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  1. Two laccase isoenzymes (LacA and LacB) were isolated from a novel Trichoderma harzianum S7113 isolate employing ammonium sulfate precipitation, Sephadex G100, and DEAE Sepharose ion exchange chromatography. The m...

    Authors: Alshaimaa M. Elsayed, Mohamed Mahmoud, Ghada S. A. Abdel Karim, Mohamed Abdelraof and Abdelmageed M. Othman
    Citation: Microbial Cell Factories 2023 22:1
  2. Over the 70 years since the introduction of plastic into everyday items, plastic waste has become an increasing problem. With over 360 million tonnes of plastics produced every year, solutions for plastic recy...

    Authors: Raphael Loll-Krippleber, Victoria A. Sajtovich, Michael W. Ferguson, Brandon Ho, Andrew R. Burns, Brandon J. Payliss, Joseph Bellissimo, Sydney Peters, Peter J. Roy, Haley D. M. Wyatt and Grant W. Brown
    Citation: Microbial Cell Factories 2022 21:280
  3. Melanin is a natural pigment that can be applied in different fields such as medicine, environment, pharmaceutical, and nanotechnology. Studies carried out previously showed that the melanin produced by the mel1 ...

    Authors: William Bartolomeu Medeiros, Kelly Johana Dussán Medina and Sandra Regina Pombeiro Sponchiado
    Citation: Microbial Cell Factories 2022 21:278
  4. The biosynthesis of silver nanoparticles (AgNPs) is an area of interest for researchers due to its eco-friendly approach. The use of biological approaches provides a clean and promising alternative process for...

    Authors: Hany M. Abdelmoneim, Tarek H. Taha, Mohamed S. Elnouby and Hala Mohamed AbuShady
    Citation: Microbial Cell Factories 2022 21:277
  5. Poly γ-glutamic acid (γ-PGA) is a promising biopolymer for various applications. For glutamic acid-independent strains, the titer of γ-PGA is too low to meet the industrial demand. In this study, we isolated a...

    Authors: Dexin Wang, Xiaoping Fu, Dasen Zhou, Jiaqi Gao and Wenqin Bai
    Citation: Microbial Cell Factories 2022 21:276
  6. Itaconic acid, an unsaturated C5 dicarbonic acid, has significant market demand and prospects. It has numerous biological functions, such as anti-cancer, anti-inflammatory, and anti-oxidative in medicine, and ...

    Authors: Jiao Feng, Chunqiu Li, Hao He, Sheng Xu, Xin Wang and Kequan Chen
    Citation: Microbial Cell Factories 2022 21:275
  7. Extremolytes enable microbes to withstand even the most extreme conditions in nature. Due to their unique protective properties, the small organic molecules, more and more, become high-value active ingredients...

    Authors: Lukas Jungmann, Sarah Lisa Hoffmann, Caroline Lang, Raphaela De Agazio, Judith Becker, Michael Kohlstedt and Christoph Wittmann
    Citation: Microbial Cell Factories 2022 21:274
  8. Clostridium thermocellum is a promising candidate for consolidated bioprocessing of lignocellulosic biomass to ethanol. The low ethanol tolerance of this microorganism is one of the remaining obstacles to industr...

    Authors: Teun Kuil, Johannes Yayo, Johanna Pechan, Jan Küchler and Antonius J. A. van Maris
    Citation: Microbial Cell Factories 2022 21:273
  9. Raw starch-degrading enzyme (RSDE) is applied in biorefining of starch to produce biofuels efficiently and economically. At present, RSDE is obtained via secretion by filamentous fungi such as Penicillium oxalicu...

    Authors: Shuai Zhao, Ming-Zhu Tan, Rui-Xian Wang, Fa-Ting Ye, Yuan-Peng Chen, Xue-Mei Luo and Jia-Xun Feng
    Citation: Microbial Cell Factories 2022 21:272
  10. α-Humulene is an important biologically active sesquiterpene, whose heterologous production in microorganisms is a promising alternative biotechnological process to plant extraction and chemical synthesis. In ...

    Authors: Qi Guo, Qian-Qian Peng, Ying-Ying Chen, Ping Song, Xiao-Jun Ji, He Huang and Tian-Qiong Shi
    Citation: Microbial Cell Factories 2022 21:271
  11. Resveratrol is a plant-derived phenylpropanoid with diverse biological activities and pharmacological applications. Plant-based extraction could not satisfy ever-increasing market demand, while chemical synthe...

    Authors: Mengyao Zhang, Qidou Gao, Yijuan Liu, Zhumei Fang, Zhiwei Gong, Zongbao K. Zhao and Xiaobing Yang
    Citation: Microbial Cell Factories 2022 21:270
  12. 2-Phenylethanol (2-PE), a higher alcohol with a rose-like odor, inhibits growth of the producer strains. However, the limited knowledge regarding 2-PE tolerance mechanisms renders our current knowledge base in...

    Authors: Huili Xia, Yue Kang, Zilin Ma, Cuiyu Hu, Qiao Yang, Xiaoling Zhang, Shihui Yang, Jun Dai and Xiong Chen
    Citation: Microbial Cell Factories 2022 21:269
  13. The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that ...

    Authors: Ramon Roca-Pinilla, Leszek Lisowski, Anna Arís and Elena Garcia-Fruitós
    Citation: Microbial Cell Factories 2022 21:267
  14. Genetic modifications in Bacillus subtilis have allowed the conversion of myo-inositol into scyllo-inositol, which is proposed as a therapeutic agent for Alzheimer’s disease. This conversion comprises two reactio...

    Authors: Yuzheng Wu, Honami Kawabata, Kyosuke Kita, Shu Ishikawa, Kan Tanaka and Ken-ichi Yoshida
    Citation: Microbial Cell Factories 2022 21:266
  15. Continuous processing with enzyme reuse is a well-known engineering strategy to enhance the efficiency of biocatalytic transformations for chemical synthesis. In one-pot multistep reactions, continuous process...

    Authors: Katharina N. Schwaiger and Bernd Nidetzky
    Citation: Microbial Cell Factories 2022 21:265
  16. The immobilized technology for microbial or cells has the advantages of high microbial activity, high microbial density per unit space, good tolerance, strong shock, load resistance, high processing efficiency...

    Authors: Zhi-Hao Zhong and Yu-Qing Zhang
    Citation: Microbial Cell Factories 2022 21:264
  17. Phospholipase D (PLD) is highly valuable in the food and medicine industries, where it is used to convert low-cost phosphatidylcholine into high-value phospholipids (PLs). Despite being overexpressed in Streptomy...

    Authors: Juntan Wang, Haihua Zhu, Huiyi Shang, Bishan Guo, Mengxue Zhang, Fayun Wang, Lipan Zhang, Jun Xu and Hui Wang
    Citation: Microbial Cell Factories 2022 21:263
  18. Pyocyanin, a specific extracellular secondary metabolite pigment produced by Pseudomonas aeruginosa, exhibits redox activity and has toxic effects on mammalian cells, making it a new and potent alternative for tr...

    Authors: Ahmed A. Abdelaziz, Amal M. Abo Kamer, Khaled B. Al-Monofy and Lamiaa A. Al-Madboly
    Citation: Microbial Cell Factories 2022 21:262
  19. Antarctica has one of the most extreme environments in the world. This region is inhabited by specifically adapted microorganisms that produce various unique secondary metabolites (e.g. pigments) enabling thei...

    Authors: Michal Styczynski, Agata Rogowska, Christine Nyabayo, Przemyslaw Decewicz, Filip Romaniuk, Cezary Pączkowski, Anna Szakiel, Roderich Suessmuth and Lukasz Dziewit
    Citation: Microbial Cell Factories 2022 21:261
  20. Membrane proteins (MPs) are an important class of molecules with a wide array of cellular functions and are part of many metabolic pathways. Despite their great potential—as therapeutic drug targets or in micr...

    Authors: Chiara Guidi, Lien De Wannemaeker, Jasmine De Baets, Wouter Demeester, Jo Maertens, Brecht De Paepe and Marjan De Mey
    Citation: Microbial Cell Factories 2022 21:260
  21. Owing to CRISPR-Cas9 and derivative technologies, genetic studies on microorganisms have dramatically increased. However, the CRISPR-Cas9 system is still difficult to utilize in many wild-type Bacillus strains ow...

    Authors: Man Su Kim, Da-Eun Jeong and Soo-Keun Choi
    Citation: Microbial Cell Factories 2022 21:259
  22. Expression of affinity-tagged recombinant proteins for crystallography, protein–protein interaction, antibody generation, therapeutic applications, etc. mandates the generation of high-yield soluble proteins. ...

    Authors: Amruta A. Shendge and Jacinta S. D’Souza
    Citation: Microbial Cell Factories 2022 21:258
  23. Spray drying is the most cost-effective production method for lactic acid bacteria starters, but heat and oxidative stresses result in low survival rates. The heat stress and oxidative stress tolerance of Lactica...

    Authors: Chenchen Zhang, Haohao Cheng, Yuemei Han, Yunchao Wa, Dawei Chen, Chengran Guan, Yujun Huang and Ruixia Gu
    Citation: Microbial Cell Factories 2022 21:257
  24. The global market for sweeteners is increasing, and the food industry is constantly looking for new low-caloric sweeteners. The natural sweetener 5-keto-d-fructose is one such candidate. 5-Keto-d-fructose has a s...

    Authors: Svenja Battling, Tobias Engel, Elena Herweg, Paul-Joachim Niehoff, Matthias Pesch, Theresa Scholand, Marie Schöpping, Nina Sonntag and Jochen Büchs
    Citation: Microbial Cell Factories 2022 21:255
  25. Rhodosporidium toruloides is capable of co-utilization of complex carbon sources and robust growth from lignocellulosic hydrolysates. This oleaginous yeast is therefore an attractive host for heterologous produc...

    Authors: Peter B. Otoupal, Gina M. Geiselman, Asun M. Oka, Carolina A. Barcelos, Hemant Choudhary, Duy Dinh, Wenqing Zhong, HeeJin Hwang, Jay D. Keasling, Aindrila Mukhopadhyay, Eric Sundstrom, Robert W. Haushalter, Ning Sun, Blake A. Simmons and John M. Gladden
    Citation: Microbial Cell Factories 2022 21:254
  26. Despite decades of engineering efforts, recombinant Saccharomyces cerevisiae are still less efficient at converting d-xylose sugar to ethanol compared to the preferred sugar d-glucose. Using GFP-based biosensors ...

    Authors: Celina Borgström, Viktor C. Persson, Oksana Rogova, Karen O. Osiro, Ester Lundberg, Peter Spégel and Marie Gorwa-Grauslund
    Citation: Microbial Cell Factories 2022 21:253
  27. Cottonseed meal (CSM) is the main by-product of the cottonseed oil extraction process with high protein content, which is an important protein source for feed industry. However, CSM contains free gossypol (FG)...

    Authors: Zhenting Zhang, Danlu Yang, Ling Liu, Zhangbing Chang and Nan Peng
    Citation: Microbial Cell Factories 2022 21:252
  28. The starch in waste bread (WB) from industrial sandwich production was directly converted to ethanol by an amylolytic, ethanologenic thermophile (Parageobacillus thermoglucosidasius strain TM333) under 5 differen...

    Authors: Christopher C. Ibenegbu and David J. Leak
    Citation: Microbial Cell Factories 2022 21:251
  29. Cortisone is a metabolite belonging to the corticosteroid class that is used pharmaceutically directly as a drug or prodrug. In addition to its large consumption, its use is linked to several side effects, so ...

    Authors: Stefania Costa, Paola Tedeschi, Luca Ferraro, Sarah Beggiato, Alessandro Grandini, Stefano Manfredini, Raissa Buzzi, Gianni Sacchetti and Giuseppe Valacchi
    Citation: Microbial Cell Factories 2022 21:250
  30. Genomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have remained enigmatic. The ascomycete genus Epicoccum, belonging to the fami...

    Authors: Tao Zhang, Guowei Cai, Xiaoting Rong, Jingwen Xu, Bingya Jiang, Hao Wang, Xinxin Li, Lu Wang, Ran Zhang, Wenni He and Liyan Yu
    Citation: Microbial Cell Factories 2022 21:249
  31. Polyamide (nylon) is an important material, which has aroused plenty of attention from all aspects. PA 5.4 is one kind of nylon with excellent property, which consists of cadaverine and succinic acid. Due to t...

    Authors: Siyuan Gao, Jiachen Lu, Tongtao Wang, Sheng Xu, Xin Wang, Kequan Chen and Pingkai Ouyang
    Citation: Microbial Cell Factories 2022 21:248
  32. Industrial bioethanol production may involve a low pH environment caused by inorganic acids, improving the tolerance of Saccharomyces cerevisiae to a low pH environment is of industrial importance to increase eth...

    Authors: Yajing Wu, Bo Li, Bu Miao, Caiyun Xie and Yue-Qin Tang
    Citation: Microbial Cell Factories 2022 21:247
  33. α-Ionone is highly valued in cosmetics and perfumery with a global usage of 100–1000 tons per year. Metabolic engineering by microbial fermentation offers a promising way to produce natural (R)-α-ionone in a cost...

    Authors: Ching-Ning Huang, Xiaohui Lim, Leonard Ong, Chinchin Lim, Xixian Chen and Congqiang Zhang
    Citation: Microbial Cell Factories 2022 21:246
  34. The remains of the heart tissue of Thaddeus Kosciuszko have been investigated as the possible cause of disease and death of the hero of Polish and American nations. Three specimens, DNA isolated from scrapping...

    Authors: Michał Witt, Miron Tokarski, Ewa Ziętkiewicz, Arleta Lebioda, Maria Szczypek, Wojciech Falkowski, Przemysław Mrozowski, Teresa Kulak, Małgorzata Sobieszczańska, Magdalena Mrugalska-Banaszak, Tomasz Jurek and Tadeusz Dobosz
    Citation: Microbial Cell Factories 2022 21:245
  35. Due to its high expression capability, recombination of Escherichia coli and pET vector has become the bioengineering preferred expression system. Because β-lactamases mediate bacterial antimicrobial resistance, ...

    Authors: Lele Li, Hui Li, Qingwu Tian, Baosheng Ge, Xiaotong Xu, Yuanyuan Chi, Huaizhi Zhao, Yanfei Liu, Nan Jia, Tingting Zhou, Yuanqi Zhu and Yusun Zhou
    Citation: Microbial Cell Factories 2022 21:244
  36. Ethyl acetate is a bulk chemical traditionally produced via energy intensive chemical esterification. Microbial production of this compound offers promise as a more sustainable alternative process. So far, eff...

    Authors: James C. Dykstra, Jelle van Oort, Ali Tafazoli Yazdi, Eric Vossen, Constantinos Patinios, John van der Oost, Diana Z. Sousa and Servé W. M. Kengen
    Citation: Microbial Cell Factories 2022 21:243
  37. Malic acid, a dicarboxylic acid mainly used in the food industry, is currently produced from fossil resources. The utilization of low-cost substrates derived from biomass could render microbial processes econo...

    Authors: Aline Kövilein, Vera Aschmann, Lena Zadravec and Katrin Ochsenreither
    Citation: Microbial Cell Factories 2022 21:242
  38. Recent studies have demonstrated that gut microbiota plays critical roles in various human diseases. High-throughput technology has been widely applied to characterize the microbial ecosystems, which led to an...

    Authors: Peishun Li, Hao Luo, Boyang Ji and Jens Nielsen
    Citation: Microbial Cell Factories 2022 21:241
  39. Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain. Lack of research on its ...

    Authors: Zhenxin Li, Songbai Yang, Zhengyu Zhang, Yuanjie Wu, Jiawei Tang, Luoju Wang and Shaoxin Chen
    Citation: Microbial Cell Factories 2022 21:240
  40. Caveolae are invaginated plasma membrane domains of 50–100 nm in diameter involved in many important physiological functions in eukaryotic cells. They are composed of different proteins, including the membrane...

    Authors: A. Flourieusse, P. Bourgeois, E. Schenckbecher, J. Palvair, D. Legrand, C. Labbé, T. Bescond, L. Avoscan, S. Orlowski, A. Rouleau and A. Frelet-Barrand
    Citation: Microbial Cell Factories 2022 21:239
  41. Our recent multi-omics analyses of glucoamylase biosynthesis in Aspergillus niger (A. niger) suggested that lipid catabolism was significantly up-regulated during high-yield period under oxygen limitation. Since ...

    Authors: Jie Qi, Xianzun Xiao, Liming Ouyang, Chenghan Yang, Yingping Zhuang and Lixin Zhang
    Citation: Microbial Cell Factories 2022 21:238
  42. Lactobacillus species dominate the vaginal microflora performing a first-line defense against vaginal infections. Extracellular vesicles (EVs) released by lactobacilli are considered mediators of their beneficial...

    Authors: Vanessa Croatti, Carola Parolin, Barbara Giordani, Claudio Foschi, Stefano Fedi and Beatrice Vitali
    Citation: Microbial Cell Factories 2022 21:237
  43. Bacteriocins are ribosomally synthesized antimicrobial peptides, that either kill target bacteria or inhibit their growth. Bacteriocins are used in food preservation and are of increasing interest as potential...

    Authors: Christian K. Desiderato, Katharina M. Hasenauer, Sebastian J. Reich, Oliver Goldbeck, Lalaina Holivololona, Kirill V. Ovchinnikov, Alexander Reiter, Marco Oldiges, Dzung B. Diep, Bernhard J. Eikmanns and Christian U. Riedel
    Citation: Microbial Cell Factories 2022 21:236
  44. Natural life systems can be significantly modified at the genomic scale by human intervention, demonstrating the great innovation capacity of genome engineering. Large epi-chromosomal DNA structures were estab...

    Authors: Junchang Su, Pengju Wang, Ju Li, Dongdong Zhao, Siwei Li, Feiyu Fan, Zhubo Dai, Xiaoping Liao, Zhitao Mao, Chunzhi Zhang, Changhao Bi and Xueli Zhang
    Citation: Microbial Cell Factories 2022 21:235
  45. Trichoderma spp. are important agricultural biocontrol microorganisms that are often used as effective components of microbial fungicides and microbial biofertilizers. However, most of these products are prepared...

    Authors: Dazhi Hao, Bo Lang, Yongkun Wang, Xinhua Wang, Tong Liu and Jie Chen
    Citation: Microbial Cell Factories 2022 21:234
  46. Caprazamycins are liponucleoside antibiotics showing bioactivity against Gram-positive bacteria including clinically relevant Mycobacterium tuberculosis by targeting the bacterial MraY-translocase. Their chemical...

    Authors: Daniel Bär, Benjamin Konetschny, Andreas Kulik, Houchao Xu, Davide Paccagnella, Patrick Beller, Nadine Ziemert, Jeroen S. Dickschat and Bertolt Gust
    Citation: Microbial Cell Factories 2022 21:232
  47. A representative hydrogen-oxidizing bacterium Cupriavidus necator H16 has attracted much attention as hosts to recycle carbon dioxide (CO2) into a biodegradable polymer, poly(R)-3-hydroxybutyrate (PHB). Although

    Authors: Soyoung Kim, Yong Jae Jang, Gyeongtaek Gong, Sun-Mi Lee, Youngsoon Um, Kyoung Heon Kim and Ja Kyong Ko
    Citation: Microbial Cell Factories 2022 21:231

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