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  1. Microbial metabolism is highly dependent on the environmental conditions. Especially, the substrate concentration, as well as oxygen availability, determine the metabolic rates. In large-scale bioreactors, mic...

    Authors: Eleni Vasilakou, Mark C. M. van Loosdrecht and S. Aljoscha Wahl

    Citation: Microbial Cell Factories 2020 19:116

    Content type: Research

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  2. l-Serine has wide and increasing applications in industries with fast-growing market demand. Although strategies for achieving and improving l-serine production in Corynebacterium glutamicum (C. glutamicum) have ...

    Authors: Xiaomei Zhang, Yujie Gao, Ziwei Chen, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Mattheos A. G. Koffas and Zhenghong Xu

    Citation: Microbial Cell Factories 2020 19:115

    Content type: Research

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  3. Phthalic acid esters (PAEs) are widely used as plasticizers or additives during the industrial manufacturing of plastic products. PAEs have been detected in both aquatic and terrestrial environments due to the...

    Authors: Junmei Ding, Yang Zhou, Chaofan Wang, Zheng Peng, Yuelin Mu, Xianghua Tang and Zunxi Huang

    Citation: Microbial Cell Factories 2020 19:114

    Content type: Research

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  4. Corynebacterium glutamicum is a traditional food-grade industrial microorganism, in which an efficient endotoxin-free recombinant protein expression factory is under developing in recent years. However, the intri...

    Authors: Manman Sun, Xiong Gao, Zihao Zhao, An Li, Yali Wang, Yankun Yang, Xiuxia Liu and Zhonghu Bai

    Citation: Microbial Cell Factories 2020 19:113

    Content type: Research

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  5. The signal peptides (SPs) of secretory proteins are frequently used or modified to guide recombinant proteins outside the cytoplasm of prokaryotic cells. In the periplasmic space and extracellular environment,...

    Authors: Jianhua Gao, Hongmei Qian, Xiaoqin Guo, Yi Mi, Junpei Guo, Juanli Zhao, Chao Xu, Ting Zheng, Ming Duan, Zhongwei Tang, Chaoyang Lin, Zhicheng Shen, Yiwei Jiang and Xingchun Wang

    Citation: Microbial Cell Factories 2020 19:112

    Content type: Research

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  6. Mithramycin is an anti-tumor compound of the aureolic acid family produced by Streptomyces argillaceus. Its biosynthesis gene cluster has been cloned and characterized, and several new analogs with improved pharm...

    Authors: Daniel Zabala, Lijiang Song, Yousef Dashti, Gregory L. Challis, José A. Salas and Carmen Méndez

    Citation: Microbial Cell Factories 2020 19:111

    Content type: Research

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  7. Aromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are characterized by their polycyclic aromatic structure. The b...

    Authors: Jia Wang, Ruihua Zhang, Xin Chen, Xinxiao Sun, Yajun Yan, Xiaolin Shen and Qipeng Yuan

    Citation: Microbial Cell Factories 2020 19:110

    Content type: Review

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  8. The biosynthesis of high value-added compounds using metabolically engineered strains has received wide attention in recent years. Myo-inositol (inositol), an important compound in the pharmaceutics, cosmetics...

    Authors: Ran You, Lei Wang, Congrong Shi, Hao Chen, Shasha Zhang, Meirong Hu and Yong Tao

    Citation: Microbial Cell Factories 2020 19:109

    Content type: Research

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  9. Metabolic engineering frequently needs genomic integration of many heterologous genes for biosynthetic pathway assembly. Despite great progresses in genome editing for the model microorganism Escherichia coli, th...

    Authors: Buli Su, Dandan Song and Honghui Zhu

    Citation: Microbial Cell Factories 2020 19:108

    Content type: Research

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  10. The obligate aerobe Azotobacter vinelandii is a model organism for the study of biological nitrogen fixation (BNF). This bacterium regulates the process of BNF through the two component NifL and NifA system, wher...

    Authors: Mary H. Plunkett, Carolann M. Knutson and Brett M. Barney

    Citation: Microbial Cell Factories 2020 19:107

    Content type: Research

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  11. We evaluated the functional capacity of plantaricin-producing Lactobacillus plantarum SF9C and S-layer-carrying Lactobacillus brevis SF9B to withstand gastrointestinal transit and to compete among the gut microbi...

    Authors: Katarina Butorac, Martina Banić, Jasna Novak, Andreja Leboš Pavunc, Ksenija Uroić, Ksenija Durgo, Nada Oršolić, Marina Kukolj, Slobodanka Radović, Simone Scalabrin, Jurica Žučko, Antonio Starčević, Jagoda Šušković and Blaženka Kos

    Citation: Microbial Cell Factories 2020 19:106

    Content type: Research

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  12. 2-Acetamidophenol (AAP) is an aromatic compound with the potential for antifungal, anti-inflammatory, antitumor, anti-platelet, and anti-arthritic activities. Due to the biosynthesis of AAP is not yet fully un...

    Authors: Shuqi Guo, Yunxiao Wang, Wei Wang, Hongbo Hu and Xuehong Zhang

    Citation: Microbial Cell Factories 2020 19:105

    Content type: Research

    Published on:

  13. Marine macroalgae Gelidium amansii is a promising feedstock for production of sustainable biochemicals to replace petroleum and edible biomass. Different from terrestrial lignocellulosic biomass, G. amansii is co...

    Authors: Peng Liu, Jiaxiao Xie, Huanghong Tan, Feng Zhou, Lihua Zou and Jia Ouyang

    Citation: Microbial Cell Factories 2020 19:104

    Content type: Research

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  14. Astaxanthin is a kind of tetraterpene and has strong antioxygenic property. The biosynthesis of astaxanthin in engineered microbial chassis has greater potential than its chemical synthesis and extraction from...

    Authors: Dan-Dan Qi, Jin Jin, Duo Liu, Bin Jia and Ying-Jin Yuan

    Citation: Microbial Cell Factories 2020 19:103

    Content type: Research

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  15. Acetoin, especially the optically pure (3S)- or (3R)-enantiomer, is a high-value-added bio-based platform chemical and important potential pharmaceutical intermediate. Over the past decades, intense efforts have ...

    Authors: Lingxue Lu, Yufeng Mao, Mengyun Kou, Zhenzhen Cui, Biao Jin, Zhishuai Chang, Zhiwen Wang, Hongwu Ma and Tao Chen

    Citation: Microbial Cell Factories 2020 19:102

    Content type: Research

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  16. Poly-γ-glutamic acid (γ-PGA) is a promising biopolymer and has been applied in many fields. Bacillus siamensis SB1001 was a newly isolated poly-γ-glutamic acid producer with sucrose as its optimal carbon source. ...

    Authors: Dexin Wang, Hyangmi Kim, Sungbeom Lee, Dae-Hyuk Kim and Min-Ho Joe

    Citation: Microbial Cell Factories 2020 19:101

    Content type: Research

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  17. Large-scale genome reduction has been performed to significantly improve the performance of microbial chassis. Identification of the essential or dispensable genes is pivotal for genome reduction to avoid synt...

    Authors: Qing-Ting Bu, Yue-Ping Li, Huang Xie, Jue Wang, Zi-Yue Li, Xin-Ai Chen, Xu-Ming Mao and Yong-Quan Li

    Citation: Microbial Cell Factories 2020 19:99

    Content type: Research

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  18. An increasing rate of antibiotic resistance among Gram-negative bacterial pathogens has created an urgent need to discover novel therapeutic agents to combat infectious diseases. Use of bacteriocins as therape...

    Authors: Preeti Sharma, Muzamil Rashid and Sukhraj Kaur

    Citation: Microbial Cell Factories 2020 19:98

    Content type: Research

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  19. For decades, plastic has been a valuable global product due to its convenience and low price. For example, polyethylene terephthalate (PET) was one of the most popular materials for disposable bottles due to i...

    Authors: Ji Won Kim, Su-Bin Park, Quynh-Giao Tran, Dae-Hyun Cho, Dong-Yun Choi, Yong Jae Lee and Hee-Sik Kim

    Citation: Microbial Cell Factories 2020 19:97

    Content type: Research

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  20. Xylose transport is one of the bottlenecks in the conversion of lignocellulosic biomass to ethanol. Xylose consumption by the wild-type strains of xylose-utilizing yeasts occurs once glucose is depleted result...

    Authors: Roksolana Vasylyshyn, Olena Kurylenko, Justyna Ruchala, Nadiya Shevchuk, Neringa Kuliesiene, Galina Khroustalyova, Alexander Rapoport, Rimantas Daugelavicius, Kostyantyn Dmytruk and Andriy Sibirny

    Citation: Microbial Cell Factories 2020 19:96

    Content type: Research

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  21. Gallic acid has received a significant amount of interest for its biological properties. Thus, there have been recent attempts to apply this substance in various industries and in particular the feed industry....

    Authors: Apinun Kanpiengjai, Chartchai Khanongnuch, Saisamorn Lumyong, Dietmar Haltrich, Thu-Ha Nguyen and Suwapat Kittibunchakul

    Citation: Microbial Cell Factories 2020 19:95

    Content type: Research

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  22. Obesity is a major problem worldwide and severely affects public safety. As a metabolite of gut microbiota, endogenous butyric acid participates in energy and material metabolism. Considering the serious side ...

    Authors: Liang Bai, Mengxue Gao, Xiaoming Cheng, Guangbo Kang, Xiaocang Cao and He Huang

    Citation: Microbial Cell Factories 2020 19:94

    Content type: Research

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  23. The phenylbutanoid 4-(4-hydroxyphenyl)butan-2-one, commonly known as raspberry ketone, is responsible for the typical scent and flavor of ripe raspberries. Chemical production of nature-identical raspberry ket...

    Authors: Lars Milke, Mario Mutz and Jan Marienhagen

    Citation: Microbial Cell Factories 2020 19:92

    Content type: Research

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  24. Docosahexaenoic acid (DHA) is essential for human diet. However, high production cost of DHA using C. cohnii makes it currently less competitive commercially, which is mainly caused by low DHA productivity. In re...

    Authors: Liangsen Liu, Fangzhong Wang, Guangsheng Pei, Jinyu Cui, Jinjin Diao, Mingming Lv, Lei Chen and Weiwen Zhang

    Citation: Microbial Cell Factories 2020 19:91

    Content type: Research

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  25. Autoimmune diseases have been associated with changes in the gut microbiome. In this study, the gut microbiome was evaluated in individuals with dry eye and bacterial compositions were correlated to dry eye (D...

    Authors: Roberto Mendez, Arjun Watane, Monika Farhangi, Kara M. Cavuoto, Tom Leith, Shrish Budree, Anat Galor and Santanu Banerjee

    Citation: Microbial Cell Factories 2020 19:90

    Content type: Research

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  26. Biological routes for ethylene glycol production have been developed in recent years by constructing the synthesis pathways in different microorganisms. However, no microorganisms have been reported yet to pro...

    Authors: Zhongxi Zhang, Yang Yang, Yike Wang, Jinjie Gu, Xiyang Lu, Xianyan Liao, Jiping Shi, Chul Ho Kim, Gary Lye, Frank Baganz and Jian Hao

    Citation: Microbial Cell Factories 2020 19:89

    Content type: Research

    Published on:

  27. Trypsin has many applications in food and pharmaceutical manufacturing. Although commercial trypsin is usually extracted from porcine pancreas, this source carries the risks of infectivity and immunogenicity. ...

    Authors: Yunfeng Zhang, Qixing Liang, Chuanzhi Zhang, Juan Zhang, Guocheng Du and Zhen Kang

    Citation: Microbial Cell Factories 2020 19:88

    Content type: Research

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  28. (S)-1-phenyl-1,2-ethanediol is an important chiral intermediate in the synthesis of liquid crystals and chiral biphosphines. (S)-carbonyl reductase II from Candida parapsilosis catalyzes the conversion of 2-hydro...

    Authors: Junchao Rao, Rongzhen Zhang, Guanyu Xu, Lihong Li and Yan Xu

    Citation: Microbial Cell Factories 2020 19:87

    Content type: Research

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  29. Recombinant proteins are often engineered with an N-terminal signal peptide, which facilitates their secretion to the oxidising environment of the periplasm (gram-negative bacteria) or the culture supernatant ...

    Authors: Kiavash Mirzadeh, Patrick J. Shilling, Rageia Elfageih, Alister J. Cumming, Huanhuan L. Cui, Maja Rennig, Morten H. H. Nørholm and Daniel O. Daley

    Citation: Microbial Cell Factories 2020 19:85

    Content type: Research

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  30. Phytases are widely utilized in feed industry to increase the utilization of phosphorus, minerals, and amino acids for improvement of animal and human nutrition. At present, all known β-propeller phytases (BPP...

    Authors: Xianjuan Hou, Zhen Shen, Na Li, Xiaowei Kong, Kangliang Sheng, Jingmin Wang and Yongzhong Wang

    Citation: Microbial Cell Factories 2020 19:84

    Content type: Research

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  31. Dietary lignans belong to the group of phytoestrogens together with coumestans, stilbenes and isoflavones, and themselves do not exhibit oestrogen-like properties. Nonetheless, the gut microbiota converts them...

    Authors: Giulia Corona, Anna Kreimes, Monica Barone, Silvia Turroni, Patrizia Brigidi, Enver Keleszade and Adele Costabile

    Citation: Microbial Cell Factories 2020 19:82

    Content type: Research

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  32. Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger. Compared to the traditional ways of process optimization, the metabolic engineering strategie...

    Authors: Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang, Ju Chu, Yufei Sui and Yingping Zhuang

    Citation: Microbial Cell Factories 2020 19:81

    Content type: Research

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  33. The bioconversion of phytosterols into high value-added steroidal intermediates, including the 9α-hydroxy-4-androstene-3,17-dione (9-OHAD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), is the cornerstone i...

    Authors: Liang-Bin Xiong, Hao-Hao Liu, Ming Zhao, Yong-Jun Liu, Lu Song, Zhi-Yong Xie, Yi-Xin Xu, Feng-Qing Wang and Dong-Zhi Wei

    Citation: Microbial Cell Factories 2020 19:80

    Content type: Research

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  34. Microbes are rich sources of enzymes and esterases are one of the most important classes of enzymes because of their potential for application in the field of food, agriculture, pharmaceuticals and bioremediat...

    Authors: Jayita Sarkar, Arindam Dutta, Piyali Pal Chowdhury, Joydeep Chakraborty and Tapan K. Dutta

    Citation: Microbial Cell Factories 2020 19:77

    Content type: Research

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  35. Aspergillus niger is a filamentous fungus used for the majority of global citric acid production. Recent developments in genome editing now enable biotechnologists to engineer and optimize A. niger. Currently, ho...

    Authors: Lihui Zhang, Xiaomei Zheng, Timothy C. Cairns, Zhidan Zhang, Depei Wang, Ping Zheng and Jibin Sun

    Citation: Microbial Cell Factories 2020 19:76

    Content type: Research

    Published on:

  36. Resistance to therapy is one of the major factors that contribute to dismal survival statistics in pancreatic cancer. While there are many tumor intrinsic and tumor microenvironment driven factors that contrib...

    Authors: Kousik Kesh, Roberto Mendez, Leila Abdelrahman, Santanu Banerjee and Sulagna Banerjee

    Citation: Microbial Cell Factories 2020 19:75

    Content type: Research

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  37. In the course of drug discovery and development process, sufficient reference standards of drug metabolites are required, especially for preclinical/clinical or new therapeutic drugs. Whole-cell synthesis of d...

    Authors: Gianluca Catucci, Gianfranco Gilardi and Sheila J. Sadeghi

    Citation: Microbial Cell Factories 2020 19:74

    Content type: Research

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  38. Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial e...

    Authors: Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim and Joong-Hoon Ahn

    Citation: Microbial Cell Factories 2020 19:73

    Content type: Research

    Published on:

  39. Caffeine, theobromine and theophylline are main purine alkaloid in tea. Theophylline is the downstream metabolite and it remains at a very low level in Camellia sinensis. In our previous study, Aspergillus sydowi...

    Authors: Binxing Zhou, Cunqiang Ma, Tao Xia, Xiaohong Li, Chengqin Zheng, Tingting Wu and Xiaohui Liu

    Citation: Microbial Cell Factories 2020 19:72

    Content type: Research

    Published on:

  40. Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal scr...

    Authors: Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon…

    Citation: Microbial Cell Factories 2020 19:71

    Content type: Research

    Published on:

  41. Genome streamlining is a feasible strategy for constructing an optimum microbial chassis for synthetic biology applications. Genomic islands (GIs) are usually regarded as foreign DNA sequences, which can be ob...

    Authors: Peixin Liang, Yiting Zhang, Bo Xu, Yuxin Zhao, Xiangsheng Liu, Weixia Gao, Ting Ma, Chao Yang, Shufang Wang and Ruihua Liu

    Citation: Microbial Cell Factories 2020 19:70

    Content type: Research

    Published on:

  42. Trichoderma species are among the most effective cell factories to produce recombinant proteins, whose productivity relies on the molecular toolkit and promoters available for the expression of the target protein...

    Authors: Nohemí Carreras-Villaseñor, José Guillermo Rico-Ruiz, Ricardo A. Chávez Montes, Lenin Yong-Villalobos, José Fabricio López-Hernández, Pedro Martínez-Hernández, Luis Herrera-Estrella, Alfredo Herrera-Estrella and Damar López-Arredondo

    Citation: Microbial Cell Factories 2020 19:69

    Content type: Research

    Published on:

  43. Worldwide 3.4 billion tonnes of municipal solid waste (MSW) will be produced annually by 2050, however, current approaches to MSW management predominantly involve unsustainable practices like landfilling and i...

    Authors: Aritha Dornau, James F. Robson, Gavin H. Thomas and Simon J. McQueen-Mason

    Citation: Microbial Cell Factories 2020 19:68

    Content type: Research

    Published on:

  44. Microbial de novo production of l-serine, which is widely used in a range of cosmetic and pharmaceutical products, has attracted increasing attention due to its environmentally friendly characteristics. Previous ...

    Authors: Chenyang Wang, Junjun Wu, Binchao Shi, Jiping Shi and Zhijun Zhao

    Citation: Microbial Cell Factories 2020 19:66

    Content type: Research

    Published on:

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