipra Sharma

    Citation: Microbial Cell Factories 2020 19:215

    Content type: Research

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  7. Wheat sheath blight, a soil borne fungal disease caused by Rhizoctonia cerealis, is considered as one of the most serious threats to wheat worldwide. Bacillus subtilis Z-14 was isolated from soil sampled from a w...

    Authors: Xuechao Zhang, Xiaojun Guo, Cuihong Wu, Chengcui Li, Dongdong Zhang and Baocheng Zhu

    Citation: Microbial Cell Factories 2020 19:214

    Content type: Research

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  8. Colorectal cancer (CRC) is a major clinical challenge, and the gut microbiome plays important roles in the occurrence and metastasis of CRC. Lactobacillus and their metabolites are thought to be able to suppress ...

    Authors: Yuan-Chun Yue, Bao-Yu Yang, Jing Lu, Shu-Wen Zhang, Liu Liu, Khaled Nassar, Xiao-Xi Xu, Xiao-Yang Pang and Jia-Ping Lv

    Citation: Microbial Cell Factories 2020 19:213

    Content type: Research

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  9. In this study, the self-extracted constipation treatment of traditional Chinese medicine extracts was applied to constipated rats. To explore the mechanism and role of the Chinese medicine for the treatment of...

    Authors: Sihan Li, Youcheng He, Haiou Zhang, Rong Zheng, Ruoying Xu, Qihong Liu, Shuihua Tang, Xiao Ke and Minghan Huang

    Citation: Microbial Cell Factories 2020 19:212

    Content type: Research

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  10. Xylitol accumulation is a major barrier for efficient ethanol production through heterologous xylose reductase-xylitol dehydrogenase (XR-XDH) pathway in recombinant Saccharomyces cerevisiae. Mutated NADH-preferri...

    Authors: Cai-Yun Xie, Bai-Xue Yang, Qing-Ran Song, Zi-Yuan Xia, Min Gou and Yue-Qin Tang

    Citation: Microbial Cell Factories 2020 19:211

    Content type: Research

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  11. The development of sustainable routes to the bio-manufacture of gaseous hydrocarbons will contribute widely to future energy needs. Their realisation would contribute towards minimising over-reliance on fossil...

    Authors: Mohamed Amer, Helen Toogood and Nigel S. Scrutton

    Citation: Microbial Cell Factories 2020 19:209

    Content type: Review

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  12. In an effort to ensure future energy security, reduce greenhouse gas emissions and create domestic jobs, the US has invested in technologies to develop sustainable biofuels and bioproducts from renewable carbo...

    Authors: Gina M. Geiselman, James Kirby, Alexander Landera, Peter Otoupal, Gabriella Papa, Carolina Barcelos, Eric R. Sundstrom, Lalitendu Das, Harsha D. Magurudeniya, Maren Wehrs, Alberto Rodriguez, Blake A. Simmons, Jon K. Magnuson, Aindrila Mukhopadhyay, Taek Soon Lee, Anthe George…

    Citation: Microbial Cell Factories 2020 19:208

    Content type: Research

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  13. Magnetosomes produced by magnetotactic bacteria represent magnetic nanoparticles with unprecedented characteristics. However, their use in many biotechnological applications has so far been hampered by their c...

    Authors: Cornelius N. Riese, René Uebe, Sabine Rosenfeldt, Anna S. Schenk, Valérie Jérôme, Ruth Freitag and Dirk Schüler

    Citation: Microbial Cell Factories 2020 19:206

    Content type: Research

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  14. Plipastatin is a potent Bacillus antimicrobial lipopeptide with the prospect to replace conventional antifungal chemicals for controlling plant pathogens. However, the application of this lipopeptide has so far b...

    Authors: Maliheh Vahidinasab, Lars Lilge, Aline Reinfurt, Jens Pfannstiel, Marius Henkel, Kambiz Morabbi Heravi and Rudolf Hausmann

    Citation: Microbial Cell Factories 2020 19:205

    Content type: Research

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  15. Lipids from oleaginous yeasts emerged as a sustainable alternative to vegetable oils and animal fat to produce biodiesel, the biodegradable and environmentally friendly counterpart of petro-diesel fuel. To dev...

    Authors: Francesca Martani, Letizia Maestroni, Mattia Torchio, Diletta Ami, Antonino Natalello, Marina Lotti, Danilo Porro and Paola Branduardi

    Citation: Microbial Cell Factories 2020 19:204

    Content type: Research

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  16. Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this inc...

    Authors: Wallace Jeng Yang Chee, Shu Yih Chew and Leslie Thian Lung Than

    Citation: Microbial Cell Factories 2020 19:203

    Content type: Review

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  17. In industrial fermentation, pH fluctuation resulted from microbial metabolism influences the strain performance and the final production. The common way to control pH is adding acid or alkali after probe detec...

    Authors: Chenyi Li, Xiaopeng Gao, Xiao Peng, Jinlin Li, Wenxin Bai, Jiadong Zhong, Mengchao He, Ke Xu, Ying Wang and Chun Li

    Citation: Microbial Cell Factories 2020 19:202

    Content type: Research

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  18. Vitamins’ deficiency in humans is an important threat worldwide and requires solutions. In the concept of natural biofactory for bioactive compounds production, microalgae represent one of the most promising t...

    Authors: Angelo Del Mondo, Arianna Smerilli, Elisabet Sané, Clementina Sansone and Christophe Brunet

    Citation: Microbial Cell Factories 2020 19:201

    Content type: Review

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  19. Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol®), remains limited despite growing global demands. Low yields of the critical taxadiene precursor remains a key bottleneck in ...

    Authors: Behnaz Nowrouzi, Rachel A. Li, Laura E. Walls, Leo d’Espaux, Koray Malcı, Lungang Liang, Nestor Jonguitud-Borrego, Albert I. Lerma-Escalera, Jose R. Morones-Ramirez, Jay D. Keasling and Leonardo Rios-Solis

    Citation: Microbial Cell Factories 2020 19:200

    Content type: Research

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  20. The methylotrophic yeast, Pichia pastoris has been widely used for the production of human therapeutics, but production of granulocyte colony-stimulating factor (G-CSF) in this yeast is low.The work reported here...

    Authors: Sakshi Aggarwal and Saroj Mishra

    Citation: Microbial Cell Factories 2020 19:199

    Content type: Research

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  21. Nicotinamide adenine dinucleotide phosphate (NADPH) is an important cofactor ensuring intracellular redox balance, anabolism and cell growth in all living systems. Our recent multi-omics analyses of glucoamyla...

    Authors: Yu-fei Sui, Tabea Schütze, Li-ming Ouyang, Hongzhong Lu, Peng Liu, Xianzun Xiao, Jie Qi, Ying-Ping Zhuang and Vera Meyer

    Citation: Microbial Cell Factories 2020 19:198

    Content type: Research

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  22. In Saccharomyces cerevisiae, alpha-glucosidase (maltase) is a key enzyme in maltose metabolism. In addition, the overexpression of the alpha-glucosidase-encoding gene MAL62 has been shown to increase the freezing...

    Authors: Xi Sun, Jun Zhang, Zhi-Hua Fan, Ping Xiao, Feng Li, Hai-Qing Liu and Wen-Bi Zhu

    Citation: Microbial Cell Factories 2020 19:196

    Content type: Research

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  23. A new Bacillus thuringiensis X023 (BtX023) with high insecticidal activity was isolated in Hunan Province, China. The addition of metals (Cu, Fe, Mg and Mn) to the medium could influence the formation of spores a...

    Authors: Zhuolin Liu, Junyan Xie, Ziru Deng, Mulan Wang, Dandan Dang, Sha Luo, Yunfeng Wang, Yunjun Sun, Liqiu Xia and Xuezhi Ding

    Citation: Microbial Cell Factories 2020 19:195

    Content type: Research

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  24. Enzymatic quantification of creatinine has become an essential method for clinical evaluation of renal function. Although creatinase (CR) is frequently used for this purpose, its poor thermostability severely ...

    Authors: Xue Bai, Daixi Li, Fuqiang Ma, Xi Deng, Manjie Luo, Yan Feng and Guangyu Yang

    Citation: Microbial Cell Factories 2020 19:194

    Content type: Research

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  25. The highly pathogenic avian influenza (HPAI) H5N1 virus poses a potential threat to the poultry industry. The currently available avian influenza H5N1 vaccines for poultry are clade-specific. Therefore, an eff...

    Authors: Han Lei, Tong Gao, Qianhong Cen and Xiaojue Peng

    Citation: Microbial Cell Factories 2020 19:193

    Content type: Research

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  26. Nowadays, microbial infections have caused increasing economic losses in aquaculture industry and deteriorated worldwide environments. Many of these infections are caused by opportunistic pathogens through cel...

    Authors: Weiwei Dong, Yuyuan Cai, Zhilong Xu, Biao Fu, Qitong Chen, Yuxin Cui, Zhiyong Ruan, Yunxiang Liang, Nan Peng and Shumiao Zhao

    Citation: Microbial Cell Factories 2020 19:191

    Content type: Research

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  27. Heme proteins and heme-derived molecules are essential in numerous cellular processes. Research into their in vitro functionality requires the production of large amounts of protein. Unfortunately, high yield ...

    Authors: Kerstin Fiege and Nicole Frankenberg-Dinkel

    Citation: Microbial Cell Factories 2020 19:190

    Content type: Technical notes

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  28. Corynebacterium glutamicum thrives under oxidative stress caused by the inevitably extreme environment during fermentation as it harbors antioxidative stress genes. Antioxidant genes are controlled by pathway-spe...

    Authors: Meiru Si, Can Chen, Jingyi Zhong, Xiaona Li, Yang Liu, Tao Su and Ge Yang

    Citation: Microbial Cell Factories 2020 19:189

    Content type: Research

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  29. l-rhamnose (6-deoxy-mannose) occurs in nature mainly as a component of certain plant structural polysaccharides and bioactive metabolites but has also been found in some microorganisms and animals. The release of...

    Authors: Andrew P. MacCabe, Elpinickie I. Ninou, Ester Pardo and Margarita Orejas

    Citation: Microbial Cell Factories 2020 19:188

    Content type: Research

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  30. Mycobacterium neoaurum strains can transform phytosterols to 4-androstene-3,17-dione (4-AD), a key intermediate for the synthesis of advanced steroidal medicines. In this work, we presented the complete genome se...

    Authors: Hongwei Wang, Shikui Song, Fei Peng, Fei Yang, Tian Chen, Xin Li, Xiyao Cheng, Yijun He, Yongqi Huang and Zhengding Su

    Citation: Microbial Cell Factories 2020 19:187

    Content type: Research

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  31. Bovine viral diarrhea virus (BVDV) is one of the main causes of infectious diseases in cattle and causes large financial losses to the cattle industry worldwide. In this study, Lactobacillus casei strain W56 (Lc ...

    Authors: Shuo Jia, Xinning Huang, Hua Li, Dianzhong Zheng, Li Wang, Xinyuan Qiao, Yanping Jiang, Wen Cui, Lijie Tang, Yijing Li and Yigang Xu

    Citation: Microbial Cell Factories 2020 19:186

    Content type: Research

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  32. Bacterial spores displaying heterologous antigens or enzymes have long been proposed as mucosal vaccines, functionalized probiotics or biocatalysts. Two main strategies have been developed to display heterolog...

    Authors: Claudia Petrillo, Stefany Castaldi, Mariamichela Lanzilli, Anella Saggese, Giuliana Donadio, Loredana Baccigalupi, Ezio Ricca and Rachele Isticato

    Citation: Microbial Cell Factories 2020 19:185

    Content type: Research

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  33. Marine fungi are an important repository of bioactive molecules with great potential in different technological fields, the annual number of new compounds isolated from marine fungi is impressive and the gener...

    Authors: Lorenzo Botta, Raffaele Saladino, Paolo Barghini, Massimiliano Fenice and Marcella Pasqualetti

    Citation: Microbial Cell Factories 2020 19:184

    Content type: Research

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  34. Resistance towards known antimalarial drugs poses a significant problem, urging for novel drugs that target vital proteins in the malaria parasite Plasmodium falciparum. However, recombinant production of malaria...

    Authors: Karen Molbaek, Maria Tejada, Christina Hoeier Ricke, Peter Scharff-Poulsen, Peter Ellekvist, Claus Helix-Nielsen, Nirbhay Kumar, Dan A. Klaerke and Per Amstrup Pedersen

    Citation: Microbial Cell Factories 2020 19:183

    Content type: Research

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  35. FODMAPs (Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) intake is associated with the onset of irritable bowel syndrome symptoms. FODMAPs in wheat-derived baked goods may be reduced...

    Authors: Marta Acín Albiac, Raffaella Di Cagno, Pasquale Filannino, Vincenzo Cantatore and Marco Gobbetti

    Citation: Microbial Cell Factories 2020 19:182

    Content type: Research

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  36. Chitinase and chitin-oligosaccaride can be used in multiple field, so it is important to develop a high-yield chitinase producing strain. Here, a recombinant Pichia pastoris with 4 copies of ChiA gene from Bacill...

    Authors: Wen Song, Nuo Zhang, Mo Yang, Yuling Zhou, Nisha He and Guimin Zhang

    Citation: Microbial Cell Factories 2020 19:181

    Content type: Research

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  37. Epothilone B is a natural product that stabilizes microtubules, similar to paclitaxel (Taxol); therefore, epothilone B and several derivatives have shown obvious antitumour activities. Some of these products a...

    Authors: Junheng Liang, Huimin Wang, Xiaoying Bian, Youming Zhang, Guoping Zhao and Xiaoming Ding

    Citation: Microbial Cell Factories 2020 19:180

    Content type: Research

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  38. Sugars and triglycerides are common carbon sources for microorganisms. Nonetheless, a systematic comparative interpretation of metabolic changes upon vegetable oil or glucose as sole carbon source is still lac...

    Authors: Arief Izzairy Zamani, Susann Barig, Sarah Ibrahim, Hirzun Mohd. Yusof, Julia Ibrahim, Jaime Yoke Sum Low, Shwu Fun Kua, Syarul Nataqain Baharum, Klaus-Peter Stahmann and Chyan Leong Ng

    Citation: Microbial Cell Factories 2020 19:179

    Content type: Research

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  39. Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclod...

    Authors: Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, Nicolas Canu, Muriel Gondry, Olivier Lequin and Pascal Belin

    Citation: Microbial Cell Factories 2020 19:178

    Content type: Research

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  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yunchang Xie, Jiawen Chen, Bo Wang, Tai Chen, Junyu Chen, Yuan Zhang, Xiaoying Liu and Qi Chen

    Citation: Microbial Cell Factories 2020 19:177

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2020 19:159

  41. Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape and function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de...

    Authors: Jorge Royes, Valérie Biou, Nathalie Dautin, Christophe Tribet and Bruno Miroux

    Citation: Microbial Cell Factories 2020 19:176

    Content type: Review

    Published on:

  42. Inclusion bodies (IBs) are biologically active protein aggregates forming natural nanoparticles with a high stability and a slow-release behavior. Because of their nature, IBs have been explored to be used as ...

    Authors: Ramon Roca-Pinilla, Sara Fortuna, Antonino Natalello, Alejandro Sánchez-Chardi, Diletta Ami, Anna Arís and Elena Garcia-Fruitós

    Citation: Microbial Cell Factories 2020 19:175

    Content type: Research

    Published on:

  43. One major mission of microbial breeding is high-level production of desired metabolites. Overproduction of intermediate metabolites in core pathways is challenging as it may impair cell growth and viability.

    Authors: Qingyang Li, Peng Zhao, Hang Yin, Zhaonan Liu, Haifeng Zhao and Pingfang Tian

    Citation: Microbial Cell Factories 2020 19:174

    Content type: Research

    Published on:

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