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  1. Substrate-limited fed-batch conditions have the favorable effect of preventing overflow metabolism, catabolite repression, oxygen limitation or inhibition caused by elevated substrate or osmotic concentrations...

    Authors: Tobias Habicher, Tobias Klein, Jacqueline Becker, Andreas Daub and Jochen Büchs

    Citation: Microbial Cell Factories 2021 20:51

    Content type: Research

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  2. Xylitol is a five-carbon sugar alcohol that has numerous beneficial health properties. It has almost the same sweetness as sucrose but has lower energy value compared to the sucrose. Metabolism of xylitol is i...

    Authors: Tai Man Louie, Kailin Louie, Samuel DenHartog, Sridhar Gopishetty, Mani Subramanian, Mark Arnold and Shuvendu Das

    Citation: Microbial Cell Factories 2021 20:50

    Content type: Research

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  3. In recent years, the production of inclusion bodies that retained substantial catalytic activity was demonstrated. These catalytically active inclusion bodies (CatIBs) were formed by genetic fusion of an ag...

    Authors: Kira Küsters, Martina Pohl, Ulrich Krauss, Gizem Ölçücü, Sandor Albert, Karl-Erich Jaeger, Wolfgang Wiechert and Marco Oldiges

    Citation: Microbial Cell Factories 2021 20:49

    Content type: Research

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  4. Humic substances (HS) form the largest proportion among all the constituents of soil organic matter and are a key component of the terrestrial ecosystem. HS plays a multifunctional role in the environment by c...

    Authors: Iniyakumar Muniraj, Syed Shameer, Priyadharshini Ramachandran and Sivakumar Uthandi

    Citation: Microbial Cell Factories 2021 20:48

    Content type: Research

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  5. Natural products are a valuable source of biologically active compounds that have applications in medicine and agriculture. One disadvantage with natural products is the slow, time-consuming strain improvement...

    Authors: Špela Pikl, Andrés Felipe Carrillo Rincón, Lucija Slemc, Dušan Goranovič, Martina Avbelj, Krešimir Gjuračić, Hilda Sucipto, Katja Stare, Špela Baebler, Martin Šala, Meijin Guo, Andriy Luzhetskyy, Hrvoje Petković and Vasilka Magdevska

    Citation: Microbial Cell Factories 2021 20:47

    Content type: Research

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  6. With the long-term goal of developing an ultra-sensitive microcantilever-based biosensor for versatile biomarker detection, new controlled bioreceptor-analytes systems are being explored to overcome the disadv...

    Authors: Nurul Akmal Che Lah, Robert Gray and Sonia Trigueros

    Citation: Microbial Cell Factories 2021 20:46

    Content type: Research

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  7. Pediococcus pentosaceus, a promising strain of lactic acid bacteria (LAB), is gradually attracting attention, leading to a rapid increase in experimental research. Due to increased demand for practical applicatio...

    Authors: Shiman Jiang, Lingzhi Cai, Longxian Lv and Lanjuan Li

    Citation: Microbial Cell Factories 2021 20:45

    Content type: Review

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  8. Protein secretion in bacteria is an attractive strategy for heterologous protein production because it retains the high titers and tractability of bacterial hosts while simplifying downstream processing. Tradi...

    Authors: Lisa Ann Burdette, Han Teng Wong and Danielle Tullman-Ercek

    Citation: Microbial Cell Factories 2021 20:44

    Content type: Research

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  9. Nannochloropsis is a marine microalga that has been extensively studied. The major carotenoid produced by this group of microalgae is violaxanthin, which exhibits anti-inflammatory, anti-photoaging, and antiprol...

    Authors: Su-Bin Park, Jin-Ho Yun, Ae Jin Ryu, Joohyun Yun, Ji Won Kim, Sujin Lee, Saehae Choi, Dae-Hyun Cho, Dong-Yun Choi, Yong Jae Lee and Hee-Sik Kim

    Citation: Microbial Cell Factories 2021 20:43

    Content type: Research

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  10. The co-culture strategy which mimics natural ecology by constructing an artificial microbial community is a useful tool to activate the biosynthetic gene clusters to generate new metabolites. However, the conv...

    Authors: Yu Sun, Wen-Cai Liu, Xuan Shi, Hai-Zhou Zheng, Zhi-Hui Zheng, Xin-Hua Lu, Yan Xing, Kai Ji, Mei Liu and Yue-Sheng Dong

    Citation: Microbial Cell Factories 2021 20:42

    Content type: Research

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  11. Microbes are present in almost every environment on Earth, even in those with extreme environmental conditions such as Antarctica, where rocks may represent the main refuge for life. Lithobiontic communities a...

    Authors: V. Carrasco, V. Amarelle, S. Lagos-Moraga, C. P. Quezada, R. Espinoza-González, R. Faccio, E. Fabiano and J. M. Pérez-Donoso

    Citation: Microbial Cell Factories 2021 20:41

    Content type: Research

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  12. Microbial surfactants called biosurfactants, thanks to their high biodegradability, low toxicity and stability can be used not only in bioremediation and oil processing, but also in the food and cosmetic indus...

    Authors: Olga Marchut-Mikołajczyk, Piotr Drożdżyński, Arkadiusz Polewczyk, Wojciech Smułek and Tadeusz Antczak

    Citation: Microbial Cell Factories 2021 20:40

    Content type: Research

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  13. Cyanobacteria are promising hosts for the production of various industrially important compounds such as succinate. This study focuses on introduction of the glyoxylate shunt, which is naturally present in onl...

    Authors: Claudia Durall, Kateryna Kukil, Jeffrey A. Hawkes, Alessia Albergati, Peter Lindblad and Pia Lindberg

    Citation: Microbial Cell Factories 2021 20:39

    Content type: Research

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  14. Violaceins have attracted much attention as potential targets used in medicines, food additives, insecticides, cosmetics and textiles, but low productivity was the key factor to limit their large-scale applica...

    Authors: Yuyang Zhang, Hongping Chen, Yao Zhang, Huifang Yin, Chenyan Zhou and Yan Wang

    Citation: Microbial Cell Factories 2021 20:38

    Content type: Research

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  15. Exploring a simple and versatile technique for direct immobilization of target enzymes from cell lysate without prior purification is urgently needed. Thus, a novel all-in-one strategy for purification and imm...

    Authors: Lixi Cai, Yunmen Chu, Xin Liu, Yue Qiu, Zhongqi Ge and Guangya Zhang

    Citation: Microbial Cell Factories 2021 20:37

    Content type: Research

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  16. Extracellular metabolites of short chain fatty acids (SCFA) excreted by gut microbiota have been reported to play an important role in the regulation of intestinal homeostasis. Apart from supplying energy, SCF...

    Authors: Atchareeya Nakkarach, Hooi Ling Foo, Adelene Ai-Lian Song, Nur Elina Abdul Mutalib, Sunee Nitisinprasert and Ulaiwan Withayagiat

    Citation: Microbial Cell Factories 2021 20:36

    Content type: Research

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  17. Because of its tractability and straightforward cultivation, the magnetic bacterium Magnetospirillum gryphiswaldense has emerged as a model for the analysis of magnetosome biosynthesis and bioproduction. However,...

    Authors: Theresa Zwiener, Marina Dziuba, Frank Mickoleit, Christian Rückert, Tobias Busche, Jörn Kalinowski, René Uebe and Dirk Schüler

    Citation: Microbial Cell Factories 2021 20:35

    Content type: Research

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  18. Anthranilate is a platform chemical used by the industry in the synthesis of a broad range of high-value products, such as dyes, perfumes and pharmaceutical compounds. Currently anthranilate is produced via ch...

    Authors: Joosu Kuivanen, Matti Kannisto, Dominik Mojzita, Heiko Rischer, Mervi Toivari and Jussi Jäntti

    Citation: Microbial Cell Factories 2021 20:34

    Content type: Research

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  19. The display of recombinant proteins on cell surfaces has a plethora of applications including vaccine development, screening of peptide libraries, whole-cell biocatalysts and biosensor development for diagnost...

    Authors: Sonia Nicchi, Maria Giuliani, Fabiola Giusti, Laura Pancotto, Domenico Maione, Isabel Delany, Cesira L. Galeotti and Cecilia Brettoni

    Citation: Microbial Cell Factories 2021 20:33

    Content type: Research

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  20. Natural glycolysis encounters the decarboxylation of glucose partial oxidation product pyruvate into acetyl-CoA, where one-third of the carbon is lost at CO2. We previously constructed a carbon saving pathway, EP...

    Authors: Ying Li, He Xian, Ya Xu, Yuan Zhu, Zhijie Sun, Qian Wang and Qingsheng Qi

    Citation: Microbial Cell Factories 2021 20:32

    Content type: Research

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  21. Chronic atrophic gastritis (CAG) is well-known related with multiple pathogenic factors and normally therapies comprised by western or Chinese medicines. The present study was designed to identify the bacteria...

    Authors: Minghan Huang, Sihan Li, Youcheng He, Cuili Lin, Yueming Sun, Mingzhu Li, Rong Zheng, Ruoying Xu, Ping Lin and Xiao Ke

    Citation: Microbial Cell Factories 2021 20:31

    Content type: Research

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  22. Protein aggregation is a biological event observed in expression systems in which the recombinant protein is produced under stressful conditions surpassing the homeostasis of the protein quality control system...

    Authors: Jose Vicente Carratalá, Andrés Cisneros, Elijah Hellman, Antonio Villaverde and Neus Ferrer-Miralles

    Citation: Microbial Cell Factories 2021 20:30

    Content type: Research

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  23. Cembranoids are one kind of diterpenoids with multiple biological activities. The tobacco cembratriene-ol (CBT-ol) and cembratriene-diol (CBT-diol) have high anti-insect and anti-fungal activities, which is at...

    Authors: Yu Zhang, Shiquan Bian, Xiaofeng Liu, Ning Fang, Chunkai Wang, Yanhua Liu, Yongmei Du, Michael P. Timko, Zhongfeng Zhang and Hongbo Zhang

    Citation: Microbial Cell Factories 2021 20:29

    Content type: Technical notes

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  24. Norvancomycin has been widely used in clinic to treat against MRSA (Methicillin-resistant Staphylococcus aureus) and MRSE (Methicillin-resistant Staphylococcus epidermidis) infections in China. Amycolatopsis orie...

    Authors: Xingxing Li, Cong Zhang, Ying Zhao, Xuan Lei, Zhibo Jiang, Xuexia Zhang, Zhihui Zheng, Shuyi Si, Lifei Wang and Bin Hong

    Citation: Microbial Cell Factories 2021 20:28

    Content type: Research

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  26. Engine oil used in automobiles is a threat to soil and water due to the recalcitrant properties of its hydrocarbons. It pollutes surrounding environment which affects both flora and fauna. Microbes can degrade...

    Authors: Khem Raj Meena, Rajni Dhiman, Kailash Singh, Sachin Kumar, Abhishek Sharma, Shamsher S. Kanwar, Rittick Mondal, Sandip Das, Octavio L. Franco and Amit Kumar Mandal

    Citation: Microbial Cell Factories 2021 20:26

    Content type: Research

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  27. Alzheimer’s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive...

    Authors: Dana Vigasova, Michal Nemergut, Barbora Liskova and Jiri Damborsky

    Citation: Microbial Cell Factories 2021 20:25

    Content type: Review

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  28. Porcine Parvovirus (PPV) is a Parvovirinae virus that can cause embryonic and fetal loss and death and mummification in affected fetal pigs. Unlike conventional vaccines, virus-like particles (VLPs) inherit the n...

    Authors: Deqiang Yang, Lei Chen, Jinkun Duan, Yao Yu, Jungang Zhou and Hong Lu

    Citation: Microbial Cell Factories 2021 20:24

    Content type: Research

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  29. Lactic acid bacteria can synthesize dextran and oligosaccharides with different functionality, depending on the strain and fermentation conditions. As natural structure-forming agent, dextran has proven useful...

    Authors: Prabin Koirala, Ndegwa Henry Maina, Hanna Nihtilä, Kati Katina and Rossana Coda

    Citation: Microbial Cell Factories 2021 20:23

    Content type: Research

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  30. A considerable challenge in the development of bioprocesses for producing chemicals and fuels has been the high cost of feedstocks relative to oil prices, making it difficult for these processes to compete wit...

    Authors: Aditya Vikram Pandit, Emma Harrison and Radhakrishnan Mahadevan

    Citation: Microbial Cell Factories 2021 20:22

    Content type: Research

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  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: George Seghal Kiran, Anuj Nishanth Lipton, Sethu Priyadharshini, Kumar Anitha, Lucia Elizabeth Cruz Suárez, Mariadhas Valan Arasu, Ki Choon Choi, Joseph Selvin and Naif Abdullah Al-Dhabi

    Citation: Microbial Cell Factories 2021 20:21

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2014 13:114

  32. Many fungi grow as saprobic organisms and obtain nutrients from a wide range of dead organic materials. Among saprobes, fungal species that grow on wood or in polluted environments have evolved prolific mechan...

    Authors: Michael Dare Asemoloye, Mario Andrea Marchisio, Vijai Kumar Gupta and Lorenzo Pecoraro

    Citation: Microbial Cell Factories 2021 20:20

    Content type: Review

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  33. Eukaryotes use distinct networks of biogenesis factors to synthesize, fold, monitor, traffic, and secrete proteins. During heterologous expression, saturation of any of these networks may bottleneck titer and ...

    Authors: Troy R. Alva, Melanie Riera and Justin W. Chartron

    Citation: Microbial Cell Factories 2021 20:19

    Content type: Research

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  34. To assess the long-term safety and efficacy of monotherapy with a single fresh fecal microbiota transplant (FMT) for recurrent ulcerative colitis (UC).

    Authors: Haiming Fang, Lian Fu, Xuejun Li, Chunxia Lu, Yuan Su, Kangwei Xiong and Lijiu Zhang

    Citation: Microbial Cell Factories 2021 20:18

    Content type: Research

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  35. α,β-Unsaturated aldehydes are widely used in the organic synthesis of fine chemicals for application in products such as flavoring agents, fragrances and pharmaceuticals. In the selective oxidation of α,β-unsa...

    Authors: Yan Qiao, Can Wang, Yin Zeng, Tairan Wang, Jingjing Qiao, Chenze Lu, Zhao Wang and Xiangxian Ying

    Citation: Microbial Cell Factories 2021 20:17

    Content type: Research

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  36. Bifidobacterium spp. are representative probiotics that play an important role in the health of their hosts. Among various Bifidobacterium spp., B. bifidum BGN4 exhibits relatively high cell adhesion to colonic c...

    Authors: Nayoun Hong, Seockmo Ku, Kyungjin Yuk, Tony V. Johnston, Geun Eog Ji and Myeong Soo Park

    Citation: Microbial Cell Factories 2021 20:16

    Content type: Research

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  37. Genetic modification of Rhodococcus jostii RHA1 was carried out in order to optimise the production of pyridine-2,4-dicarboxylic acid and pyridine-2,5-dicarboxylic acid bioproducts from lignin or lignocellulose b...

    Authors: Edward M. Spence, Leonides Calvo-Bado, Paul Mines and Timothy D. H. Bugg

    Citation: Microbial Cell Factories 2021 20:15

    Content type: Research

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  38. Chlorophyllase catalyzes the hydrolysis of chlorophyll and produces chlorophyllide and phytol. Cyanobacterial chlorophyllases are likely to be more highly heterologously expressed than plant chlorophyllases....

    Authors: Sitian Gu, Xiaojun Dai, Zhengjun Xu, Qiwen Niu, Jiang Jiang and Yuanfa Liu

    Citation: Microbial Cell Factories 2021 20:14

    Content type: Research

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  39. The E. coli pET system is the most widely used protein over-expression system worldwide. It relies on the assumption that all cells produce target protein and it is generally believed that integral membrane prote...

    Authors: Jack James, Benjamin Yarnall, Andy Koranteng, Jane Gibson, Tahmina Rahman and Declan A. Doyle

    Citation: Microbial Cell Factories 2021 20:13

    Content type: Research

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  40. Clostridium sp. strain CT7 is a new emerging microbial cell factory with high butanol production ratio owing to its non-traditional butanol fermentation mode with uncoupled acetone and 1,3-propanediol formation....

    Authors: Yujia Jiang, Ruofan Wu, Jiasheng Lu, Weiliang Dong, Jie Zhou, Wenming Zhang, Fengxue Xin and Min Jiang

    Citation: Microbial Cell Factories 2021 20:12

    Content type: Research

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  41. d-Amino acids are increasingly used as building blocks to produce pharmaceuticals and fine chemicals. However, establishing a universal biocatalyst for the general synthesis of d-amino acids from cheap and readil...

    Authors: Dan-Ping Zhang, Xiao-Ran Jing, Lun-Jie Wu, An-Wen Fan, Yao Nie and Yan Xu

    Citation: Microbial Cell Factories 2021 20:11

    Content type: Research

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  42. Freezing stress is the key factor that affecting the cell activity and fermentation performance of baker’s yeast in frozen dough production. Generally, cells protect themselves from injury and maintain metabol...

    Authors: Lu Meng, Xu Yang, Xue Lin, Huan-Yuan Jiang, Xiao-Ping Hu and Si-Xin Liu

    Citation: Microbial Cell Factories 2021 20:10

    Content type: Research

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  43. Growth factors (GFs) are signaling proteins that affect cellular processes such as growth, proliferation, and differentiation. GFs are used as cosmeceuticals, exerting anti-wrinkle, anti-aging, and whitening e...

    Authors: Young Su Kim, Hye-Jeong Lee, Man-ho Han, Nam-kyung Yoon, Yeu-chun Kim and Jungoh Ahn

    Citation: Microbial Cell Factories 2021 20:9

    Content type: Research

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  44. Pichia pastoris (Komagataella phaffii) is an important platform for heterologous protein production due to its growth to high cell density and outstanding secretory capabilities. Recent developments in synthetic ...

    Authors: Laura Navone, Thomas Vogl, Pawarisa Luangthongkam, Jo-Anne Blinco, Carlos Luna-Flores, Xiaojing Chen, Juhani von Hellens and Robert Speight

    Citation: Microbial Cell Factories 2021 20:8

    Content type: Research

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  45. The sesquiterpene germacrene A is a direct precursor of ß-elemene that is a major component of the Chinese medicinal herb Curcuma wenyujin with prominent antitumor activity. The microbial platform for germacrene ...

    Authors: Weixin Zhang, Junqi Guo, Zheng Wang, Yanwei Li, Xiangfeng Meng, Yu Shen and Weifeng Liu

    Citation: Microbial Cell Factories 2021 20:7

    Content type: Research

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  46. The majority of microbial fermentations are currently performed in the batch or fed-batch manner with the high process complexity and huge water consumption. The continuous microbial production can contribute ...

    Authors: Hui Liu, Yujin Cao, Jing Guo, Xin Xu, Qi Long, Lili Song and Mo Xian

    Citation: Microbial Cell Factories 2021 20:6

    Content type: Research

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  47. Phaffia rhodozyma has many desirable properties for astaxanthin production, including rapid heterotrophic metabolism and high cell densities in fermenter culture. The low optimal temperature range (17–21 °C) for...

    Authors: Li-Li Miao, Shuang Chi, Ting-Ting Hou, Zhi-Pei Liu and Ying Li

    Citation: Microbial Cell Factories 2021 20:5

    Content type: Research

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  48. Biosynthesis of l-tert-leucine (l-tle), a significant pharmaceutical intermediate, by a cofactor regeneration system friendly and efficiently is a worthful goal all the time. The cofactor regeneration system of l...

    Authors: Langxing Liao, Yonghui Zhang, Yali Wang, Yousi Fu, Aihui Zhang, Ruodian Qiu, Shuhao Yang and Baishan Fang

    Citation: Microbial Cell Factories 2021 20:3

    Content type: Research

    Published on:

  49. Cellobiose dehydrogenase from Phanerochaete chrysosporium (PcCDH) is a key enzyme in lignocellulose depolymerization, biosensors and biofuel cells. For these applications, it should retain important molecular and...

    Authors: Lena Wohlschlager, Florian Csarman, Hucheng Chang, Elisabeth Fitz, Bernhard Seiboth and Roland Ludwig

    Citation: Microbial Cell Factories 2021 20:2

    Content type: Research

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  50. Rhamnolipids (RLs) are surface-active compounds and belong to the class of glycolipid biosurfactants, mainly produced from Pseudomonas aeruginosa. Due to their non-toxicity, high biodegradability, low surface ten...

    Authors: Priyanka Thakur, Neeraj K. Saini, Vijay Kumar Thakur, Vijai Kumar Gupta, Reena V. Saini and Adesh K. Saini

    Citation: Microbial Cell Factories 2021 20:1

    Content type: Review

    Published on:

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Microbial Cell Factories

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