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  1. The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases. For translation into clinical use, large quantities of correctly folded ...

    Authors: Benjamin Schmuck, Gefei Chen, Josef Pelcman, Nina Kronqvist, Anna Rising and Jan Johansson

    Citation: Microbial Cell Factories 2021 20:150

    Content type: Research

    Published on:

  2. The intracellular ATP level is an indicator of cellular energy state and plays a critical role in regulating cellular metabolism. Depletion of intracellular ATP in (facultative) aerobes can enhance glycolysis,...

    Authors: Zongjie Dai, Yan Zhu, Hongjun Dong, Chunhua Zhao, Yanping Zhang and Yin Li

    Citation: Microbial Cell Factories 2021 20:149

    Content type: Research

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  3. Tailoring gene expression to balance metabolic fluxes is critical for the overproduction of metabolites in yeast hosts, and its implementation requires coordinated regulation at both transcriptional and transl...

    Authors: Liping Xu, Pingping Liu, Zhubo Dai, Feiyu Fan and Xueli Zhang

    Citation: Microbial Cell Factories 2021 20:148

    Content type: Research

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  4. Fatty acid-based substances play an important role in many products, from food supplements to pharmaceutical products and biofuels. The production of fatty acids, mainly in their esterified form as triacylglyc...

    Authors: Simon Arhar, Gabriela Gogg-Fassolter, Mojca Ogrizović, Klavdija Pačnik, Katharina Schwaiger, Mia Žganjar, Uroš Petrovič and Klaus Natter

    Citation: Microbial Cell Factories 2021 20:147

    Content type: Research

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  5. trans-cinnamic acid (t-CA) is a phenylpropanoid with a broad spectrum of biological activities including antioxidant and antibacterial activities, and it also has high potential in food and cosmetic applications...

    Authors: Jaewoo Son, Jun Hong Jang, In Hyeok Choi, Chang Gyu Lim, Eun Jung Jeon, Hyun Bae Bang and Ki Jun Jeong

    Citation: Microbial Cell Factories 2021 20:145

    Content type: Research

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  6. Adenosine 5′-triphosphate (ATP) plays both a central role as an intracellular energy source, and a crucial extracellular signaling role in diverse physiological processes of animals and plants. However, there ...

    Authors: Xin Ping Li, Lu Lu Zhou, Yan Hua Guo and Jian Wen Wang

    Citation: Microbial Cell Factories 2021 20:144

    Content type: Research

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  7. The antimicrobial peptide LL37 is produced by white blood cells (mainly neutrophils) and various epithelial cells, and has the outstanding advantages of participating in immune regulation, causing chemotaxis o...

    Authors: Na Zhan, Licong Zhang, Hong Yang, Yalan Zheng, Xinke Wei, Jiajun Wang and Anshan Shan

    Citation: Microbial Cell Factories 2021 20:143

    Content type: Research

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  8. Vanillin is one of the important phenolic inhibitors in Saccharomyces cerevisiae for bioconversion of lignocellulosic materials and has been reported to inhibit the translation process in cells. In our previous s...

    Authors: Wenyan Cao, Weiquan Zhao, Bolun Yang, Xinning Wang, Yu Shen, Tiandi Wei, Wensheng Qin, Zailu Li and Xiaoming Bao

    Citation: Microbial Cell Factories 2021 20:142

    Content type: Research

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  9. Acetoin utilization protein (acuC) is a type I histone deacetylase which is highly conserved in bacteria. The acuC gene is related to the acetylation/deacetylation posttranslational modification (PTM) system in S...

    Authors: Zhudong Liu, Jie Xiao, Jianli Tang, Yang Liu, Ling Shuai, Li Cao, Ziyuan Xia, Xuezhi Ding, Jie Rang and Liqiu Xia

    Citation: Microbial Cell Factories 2021 20:141

    Content type: Research

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  10. Biological nitrogen fixation is catalyzed by Mo-, V- and Fe-nitrogenases that are encoded by nif, vnf and anf genes, respectively. NifB is the key protein in synthesis of the cofactors of all nitrogenases. Most d...

    Authors: Qin Li, Haowei Zhang, Liqun Zhang and Sanfeng Chen

    Citation: Microbial Cell Factories 2021 20:139

    Content type: Research

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  11. Myo-Inositol Phosphate Synthase (MIP) catalyzes the conversion of glucose 6- phosphate into inositol phosphate, an essential nutrient and cell signaling molecule. Data obtained, first in bovine brain and later...

    Authors: Erika Steele, Hana D. Alebous, Macy Vickers, Mary E. Harris and Margaret D. Johnson

    Citation: Microbial Cell Factories 2021 20:138

    Content type: Research

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  12. In China, during the cultivation process of Pleurotus ostreatus, the yield and quality of fruiting bodies are easily affected by high temperatures in summer. Nitric oxide (NO) plays an important regulatory role i...

    Authors: Ludan Hou, Mengran Zhao, Chenyang Huang, Qi He, Lijiao Zhang and Jinxia Zhang

    Citation: Microbial Cell Factories 2021 20:137

    Content type: Research

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  13. Trichoderma reesei is currently the main strain for the commercial production of cellulase. Cellulose induced protein 1 (Cip1) is one of the most abundant proteins in extracellular proteins of T. reesei. Reported...

    Authors: Hexue Jia, Wan Sun, Xuezhi Li and Jian Zhao

    Citation: Microbial Cell Factories 2021 20:136

    Content type: Research

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  14. Monoclonal antibodies, antibody fragments and fusion proteins derived thereof have revolutionized the practice of medicine. Major challenges faced by the biopharmaceutical industry are however high production...

    Authors: Yanyan Wang, Xiaowei Li, Xin Chen, Jens Nielsen, Dina Petranovic and Verena Siewers

    Citation: Microbial Cell Factories 2021 20:134

    Content type: Research

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  15. Flonicamid (N-cyanomethyl-4-trifluoromethylnicotinamide, FLO) is a new type of pyridinamide insecticide that regulates insect growth. Because of its wide application in agricultural production and high solubility...

    Authors: Yun-Xiu Zhao, Li Wang, Ke-Xin Chen, Neng-Dang Jiang, Shi-Lei Sun, Feng Ge and Yi-Jun Dai

    Citation: Microbial Cell Factories 2021 20:133

    Content type: Research

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  16. Attenuated Listeria monocytogenes (Lm) has been widely used as a vaccine vector in the prevention and treatment of pathogen infection and tumor diseases. In addition, previous studies have proved that the atten...

    Authors: Qianyu Ji, Junfei Ma, Shuying Wang and Qing Liu

    Citation: Microbial Cell Factories 2021 20:132

    Content type: Research

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  17. Synechocystis sp. PCC 6803 provides a well-established reference point to cyanobacterial metabolic engineering as part of basic photosynthesis research, as well as in the development of next-generation biotechnol...

    Authors: Csaba Nagy, Kati Thiel, Edita Mulaku, Henna Mustila, Paula Tamagnini, Eva-Mari Aro, Catarina C. Pacheco and Pauli Kallio

    Citation: Microbial Cell Factories 2021 20:130

    Content type: Research

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  18. Xylanase-containing enzyme cocktails are used on an industrial scale to convert xylan into value-added products, as they hydrolyse the β-1,4-glycosidic linkages between xylopyranosyl residues. In the present s...

    Authors: Svini Dileepa Marasinghe, Eunyoung Jo, Sachithra Amarin Hettiarachchi, Youngdeuk Lee, Tae-Yang Eom, Yehui Gang, Yoon-Hyeok Kang and Chulhong Oh

    Citation: Microbial Cell Factories 2021 20:129

    Content type: Research

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  19. The molecular machinery of the complex microbiological cell factory of biomethane production is not fully understood. One of the process control elements is the regulatory role of hydrogen (H2). Reduction of carb...

    Authors: Balázs Kakuk, Roland Wirth, Gergely Maróti, Márk Szuhaj, Gábor Rakhely, Krisztián Laczi, Kornél L. Kovács and Zoltán Bagi

    Citation: Microbial Cell Factories 2021 20:127

    Content type: Research

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  20. The fungal cell wall is an essential and robust external structure that protects the cell from the environment. It is mainly composed of polysaccharides with different functions, some of which are necessary fo...

    Authors: Vanessa S. D. Carvalho, Laura Gómez-Delgado, M. Ángeles Curto, M. Belén Moreno, Pilar Pérez, Juan Carlos Ribas and Juan Carlos G. Cortés

    Citation: Microbial Cell Factories 2021 20:126

    Content type: Technical Notes

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  21. Genome-scale metabolic model (GSMM) is a powerful tool for the study of cellular metabolic characteristics. With the development of multi-omics measurement techniques in recent years, new methods that integrat...

    Authors: Jingru Zhou, Yingping Zhuang and Jianye Xia

    Citation: Microbial Cell Factories 2021 20:125

    Content type: Research

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  22. The manufacture of recombinant therapeutics is a fastest-developing section of therapeutic pharmaceuticals and presently plays a significant role in disease management. Yeasts are established eukaryotic host f...

    Authors: Aravind Madhavan, K. B. Arun, Raveendran Sindhu, Jayaram Krishnamoorthy, R. Reshmy, Ranjna Sirohi, Arivalagan Pugazhendi, Mukesh Kumar Awasthi, George Szakacs and Parameswaran Binod

    Citation: Microbial Cell Factories 2021 20:124

    Content type: Review

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  23. Klebsiella pneumoniae is a bacterium that can be used as producer for numerous chemicals. Glycerol can be catabolised by K. pneumoniae and dihydroxyacetone is an intermediate of this catabolism pathway. Here dihy...

    Authors: Shaoqi Sun, Yike Wang, Lin Shu, Xiyang Lu, Qinghui Wang, Chenguang Zhu, Jiping Shi, Gary J. Lye, Frank Baganz and Jian Hao

    Citation: Microbial Cell Factories 2021 20:123

    Content type: Research

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  24. The development and utilization of probiotics had many environmental benefits for replacing antibiotics in animal production. Bacteria in the intestinal mucosa have better adhesion to the host intestinal epith...

    Authors: Yang He, Xuan Liu, Yuanyang Dong, Jiaqi Lei, Koichi Ito and Bingkun Zhang

    Citation: Microbial Cell Factories 2021 20:122

    Content type: Research

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  25. 3-Phenylpropanol with a pleasant odor is widely used in foods, beverages and cosmetics as a fragrance ingredient. It also acts as the precursor and reactant in pharmaceutical and chemical industries. Currently...

    Authors: Zhenning Liu, Xue Zhang, Dengwei Lei, Bin Qiao and Guang-Rong Zhao

    Citation: Microbial Cell Factories 2021 20:121

    Content type: Research

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  26. The quest for a chemical surfactant substitute has been fuelled by increased environmental awareness. The benefits that biosurfactants present like biodegradability, and biocompatibility over their chemical an...

    Authors: Swayansu Sabyasachi Mohanty, Yamini Koul, Sunita Varjani, Ashok Pandey, Huu Hao Ngo, Jo-Shu Chang, Jonathan W. C. Wong and Xuan-Thanh Bui

    Citation: Microbial Cell Factories 2021 20:120

    Content type: Review

    Published on:

  27. 3-Ketosteroid Δ1-dehydrogenases (KSTDs) are the enzymes involved in microbial cholesterol degradation and modification of steroids. They catalyze dehydrogenation between C1 and C2 atoms in ring A of the polycycli...

    Authors: Patrycja Wójcik, Michał Glanowski, Agnieszka M. Wojtkiewicz, Ali Rohman and Maciej Szaleniec

    Citation: Microbial Cell Factories 2021 20:119

    Content type: Research

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  28. Biodegradation of antibiotics is a promising method for the large-scale removal of antibiotic residues in the environment. However, the enzyme that is involved in the biodegradation process is the key informat...

    Authors: Peng Wang, Chen Shen, Qinqin Cong, Kaili Xu and Jialin Lu

    Citation: Microbial Cell Factories 2021 20:117

    Content type: Research

    Published on:

  29.  A key focus of synthetic biology is to develop microbial or cell-free based biobased routes to value-added chemicals such as fragrances. Originally, we developed the EcoFlex system, a Golden Gate toolkit, to ...

    Authors: Simon J. Moore, Yonek B. Hleba, Sarah Bischoff, David Bell, Karen M. Polizzi and Paul S. Freemont

    Citation: Microbial Cell Factories 2021 20:116

    Content type: Research

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  30. Interleukin-15 (IL-15) is a critical cytokine for the development, proliferation, and function of natural killer (NK) cells, NKT cells, and CD8+ memory T cells and has become one of the most promising protein mol...

    Authors: Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, Jing Wu, Yin Yu, Fang Fang, Yugang Guo and Weihua Xiao

    Citation: Microbial Cell Factories 2021 20:115

    Content type: Research

    Published on:

  31. The current shift from a fossil-resource based economy to a more sustainable, bio-based economy requires development of alternative production routes based on utilization of biomass for the many chemicals that...

    Authors: Thomas Nicolaï, Quinten Deparis, María R. Foulquié-Moreno and Johan M. Thevelein

    Citation: Microbial Cell Factories 2021 20:114

    Content type: Research

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  32. Menaquinone (MK-7) is a highly valuable vitamin K2 produced by Bacillus subtilis. Common static metabolic engineering approaches for promoting the production of MK-7 have been studied previously. However, these a...

    Authors: Jing Wu, Wei Li, Shi-guang Zhao, Sen-he Qian, Zhou Wang, Meng-jie Zhou, Wen-song Hu, Jian Wang, Liu-xiu Hu, Yan Liu and Zheng-lian Xue

    Citation: Microbial Cell Factories 2021 20:113

    Content type: Research

    Published on:

  33. Macro- and microalgae-based foods are becoming popular due to their high nutritious value. The algal biomass is enriched with polysaccharides, protein, polyunsaturated fatty acids, carotenoids, vitamins and mi...

    Authors: Anil Kumar Patel, Reeta Rani Singhania, Mukesh Kumar Awasthi, Sunita Varjani, Shashi Kant Bhatia, Mei-Ling Tsai, Shu-Ling Hsieh, Chiu-Wen Chen and Cheng-Di Dong

    Citation: Microbial Cell Factories 2021 20:112

    Content type: Review

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  34. Pamamycins are macrodiolides of polyketide origin which form a family of differently large homologues with molecular weights between 579 and 663. They offer promising biological activity against pathogenic fun...

    Authors: Lars Gläser, Martin Kuhl, Julian Stegmüller, Christian Rückert, Maksym Myronovskyi, Jörn Kalinowski, Andriy Luzhetskyy and Christoph Wittmann

    Citation: Microbial Cell Factories 2021 20:111

    Content type: Research

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  35. CssR, the product of the Corynebacterium glutamicum ncgl1578 gene cotranscribed with ncgl1579, is a TetR (tetracycline regulator) family repressor. Although many TetR-type regulators in C. glutamicum have been ex...

    Authors: Yang Liu, Wenzhi Yang, Tao Su, Chengchuan Che, Guizhi Li, Can Chen and Meiru Si

    Citation: Microbial Cell Factories 2021 20:110

    Content type: Research

    Published on:

  36. Plant-based milk alternatives are more popular than ever, and chickpea-based milks are among the most commercially relevant products. Unfortunately, limited nutritional value because of low levels of the essen...

    Authors: Muzi Tangyu, Michel Fritz, Rosa Aragao-Börner, Lijuan Ye, Biljana Bogicevic, Christoph J. Bolten and Christoph Wittmann

    Citation: Microbial Cell Factories 2021 20:109

    Content type: Research

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  37. Human milk is the gold standard for nutrition of infant growth, whose nutritional value is mainly attributed to human milk oligosaccharides (HMOs). HMOs, the third most abundant component of human milk after l...

    Authors: Shunhao Zhang, Tianle Li, Jing Xie, Demao Zhang, Caixia Pi, Lingyun Zhou and Wenbin Yang

    Citation: Microbial Cell Factories 2021 20:108

    Content type: Review

    Published on:

    The Correction to this article has been published in Microbial Cell Factories 2021 20:140

  38. Uprising fossil fuel depletion and deterioration of ecological reserves supply have led to the search for alternative renewable and sustainable energy sources and chemicals. Although first generation biorefine...

    Authors: Gunasekaran Rajeswari, Samuel Jacob, Anuj Kumar Chandel and Vinod Kumar

    Citation: Microbial Cell Factories 2021 20:107

    Content type: Review

    Published on:

  39. Commercial xylose purification produces xylose mother liquor (XML) as a major byproduct, which has become an inexpensive and abundant carbon source. A portion of this XML has been used to produce low-value-add...

    Authors: Lihua Zhang, Zhen Chen, Junhua Wang, Wei Shen, Qi Li and Xianzhong Chen

    Citation: Microbial Cell Factories 2021 20:105

    Content type: Research

    Published on:

  40. Protein Glycan Coupling Technology (PGCT) uses purposely modified bacterial cells to produce recombinant glycoconjugate vaccines. This vaccine platform holds great potential in this context, namely due to its ...

    Authors: Jasmin J. Samaras, Marta Mauri, Emily J. Kay, Brendan W. Wren and Martina Micheletti

    Citation: Microbial Cell Factories 2021 20:104

    Content type: Research

    Published on:

  41. Pseudomonas aeruginosa, the rhamnolipids-producer, is one of dominant bacteria in oil reservoirs. Although P. aeruginosa strains are facultative bacteria, the anaerobic biosynthesis mechanism of rhamnolipids is u...

    Authors: Feng Zhao, Qingzhi Wang, Ying Zhang and Liying Lei

    Citation: Microbial Cell Factories 2021 20:103

    Content type: Research

    Published on:

  42. As treatment of Staphylococcus aureus (S. aureus) osteomyelitis is often hindered by the development of antibiotic tolerance, novel antibacterial therapeutics are required. Here we found that the cell-free supern...

    Authors: Fan Zhang, Bowei Wang, Shiluan Liu, Yuhui Chen, Yihuang Lin, Zixian Liu, Xianrong Zhang and Bin Yu

    Citation: Microbial Cell Factories 2021 20:102

    Content type: Research

    Published on:

  43. Pinene is a monoterpene, that is used in the manufacture of fragrances, insecticide, fine chemicals, and renewable fuels. Production of pinene by metabolic-engineered microorganisms is a sustainable method. Pu...

    Authors: Xiaomin Wu, Guang Ma, Chuanyang Liu, Xin-yuan Qiu, Lu Min, Jingyu Kuang and Lingyun Zhu

    Citation: Microbial Cell Factories 2021 20:101

    Content type: Research

    Published on:

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