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  1. Prolyl endopeptidase from Aspergillus niger (AN-PEP) is a prominent serine proteinase with various potential applications in the food and pharmaceutical industries. However, the availability of efficient and low-...

    Authors: Minglu Liu, Meng Hu, Hui Zhou, Zhiyang Dong and Xiuzhen Chen
    Citation: Microbial Cell Factories 2023 22:93
    Content type: Research Published on:

  2. Pichia pastoris (Komagataella phaffii) is widely used for industrial production of heterologous proteins due to high secretory capabilities but selection of highly productive engineered strains remains a limiting...

    Authors: Laura Navone, Kaylee Moffitt, James Behrendorff, Pawel Sadowski, Carol Hartley and Robert Speight
    Citation: Microbial Cell Factories 2023 22:92
    Content type: Research Published on:

  3. Biological nitrogen fixation converting atmospheric dinitrogen to ammonia is an important way to provide nitrogen for plants. Pseudomonas stutzeri DSM4166 is a diazotrophic Gram-negative bacterium isolated from t...

    Authors: Guangle Yu, Xiaochen Li, Qiuyue Duan, Jun Fu, Youming Zhang, Hailong Wang and Ji Luan
    Citation: Microbial Cell Factories 2023 22:91
    Content type: Research Published on:

  4. Although microalgae and plants are traditionally used for obtaining natural pigments, overexploitation and overharvesting threaten them. Bacteria represent a superior alternative for the production of pigments...

    Authors: Noura Sh. A. Hagaggi and Usama M. Abdul-Raouf
    Citation: Microbial Cell Factories 2023 22:90
    Content type: Research Published on:

  5. Aromatic α-hydroxy ketones, such as S-2-hydroxypropiophenone (2-HPP), are highly valuable chiral building blocks useful for the synthesis of various pharmaceuticals and natural products. In the present study, ena...

    Authors: Reihaneh Kordesedehi, Mohammad Ali Asadollahi, Azar Shahpiri, Davoud Biria and Pablo Iván Nikel
    Citation: Microbial Cell Factories 2023 22:89
    Content type: Research Published on:

  6. Acetic acid and furfural (AF) are two major inhibitors of microorganisms during lignocellulosic ethanol production. In our previous study, we successfully engineered Zymomonas mobilis 532 (ZM532) strain by genome...

    Authors: Samina Shabbir, Weiting Wang, Mohsin Nawaz, Prerona Boruah, Muhammad Fakhar-e-Alam Kulyar, Mao Chen, Bo Wu, Panting Liu, Yonghua Dai, Lingling Sun, Qiyu Gou, Renbin Liu, Guoquan Hu, Tahira Younis and Mingxiong He
    Citation: Microbial Cell Factories 2023 22:88
    Content type: Research Published on:

  8. Expression systems for lactic acid bacteria have been developed for metabolic engineering applications as well as for food-grade recombinant protein production. But the industrial applications of lactic acid b...

    Authors: Nisit Watthanasakphuban, Pimsiriya Srila, Phitsanu Pinmanee, Kamonwan Sompinit, Kittipong Rattanaporn and Clemens Peterbauer
    Citation: Microbial Cell Factories 2023 22:86
    Content type: Research Published on:

  9. Bacterial siderophores are chelating compounds with the potential of application in agriculture, due to their plant growth-promoting (PGP) properties, however, high production and purification costs are limiti...

    Authors: M. Musialowski, Ł. Kowalewska, R. Stasiuk, T. Krucoń and K. Debiec-Andrzejewska
    Citation: Microbial Cell Factories 2023 22:85
    Content type: Research Published on:

  10. Nature has provided unique molecular scaffolds for applications including therapeutics, agriculture, and food. Due to differences in ecological environments and laboratory conditions, engineering is often nece...

    Authors: Elena Heng, Yi Wee Lim, Chung Yan Leong, Veronica W. P. Ng, Siew Bee Ng, Yee Hwee Lim and Fong Tian Wong
    Citation: Microbial Cell Factories 2023 22:84
    Content type: Research Published on:

  11. Various factors contribute to the development of the acute inflammation process, like the pro-inflammatory cytokines, certain enzymes as well as oxidative stress mediators. The anti-inflammatory potential of t...

    Authors: Asmaa Saleh, Walaa A. Negm, Thanaa A. El-Masry, Duaa Eliwa, Badriyah Alotaibi, Manal E. Alosaimi, Khalid Nijr Alotaibi, Sameh Magdeldin, Sebaey Mahgoub and Engy Elekhnawy
    Citation: Microbial Cell Factories 2023 22:83
    Content type: Research Published on:

  12. Di(2-ethylhexyl) phthalate (DEHP) is a widely detected plasticizer and a priority pollutant of utmost concern for its adverse impact on humans, wildlife and the environment. To eliminate such toxic burden, bio...

    Authors: Mousumi Bhattacharyya, Rinita Dhar, Suman Basu, Avijit Das, Darren M. Reynolds and Tapan K. Dutta
    Citation: Microbial Cell Factories 2023 22:82
    Content type: Research Published on:

  13. Recombinant proteins cover a wide range of biomedical, biotechnological, and industrial needs. Although there are diverse available protocols for their purification from cell extracts or from culture media, ma...

    Authors: Jose Vicente Carratalá, Jan Atienza-Garriga, Hèctor López-Laguna, Esther Vázquez, Antonio Villaverde, Julieta M. Sánchez and Neus Ferrer-Miralles
    Citation: Microbial Cell Factories 2023 22:81
    Content type: Research Published on:

  14. In spite of the fact that recombinant enzymes are preferably biotechnologically obtained using recombinant clones, the purification of proteins from native microorganisms, including those encoded by bacterioph...

    Authors: Beata Łubkowska, Edyta Czajkowska, Aleksandra Stodolna, Michał Sroczyński, Agnieszka Zylicz-Stachula, Ireneusz Sobolewski and Piotr M. Skowron
    Citation: Microbial Cell Factories 2023 22:80
    Content type: Research Published on:

    The Correction to this article has been published in Microbial Cell Factories 2023 22:146

  15. Mucormycosis disease, which has recently expanded with the Covid 19 pandemic in many countries, endangers patients' lives, and treatment with common drugs is fraught with unfavorable side effects.

    Authors: Amr S. Al-kashef, Mohamed U. Nooman, Mona M. Rashad, Amr H. Hashem and Mohamed Abdelraof
    Citation: Microbial Cell Factories 2023 22:79
    Content type: Research Published on:

  16. Metal oxide nanoparticles (NPs) are becoming valuable due to their novel applications. The green synthesis of TiO2 NPs is more popular as a flexible and eco-friendly method compared to traditional chemical synthe...

    Authors: Rasha A. Metwally, Jehan El Nady, Shaker Ebrahim, Amany El Sikaily, Nermeen A. El-Sersy, Soraya A. Sabry and Hanan A. Ghozlan
    Citation: Microbial Cell Factories 2023 22:78
    Content type: Research Published on:

  17. Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as str...

    Authors: Gerrit Haeger, Jessika Wirges, Nicole Tanzmann, Sven Oyen, Tristan Jolmes, Karl-Erich Jaeger, Ulrich Schörken, Johannes Bongaerts and Petra Siegert
    Citation: Microbial Cell Factories 2023 22:77
    Content type: Research Published on:

  18. Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains...

    Authors: Zhenke Wu, Xiqin Liang, Mingkai Li, Mengyu Ma, Qiusheng Zheng, Defang Li, Tianyue An and Guoli Wang
    Citation: Microbial Cell Factories 2023 22:76
    Content type: Review Published on:

  19. Coenzyme A (CoA) is a carrier of acyl groups. This cofactor is synthesized from pantothenic acid in five steps. The phosphorylation of pantothenate is catalyzed by pantothenate kinase (CoaA), which is a key st...

    Authors: Hirotaka Kudo, Sho Ono, Kenta Abe, Mami Matsuda, Tomohisa Hasunuma, Tomoyasu Nishizawa, Munehiko Asayama, Hirofumi Nishihara and Shigeru Chohnan
    Citation: Microbial Cell Factories 2023 22:75
    Content type: Research Published on:

  20. Two important flavonoids, kaempferol and quercetin possess remarkably potent biological impacts on human health. However, their structural complexity and low abundance in nature make both bulk chemical synthes...

    Authors: Musa Tartik, Juan Liu, Marta Tous Mohedano, Jiwei Mao and Yun Chen
    Citation: Microbial Cell Factories 2023 22:74
    Content type: Research Published on:

  21. Algae are prominent producers of carotenoids and polyunsaturated fatty acids which are greatly prized in the food and pharmaceutic industry. Fucoxanthin represents a notable high-value carotenoid produced excl...

    Authors: Antonín Střížek, Pavel Přibyl, Martin Lukeš, Tomáš Grivalský, Jiří Kopecký, Tomáš Galica and Pavel Hrouzek
    Citation: Microbial Cell Factories 2023 22:73
    Content type: Research Published on:

  22. Laccases are multicopper enzymes that oxidize a wide range of aromatic and non-aromatic compounds in the presence of oxygen. The majority of industrially relevant laccases are derived from fungi and are produc...

    Authors: Silja Välimets, Patricia Pedetti, Ludovika Jessica Virginia, Mai Ngoc Hoang, Michael Sauer and Clemens Peterbauer
    Citation: Microbial Cell Factories 2023 22:72
    Content type: Research Published on:

  23. Amino acid production features of Corynebacterium glutamicum were extensively studied in the last two decades. Many metabolic pathways, regulatory and transport principles are known, but purely rational approache...

    Authors: Rico Zuchowski, Simone Schito, Friederike Neuheuser, Philipp Menke, Daniel Berger, Niels Hollmann, Srushti Gujar, Lea Sundermeyer, Christina Mack, Astrid Wirtz, Oliver H. Weiergräber, Tino Polen, Michael Bott, Stephan Noack and Meike Baumgart
    Citation: Microbial Cell Factories 2023 22:71
    Content type: Research Published on:

  24. Alternaria alternata that threatens pepper production and causes major economic harm is responsible for the leaf spot/blight disease. Chemical fungicides have been widely employed; unfortunately, fungicidal resis...

    Authors: Shereen A. Soliman, Reda E. Abdelhameed and Rabab A. Metwally
    Citation: Microbial Cell Factories 2023 22:70
    Content type: Research Published on:

  25. Intracellular biomacromolecules, such as industrial enzymes and biopolymers, represent an important class of bio-derived products obtained from bacterial hosts. A common key step in the downstream separation o...

    Authors: Jeremy David Adams, Kyle B. Sander, Craig S. Criddle, Adam P. Arkin and Douglas S. Clark
    Citation: Microbial Cell Factories 2023 22:69
    Content type: Research Published on:

  26. This study aimed to isolate a novel thermotolerant bacterium that is capable of synthesizing polyhydroxyalkanoate from glycerol under high temperature conditions.

    Authors: Anuyut Yootoum, Kittisak Jantanasakulwong, Pornchai Rachtanapun, Churairat Moukamnerd, Thanongsak Chaiyaso, Chayakorn Pumas, Nuttapol Tanadchangsaeng, Masanori Watanabe, Toshiaki Fukui and Chayatip Insomphun
    Citation: Microbial Cell Factories 2023 22:68
    Content type: Research Published on:

  27. Natural killer (NK) cell-based immunotherapies have demonstrated substantial potential for the treatment of hematologic malignancies. However, its application is limited due to the difficulty in the production...

    Authors: Yangyang Li, Siqi Xie, Minhua Chen, Hao Li, Yehai Wang, Yan Fan, Kang An, Yu Wu and Weihua Xiao
    Citation: Microbial Cell Factories 2023 22:67
    Content type: Research Published on:

  28. Cycloartane-type triterpenoids possess important biological activities, including immunostimulant, wound healing, and telomerase activation. Biotransformation is one of the derivatization strategies of natural...

    Authors: Melis Küçüksolak, Sinem Yılmaz, Petek Ballar-Kırmızıbayrak and Erdal Bedir
    Citation: Microbial Cell Factories 2023 22:66
    Content type: Research Published on:

  29. Highly efficient production of L-phenylalanine (L-Phe) in E. coli has been achieved by multiple rounds of random mutagenesis and modification of key genes of the shikimate (SHIK) and L-Phe branch pathways. In thi...

    Authors: Wei Sun, Dongqin Ding, Danyang Bai, Yang Lin, Yaru Zhu, Cuiying Zhang and Dawei Zhang
    Citation: Microbial Cell Factories 2023 22:65
    Content type: Research Published on:

  30. Icaritin is an aglycone of flavonoid glycosides from Herba Epimedii. It has good performance in the treatment of hepatocellular carcinoma in clinical trials. However, the natural icaritin content of Herba Epimedi...

    Authors: Yu Lin, Wen-wen Chen, Bo Ding, Man Guo, Meng Liang, Hao Pang, Yu-tuo Wei, Ri-bo Huang and Li-qin Du
    Citation: Microbial Cell Factories 2023 22:64
    Content type: Research Published on:

  31. Adaptation to alkalinization of the medium in fungi involves an extensive remodeling of gene expression. Komagataella phaffii is an ascomycetous yeast that has become an organism widely used for heterologous prot...

    Authors: Marcel Albacar, Abdelghani Zekhnini, Jorge Pérez-Valle, José L. Martínez, Antonio Casamayor and Joaquín Ariño
    Citation: Microbial Cell Factories 2023 22:63
    Content type: Research Published on:

    The Correction to this article has been published in Microbial Cell Factories 2023 22:210

  32. Yarrowia lipolytica is a well-studied oleaginous yeast known for its ability to accumulate and store intracellular lipids, while growing on diverse, non-conventional substrates. Amongst them, crude glycerol, a lo...

    Authors: Asimina Tsirigka, Eleni Theodosiou, Sotiris I. Patsios, Antiopi Tsoureki, Aggeliki Andreadelli, Elisavet Papa, Amalia Aggeli, Anastasios J. Karabelas and Antonios M. Makris
    Citation: Microbial Cell Factories 2023 22:62
    Content type: Research Published on:

  33. Research development in the precise control of gene expression in plant cells is an emerging necessity that would lead to the elucidation of gene function in these biological systems. Conventional gene-interfe...

    Authors: Hossein Alishah Aratboni, Nahid Rafiei, Ashanti Concepción Uscanga-Palomeque, Itza Eloisa Luna Cruz, Roberto Parra-Saldivar and Jose Ruben Morones-Ramirez
    Citation: Microbial Cell Factories 2023 22:61
    Content type: Research Published on:

  34. Orsellinic acid (2,4-dihydroxy-6-methylbenzoic acid, OA) and its structural analog o-Orsellinaldehyde, have become widely used intermediates in clinical drugs synthesis. Although the research on the biosynthesis ...

    Authors: Haiyan Han, Chunyan Yu, Jianzhao Qi, Pengchao Wang, Peipei Zhao, Wenbing Gong, Chunliang Xie, Xuekui Xia and Chengwei Liu
    Citation: Microbial Cell Factories 2023 22:60
    Content type: Research Published on:

  35. Heme proteins, such as hemoglobin, horseradish peroxidase and cytochrome P450 (CYP) enzyme, are highly versatile and have widespread applications in the fields of food, healthcare, medical and biological analy...

    Authors: Jianzhong Ge, Xiaolu Wang, Yingguo Bai, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huiying Luo, Bin Yao, Huoqing Huang and Jie Zhang
    Citation: Microbial Cell Factories 2023 22:59
    Content type: Research Published on:

  37. Perylenequinones from Shiraia fruiting bodies are excellent photosensitizers and widely used for anti-cancer photodynamic therapy (PDT). The lower yield of Shiraia perylenequinones becomes a significant bottlenec...

    Authors: Wen Hao Shen, Rui Peng Cong, Xin Ping Li, Qun Yan Huang, Li Ping Zheng and Jian Wen Wang
    Citation: Microbial Cell Factories 2023 22:57
    Content type: Research Published on:

  38. l‑Fucose is a rare sugar that has beneficial biological activities, and its industrial production is mainly achieved with brown algae through acidic/enzymatic fucoidan hydrolysis and a cumbersome purification p.....

    Authors: Cong Fu, Xuexia Xu, Yukang Xie, Yufei Liu, Min Liu, Ai Chen, Jenny M. Blamey, Jiping Shi, Suwen Zhao and Junsong Sun
    Citation: Microbial Cell Factories 2023 22:56
    Content type: Research Published on:

  39. Escherichia coli heat labile toxin B subunit (LTB) is one of the most popular oral vaccine adjuvants and intestine adsorption enhancers. It is often expressed as a fusion partner with target antigens to enhance t...

    Authors: Kum-Kang So, Ngoc My Tieu Le, Ngoc-Luong Nguyen and Dae-Hyuk Kim
    Citation: Microbial Cell Factories 2023 22:55
    Content type: Research Published on:

  40. The strain Lsc-8 can produce a current density of 33.08 µA cm−2 using carboxymethylcellulose (CMC) as a carbon source in a three-electrode configuration. A co-culture system of strain Lsc-8 and Geobacter sulfurre...

    Authors: Lianbin Cao, Hongmei Sun, Yamei Ma, Mingguo Lu, Mengrui Zhao, Enzhong Li and Ying Liu
    Citation: Microbial Cell Factories 2023 22:54
    Content type: Research Published on:

  41. 9α-hydroxyandrost-4-ene-3,17-dione (9-OHAD) is a significant intermediate for the synthesis of glucocorticoid drugs. However, in the process of phytosterol biotransformation to manufacture 9-OHAD, product degr...

    Authors: Xiangcen Liu, Jingxian Zhang, Chenyang Yuan, Guilin Du, Suwan Han, Jiping Shi, Junsong Sun and Baoguo Zhang
    Citation: Microbial Cell Factories 2023 22:53
    Content type: Research Published on:

  42. Thraustochytrids accumulate lipids with a high content of docosahexaenoic acid (DHA). Although their growth and DHA content are significantly affected by the dissolved oxygen (DO) supply, the role of DO on the...

    Authors: Lu Liu, Xingyu Zhu, Huike Ye, Yingying Wen, Biswarup Sen and Guangyi Wang
    Citation: Microbial Cell Factories 2023 22:52
    Content type: Research Published on:

  43. ε-Poly-L-lysine (ε-PL) is a natural and safe food preservative that is mainly produced by filamentous and aerobic bacteria Streptomyces albulus. During ε-PL biosynthesis, a large amount of ATP is used for the pol...

    Authors: Hao Yang, Daojun Zhu, Lang Kai, Liang Wang, Hongjian Zhang, Jianhua Zhang and Xusheng Chen
    Citation: Microbial Cell Factories 2023 22:51
    Content type: Research Published on:

  44. The lipopeptide herbicolin A (HA) secreted by the biocontrol agent Pantoea agglomerans ZJU23 is a promising antifungal drug to combat fungal pathogens by targeting lipid rafts, both in agricultural and clinical s...

    Authors: Hongkai Wang, Yaqi Zhou, Sunde Xu, Boyan Zhang, Tomislav Cernava, Zhonghua Ma and Yun Chen
    Citation: Microbial Cell Factories 2023 22:50
    Content type: Research Published on:

  46. Improving the resistance of Saccharomyces cerevisiae to vanillin, derived from lignin, will benefit the design of robust cell factories for lignocellulosic biorefining. The transcription factor Yrr1p mediates S. ...

    Authors: Weiquan Zhao, Xinning Wang, Bolun Yang, Ying Wang, Zailu Li and Xiaoming Bao
    Citation: Microbial Cell Factories 2023 22:48
    Content type: Research Published on:

  47. Microbially produced bioplastics are specially promising materials since they can be naturally synthesized and degraded, making its end-of-life management more amenable to the environment. A prominent example ...

    Authors: Manuel S. Godoy, Santiago R. de Miguel and M. Auxiliadora Prieto
    Citation: Microbial Cell Factories 2023 22:47
    Content type: Research Published on:

  48. Resveratrol is a commercially available stilbenoid widely used as dietary supplements, functional food ingredients, and cosmetic ingredients due to its diverse physiological activities. The production of resve...

    Authors: Lijun Meng, Mengxue Diao, Qingyan Wang, Longyun Peng, Jianxiu Li and Nengzhong Xie
    Citation: Microbial Cell Factories 2023 22:46
    Content type: Research Published on:

  49. Exopolysaccharides (EPS) secreted by beneficial lactobacilli exert a plethora of positive activities, but little is known about their effects on biofilms of opportunistic vaginal pathogens and especially on bi...

    Authors: Barbara Giordani, Marina Naldi, Vanessa Croatti, Carola Parolin, Ülfet Erdoğan, Manuela Bartolini and Beatrice Vitali
    Citation: Microbial Cell Factories 2023 22:45
    Content type: Research Published on:

  50. Micafungin is an echinocandin-type antifungal agent used for the clinical treatment of invasive fungal infections. It is semisynthesized from the sulfonated lipohexapeptide FR901379, a nonribosomal peptide pro...

    Authors: Ping Men, Yu Zhou, Li Xie, Xuan Zhang, Wei Zhang, Xuenian Huang and Xuefeng Lu
    Citation: Microbial Cell Factories 2023 22:44
    Content type: Research Published on:
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Companion Journals

Microbial Cell Factories is a companion journal to:

Biotechnology for Biofuels and Bioproducts

Biotechnology for the Environment

Blue Biotechnology

Biotechnology for Sustainable Materials

Fungal Biology and Biotechnology


Microbial Cell Factories

ISSN: 1475-2859

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