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  1. Content type: RESEARCH

    The fungus Ashbya gossypii is an important industrial producer of the vitamin riboflavin. Using this microbe, riboflavin is manufactured in a two-stage process based on a rich medium with vegetable oil, yeast ext...

    Authors: Susanne Katharina Schwechheimer, Judith Becker, Lindsay Peyriga, Jean-Charles Portais and Christoph Wittmann

    Citation: Microbial Cell Factories 2018 17:162

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  2. Content type: RESEARCH

    Proteins can be secreted from a host organism with the aid of N-terminal secretion signals. The budding yeast Pichia pastoris (Komagataella sp.) is widely employed to secrete proteins of academic and industrial i...

    Authors: Juan J. Barrero, Jason C. Casler, Francisco Valero, Pau Ferrer and Benjamin S. Glick

    Citation: Microbial Cell Factories 2018 17:161

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  3. Content type: RESEARCH

    The canonical heterotrimeric G protein-cAMP/PKA pathway regulates numerous cellular processes in filamentous fungi. Chaetomium globosum, a saprophytic fungus, is known for producing many secondary metabolites, in...

    Authors: Yang Hu, Yanjie Liu, Xiaoran Hao, Dan Wang, Oren Akhberdi, Biyun Xiang and Xudong Zhu

    Citation: Microbial Cell Factories 2018 17:160

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  4. Content type: RESEARCH

    Whole cells of Gluconobacter oxydans are widely used in various biocatalytic processes. Sorbitol at high concentrations is commonly used in complex media to prepare biocatalysts. Exploiting an alternative process...

    Authors: Jinxin Yan, Jing Xu, Menghao Cao, Zhong Li, Chengpeng Xu, Xinyu Wang, Chunyu Yang, Ping Xu, Chao Gao and Cuiqing Ma

    Citation: Microbial Cell Factories 2018 17:158

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  5. Content type: RESEARCH

    Microbial production of chemicals from renewable carbon sources enables a sustainable route to many bioproducts. Sugar streams, such as those derived from biomass pretreated with ionic liquids (IL), provide ef...

    Authors: Thomas Eng, Philipp Demling, Robin A. Herbert, Yan Chen, Veronica Benites, Joel Martin, Anna Lipzen, Edward E. K. Baidoo, Lars M. Blank, Christopher J. Petzold and Aindrila Mukhopadhyay

    Citation: Microbial Cell Factories 2018 17:159

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  6. Content type: RESEARCH

    Outer membrane vesicles (OMVs) are nanoparticles released by Gram-negative bacteria and can be used as vaccines. Often, detergents are used to promote release of OMVs and to remove the toxic lipopolysaccharide...

    Authors: Matthias J. H. Gerritzen, Ronald H. W. Maas, Jan van den Ijssel, Lonneke van Keulen, Dirk E. Martens, René H. Wijffels and Michiel Stork

    Citation: Microbial Cell Factories 2018 17:157

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  7. Content type: RESEARCH

    Bacillus spp. are a genus of biocontrol bacteria widely used for antibiosis, while Trichoderma spp. are biocontrol fungi that are abundantly explored. In this study, a liquid co-cultivation of these two organisms...

    Authors: Qiong Wu, Mi Ni, Kai Dou, Jun Tang, Jianhong Ren, Chuanjin Yu and Jie Chen

    Citation: Microbial Cell Factories 2018 17:155

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  9. Content type: RESEARCH

    Coffee silverskin, a by-product from coffee roasting industries, was evaluated as a feedstock for biobutanol production by acetone–butanol–ethanol fermentation. This lignocellulosic biomass contained approxima...

    Authors: María Hijosa-Valsero, Jerson Garita-Cambronero, Ana I. Paniagua-García and Rebeca Díez-Antolínez

    Citation: Microbial Cell Factories 2018 17:154

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  10. Content type: RESEARCH

    Following cellulose, chitin is the most abundant renewable resource and is composed of the monomeric amino sugar N-acetyl-d-glucosamine (GlcNAc). Although many yeasts, including Saccharomyces cerevisiae, have los...

    Authors: Kentaro Inokuma, Mami Matsuda, Daisuke Sasaki, Tomohisa Hasunuma and Akihiko Kondo

    Citation: Microbial Cell Factories 2018 17:153

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  11. Content type: RESEARCH

    Production of isoprenoids, a large and diverse class of commercially important chemicals, can be achieved through engineering metabolism in microorganisms. Several attempts have been made to reroute metabolic ...

    Authors: Manisha Wadhwa, Sumana Srinivasan, Anand K. Bachhawat and K. V. Venkatesh

    Citation: Microbial Cell Factories 2018 17:152

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  12. Content type: RESEARCH

    Genetic tools including constitutive and inducible promoters have been developed over the last few decades for strain engineering in Streptomyces. Inducible promoters are useful for controlling gene expression, h...

    Authors: Yuji Noguchi, Norimasa Kashiwagi, Atsuko Uzura, Chiaki Ogino, Akihiko Kondo, Haruo Ikeda and Masahiro Sota

    Citation: Microbial Cell Factories 2018 17:151

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  13. Content type: RESEARCH

    Epimutations arising from transcriptional slippage seem to have more important role in regulating gene expression than earlier though. Since the level and the fidelity of transcription primarily determine the ...

    Authors: Ewa Wons, Dawid Koscielniak, Monika Szadkowska and Marian Sektas

    Citation: Microbial Cell Factories 2018 17:150

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  14. Content type: RESEARCH

    The non-proteinogenic aromatic amino acid, p-amino-l-phenylalanine (l-PAPA) is a high-value product with a broad field of applications. In nature, l-PAPA occurs as an intermediate of the chloramphenicol biosynthe...

    Authors: Behrouz Mohammadi Nargesi, Natalie Trachtmann, Georg A. Sprenger and Jung-Won Youn

    Citation: Microbial Cell Factories 2018 17:149

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  15. Content type: RESEARCH

    The bacterium E. coli is a major host for recombinant protein production of non-glycosylated products. Depending on the expression strategy, the recombinant protein can be located intracellularly. In many cases t...

    Authors: Christoph Slouka, Julian Kopp, Stefan Hutwimmer, Michael Strahammer, Daniel Strohmer, Elisabeth Eitenberger, Andreas Schwaighofer and Christoph Herwig

    Citation: Microbial Cell Factories 2018 17:148

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  16. Content type: RESEARCH

    Microbial biosynthesis of natural products holds promise for preclinical studies and treating diseases. For instance, pinocembrin is a natural flavonoid with important pharmacologic characteristics and is wide...

    Authors: Sha Tao, Ying Qian, Xin Wang, Weijia Cao, Weichao Ma, Kequan Chen and Pingkai Ouyang

    Citation: Microbial Cell Factories 2018 17:147

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  17. Content type: RESEARCH

    The yeast Kluyveromyces marxianus is an emerging cell factory for heterologous protein biosynthesis and its use holds tremendous advantages for multiple applications. However, which genes influence the productivi...

    Authors: Yang Liu, Wen-Juan Mo, Tian-Fang Shi, Meng-Zhu Wang, Jun-Gang Zhou, Yao Yu, Wen-Shan Yew and Hong Lu

    Citation: Microbial Cell Factories 2018 17:144

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  18. Content type: RESEARCH

    Dengue is a rapidly spreading mosquito borne tropical viral disease affecting hundreds of millions of people across the globe annually. The dengue virus (DENV) includes four genetically distinct serotypes that...

    Authors: Jyotiranjan Bal, Hee-Young Jung, Luong Ngoc Nguyen, Jisang Park, Yong-Suk Jang and Dae-Hyuk Kim

    Citation: Microbial Cell Factories 2018 17:146

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  19. Content type: RESEARCH

    Anthocyanins such as cyanidin 3-O-glucoside (C3G) have wide applications in industry as food colorants. Their current production heavily relies on extraction from plant tissues. Development of a sustainable metho...

    Authors: Jian Zha, Ying Zang, Matthew Mattozzi, Jens Plassmeier, Mamta Gupta, Xia Wu, Sonya Clarkson and Mattheos A. G. Koffas

    Citation: Microbial Cell Factories 2018 17:143

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  20. Content type: RESEARCH

    Oleaginous yeast Yarrowia lipolytica is an organism of choice for the development of biofuel and oleochemicals. It has become a chassis for metabolic engineering in order to produce targeted lipids. Understanding...

    Authors: Coraline Rigouin, Christian Croux, Vinciane Borsenberger, Maher Ben Khaled, Thierry Chardot, Alain Marty and Florence Bordes

    Citation: Microbial Cell Factories 2018 17:142

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  21. Content type: RESEARCH

    Biosynthesis of steroidal drugs is of great benefit in pharmaceutical manufacturing as the process involves efficient enzymatic catalysis at ambient temperature and atmospheric pressure compared to chemical sy...

    Authors: Shuhong Mao, Jian-Wen Wang, Fufeng Liu, Zhangliang Zhu, Dengke Gao, Qianqian Guo, Panpan Xu, Zheng Ma, Yali Hou, Xiaotao Cheng, Dengyue Sun, Fuping Lu and Hui-Min Qin

    Citation: Microbial Cell Factories 2018 17:141

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  22. Content type: RESEARCH

    Scheffersomyces stipitis is an important yeast species in the field of biorenewables due to its desired capacity for xylose utilization. It has been recognized that redox balance plays a critical role in S. stipi...

    Authors: Matthew Hilliard, Andrew Damiani, Q. Peter He, Thomas Jeffries and Jin Wang

    Citation: Microbial Cell Factories 2018 17:140

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  23. Content type: RESEARCH

    Lactic acid bacteria (LAB) are one of the microorganisms of choice for the development of protein delivery systems for therapeutic purposes. Although there are numerous tools to facilitate genome engineering o...

    Authors: Laura Ortiz-Velez, Javiera Ortiz-Villalobos, Abby Schulman, Jee-Hwan Oh, Jan-Peter van Pijkeren and Robert A. Britton

    Citation: Microbial Cell Factories 2018 17:138

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  24. Content type: RESEARCH

    The recycling of agro-industrial wastes is at present limited by the availability of efficient and low-cost enzyme cocktails. The use of these materials as culture media to produce the enzymes can contribute t...

    Authors: María-Efigenia Álvarez-Cao, Agustín Rico-Díaz, María-Esperanza Cerdán, Manuel Becerra and María-Isabel González-Siso

    Citation: Microbial Cell Factories 2018 17:137

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  25. Content type: RESEARCH

    Physiological aggregation of a recombinant enzyme into enzymatically active inclusion bodies could be an excellent strategy to obtain immobilized enzymes for industrial biotransformation processes. However, it...

    Authors: Romana Koszagova, Tomas Krajcovic, Klaudia Palencarova-Talafova, Vladimir Patoprsty, Alica Vikartovska, Kristyna Pospiskova, Ivo Safarik and Jozef Nahalka

    Citation: Microbial Cell Factories 2018 17:139

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  26. Content type: RESEARCH

    β-Ionone is a fragrant terpenoid that generates a pleasant floral scent and is used in diverse applications as a cosmetic and flavoring ingredient. A growing consumer desire for natural products has increased ...

    Authors: Jeffrey J. Czajka, Justin A. Nathenson, Veronica T. Benites, Edward E. K. Baidoo, Qianshun Cheng, Yechun Wang and Yinjie J. Tang

    Citation: Microbial Cell Factories 2018 17:136

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  27. Content type: Review

    Biotechnological processes use microbes to convert abundant molecules, such as glucose, into high-value products, such as pharmaceuticals, commodity and fine chemicals, and energy. However, from the outset of ...

    Authors: Kevin James Metcalf, Marilyn F. Slininger Lee, Christopher Matthew Jakobson and Danielle Tullman-Ercek

    Citation: Microbial Cell Factories 2018 17:135

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  28. Content type: RESEARCH

    Gram-positive bacterium Bacillus subtilis has been extensively studied as a microbial cell factory for high-level producing a wide range of interesting products. Green fluorescent protein (GFP) is commonly used a...

    Authors: Haojie Cao and Oscar P. Kuipers

    Citation: Microbial Cell Factories 2018 17:134

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  29. Content type: RESEARCH

    Erythritol is a four-carbon sugar alcohol with sweetening properties that is used by the agro-food industry as a food additive. In the yeast Yarrowia lipolytica, the last step of erythritol synthesis involves the...

    Authors: Huiling Cheng, Siqi Wang, Muhammad Bilal, Xuemei Ge, Can Zhang, Patrick Fickers and Hairong Cheng

    Citation: Microbial Cell Factories 2018 17:133

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  31. Content type: RESEARCH

    Tubercidin (TBN), an adenosine analog with potent antimycobacteria and antitumor bioactivities, highlights an intriguing structure, in which a 7-deazapurine core is linked to the ribose moiety by an N-glycosidic ...

    Authors: Yan Liu, Rong Gong, Xiaoqin Liu, Peichao Zhang, Qi Zhang, You-Sheng Cai, Zixin Deng, Margit Winkler, Jianguo Wu and Wenqing Chen

    Citation: Microbial Cell Factories 2018 17:131

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  32. Content type: RESEARCH

    Flavonoid glycosides have many beneficial effects on health, but these bioactivities tend to decrease after oral administration owing to their poor lipophilicity. In this study, a facile whole-cell-based metho...

    Authors: Xuan Xin, Mengmeng Zhang, Xiaofeng Li, Furao Lai and Guanglei Zhao

    Citation: Microbial Cell Factories 2018 17:130

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  33. Content type: Technical Notes

    Filamentous fungi including Aspergillus niger are cell factories for the production of organic acids, proteins and bioactive compounds. Traditionally, stirred-tank reactors (STRs) are used to cultivate them under...

    Authors: Tutku Kurt, Anna-Maria Marbà-Ardébol, Zeynep Turan, Peter Neubauer, Stefan Junne and Vera Meyer

    Citation: Microbial Cell Factories 2018 17:128

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  34. Content type: RESEARCH

    Recent interest has been focused on the production of platform chemicals from renewable biomass due to increasing concerns on global warming and depletion of fossil fuel reserves. Microbial production of platf...

    Authors: Kei-Anne Baritugo, Hee Taek Kim, Yokimiko David, Tae Uk Khang, Sung Min Hyun, Kyoung Hee Kang, Ju Hyun Yu, Jong Hyun Choi, Jae Jun Song, Jeong Chan Joo and Si Jae Park

    Citation: Microbial Cell Factories 2018 17:129

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  35. Content type: RESEARCH

    Bacterial strains of the genus Geobacillus grow at high temperatures of 50–75 °C and could thus be useful for biotechnological applications. However, genetic manipulation of these species is difficult because the...

    Authors: Megumi Miyano, Kosei Tanaka, Shu Ishikawa, Kotaro Mori, Andrés Miguel-Arribas, Wilfried J. J. Meijer and Ken-ichi Yoshida

    Citation: Microbial Cell Factories 2018 17:127

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  36. Content type: RESEARCH

    Recent biotechnological advancements have allowed for the adoption of Lactococcus lactis, a typical component of starter cultures used in food industry, as the host for the production of food-grade recombinant ta...

    Authors: Mohamed Boumaiza, Andrea Colarusso, Ermenegilda Parrilli, Elena Garcia-Fruitós, Angela Casillo, Anna Arís, Maria Michela Corsaro, Delia Picone, Serena Leone and Maria Luisa Tutino

    Citation: Microbial Cell Factories 2018 17:126

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  37. Content type: RESEARCH

    Emergence of antibiotic resistance and growing consumer trend towards foods containing biopreservatives stimulated the search for alternative antimicrobials. This research is aimed at characterizing, investiga...

    Authors: Samson Baranzan Wayah and Koshy Philip

    Citation: Microbial Cell Factories 2018 17:125

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  38. Content type: RESEARCH

    β-Mannanase catalyzes the cleavage of β-1,4-linked internal linkages of mannan backbone randomly to produce new chain ends. Alkaline and thermostable β-mannanases provide obvious advantages for many applicatio...

    Authors: Cheng Zhou, Yanfen Xue and Yanhe Ma

    Citation: Microbial Cell Factories 2018 17:124

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  39. Content type: RESEARCH

    Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response (UPR) usually apparent through increased intracellular l...

    Authors: Gustavo Roth, Ana Letícia Vanz, Heinrich Lünsdorf, Manfred Nimtz and Ursula Rinas

    Citation: Microbial Cell Factories 2018 17:123

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  41. Content type: RESEARCH

    Lipopeptides are a promising group of surface-active compounds of microbial origin (biosurfactants). These diverse molecules are produced mainly by Bacillus and Pseudomonas strains. Because of their attractive ph...

    Authors: Piotr Biniarz, François Coutte, Frédérique Gancel and Marcin Łukaszewicz

    Citation: Microbial Cell Factories 2018 17:121

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  42. Content type: Review

    For years, microbes have been widely applied as chassis in the construction of synthetic metabolic pathways. However, the lack of in vivo enzyme clustering of heterologous metabolic pathways in these organisms...

    Authors: Xin-yuan Qiu, Si-Si Xie, Lu Min, Xiao-Min Wu, Lv-Yun Zhu and Lingyun Zhu

    Citation: Microbial Cell Factories 2018 17:120

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  43. Content type: Correction

    Upon publication of this article [1], it was brought to our attention that revised Fig. 1 supplied by the author during proof correction was unfortunately not presented in the original version of the article. ...

    Authors: Katherina Garcia Vanegas, Arésu Bondrup Larsen, Michael Eichenberger, David Fischer, Uffe Hasbro Mortensen and Michael Naesby

    Citation: Microbial Cell Factories 2018 17:119

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    The original article was published in Microbial Cell Factories 2018 17:107

  44. Content type: RESEARCH

    Acid stress is often encountered during industrial fermentation as a result of the accumulation of acidic metabolites. Acid stress increases the intracellular acidity and can cause DNA damage and denaturation ...

    Authors: Xianxing Gao, Xiaofeng Yang, Jiahui Li, Yan Zhang, Ping Chen and Zhanglin Lin

    Citation: Microbial Cell Factories 2018 17:118

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  45. Content type: RESEARCH

    Phenazine-1-carboxamide (PCN), a phenazine derivative, is strongly antagonistic to fungal phytopathogens. The high PCN biocontrol activity fascinated researcher’s attention in isolating and identifying novel b...

    Authors: Huasong Peng, Pingyuan Zhang, Muhammad Bilal, Wei Wang, Hongbo Hu and Xuehong Zhang

    Citation: Microbial Cell Factories 2018 17:117

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  46. Content type: RESEARCH

    Pine wilt disease, caused by the pinewood nematode Bursaphelenchus xylophilus (PWN), is an important destructive disease of pine forests worldwide. In addition to behaving as a plant-parasitic nematode that feeds...

    Authors: Chihang Cheng, Jialing Qin, Choufei Wu, Mengying Lei, Yongjun Wang and Liqin Zhang

    Citation: Microbial Cell Factories 2018 17:116

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  47. Content type: RESEARCH

    Cis, cis-muconic acid (MA) is a dicarboxylic acid of recognized industrial value. It provides direct access to adipic acid and terephthalic acid, prominent monomers of commercial plastics.

    Authors: Judith Becker, Martin Kuhl, Michael Kohlstedt, Sören Starck and Christoph Wittmann

    Citation: Microbial Cell Factories 2018 17:115

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  49. Content type: RESEARCH

    Malate is a C4-dicarboxylic acid widely used as an acidulant in the food and beverage industry. Rational engineering has been performed in the past for the development of microbial strains capable of efficient...

    Authors: Debora Trichez, Clément Auriol, Audrey Baylac, Romain Irague, Clémentine Dressaire, Marc Carnicer-Heras, Stéphanie Heux, Jean Marie François and Thomas Walther

    Citation: Microbial Cell Factories 2018 17:113

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  50. Content type: RESEARCH

    The yeast Komagataella phaffii, better known as Pichia pastoris, is a commonly used host for recombinant protein production. Here expression vectors are reported that address the different steps of the transcript...

    Authors: Loknath Gidijala, Stefan Uthoff, Sebastiaan J. van Kampen, Alexander Steinbüchel and Raymond M. D. Verhaert

    Citation: Microbial Cell Factories 2018 17:112

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