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Microbial Cell Factories


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  1. Content type: Review


    Authors: Nabih A Baeshen, Mohammed N Baeshen, Abdullah Sheikh, Roop S Bora, Mohamed Morsi M Ahmed, Hassan A I Ramadan, Kulvinder Singh Saini and Elrashdy M Redwan

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Thematic series
Engineering cell factories for production of bulk and fine chemicals: from designing principles to industrial-scale production
Edited by Yin Li
Collection published: 24 June 2017


Thematic series
CRISPR/Cas9 and the microbial cell factory
Edited by George Guo-Qiang Chen
Collection published: 16 February 2017


Thematic series
Microbial food biotechnology
Edited by: Prof Maria Papagianni
Collection published: 3 May 2016


Thematic series
Systems biotechnology and metabolic engineering
Edited by: Prof Sang Yup Lee
Collection published: 19 June 2014

Thematic series
Added value chemicals and biofuels
Edited by: Prof Akihiko Kondo
Collection published: 9 June 2014

Thematic series
Yeast biotechnology
Microbial Cell Factories
Edited by: Prof Diethard Mattanovich
Collection published: 6 May 2014

Thematic series
Recombinant protein quality: approaches for the quantitative evaluation of functional and structural features of purified proteins and antibodies
Edited by: Prof Ario de Marco
Collection published: 11 April 2014

Cross journal collection
Reviewer acknowledgements 2013
Collection published: 26 February 2014

Engineering cell factories for production of bulk and fine chemicals: from designing principles to industrial-scale production

As "the Stone Age did not end for lack of stone, and the Oil Age will end long before the world runs out of oil", biotechnological production of fuels, chemicals, and materials is becoming an emerging field that attracts great interest worldwide. Owing to the rapid development of metabolic engineering and synthetic biology, many high-value fine chemicals, as well as a few low-value bulk chemicals, have been successfully produced by engineered cell factories and scaled-up to industrial scales. Theoretically, most chemicals can be produced by microorganisms. However, developing microbial cell factories that are of commercial value may take many years of effort, during which many hurdles have to be overcome to make the innovation a success.
In this themed Special Issue, the readers will see a collection of articles that describe the commercial success of engineered cell factories. Engineering principles and progresses on how to design, select, construct, screen, and optimize microbial cell factories are presented, together with the perspectives on future challenges.

Edited by Yin Li, Institute of Microbiology, Chinese Academy of Sciences

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Aims and scope

Microbial Cell Factories is an open access peer-reviewed journal that covers any topic related to the development, use and investigation of microbial cells as producers of recombinant proteins and natural products, or as catalyzers of biological transformations of industrial interest. Microbial Cell Factories is the world leading, primary research journal fully focusing on Applied Microbiology.

The journal is divided into the following editorial sections:

Metabolic engineering
Synthetic biology
Whole-cell biocatalysis
Microbial regulations
Recombinant protein production/bioprocessing
Production of natural compounds
Systems biology of cell factories
Microbial production processes

Selection, characterization, and thermal stabilization of llama single domain antibodies towards Ebola virus glycoprotein

The Ebola virus envelope glycoprotein (GP) is essential to its pathogenicity. Jinny Liu and colleagues obtained three promising GP binding antibodies, from a llama immune phage display library, that may be useful in diagnostic or therapeutic applications.


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