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  1. Content type: RESEARCH

    In the l-histidine (His) biosynthetic pathway of Escherichia coli, the first key enzyme, ATP-phosphoribosyltransferase (ATP-PRT, HisG), is subject to different types of inhibition. Eliminating the feedback inhibi...

    Authors: Evgeniya A. Malykh, Ivan A. Butov, Anna B. Ravcheeva, Alexander A. Krylov, Sergey V. Mashko and Nataliya V. Stoynova

    Citation: Microbial Cell Factories 2018 17:42

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  2. Content type: RESEARCH

    Members of the genus Streptomyces are Gram-positive bacteria that are used as important cell factories to produce secondary metabolites and secrete heterologous proteins. They possess some of the largest bacteria...

    Authors: Konstantinos C. Tsolis, Evridiki-Pandora Tsare, Georgia Orfanoudaki, Tobias Busche, Katerina Kanaki, Reshmi Ramakrishnan, Frederic Rousseau, Joost Schymkowitz, Christian Rückert, Jörn Kalinowski, Jozef Anné, Spyridoula Karamanou, Maria I. Klapa and Anastassios Economou

    Citation: Microbial Cell Factories 2018 17:43

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  3. Content type: Research

    The soil bacterium Pseudomonas putida KT2440 is a “generally recognized as safe”-certified strain with robust property and versatile metabolism. Thus, it is an ideal candidate for synthetic biology, biodegradatio...

    Authors: Jun Sun, Qingzhuo Wang, Yu Jiang, Zhiqiang Wen, Lirong Yang, Jianping Wu and Sheng Yang

    Citation: Microbial Cell Factories 2018 17:41

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  4. Content type: RESEARCH

    To produce 1-propanol as a potential biofuel, metabolic engineering of microorganisms, such as E. coli, has been studied. However, 1-propanol production using metabolically engineered Saccharomyces cerevisiae, wh...

    Authors: Yuya Nishimura, Terumi Matsui, Jun Ishii and Akihiko Kondo

    Citation: Microbial Cell Factories 2018 17:38

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  5. Content type: RESEARCH

    Rhamnolipids are the most extensively studied biosurfactants and has been successfully used in various areas from bioremediation to industrial fields. Rhamnolipids structural composition decide their physicoch...

    Authors: Feng Zhao, Rongjiu Shi, Fang Ma, Siqin Han and Ying Zhang

    Citation: Microbial Cell Factories 2018 17:39

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  6. Content type: RESEARCH

    The market for recombinant proteins is on the rise, and Gram-positive strains are widely exploited for this purpose. Bacillus subtilis is a profitable host for protein production thanks to its ability to secrete ...

    Authors: Roberto Ferro, Maja Rennig, Cristina Hernández-Rollán, Daniel O. Daley and Morten H. H. Nørholm

    Citation: Microbial Cell Factories 2018 17:37

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  7. Content type: Review

    Microalgae have recently attracted considerable interest worldwide, due to their extensive application potential in the renewable energy, biopharmaceutical, and nutraceutical industries. Microalgae are renewab...

    Authors: Muhammad Imran Khan, Jin Hyuk Shin and Jong Deog Kim

    Citation: Microbial Cell Factories 2018 17:36

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  8. Content type: RESEARCH

    Phenolic compounds generated in hydrolysis of lignocellulosic materials are major limiting factors for biological production of solvents by Clostridia, but it lacks the attention on the study of adaptation or res...

    Authors: Jun Liu, Qinlu Lin, Xueying Chai, Yunchuan Luo and Ting Guo

    Citation: Microbial Cell Factories 2018 17:35

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  9. Content type: RESEARCH

    Photosynthetic cyanobacteria have been studied as potential host organisms for direct solar-driven production of different carbon-based chemicals from CO2 and water, as part of the development of sustainable futu...

    Authors: Kati Thiel, Edita Mulaku, Hariharan Dandapani, Csaba Nagy, Eva-Mari Aro and Pauli Kallio

    Citation: Microbial Cell Factories 2018 17:34

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  10. Content type: Review

    Pioneered exactly 20 years ago, yeast surface display (YSD) continues to take a major role in protein engineering among the high-throughput display methodologies that have been developed to date. The classical...

    Authors: Doreen Könning and Harald Kolmar

    Citation: Microbial Cell Factories 2018 17:32

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  11. Content type: RESEARCH

    Tannases are tannin-degrading enzymes that have been described in fungi and bacteria as an adaptative mechanism to overcome the stress conditions associated with the presence of these phenolic compounds.

    Authors: Julen Tomás-Cortázar, Laura Plaza-Vinuesa, Blanca de las Rivas, José Luis Lavín, Diego Barriales, Leticia Abecia, José Miguel Mancheño, Ana M. Aransay, Rosario Muñoz, Juan Anguita and Héctor Rodríguez

    Citation: Microbial Cell Factories 2018 17:33

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  12. Content type: RESEARCH

    Syringolin, synthesized by a mixed non-ribosomal peptide synthetase/polyketide synthetase in Pseudomonas syringae pv. syringae (Pss) B728a, is a novel eukaryotic proteasome inhibitor. Meanwhile, directly modifyin...

    Authors: Fan Huang, Jianli Tang, Lian He, Xuezhi Ding, Shaoya Huang, Youming Zhang, Yunjun Sun and Liqiu Xia

    Citation: Microbial Cell Factories 2018 17:31

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  13. Content type: RESEARCH

    Chinese Nong-flavor (NF) liquor is continuously and stably produced by solid-state fermentation technology for 1000 years, resulting in enrichment of special microbial community and enzymes system in its start...

    Authors: Zhuolin Yi, Yang Fang, Kaize He, Dayu Liu, Huibo Luo, Dong Zhao, Hui He, Yanling Jin and Hai Zhao

    Citation: Microbial Cell Factories 2018 17:30

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  14. Content type: RESEARCH

    The direct link between inflammatory bowel diseases and colorectal cancer is well documented. Previous studies have reported that some lactic acid bacterial strains could inhibit colon cancer progression howev...

    Authors: Nehal M. El-Deeb, Abdelrahman M. Yassin, Lamiaa A. Al-Madboly and Amr El-Hawiet

    Citation: Microbial Cell Factories 2018 17:29

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  15. Content type: RESEARCH

    Inorganic polyphosphate bodies (PPB) have recently been linked to a variety of functions in mammalian cells. To improve the yield of PPB from Synechococcus sp. PCC 7002 and characterize its form, in this study, a...

    Authors: Fengzheng Gao, Haohao Wu, Mingyong Zeng, Min Huang and Guangxin Feng

    Citation: Microbial Cell Factories 2018 17:27

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  16. Content type: RESEARCH

    The deep-sea-derived microbe Streptomyces koyangensis SCSIO 5802 produces neoabyssomicins A–B (12) and abyssomicins 2 (3) and 4 (4). Neoabyssomicin A (1) augments human immunodeficiency virus-1 (HIV-1) replicati...

    Authors: Jiajia Tu, Siting Li, Jiang Chen, Yongxiang Song, Shaobin Fu, Jianhua Ju and Qinglian Li

    Citation: Microbial Cell Factories 2018 17:28

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  17. Content type: RESEARCH

    Genome sequencing revealed that Streptomyces sp. can dedicate up to ~ 10% of their genomes for the biosynthesis of bioactive secondary metabolites. However, the majority of these biosynthetic gene clusters are on...

    Authors: Dimitris Kallifidas, Guangde Jiang, Yousong Ding and Hendrik Luesch

    Citation: Microbial Cell Factories 2018 17:25

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  18. Content type: RESEARCH

    Dengue is listed as a neglected tropical disease by the Center for Disease Control and Preservation, as there are insufficient integrated surveillance strategies, no effective treatment, and limited licensed v...

    Authors: Jyotiranjan Bal, Nguyen Ngoc Luong, Jisang Park, Ki-Duk Song, Yong-Suk Jang and Dae-Hyuk Kim

    Citation: Microbial Cell Factories 2018 17:24

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  19. Content type: RESEARCH

    Kojibiose as a prebiotic and inhibitor of α-glucosidase exhibits potential for a wide range of applications in the food and medicine fields; however, large-scale separation and extraction of kojibiose from nat...

    Authors: Miaomiao Wang, Jing Wu and Dan Wu

    Citation: Microbial Cell Factories 2018 17:23

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  20. Content type: RESEARCH

    Lactobacillus casei is widely used in the dairy and pharmaceutical industries and a promising candidate for use as cell factories. Recently, genome sequencing and functional genomics provide the possibility for r...

    Authors: Yongping Xin, Tingting Guo, Yingli Mu and Jian Kong

    Citation: Microbial Cell Factories 2018 17:21

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  21. Content type: RESEARCH

    Porcine epidemic diarrhea caused by porcine epidemic diarrhea virus (PEDV) has led to serious economic losses to the swine industry worldwide. In this study, an oral recombinant Lactobacillus casei vaccine agains...

    Authors: Sunting Ma, Li Wang, Xuewei Huang, Xiaona Wang, Su Chen, Wen Shi, Xinyuan Qiao, Yanping Jiang, Lijie Tang, Yigang Xu and Yijing Li

    Citation: Microbial Cell Factories 2018 17:20

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  22. Content type: RESEARCH

    Fatty aldehydes are industrially relevant compounds, which also represent a common metabolic intermediate in the microbial synthesis of various oleochemicals, including alkanes, fatty alcohols and wax esters. ...

    Authors: Tapio Lehtinen, Elena Efimova, Suvi Santala and Ville Santala

    Citation: Microbial Cell Factories 2018 17:19

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  23. Content type: Research

    Antibiotic residues can cause antibiotic resistance in livestock and their food safety-related issues have increased the consumer demand for products lacking these residues. Hence, developing safe and effectiv...

    Authors: Min Zhang, Yuanlong Shan, Hongtao Gao, Bin Wang, Xin Liu, Yuanyuan Dong, Xiuming Liu, Na Yao, Yonggang Zhou, Xiaowei Li and Haiyan Li

    Citation: Microbial Cell Factories 2018 17:18

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  24. Content type: RESEARCH

    Chimeric virus-like particles (VLP) allow the display of foreign antigens on their surface and have proved valuable in the development of safe subunit vaccines or drug delivery. However, finding an inexpensive...

    Authors: David Wetzel, Theresa Rolf, Manfred Suckow, Andreas Kranz, Andreas Barbian, Jo-Anne Chan, Joachim Leitsch, Michael Weniger, Volker Jenzelewski, Betty Kouskousis, Catherine Palmer, James G. Beeson, Gerhard Schembecker, Juliane Merz and Michael Piontek

    Citation: Microbial Cell Factories 2018 17:17

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  25. Content type: RESEARCH

    The deep-sea environment harbors a vast pool of novel enzymes. Owing to the limitations of cultivation, cultivation-independent has become an effective method for mining novel enzymes from the environment. Bas...

    Authors: Ying-Yi Huo, Shu-Ling Jian, Hong Cheng, Zhen Rong, Heng-Lin Cui and Xue-Wei Xu

    Citation: Microbial Cell Factories 2018 17:16

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  26. Content type: RESEARCH

    The CRISPR/dCas9 system is a powerful tool to activate the transcription of target genes in eukaryotic or prokaryotic cells, but lacks assays in complex conditions, such as the biosynthesis of secondary metabo...

    Authors: Ran Peng, Ye Wang, Wan-wan Feng, Xin-jing Yue, Jiang-he Chen, Xiao-zhuang Hu, Zhi-feng Li, Duo-hong Sheng, You-ming Zhang and Yue-zhong Li

    Citation: Microbial Cell Factories 2018 17:15

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  27. Content type: Research

    Due to the important role of rifamycin in curing tuberculosis infection, the study on rifamycin has never been stopped. Although RifZ, which locates within the rifamycin biosynthetic cluster, has recently been...

    Authors: Chao Lei, Jingzhi Wang, Yuanyuan Liu, Xinqiang Liu, Guoping Zhao and Jin Wang

    Citation: Microbial Cell Factories 2018 17:14

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  28. Content type: RESEARCH

    The conjugative plasmid, pLS20, isolated from Bacillus subtilis natto, has an outstanding capacity for rapid self-transfer. In addition, it can function as a helper plasmid, mediating the mobilization of an indep...

    Authors: Megumi Miyano, Kosei Tanaka, Shu Ishikawa, Shinji Takenaka, Andrés Miguel-Arribas, Wilfried J. J. Meijer and Ken-ichi Yoshida

    Citation: Microbial Cell Factories 2018 17:13

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  29. Content type: RESEARCH

    Cocoa butter (CB) extracted from cocoa beans (Theobroma cacao) is the main raw material for chocolate production, but CB supply is insufficient due to the increased chocolate demand and limited CB production. CB ...

    Authors: Yongjun Wei, David Bergenholm, Michael Gossing, Verena Siewers and Jens Nielsen

    Citation: Microbial Cell Factories 2018 17:11

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  30. Content type: RESEARCH

    Synthetic organism-based biotechnologies are increasingly being proposed for environmental applications, such as in situ sensing. Typically, the novel function of these organisms is delivered by compiling gene...

    Authors: Jillian M. Couto, Anne McGarrity, Julie Russell and William T. Sloan

    Citation: Microbial Cell Factories 2018 17:8

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  31. Content type: RESEARCH

    Azotobacter vinelandii is a bacterium that produces alginate and polyhydroxybutyrate (P3HB); however, the role of NAD(P)H/NAD(P)+ ratios on the metabolic fluxes through biosynthesis pathways of these biopolymers ...

    Authors: Andres García, Pau Ferrer, Joan Albiol, Tania Castillo, Daniel Segura and Carlos Peña

    Citation: Microbial Cell Factories 2018 17:10

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  32. Content type: RESEARCH

    Pseudomonas chlororaphis HT66 isolated from the rice rhizosphere is an important plant growth-promoting rhizobacteria that produce phenazine-1-carboxamide (PCN) in high yield. Phenazine production is regulated by...

    Authors: Huasong Peng, Yi Ouyang, Muhammad Bilal, Wei Wang, Hongbo Hu and Xuehong Zhang

    Citation: Microbial Cell Factories 2018 17:9

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  33. Content type: Research

    Dunaliella salina is a unicellular green alga with a high α-linolenic acid (ALA) level, but a low eicosapentaenoic acid (EPA) level. In a previous analysis of the catalytic activity of delta 6 fatty acid desatura...

    Authors: Haisu Shi, Xue Luo, Rina Wu and Xiqing Yue

    Citation: Microbial Cell Factories 2018 17:7

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  34. Content type: Research

    The thorough understanding of the physiological and pathological processes mediated by extracellular vesicles (EVs) is challenged by purification methods which are cumbersome, not reproducible, or insufficient...

    Authors: Milica Popovic, Elisa Mazzega, Barbara Toffoletto and Ario de Marco

    Citation: Microbial Cell Factories 2018 17:6

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  35. Content type: RESEARCH

    Gamma valerolactone (GVL) treatment of lignocellulosic bomass is a promising technology for degradation of biomass for biofuel production; however, GVL is toxic to fermentative microbes. Using a combination of...

    Authors: Scott Bottoms, Quinn Dickinson, Mick McGee, Li Hinchman, Alan Higbee, Alex Hebert, Jose Serate, Dan Xie, Yaoping Zhang, Joshua J. Coon, Chad L. Myers, Robert Landick and Jeff S. Piotrowski

    Citation: Microbial Cell Factories 2018 17:5

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  36. Content type: RESEARCH

    Yeast surface display (YSD) has proven to be a versatile platform technology for antibody discovery. However, the construction of antibody Fab libraries typically is a tedious three-step process that involves ...

    Authors: Simon Rosowski, Stefan Becker, Lars Toleikis, Bernhard Valldorf, Julius Grzeschik, Deniz Demir, Iris Willenbücher, Ramona Gaa, Harald Kolmar, Stefan Zielonka and Simon Krah

    Citation: Microbial Cell Factories 2018 17:3

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  37. Content type: Research

    The construction of microbial cell factories requires cost-effective and rapid strain development through metabolic engineering. Recently, RNA-guided CRISPR technologies have been developed for metabolic engin...

    Authors: Jaehyun Park, Hyojung Shin, Sun-Mi Lee, Youngsoon Um and Han Min Woo

    Citation: Microbial Cell Factories 2018 17:4

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  38. Content type: RESEARCH

    The halophilic bacterium Chromohalobacter salexigens is a natural producer of ectoines, compatible solutes with current and potential biotechnological applications. As production of ectoines is an osmoregulated p...

    Authors: Francine Piubeli, Manuel Salvador, Montserrat Argandoña, Joaquín J. Nieto, Vicente Bernal, Jose M. Pastor, Manuel Cánovas and Carmen Vargas

    Citation: Microbial Cell Factories 2018 17:2

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  39. Content type: Research

    Mushroom showed pellet, clump and/or filamentous mycelial morphologies during submerged fermentation. Addition of microparticles including Talc (magnesium silicate), aluminum oxide and titanium oxide could con...

    Authors: Ting-Lei Tao, Feng-Jie Cui, Xiao-Xiao Chen, Wen-Jing Sun, Da-Ming Huang, Jinsong Zhang, Yan Yang, Di Wu and Wei-Min Liu

    Citation: Microbial Cell Factories 2018 17:1

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  40. Content type: RESEARCH

    The gene encoding a thermostable cellulase of family 12 was previously isolated from a Rhodothermus marinus through functional screening. CelA is a protein of 260 aminoacyl residues with a 28-residue amino-termin...

    Authors: Mohamed Belal Hamed, Spyridoula Karamanou, Solveig Ólafsdottir, Joana Sofia Martins Basílio, Kenneth Simoens, Kostantinos C. Tsolis, Lieve Van Mellaert, Eik Elísabet Guðmundsdóttir, Gudmundur Oli Hreggvidsson, Jozef Anné, Kristel Bernaerts, Olafur H. Fridjonsson and Anastassios Economou

    Citation: Microbial Cell Factories 2017 16:232

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  41. Content type: RESEARCH

    As microbial cultures are comprised of heterogeneous cells that differ according to their size and intracellular concentrations of DNA, proteins, and other constituents, the detailed identification and discri...

    Authors: Yan Ren, Yuetong Ji, Lin Teng and Heping Zhang

    Citation: Microbial Cell Factories 2017 16:233

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  42. Content type: RESEARCH

    Through pretreatment and enzymatic saccharification lignocellulosic biomass has great potential as a low-cost feedstock for production of bacterial nanocellulose (BNC), a high value-added microbial product, bu...

    Authors: Xiaozhou Zou, Guochao Wu, Stefan Stagge, Lin Chen, Leif J. Jönsson and Feng F. Hong

    Citation: Microbial Cell Factories 2017 16:229

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  43. Content type: Research

    The high level of excretion and rapid folding ability of β-fructofuranosidase (β-FFase) in Escherichia coli has suggested that β-FFase from Arthrobacter arilaitensis NJEM01 can be developed as a fusion partner.

    Authors: Cheng Cheng, Shanshan Wu, Lupeng Cui, Yulu Wu, Tianyue Jiang and Bingfang He

    Citation: Microbial Cell Factories 2017 16:231

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  44. Content type: RESEARCH

    Virus infected killer strains of the baker’s yeast Saccharomyces cerevisiae secrete protein toxins such as K28, K1, K2 and Klus which are lethal to sensitive yeast strains of the same or related species. K28 is s...

    Authors: Esther Giesselmann, Björn Becker and Manfred J. Schmitt

    Citation: Microbial Cell Factories 2017 16:228

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  45. Content type: RESEARCH

    Phloroglucinol is an important chemical which has been successfully produced by engineered Escherichia coli. However, the toxicity of phloroglucinol can enormously inhibit E. coli cell growth and viability, and t...

    Authors: Rubing Zhang, Yujin Cao, Wei Liu, Mo Xian and Huizhou Liu

    Citation: Microbial Cell Factories 2017 16:227

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