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  1. Content type: Research

    Cephalosporin C (CPC) produced by Acremonium chrysogenum is one of the most important drugs for treatment of bacterial infectious diseases. As the major stimulant, methionine is widely used in the industrial prod...

    Authors: Jiajia Liu, Wenyan Gao, Yuanyuan Pan and Gang Liu

    Citation: Microbial Cell Factories 2018 17:87

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  2. Content type: Correction

    Upon publication of this article [1], it was brought to our attention that Figs. 3, 4 and 5 are incorrectly presented in the original version of the article. The figures were inadvertently swapped in the origi...

    Authors: Zothanpuia, Ajit Kumar Passari, Vincent Vineeth Leo, Preeti Chandra, Brijesh Kumar, Chandra Nayak, Abeer Hashem, Elsayed Fathi Abd_Allah, Abdulaziz A. Alqarawi and Bhim Pratap Singh

    Citation: Microbial Cell Factories 2018 17:86

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    The original article was published in Microbial Cell Factories 2018 17:68

  3. Content type: RESEARCH

    Geranyl acetate is widely used in the fragrance and cosmetic industries, and thus has great economic value. However, plants naturally produce a mixture of hundreds of esters, and geranyl acetate is usually onl...

    Authors: Tao Wu, Siwei Li, Bolin Zhang, Changhao Bi and Xueli Zhang

    Citation: Microbial Cell Factories 2018 17:85

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  4. Content type: RESEARCH

    Plipastatin, an antifungal lipopeptide, is synthesized by a non-ribosomal peptide synthetase (NRPS) in Bacillus subtilis. However, little information is available on the combinatorial biosynthesis strategies appl...

    Authors: Ling Gao, Jianping Guo, Yun Fan, Zhi Ma, Zhaoxin Lu, Chong Zhang, Haizhen Zhao and Xiaomei Bie

    Citation: Microbial Cell Factories 2018 17:84

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  5. Content type: RESEARCH

    Saccharomyces cerevisiae is a host for the industrial production of S-adenosyl-l-methionine (SAM), which has been widely used in pharmaceutical and nutritional supplement industries. It has been reported that the...

    Authors: Kenshi Hayakawa, Fumio Matsuda and Hiroshi Shimizu

    Citation: Microbial Cell Factories 2018 17:82

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  6. Content type: RESEARCH

    Water stress is a critical issue for plant growth in arid sandy soils. Here, we aimed to select bacteria producing polyextremotolerant surface-active compounds capable of improving water retention and humidity...

    Authors: Noura Raddadi, Lucia Giacomucci, Ramona Marasco, Daniele Daffonchio, Ameur Cherif and Fabio Fava

    Citation: Microbial Cell Factories 2018 17:83

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  7. Content type: RESEARCH

    Utilization of cocoa pod husks (CPH) in animal feed is hindered by the presence of theobromine, which is variably toxic to animals. Treatment of this agro-waste to remove theobromine, while preserving its nutr...

    Authors: Daniel Oduro-Mensah, Augustine Ocloo, Sammy T. Lowor, Cheetham Mingle, Laud K. N.-A. Okine and Naa Ayikailey Adamafio

    Citation: Microbial Cell Factories 2018 17:79

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  8. Content type: RESEARCH

    2-Keto-l-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, l-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicig...

    Authors: Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu and Yi-Xuan Zhang

    Citation: Microbial Cell Factories 2018 17:81

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  9. Content type: RESEARCH

    Gamma-aminobutyric acid (GABA) plays a significant role in the food and drug industries. Our previous study established an efficient fed-batch fermentation process for Lactobacillus brevis NCL912 production of GA...

    Authors: Qiong Wang, Xiaohua Liu, Jinheng Fu, Shuixing Wang, Yuanhong Chen, Kunpeng Chang and Haixing Li

    Citation: Microbial Cell Factories 2018 17:80

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  10. Content type: RESEARCH

    3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only a few KstDs have thus far been characterized biochemically and applied for th...

    Authors: Ruijie Zhang, Xiangcen Liu, Yushi Wang, Yuchang Han, Junsong Sun, Jiping Shi and Baoguo Zhang

    Citation: Microbial Cell Factories 2018 17:77

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  11. Content type: RESEARCH

    The characterization of the molecular determinants of metal resistance has potential biotechnological application in biosensing and bioremediation. In this context, the bacterium Thermus thermophilus HB27 is a me...

    Authors: Immacolata Antonucci, Giovanni Gallo, Danila Limauro, Patrizia Contursi, Ana Luisa Ribeiro, Alba Blesa, José Berenguer, Simonetta Bartolucci and Gabriella Fiorentino

    Citation: Microbial Cell Factories 2018 17:78

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  12. Content type: RESEARCH

    Cellulase can convert lignocellulosic feedstocks into fermentable sugars, which can be used for the industrial production of biofuels and chemicals. The high cost of cellulase production remains a challenge fo...

    Authors: Jiajia Zhang, Guoxiu Zhang, Wei Wang, Wei Wang and Dongzhi Wei

    Citation: Microbial Cell Factories 2018 17:75

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  13. Content type: RESEARCH

    l-Arabinose is the second most abundant component of hemicellulose in lignocellulosic biomass, next to d-xylose. However, few microorganisms are capable of utilizing pentoses, and catabolic genes and operons enab...

    Authors: Hideo Kawaguchi, Kumiko Yoshihara, Kiyotaka Y. Hara, Tomohisa Hasunuma, Chiaki Ogino and Akihiko Kondo

    Citation: Microbial Cell Factories 2018 17:76

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  14. Content type: RESEARCH

    The morphology of yeast cells changes during budding, depending on the growth rate and cultivation conditions. A photo-optical microscope was adapted and used to observe such morphological changes of individua...

    Authors: Anna-Maria Marbà-Ardébol, Jörn Emmerich, Michael Muthig, Peter Neubauer and Stefan Junne

    Citation: Microbial Cell Factories 2018 17:73

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  15. Content type: RESEARCH

    Despite its ability to grow and produce high-value molecules using renewable carbon sources, two main factors must be improved to use Burkholderia sacchari as a chassis for bioproduction at an industrial scale: f...

    Authors: Linda P. Guamán, Carlos Barba-Ostria, Fuzhong Zhang, Edmar R. Oliveira-Filho, José Gregório C. Gomez and Luiziana F. Silva

    Citation: Microbial Cell Factories 2018 17:74

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  16. Content type: RESEARCH

    Steroid compounds are very interesting substrates for biotransformation due to their high biological activity and a high number of inactivated carbons which make chemical modification difficult. Microbial tran...

    Authors: Ewa Kozłowska, Natalia Hoc, Jordan Sycz, Monika Urbaniak, Monika Dymarska, Jakub Grzeszczuk, Edyta Kostrzewa-Susłow, Łukasz Stępień, Elżbieta Pląskowska and Tomasz Janeczko

    Citation: Microbial Cell Factories 2018 17:71

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  17. Content type: RESEARCH

    The angelic acid moiety represents an essential modification in many biologically active products. These products are commonly known as angelates and several studies have demonstrated their therapeutic benefit...

    Authors: Roberta Callari, David Fischer, Harald Heider and Nora Weber

    Citation: Microbial Cell Factories 2018 17:72

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  18. Content type: RESEARCH

    Screening in the fed-batch operation mode is essential for biological cultivations facing challenges as oxygen limitation, osmotic inhibition, catabolite repression, substrate inhibition or overflow metabolism...

    Authors: P. Philip, D. Kern, J. Goldmanns, F. Seiler, A. Schulte, T. Habicher and J. Büchs

    Citation: Microbial Cell Factories 2018 17:69

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  19. Content type: RESEARCH

    Actinobacteria from freshwater habitats have been explored less than from other habitats in the search for compounds of pharmaceutical value. This study highlighted the abundance of actinobacteria from freshwa...

    Authors: Zothanpuia, Ajit Kumar Passari, Vincent Vineeth Leo, Preeti Chandra, Brijesh Kumar, Chandra Nayak, Abeer Hashem, Elsayed Fathi Abd_Allah, Abdulaziz A. Alqarawi and Bhim Pratap Singh

    Citation: Microbial Cell Factories 2018 17:68

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    The Correction to this article has been published in Microbial Cell Factories 2018 17:86

  20. Content type: RESEARCH

    Lignocellulosic ethanol could offer a sustainable source to meet the increasing worldwide demand for fuel. However, efficient and simultaneous metabolism of all types of sugars in lignocellulosic hydrolysates ...

    Authors: Jinfeng Sun, Kangming Tian, Jie Wang, Zixing Dong, Xiaoguang Liu, Kugenthiren Permaul, Suren Singh, Bernard A. Prior and Zhengxiang Wang

    Citation: Microbial Cell Factories 2018 17:66

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  21. Content type: RESEARCH

    Lycopene is a terpenoid pigment that has diverse applications in the food and medicine industries. A prospective approach for lycopene production is by metabolic engineering in microbial hosts, such as Escherichi...

    Authors: Hailin Chen, Meijie Li, Changqing Liu, Haibo Zhang, Mo Xian and Huizhou Liu

    Citation: Microbial Cell Factories 2018 17:65

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  22. Content type: RESEARCH

    Aureobasidium pullulans is a yeast-like fungus that can ferment xylose to generate high-value-added products, such as pullulan, heavy oil, and melanin. The combinatorial expression of two xylose reductase (XR) ge...

    Authors: Jian Guo, Siyao Huang, Yefu Chen, Xuewu Guo and Dongguang Xiao

    Citation: Microbial Cell Factories 2018 17:64

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  23. Content type: RESEARCH

    Extensive modification of genome is an efficient manner to regulate the metabolic network for producing target metabolites or non-native products using Corynebacterium glutamicum as a cell factory. Genome editing...

    Authors: Bo Wang, Qitiao Hu, Yu Zhang, Ruilin Shi, Xin Chai, Zhe Liu, Xiuling Shang, Yun Zhang and Tingyi Wen

    Citation: Microbial Cell Factories 2018 17:63

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  24. Content type: RESEARCH

    The oleaginous yeast Yarrowia lipolytica is a promising microbial cell factory due to their biochemical characteristics and native capacity to accumulate lipid-based chemicals. To create heterogenous biosynthesis...

    Authors: Jin-lai Zhang, Yang-Zi Peng, Duo Liu, Hong Liu, Ying-Xiu Cao, Bing-Zhi Li, Chun Li and Ying-Jin Yuan

    Citation: Microbial Cell Factories 2018 17:62

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  25. Content type: RESEARCH

    Type III polyketide synthases (PKSs) are simple homodimer ketosynthases that distribute across plants, fungi, and bacteria, catalyzing formation of pyrone- and resorcinol-types aromatic polyketides with variou...

    Authors: Lukuan Hou, Huiming Huang, Huayue Li, Shuyao Wang, Jianhua Ju and Wenli Li

    Citation: Microbial Cell Factories 2018 17:61

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  26. Content type: RESEARCH

    Saccharomyces cerevisiae, engineered for l-lactic acid production from glucose and xylose, is a promising production host for lignocellulose-to-lactic acid processes. However, the two principal engineering strate...

    Authors: Vera Novy, Bernd Brunner and Bernd Nidetzky

    Citation: Microbial Cell Factories 2018 17:59

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  27. Content type: RESEARCH

    2-phenylethanol (2-PE) is an important aromatic compound with a lovely rose-like scent. Saccharomyces cerevisiae is a desirable microbe for 2-PE production but its natural yield is not high, and one or two crucia...

    Authors: Zhaoyue Wang, Mingyue Jiang, Xuena Guo, Zhaozheng Liu and Xiuping He

    Citation: Microbial Cell Factories 2018 17:60

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  28. Content type: RESEARCH

    Saccharomyces cerevisiae is widely studied for production of biofuels and biochemicals. To improve production efficiency under industrially relevant conditions, coordinated expression of multiple genes by manipul...

    Authors: Liang Xiong, Yu Zeng, Rui-Qi Tang, Hal S. Alper, Feng-Wu Bai and Xin-Qing Zhao

    Citation: Microbial Cell Factories 2018 17:58

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  29. Content type: RESEARCH

    AmbLOXe is a lipoxygenase, which is up-regulated during limb-redevelopment in the Mexican axolotl, Ambystoma mexicanum, an animal with remarkable regeneration capacity. Previous studies have shown that mammalian ...

    Authors: Anne Stamm, Sarah Strauß, Peter Vogt, Thomas Scheper and Iliyana Pepelanova

    Citation: Microbial Cell Factories 2018 17:57

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  30. Content type: RESEARCH

    Klebsiella pneumoniae is a promising industrial species for bioproduction of bulk chemicals such as 1,3-propanediol, 2,3-butanediol and 3-hydroxypropionic acid (3-HP). However, lactic acid is a troublesome by-pro...

    Authors: Jingxuan Wang, Peng Zhao, Ying Li, Lida Xu and Pingfang Tian

    Citation: Microbial Cell Factories 2018 17:56

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  31. Content type: RESEARCH

    The production of recombinant proteins with proper conformation, appropriate post-translational modifications in an easily scalable and cost-effective system is challenging. Lactococcus lactis has recently been i...

    Authors: Susheel K. Singh, Régis Wendpayangde Tiendrebeogo, Bishwanath Kumar Chourasia, Ikhlaq Hussain Kana, Subhash Singh and Michael Theisen

    Citation: Microbial Cell Factories 2018 17:55

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  32. Content type: RESEARCH

    Microalgal metabolic engineering holds great promise for the overproduction of a wide range of commercial bioproducts. It demands simultaneous manipulation of multiple metabolic nodes. However, high-efficiency...

    Authors: Li-Gong Zou, Jia-Wen Chen, Dan-Lin Zheng, Srinivasan Balamurugan, Da-Wei Li, Wei-Dong Yang, Jie-Sheng Liu and Hong-Ye Li

    Citation: Microbial Cell Factories 2018 17:54

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  33. Content type: RESEARCH

    Growth conditions that bring about stress on Phaffia rhodozyma cells encourage the synthesis of astaxanthin, an antioxidant carotenoid, which protects cells against oxidative damage. Using P. rhodozyma cultures p...

    Authors: Anahí Martínez-Cárdenas, Cipriano Chávez-Cabrera, Jazmín M. Vasquez-Bahena and Luis B. Flores-Cotera

    Citation: Microbial Cell Factories 2018 17:53

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  34. Content type: RESEARCH

    Thermostable lipases from microbial sources have been substantially overexpressed in E. coli, however, these enzymes are often produced with low-level enzymatic activity and mainly in the form of inclusion bodies...

    Authors: Weiqing Zhang, Jing Lu, Shuwen Zhang, Lu Liu, Xiaoyang Pang and Jiaping Lv

    Citation: Microbial Cell Factories 2018 17:50

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  35. Content type: Review

    Torulene and torularhodin represent the group of carotenoids and are synthesized by yeasts and fungi. The most important producers of these two compounds include yeasts of Rhodotorula and Sporobolomyces genera. T...

    Authors: Anna M. Kot, Stanisław Błażejak, Iwona Gientka, Marek Kieliszek and Joanna Bryś

    Citation: Microbial Cell Factories 2018 17:49

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  36. Content type: RESEARCH

    The unicellular cyanobacterium Synechocystis sp. PCC 6803 has been widely used as a photoautotrophic host for synthetic biology studies. However, as a green chassis to capture CO2 for biotechnological application...

    Authors: Deng Liu and Himadri B. Pakrasi

    Citation: Microbial Cell Factories 2018 17:48

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  37. Content type: RESEARCH

    Chitinases are ubiquitous enzymes that have gained a recent biotechnological attention due to their ability to transform biological waste from chitin into valued chito-oligomers with wide agricultural, industr...

    Authors: Peter Elias Kidibule, Paloma Santos-Moriano, Elena Jiménez-Ortega, Mercedes Ramírez-Escudero, M. Carmen Limón, Miguel Remacha, Francisco José Plou, Julia Sanz-Aparicio and María Fernández-Lobato

    Citation: Microbial Cell Factories 2018 17:47

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  38. Content type: RESEARCH

    Hydroxycinnamoyl anthranilates, also known as avenanthramides (avns), are a group of phenolic alkaloids with anti-inflammatory, antioxidant, anti-itch, anti-irritant, and antiatherogenic activities. Some avena...

    Authors: Su Jin Lee, Geun Young Sim, Hyunook Kang, Won Seok Yeo, Bong-Gyu Kim and Joong-Hoon Ahn

    Citation: Microbial Cell Factories 2018 17:46

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  39. Content type: RESEARCH

    In industries lipolytic reactions occur in insensitive conditions such as high temperature thus novel stout esterases with unique properties are attracts to the industrial application. Protein engineering is t...

    Authors: Haofeng Gao, Chanjuan Li, Ramesh Bandikari, Ziduo Liu, Nan Hu and Qiang Yong

    Citation: Microbial Cell Factories 2018 17:45

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  40. Content type: RESEARCH

    Biodegradation of hydrocarbons in Antarctic soil has been reported to be achieved through the utilisation of indigenous cold-adapted microorganisms. Although numerous bacteria isolated from hydrocarbon-contami...

    Authors: Syahir Habib, Siti Aqlima Ahmad, Wan Lutfi Wan Johari, Mohd Yunus Abd Shukor, Siti Aisyah Alias, Khalilah Abdul Khalil and Nur Adeela Yasid

    Citation: Microbial Cell Factories 2018 17:44

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  41. Content type: RESEARCH

    In the l-histidine (His) biosynthetic pathway of Escherichia coli, the first key enzyme, ATP-phosphoribosyltransferase (ATP-PRT, HisG), is subject to different types of inhibition. Eliminating the feedback inhibi...

    Authors: Evgeniya A. Malykh, Ivan A. Butov, Anna B. Ravcheeva, Alexander A. Krylov, Sergey V. Mashko and Nataliya V. Stoynova

    Citation: Microbial Cell Factories 2018 17:42

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  42. Content type: RESEARCH

    Members of the genus Streptomyces are Gram-positive bacteria that are used as important cell factories to produce secondary metabolites and secrete heterologous proteins. They possess some of the largest bacteria...

    Authors: Konstantinos C. Tsolis, Evridiki-Pandora Tsare, Georgia Orfanoudaki, Tobias Busche, Katerina Kanaki, Reshmi Ramakrishnan, Frederic Rousseau, Joost Schymkowitz, Christian Rückert, Jörn Kalinowski, Jozef Anné, Spyridoula Karamanou, Maria I. Klapa and Anastassios Economou

    Citation: Microbial Cell Factories 2018 17:43

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  43. Content type: Research

    The soil bacterium Pseudomonas putida KT2440 is a “generally recognized as safe”-certified strain with robust property and versatile metabolism. Thus, it is an ideal candidate for synthetic biology, biodegradatio...

    Authors: Jun Sun, Qingzhuo Wang, Yu Jiang, Zhiqiang Wen, Lirong Yang, Jianping Wu and Sheng Yang

    Citation: Microbial Cell Factories 2018 17:41

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  44. Content type: RESEARCH

    To produce 1-propanol as a potential biofuel, metabolic engineering of microorganisms, such as E. coli, has been studied. However, 1-propanol production using metabolically engineered Saccharomyces cerevisiae, wh...

    Authors: Yuya Nishimura, Terumi Matsui, Jun Ishii and Akihiko Kondo

    Citation: Microbial Cell Factories 2018 17:38

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  45. Content type: RESEARCH

    Rhamnolipids are the most extensively studied biosurfactants and has been successfully used in various areas from bioremediation to industrial fields. Rhamnolipids structural composition decide their physicoch...

    Authors: Feng Zhao, Rongjiu Shi, Fang Ma, Siqin Han and Ying Zhang

    Citation: Microbial Cell Factories 2018 17:39

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