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  1. The benzoylformate decarboxylase (BFD) from Pseudomonas putida is a biotechnologically interesting biocatalyst. It catalyses the formation of chiral 2-hydroxy ketones, which are important building blocks for ster...

    Authors: Thomas G Palmen, Jens Nieveler, Bettina Frölich, Wiltrud Treffenfeldt, Martina Pohl and Jochen Büchs
    Citation: Microbial Cell Factories 2010 9:76
  2. The effect of high glucose concentration on the transcription levels of the small RNA SgrS and the messenger RNA ptsG, (encoding the glucose transporter IICBGlc), was studied in both E. coli K-12 (MG1655 and JM10...

    Authors: Alejandro Negrete, Weng-Ian Ng and Joseph Shiloach
    Citation: Microbial Cell Factories 2010 9:75
  3. The production of microbial lipids has attracted considerable interest during the past decade since they can be successfully used to produce biodiesel by catalyzed transesterification with short chain alcohols...

    Authors: Alberto Amaretti, Stefano Raimondi, Maurizio Sala, Lucia Roncaglia, Marzia De Lucia, Alan Leonardi and Maddalena Rossi
    Citation: Microbial Cell Factories 2010 9:73
  4. Pseudoalteromonas haloplanktis is a cold-adapted γ-proteobacterium isolated from Antarctic sea ice. It is characterized by remarkably high growth rates at low temperatures. P. haloplanktis is one of the model org...

    Authors: Boris Wilmes, Angelika Hartung, Michael Lalk, Manuel Liebeke, Thomas Schweder and Peter Neubauer
    Citation: Microbial Cell Factories 2010 9:72
  5. Bacterial inclusion bodies are submicron protein clusters usually found in recombinant bacteria that have been traditionally considered as undesirable products from protein production processes. However, being...

    Authors: Escarlata Rodríguez-Carmona, Olivia Cano-Garrido, Joaquin Seras-Franzoso, Antonio Villaverde and Elena García-Fruitós
    Citation: Microbial Cell Factories 2010 9:71
  6. Methylotrophic (methanol-utilizing) bacteria offer great potential as cell factories in the production of numerous products from biomass-derived methanol. Bio-methanol is essentially a non-food substrate, an a...

    Authors: Philipp Höfer, Young J Choi, Michael J Osborne, Carlos B Miguez, Patrick Vermette and Denis Groleau
    Citation: Microbial Cell Factories 2010 9:70
  7. The assembly and spatial organization of enzymes in naturally occurring multi-protein complexes is of paramount importance for the efficient degradation of complex polymers and biosynthesis of valuable product...

    Authors: Andrew S Wieczorek and Vincent JJ Martin
    Citation: Microbial Cell Factories 2010 9:69
  8. The formation of native disulfide bonds is a complex and essential post-translational modification for many proteins. The large scale production of these proteins can be difficult and depends on targeting the ...

    Authors: Feras Hatahet, Van Dat Nguyen, Kirsi EH Salo and Lloyd W Ruddock
    Citation: Microbial Cell Factories 2010 9:67
  9. The increasing regulatory requirements to which biological agents are subjected will have a great impact in the field of industrial protein expression and production. There is an expectation that in a near fut...

    Authors: Isabelle Peubez, Nicolas Chaudet, Charlotte Mignon, Géraldine Hild, Stéphanie Husson, Virginie Courtois, Karelle De Luca, Denis Speck and Régis Sodoyer
    Citation: Microbial Cell Factories 2010 9:65
  10. Insufficient availability of molecular chaperones is observed as a major bottleneck for proper protein folding in recombinant protein production. Therefore, co-production of selected sets of cell chaperones al...

    Authors: Mónica Martínez-Alonso, Elena García-Fruitós, Neus Ferrer-Miralles, Ursula Rinas and Antonio Villaverde
    Citation: Microbial Cell Factories 2010 9:64
  11. Overexpression of recombinant proteins usually triggers the induction of heat shock proteins that regulate aggregation and solubility of the overexpressed protein. The two-dimensional gel electrophoresis (2-DE...

    Authors: Chung-Hsien Cheng and Wen-Chien Lee
    Citation: Microbial Cell Factories 2010 9:63
  12. Fumonisin B1 is a cancerogenic mycotoxin produced by Fusarium verticillioides and other fungi. Sphingopyxis sp. MTA144 can degrade fumonisin B1, and a key enzyme in the catabolic pathway is an aminotransferase wh...

    Authors: Doris Hartinger, Stefan Heinl, Heidi Elisabeth Schwartz, Reingard Grabherr, Gerd Schatzmayr, Dietmar Haltrich and Wulf-Dieter Moll
    Citation: Microbial Cell Factories 2010 9:62
  13. Conjugate vaccines in which polysaccharide antigens are covalently linked to carrier proteins belong to the most effective and safest vaccines against bacterial pathogens. State-of-the art production of conjug...

    Authors: Julian Ihssen, Michael Kowarik, Sandro Dilettoso, Cyril Tanner, Michael Wacker and Linda Thöny-Meyer
    Citation: Microbial Cell Factories 2010 9:61
  14. Oxidative stress can severely compromise viability of bifidobacteria. Exposure of Bifidobacterium cells to oxygen causes accumulation of reactive oxygen species, mainly hydrogen peroxide, leading to cell death. I...

    Authors: Valeria Mozzetti, Franck Grattepanche, Déborah Moine, Bernard Berger, Enea Rezzonico, Leo Meile, Fabrizio Arigoni and Christophe Lacroix
    Citation: Microbial Cell Factories 2010 9:60
  15. Many workers have reported halotolerant bacteria from saline conditions capable of protease production. However, antibiotic resistance and heavy metal tolerance pattern of such organisms is not documented very...

    Authors: Sanjay K Singh, Vinayak R Tripathi, Rakesh K Jain, Surendra Vikram and Satyendra K Garg
    Citation: Microbial Cell Factories 2010 9:59
  16. To reduce the production cost of bioethanol obtained from fermentation of the sugars provided by degradation of lignocellulosic biomass (i.e., second generation bioethanol), it is necessary to screen for new enzy...

    Authors: David Navarro, Marie Couturier, Gabriela Ghizzi Damasceno da Silva, Jean-Guy Berrin, Xavier Rouau, Marcel Asther and Christophe Bignon
    Citation: Microbial Cell Factories 2010 9:58
  17. The flavin-dependent enzyme pyranose 2-oxidase (P2Ox) has gained increased attention during the last years because of a number of attractive applications for this enzyme. P2Ox is a unique biocatalyst with high...

    Authors: Clara Salaheddin, Yoshimitsu Takakura, Masako Tsunashima, Barbara Stranzinger, Oliver Spadiut, Montarop Yamabhai, Clemens K Peterbauer and Dietmar Haltrich
    Citation: Microbial Cell Factories 2010 9:57
  18. Recent years have seen a huge growth in the market of industrial yeasts with the need for strains affording better performance or to be used in new applications. Stress tolerance of commercial Saccharomyces cerev...

    Authors: Roberto Pérez-Torrado, Joaquín Panadero, María José Hernández-López, José Antonio Prieto and Francisca Randez-Gil
    Citation: Microbial Cell Factories 2010 9:56
  19. Chemical methods of producing dyes involve extreme temperatures and unsafe toxic compounds. Application of oxidizing enzymes obtained from fungal species, for example laccase, is an alternative to chemical syn...

    Authors: Jolanta Polak and Anna Jarosz-Wilkołazka
    Citation: Microbial Cell Factories 2010 9:51
  20. Pichia pastoris has been recognized as an effective host for recombinant protein production. A number of studies have been reported for improving this expression system. However, its physiology and cellular metab...

    Authors: Bevan KS Chung, Suresh Selvarasu, Andrea Camattari, Jimyoung Ryu, Hyeokweon Lee, Jungoh Ahn, Hongweon Lee and Dong-Yup Lee
    Citation: Microbial Cell Factories 2010 9:50
  21. The unfolded protein response (UPR) in eukaryotes upregulates factors that restore ER homeostasis upon protein folding stress and in yeast is activated by a non-conventional splicing of the HAC1 mRNA. The spliced...

    Authors: Mouna Guerfal, Stefan Ryckaert, Pieter P Jacobs, Paul Ameloot, Kathleen Van Craenenbroeck, Riet Derycke and Nico Callewaert
    Citation: Microbial Cell Factories 2010 9:49
  22. We describe a method for specific, quantitative and quick detection of human collagen prolyl 4-hydroxylase (C-P4H), the key enzyme for collagen prolyl-4 hydroxylation, in crude samples based on a sandwich ELIS...

    Authors: Ekaterina Osmekhina, Antje Neubauer, Katharina Klinzing, Johanna Myllyharju and Peter Neubauer
    Citation: Microbial Cell Factories 2010 9:48
  23. Recombinant protein production is universally employed as a solution to obtain the milligram to gram quantities of a given protein required for applications as diverse as structural genomics and biopharmaceuti...

    Authors: Cecilia Ferndahl, Nicklas Bonander, Christel Logez, Renaud Wagner, Lena Gustafsson, Christer Larsson, Kristina Hedfalk, Richard AJ Darby and Roslyn M Bill
    Citation: Microbial Cell Factories 2010 9:47
  24. Hyaluronic acid is one of the biopolymers most commonly used by the pharmaceutical industry. Thus, there is an increasing number of recent works that deal with the production of microbial hyaluronic acid. Diff...

    Authors: José A Vázquez, María I Montemayor, Javier Fraguas and Miguel A Murado
    Citation: Microbial Cell Factories 2010 9:46
  25. The production of stable and soluble proteins is one of the most important steps prior to structural and functional studies of biological importance. We investigated the parallel production in a medium through...

    Authors: Agnès Groisillier, Cécile Hervé, Alexandra Jeudy, Etienne Rebuffet, Pierre F Pluchon, Yann Chevolot, Didier Flament, Claire Geslin, Isabel M Morgado, Déborah Power, Margherita Branno, Hervé Moreau, Gurvan Michel, Catherine Boyen and Mirjam Czjzek
    Citation: Microbial Cell Factories 2010 9:45
  26. A bacterial artificial chromosomal library of Planobispora rosea, a genetically intractable actinomycete strain, was constructed using Escherichia coli-Streptomyces artificial chromosome (ESAC) and screened for t...

    Authors: Anna Giardina, Rosa Alduina, Elvira Gottardi, Valentina Di Caro, Roderich D Süssmuth and Anna M Puglia
    Citation: Microbial Cell Factories 2010 9:44
  27. Erythrose reductase (ER) catalyzes the final step of erythritol production, which is reducing erythrose to erythritol using NAD(P)H as a cofactor. ER has gained interest because of its importance in the produc...

    Authors: Dae-Hee Lee, Ye-Ji Lee, Yeon-Woo Ryu and Jin-Ho Seo
    Citation: Microbial Cell Factories 2010 9:43
  28. Single-use rocking-motion-type bag bioreactors provide advantages compared to standard stirred tank bioreactors by decreased contamination risks, reduction of cleaning and sterilization time, lower investment ...

    Authors: Julia Glazyrina, Eva-Maria Materne, Thomas Dreher, Dirk Storm, Stefan Junne, Thorsten Adams, Gerhard Greller and Peter Neubauer
    Citation: Microbial Cell Factories 2010 9:42
  29. Bacterial inclusion bodies (IBs) are key intermediates for protein production. Their quality affects the refolding yield and further purification. Recent functional and structural studies have revealed that IB...

    Authors: Britta Jürgen, Antje Breitenstein, Vlada Urlacher, Knut Büttner, Hongying Lin, Michael Hecker, Thomas Schweder and Peter Neubauer
    Citation: Microbial Cell Factories 2010 9:41
  30. In Saccharomyces cerevisiae galactose is initially metabolized through the Leloir pathway after which glucose 6-phosphate enters glycolysis. Galactose is controlled both by glucose repression and by galactose ind...

    Authors: Rosa Garcia Sanchez, Bärbel Hahn-Hägerdal and Marie F Gorwa-Grauslund
    Citation: Microbial Cell Factories 2010 9:40
  31. Aeromonas hydrophila is a serious pathogen and can cause hemorrhagic septicemia in fish. To control this disease, antibiotics and chemicals are widely used which can consequently result in "superbugs" and chemica...

    Authors: Ruidong Chen, Zhigang Zhou, Yanan Cao, Yingguo Bai and Bin Yao
    Citation: Microbial Cell Factories 2010 9:39
  32. Evolvability is an intrinsic feature of all living cells. However, newly emerging, evolved features can be undesirable when genetic circuits, designed and fabricated by rational, synthetic biological approache...

    Authors: Kinga Umenhoffer, Tamás Fehér, Gabriella Balikó, Ferhan Ayaydin, János Pósfai, Frederick R Blattner and György Pósfai
    Citation: Microbial Cell Factories 2010 9:38
  33. Staphylococcal (or micrococcal) nuclease or thermonuclease (SNase or Nuc) is a naturally-secreted nucleic acid degrading enzyme that participates in Staphylococcus aureus spread in the infected host. Purified Nuc...

    Authors: Nicolas Trémillon, Nicolas Issaly, Julien Mozo, Thomas Duvignau, Hervé Ginisty, Eric Devic and Isabelle Poquet
    Citation: Microbial Cell Factories 2010 9:37
  34. Glycerol is the major by-product accounting for up to 5% of the carbon in Saccharomyces cerevisiae ethanolic fermentation. Decreasing glycerol formation may redirect part of the carbon toward ethanol production. ...

    Authors: Julien Pagliardini, Georg Hubmann, Carine Bideaux, Sandrine Alfenore, Elke Nevoigt and Stéphane E Guillouet
    Citation: Microbial Cell Factories 2010 9:36
  35. Bioprocess development of recombinant proteins is time consuming and laborious as many factors influence the accumulation of the product in the soluble and active form. Currently, in most cases the development...

    Authors: Juozas Šiurkus, Johanna Panula-Perälä, Uwe Horn, Mario Kraft, Renata Rimšeliene and Peter Neubauer
    Citation: Microbial Cell Factories 2010 9:35
  36. Chondroitin sulphate is a complex polysaccharide having important structural and protective functions in animal tissues. Extracted from animals, this compound is used as a human anti-inflammatory drug. Among b...

    Authors: Anna Zanfardino, Odile F Restaino, Eugenio Notomista, Donatella Cimini, Chiara Schiraldi, Mario De Rosa, Maurilio De Felice and Mario Varcamonti
    Citation: Microbial Cell Factories 2010 9:34
  37. Alicyclobacillus sp. A4 is thermoacidophilic and produces many glycoside hydrolases. An extremely acidic β-1,4-glucanase (CelA4) has been isolated from Alicyclobacillus sp. A4 and purified. This glucanase with a ...

    Authors: Yingguo Bai, Jianshe Wang, Zhifang Zhang, Pengjun Shi, Huiying Luo, Huoqing Huang, Chunliang Luo and Bin Yao
    Citation: Microbial Cell Factories 2010 9:33
  38. The filamentous fungus T. reesei effectively degrades cellulose and is known to produce various cellulolytic enzymes such as β-glucosidase, endoglucanase, and cellobiohydrolase. The expression levels of each cell...

    Authors: Ryosuke Yamada, Naho Taniguchi, Tsutomu Tanaka, Chiaki Ogino, Hideki Fukuda and Akihiko Kondo
    Citation: Microbial Cell Factories 2010 9:32
  39. The prevalence of diabetes is predicted to rise significantly in the coming decades. A recent analysis projects that by the year 2030 there will be ~366 million diabetics around the world, leading to an increa...

    Authors: Chandrasekhar Gurramkonda, Sulena Polez, Natasa Skoko, Ahmad Adnan, Thomas Gäbel, Dipti Chugh, Sathyamangalam Swaminathan, Navin Khanna, Sergio Tisminetzky and Ursula Rinas
    Citation: Microbial Cell Factories 2010 9:31
  40. The selection of bacterial recombinants that harbour a desired insert, has been a key factor in molecular cloning and a series of screening procedures need to be performed for selection of clones carrying the ...

    Authors: Sampali Banerjee, Jitendra Kumar, Anjali Apte-Deshpande and Sriram Padmanabhan
    Citation: Microbial Cell Factories 2010 9:30
  41. Leishmania tarentolae, a unicellular eukaryotic protozoan, has been established as a novel host for recombinant protein production in recent years. Current protocols for protein expression in Leishmania are, howe...

    Authors: Hakan Dortay and Bernd Mueller-Roeber
    Citation: Microbial Cell Factories 2010 9:29
  42. PhaR which is a repressor protein for microbial polyhydroxyalkanoates (PHA) biosynthesis, is able to attach to bacterial PHA granules in vivo, was developed as an affinity tag for in vitro protein purification. F...

    Authors: Shuang Zhang, Zhi Hui Wang and Guo Qiang Chen
    Citation: Microbial Cell Factories 2010 9:28
  43. Recombinant gene expression is among the most important techniques used both in molecular and medical research and in industrial settings. Today, two recombinant expression systems are particularly well repres...

    Authors: Hans Peter Sørensen
    Citation: Microbial Cell Factories 2010 9:27

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