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  1. Natural life systems can be significantly modified at the genomic scale by human intervention, demonstrating the great innovation capacity of genome engineering. Large epi-chromosomal DNA structures were estab...

    Authors: Junchang Su, Pengju Wang, Ju Li, Dongdong Zhao, Siwei Li, Feiyu Fan, Zhubo Dai, Xiaoping Liao, Zhitao Mao, Chunzhi Zhang, Changhao Bi and Xueli Zhang
    Citation: Microbial Cell Factories 2022 21:235
  2. Trichoderma spp. are important agricultural biocontrol microorganisms that are often used as effective components of microbial fungicides and microbial biofertilizers. However, most of these products are prepared...

    Authors: Dazhi Hao, Bo Lang, Yongkun Wang, Xinhua Wang, Tong Liu and Jie Chen
    Citation: Microbial Cell Factories 2022 21:234
  3. The global market for lactic acid is witnessing growth on the back of increasing applications of lactic acid for manufacturing polylactic acid. Indeed, the lactic acid market is expected to reach 9.8 billion U...

    Authors: Miguel G. Acedos, Paz Gómez-Pérez, Tamara Espinosa, Christian Abarca, Bernat Ibañez and Begoña Ruiz
    Citation: Microbial Cell Factories 2022 21:233
  4. Caprazamycins are liponucleoside antibiotics showing bioactivity against Gram-positive bacteria including clinically relevant Mycobacterium tuberculosis by targeting the bacterial MraY-translocase. Their chemical...

    Authors: Daniel Bär, Benjamin Konetschny, Andreas Kulik, Houchao Xu, Davide Paccagnella, Patrick Beller, Nadine Ziemert, Jeroen S. Dickschat and Bertolt Gust
    Citation: Microbial Cell Factories 2022 21:232
  5. A representative hydrogen-oxidizing bacterium Cupriavidus necator H16 has attracted much attention as hosts to recycle carbon dioxide (CO2) into a biodegradable polymer, poly(R)-3-hydroxybutyrate (PHB). Although

    Authors: Soyoung Kim, Yong Jae Jang, Gyeongtaek Gong, Sun-Mi Lee, Youngsoon Um, Kyoung Heon Kim and Ja Kyong Ko
    Citation: Microbial Cell Factories 2022 21:231
  6. Ginsenosides are Panax plant-derived triterpenoid with wide applications in cardiovascular protection and immunity-boosting. However, the saponins content of Panax plants is fairly low, making it time-consuming a...

    Authors: Yuan Zhu, Jianxiu Li, Longyun Peng, Lijun Meng, Mengxue Diao, Shuiyuan Jiang, Jianbin Li and Nengzhong Xie
    Citation: Microbial Cell Factories 2022 21:230
  7. The production of chemicals via bio-based routes is held back by limited easy-to-use stabilisation systems. A wide range of plasmid stabilisation mechanisms can be found in the literature, however, how these m...

    Authors: James R. Allen, Mario A. Torres-Acosta, Naresh Mohan, Gary J. Lye and John M. Ward
    Citation: Microbial Cell Factories 2022 21:229
  8. The use of palm oil for our current needs is unsustainable. Replacing palm oil with oils produced by microbes through the conversion of sustainable feedstocks is a promising alternative. However, there are maj...

    Authors: Zeynep Efsun Duman-Özdamar, Vitor A. P. Martins dos Santos, Jeroen Hugenholtz and Maria Suarez-Diez
    Citation: Microbial Cell Factories 2022 21:228
  9. PAS biopolymers are recombinant polypeptides comprising the small uncharged l-amino acids Pro, Ala and/or Ser which resemble the widely used poly-ethylene glycol (PEG) in terms of pronounced hydrophilicity. Likew...

    Authors: L. Friedrich, Y. Kikuchi, Y. Matsuda, U. Binder and A. Skerra
    Citation: Microbial Cell Factories 2022 21:227
  10. The utilization of industrial wastes as feedstock in microbial-based processes is a one of the high-potential approach for the development of sustainable, environmentally beneficial and valuable bioproduction,...

    Authors: Katarzyna Drzymała-Kapinos, Aleksandra M. Mirończuk and Adam Dobrowolski
    Citation: Microbial Cell Factories 2022 21:226
  11. Propionibacterium freudenreichii is used in biotechnological applications to produce vitamin B12. Although cultured mainly in anaerobic conditions, microaerobic conditions can greatly enhance biomass formation in...

    Authors: Alexander Dank, Gabriela Biel, Tjakko Abee and Eddy J. Smid
    Citation: Microbial Cell Factories 2022 21:225
  12. ε-poly-l-lysine (ε-PL) is the main secondary metabolite of Streptomyces albulus, and it is widely used in the food industry. Polylysine synthetase (Pls) is the last enzyme in the ε-PL biosynthetic pathway. Our pr...

    Authors: Congcong Lian, Min Zhang, Jiaqi Mao, Yuanyu Liu, Xiuwen Wang, Linghui Kong, Qingshou Yao and Jiayang Qin
    Citation: Microbial Cell Factories 2022 21:224
  13. Adipic acid (AA) is one of the most important industrial chemicals used mainly for the production of Nylon 6,6 but also for making polyurethanes, plasticizers, and unsaturated polyester resins, and more recent...

    Authors: Sang-Hyun Pyo, Mahmoud Sayed, Oliver Englund Örn, Jorge Amorrortu Gallo, Nídia Fernandez Ros and Rajni Hatti-Kaul
    Citation: Microbial Cell Factories 2022 21:223
  14. The catabolite repressor/activator protein (FruR) is a global regulatory protein known to control the expression of several genes concerned with carbon utilization and energy metabolism. This study aimed to il...

    Authors: Minliang Chen, Hengyu Liang, Chao Han, Peng Zhou, Zhiwei Xing, Qianqian Chen, Yongyu Liu, Gou-an Xie and Rufei Xie
    Citation: Microbial Cell Factories 2022 21:222
  15. Chemical pesticides have defects in crop diseases control, such as narrow antimicrobial spectrum, chemicals residue risk and harm to farmland ecosystem. Antimicrobial agents from microbial sources are highly i...

    Authors: Feng Zhao, Bingxin Wang, Menglin Yuan and Sijia Ren
    Citation: Microbial Cell Factories 2022 21:221
  16. The marine thermophilic bacterium Rhodothermus marinus can degrade many polysaccharides which makes it interesting as a future cell factory. Progress using this bacterium has, however, been hampered by limited kn...

    Authors: Israt Jahan Mukti, Roya R. R. Sardari, Thordis Kristjansdottir, Gudmundur O. Hreggvidsson and Eva Nordberg Karlsson
    Citation: Microbial Cell Factories 2022 21:220

    The Correction to this article has been published in Microbial Cell Factories 2023 22:49

  17. Tunicamycin inhibits the first step of protein N-glycosylation modification. However, the physiological, transcriptomic, and N-glycomic effects of tunicamycin on important marine diatom Phaeodactylum tricornutum ...

    Authors: Jichen Chen, Hong Du, Zidong Liu, Tangcheng Li, Hua Du, Wanna Wang, Muhammad Aslam, Weizhou Chen, Ping Li, Haodong Luo, Hao Fang and Xiaojuan Liu
    Citation: Microbial Cell Factories 2022 21:219
  18. The production of androstenedione (AD) from phytosterols by Mycolicibacterium neoaurum is a multi-step biotransformation process, which requires degradation of sterol side chains, accompanied by the production of...

    Authors: Zhenhua Su, Zhenjian Zhang, Jian Yu, Congcong Yuan, Yanbing Shen, Jianxin Wang, Liqiu Su and Min Wang
    Citation: Microbial Cell Factories 2022 21:218
  19. The availability of new biological platform organisms to get access to innovative products and processes is fundamental for the progress in biotechnology and bioeconomy. The amoeba Dictyostelium discoideum repres...

    Authors: Johann E. Kufs, Christin Reimer, Emily Steyer, Vito Valiante, Falk Hillmann and Lars Regestein
    Citation: Microbial Cell Factories 2022 21:217
  20. Cellulose degradation can determine mycelial growth rate and affect yield during the growth of Flammulina filiformis. The degradation of cellulose requires the joint action of a variety of cellulases, and some ce...

    Authors: Zongqi Liu, Bing Deng, Hui Yuan, Benfeng Zhang, Jingyu Liu, Junlong Meng and Mingchang Chang
    Citation: Microbial Cell Factories 2022 21:216
  21. Flavonoids are necessary for plant growth and resistance to adversity and stress. They are also an essential nutrient for human diet and health. Among the metabolites produced in Cannabis sativa (C. sativa), phyt...

    Authors: Xuewen Zhu, Yaolei Mi, Xiangxiao Meng, Yiming Zhang, Weiqiang Chen, Xue Cao, Huihua Wan, Wei Yang, Jun Li, Sifan Wang, Zhichao Xu, Atia Tul Wahab, Shilin Chen and Wei Sun
    Citation: Microbial Cell Factories 2022 21:215
  22. Acetic acid tolerance is crucial for the development of robust cell factories for conversion of lignocellulosic hydrolysates that typically contain high levels of acetic acid. Screening mutants for growth in m...

    Authors: Maurizio Mormino, Ibai Lenitz, Verena Siewers and Yvonne Nygård
    Citation: Microbial Cell Factories 2022 21:214
  23. Linalool is a monoterpenoid, also a vital silvichemical with commercial applications in cosmetics, flavoring ingredients, and medicines. Regulation of mevalonate (MVA) pathway metabolic flux is a common strate...

    Authors: Yaoyao Zhang, Xianshuang Cao, Jin Wang and Feng Tang
    Citation: Microbial Cell Factories 2022 21:212
  24. A significant fraction of the human proteome is still inaccessible to in vitro studies since the recombinant production of several proteins failed in conventional cell factories. Eukaryotic protein kinases are...

    Authors: Andrea Colarusso, Concetta Lauro, Marzia Calvanese, Ermenegilda Parrilli and Maria Luisa Tutino
    Citation: Microbial Cell Factories 2022 21:211
  25. Flavonoid C-glycosides have many beneficial effects and are widely used in food and medicine. However, plants contain a limited number of flavonoid C-glycosides, and it is challenging to create these substances c...

    Authors: Rong Ni, Xin-Yan Liu, Jiao-Zhen Zhang, Jie Fu, Hui Tan, Ting-Ting Zhu, Jing Zhang, Hai-Long Wang, Hong-Xiang Lou and Ai-Xia Cheng
    Citation: Microbial Cell Factories 2022 21:210
  26. Authors: Shuo Jia, Xinning Huang, Hua Li, Dianzhong Zheng, Li Wang, Xinyuan Qiao, Yanping Jiang, Wen Cui, Lijie Tang, Yijing Li and Yigang Xu
    Citation: Microbial Cell Factories 2022 21:209

    The original article was published in Microbial Cell Factories 2020 19:186

  27. Glucoside natural products have been showing great medicinal values and potentials. However, the production of glucosides by plant extraction, chemical synthesis, and traditional biotransformation is insuffici...

    Authors: Fei Guo, Xingwang Zhang, Cai You, Chengjie Zhang, Fengwei Li, Nan Li, Yuwei Xia, Mingyu Liu, Zetian Qiu, Xianliang Zheng, Li Ma, Gang Zhang, Lianzhong Luo, Fei Cao, Yingang Feng, Guang-Rong Zhao…
    Citation: Microbial Cell Factories 2022 21:208
  28. Marine algae are responsible for half of the global primary production, converting carbon dioxide into organic compounds like carbohydrates. Particularly in eutrophic waters, they can grow into massive algal b...

    Authors: Theresa Dutschei, Marie-Katherin Zühlke, Norma Welsch, Tom Eisenack, Maximilian Hilkmann, Joris Krull, Carlo Stühle, Stefan Brott, Alexandra Dürwald, Lukas Reisky, Jan-Hendrik Hehemann, Dörte Becher, Thomas Schweder and Uwe T. Bornscheuer
    Citation: Microbial Cell Factories 2022 21:207
  29. Antibiotic resistance poses a major threat to human health globally. Consequently, new antibiotics are desperately required to discover and develop from unexplored habitats to treat life-threatening infections...

    Authors: Aram R. Ali, Yadollah Bahrami, Elham Kakaei, Sara Mohammadzadeh, Sasan Bouk and Nastaran Jalilian
    Citation: Microbial Cell Factories 2022 21:206
  30. Saccharomyces boulardii is a probiotic yeast that exhibits antimicrobial and anti-toxin activities. Although S. boulardii has been clinically used for decades to treat gastrointestinal disorders, several studies...

    Authors: Jungyeon Kim, Yu Eun Cheong, Sora Yu, Yong-Su Jin and Kyoung Heon Kim
    Citation: Microbial Cell Factories 2022 21:204
  31. The last big outbreaks of Ebola fever in Africa, the thousands of avian influenza outbreaks across Europe, Asia, North America and Africa, the emergence of monkeypox virus in Europe and specially the COVID-19 ...

    Authors: Marianna Teixeira de Pinho Favaro, Jan Atienza-Garriga, Carlos Martínez-Torró, Eloi Parladé, Esther Vázquez, José Luis Corchero, Neus Ferrer-Miralles and Antonio Villaverde
    Citation: Microbial Cell Factories 2022 21:203
  32. Although efficient l-tryptophan production using engineered Escherichia coli is established from glucose, the use of alternative carbon sources is still very limited. Through the application of glycerol as an alt...

    Authors: Kristin Schoppel, Natalia Trachtmann, Emil J. Korzin, Angelina Tzanavari, Georg A. Sprenger and Dirk Weuster-Botz
    Citation: Microbial Cell Factories 2022 21:201
  33. Yarrowia lipolytica, a nonconventional oleaginous yeast species, has attracted attention due to its high lipid degradation and accumulation capacities. Y. lipolytica is used as a chassis for the production of usu...

    Authors: Djamila Onésime, Léa Vidal, Stéphane Thomas, Céline Henry, Véronique Martin, Gwenaëlle André, Piotr Kubiak, Philippe Minard, Ewelina Celinska and Jean-Marc Nicaud
    Citation: Microbial Cell Factories 2022 21:200
  34. 5-hydroxytryptophan (5-HTP), the direct biosynthetic precursor of the neurotransmitter 5-hydroxytryptamine, has been shown to have unique efficacy in the treatment of a variety of disorders, including depressi...

    Authors: Zhen Zhang, Zichen Yu, Jinduo Wang, Yifa Yu, Lanxiao Li, Pengjie Sun, Xiaoguang Fan and Qingyang Xu
    Citation: Microbial Cell Factories 2022 21:198
  35. Brevilaterin A-E, a novel class of multi-component cationic antimicrobial lipopeptides, were biosynthesized by a non-ribosomal peptides synthetase (NRPS) in Brevibacillus laterosporus. However, the antimicrobial ...

    Authors: Panpan Han, Zhou Chen, Yangliu Liu, Aijin Ma, Siting Li and Yingmin Jia
    Citation: Microbial Cell Factories 2022 21:196
  36. Karst-adapted plant, Lysionotus pauciflours accumulates special secondary metabolites with a wide range of pharmacological effects for surviving in drought and high salty areas, while researchers focused more on ...

    Authors: Tianze Wu, Li Xiang, Ranran Gao, Lan Wu, Gang Deng, Wenting Wang, Yongping Zhang, Bo Wang, Liang Shen, Shilin Chen, Xia Liu and Qinggang Yin
    Citation: Microbial Cell Factories 2022 21:195
  37. Due to the detrimental effects of chemical preservatives, there has been an increasing demand for safer, healthier and natural bio-preservatives. Bacteriocins have attracted increasing interest because of thei...

    Authors: Xiaofeng Zhang, Nie Xin, Zhaolu Zhu, Xudong Li, Dadong Dai, Chunmei Pan, Donghai Peng and Ming Sun
    Citation: Microbial Cell Factories 2022 21:194
  38. O2-tolerant [NiFe]-hydrogenases offer tremendous potential for applications in H2-based technology. As these metalloenzymes undergo a complicated maturation process that requires a dedicated set of multiple acces...

    Authors: Qin Fan, Saskia Waldburger, Peter Neubauer, Sebastian L. Riedel and Matthias Gimpel
    Citation: Microbial Cell Factories 2022 21:193
  39. Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards...

    Authors: Miquel Saumell-Esnaola, Ainhoa Elejaga-Jimeno, Leyre Echeazarra, Leire Borrega-Román, Sergio Barrondo, Maider López de Jesús, Imanol González-Burguera, Alberto Gómez-Caballero, María Aranzazu Goicolea, Joan Sallés and Gontzal García del Caño
    Citation: Microbial Cell Factories 2022 21:192
  40. Escherichia coli, one of the most efficient expression hosts for recombinant proteins (RPs), is widely used in chemical, medical, food and other industries. However, conventional expression strains are unable to ...

    Authors: Zi-Xu Zhang, Fang-Tong Nong, Yu-Zhou Wang, Chun-Xiao Yan, Yang Gu, Ping Song and Xiao-Man Sun
    Citation: Microbial Cell Factories 2022 21:191
  41. Eukaryotic algae have recently emerged as hosts for metabolic engineering efforts to generate heterologous isoprenoids. Isoprenoid metabolic architectures, flux, subcellular localization, and transport dynamic...

    Authors: Julian Wichmann, Annibel Eggert, Liam D. H. Elbourne, Ian T. Paulsen, Kyle J. Lauersen and Olaf Kruse
    Citation: Microbial Cell Factories 2022 21:190
  42. The modification of glucose import capacity is an engineering strategy that has been shown to improve the characteristics of Escherichia coli as a microbial factory. A reduction in glucose import capacity can hav...

    Authors: Juan Carlos Fragoso-Jiménez, Rosa María Gutierrez-Rios, Noemí Flores, Alfredo Martinez, Alvaro R. Lara, Frank Delvigne and Guillermo Gosset
    Citation: Microbial Cell Factories 2022 21:189
  43. The anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising potentials as payloads of antitumor antibody–drug conjugates. Despite...

    Authors: Manxiang Zhu, Fan Zhang, Ting Gan, Jing Lin, Yanwen Duan and Xiangcheng Zhu
    Citation: Microbial Cell Factories 2022 21:188
  44. The lipopeptides produced by Streptomyces bikiniensis have a significant inhibitory effect on Magnaporthe oryzae, but the low yield limits its application. In this study, the anti-M. oryzae activity of the broth ...

    Authors: Wei Liu, Jiawen Wang, Huaqian Zhang, Xiaohua Qi and Chunmei Du
    Citation: Microbial Cell Factories 2022 21:187
  45. Amyrin is an important triterpenoid and precursor to a wide range of cosmetic, pharmaceutical and nutraceutical products. In this study, we metabolically engineered the oleaginous yeast, Yarrowia lipolytica to pr...

    Authors: Jing Kong, Lin Miao, Zhihui Lu, Shuhui Wang, Baixiang Zhao, Cuiying Zhang, Dongguang Xiao, Desmond Teo, Susanna Su Jan Leong, Adison Wong and Aiqun Yu
    Citation: Microbial Cell Factories 2022 21:186

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