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  1. Oxytetracycline which is derived from Streptomyces rimosus, inhibits a wide range of bacteria and is industrially important. The underlying biosynthetic processes are complex and hinder rational engineering, so i...

    Authors: Selma Beganovic, Christian Rückert-Reed, Hilda Sucipto, Wei Shu, Lars Gläser, Thomas Patschkowski, Ben Struck, Jörn Kalinowski, Andriy Luzhetskyy and Christoph Wittmann
    Citation: Microbial Cell Factories 2023 22:222
  2. Normally, a salt amount greater than 3.5% (w/v) is defined as hypersaline. Large amounts of hypersaline wastewater containing organic pollutants need to be treated before it can be discharged into the environm...

    Authors: Jie Zheng, Zhengzhi Zhang, Juan An, Yubin Xue and Bo Yu
    Citation: Microbial Cell Factories 2023 22:220
  3. Production of plant secondary metabolites in engineered microorganisms provides a scalable and sustainable alternative to their sourcing from nature or through chemical synthesis. However, the biosynthesis of ...

    Authors: Michal Poborsky, Christoph Crocoll, Mohammed Saddik Motawie and Barbara Ann Halkier
    Citation: Microbial Cell Factories 2023 22:219
  4. Identification and characterization of novel, faithful and processive DNA polymerases is a driving force in the development of DNA amplification methods. Purification of proteins from natural phages is often t...

    Authors: Pengjun Han, Huahao Fan and Yigang Tong
    Citation: Microbial Cell Factories 2023 22:217
  5. Lignocellulosic biomass plays a crucial role in creating a circular bioeconomy and minimizing environmental impact. Enset biomass is a byproduct of traditional Ethiopian Enset food processing that is thrown aw...

    Authors: Nebyat Seid, Katrin Ochsenreither and Anke Neumann
    Citation: Microbial Cell Factories 2023 22:216
  6. Seleno-methylselenocysteine (SeMCys) is an effective component of selenium supplementation with anti-carcinogenic potential that can ameliorate neuropathology and cognitive deficits. In a previous study, a SeM...

    Authors: Xian Yin, Meiyi Zhao, Yu Zhou, Hulin Yang, Yonghong Liao and Fenghuan Wang
    Citation: Microbial Cell Factories 2023 22:215
  7. The increasing prevalence of plastic waste combined with the inefficiencies of mechanical recycling has inspired interest in processes that can convert these waste streams into value-added biomaterials. To dat...

    Authors: Alexander Connor, Jessica V. Lamb, Massimiliano Delferro, Mattheos Koffas and R. Helen Zha
    Citation: Microbial Cell Factories 2023 22:214
  8. Enantio-pure α-hydroxy amides are valuable intermediates for the synthesis of chiral pharmaceuticals. The asymmetric reduction of α-keto amides to generate chiral α-hydroxy amides is a difficult and challengin...

    Authors: Ruixuan Bai, Baoling Chen and Liangyu Zheng
    Citation: Microbial Cell Factories 2023 22:213
  9. Oviedomycin is one among several polyketides known for their potential as anticancer agents. The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in Streptomyces antibioticus. However, because t...

    Authors: Boncheol Gu, Duck Gyun Kim, Do-Kyung Kim, Minji Kim, Hyun Uk Kim and Min-Kyu Oh
    Citation: Microbial Cell Factories 2023 22:212
  10. Halophiles possess several unique properties and have broad biotechnological applications including industrial biotechnology production. Halomonas spp., especially Halomonas bluephagenesis, have been engineered t...

    Authors: Chunyan Liu, Yaxin Yue, Yanfen Xue, Cheng Zhou and Yanhe Ma
    Citation: Microbial Cell Factories 2023 22:211
  11. Phenylpropanoids such as p-coumaric acid represent important precursors for the synthesis of a broad range of plant secondary metabolites including stilbenoids, flavonoids, and lignans, which are of pharmacologic...

    Authors: Mario Mutz, Dominic Kösters, Benedikt Wynands, Nick Wierckx and Jan Marienhagen
    Citation: Microbial Cell Factories 2023 22:209
  12. Zymomonas mobilis is an important industrial bacterium ideal for biorefinery and synthetic biology studies. High-throughput CRISPR-based genome editing technologies have been developed to enable targeted engineer...

    Authors: Yanli Zheng, Hongmei Fu, Jue Chen, Jie Li, Yuejie Bian, Ping Hu, Lei Lei, Yihan Liu, Jiangke Yang and Wenfang Peng
    Citation: Microbial Cell Factories 2023 22:208
  13. Providing sufficient and usable energy for the cell factory has long been a heated issue in biosynthesis as solar energy has never been rooted out from the strategy for improvement, and turning Escherichia coli (...

    Authors: Chao-Yu Lee, Kai-Wen Chen, Chih-Lu Chiang, Hsuan-Yu Kao, Hao-Cheng Yu, Hsiao-Ching Lee and Wen-Liang Chen
    Citation: Microbial Cell Factories 2023 22:207
  14. Coenzyme Q10 (CoQ10) is crucial for human beings, especially in the fields of biology and medicine. The aim of this experiment was to investigate the conditions for increasing CoQ10 production. At present, microb...

    Authors: Yujun Xiao, Yi Zheng, Yong Zhou, Chaofan Yu and Ting-E Ye
    Citation: Microbial Cell Factories 2023 22:206
  15. Edible mushrooms are delicious in flavour and rich in high-quality protein and amino acids required by humans. A transcription factor, general control nonderepressible 4 (GCN4), can regulate the expression of ...

    Authors: Lingdan Lian, Jinjin Qiao, Xiaoyu Guo, Zhenzhen Xing, Ang Ren, Mingwen Zhao and Jing Zhu
    Citation: Microbial Cell Factories 2023 22:205
  16. “ATP wasting” has been observed in 13C metabolic flux analyses of Saccharomyces cerevisiae, a yeast strain commonly used to produce ethanol. Some strains of S. cerevisiae, such as the sake strain Kyokai 7, consum...

    Authors: Futa Yatabe, Taisuke Seike, Nobuyuki Okahashi, Jun Ishii and Fumio Matsuda
    Citation: Microbial Cell Factories 2023 22:204
  17. Bacillus subtilis is one of the workhorses in industrial biotechnology and well known for its secretion potential. Efficient secretion of recombinant proteins still requires extensive optimization campaigns and s...

    Authors: Patrick Lenz, Patrick J. Bakkes, Carolin Müller, Marzena Malek, Roland Freudl, Marco Oldiges, Thomas Drepper, Karl-Erich Jaeger and Andreas Knapp
    Citation: Microbial Cell Factories 2023 22:203
  18. The application of exopolysaccharide-producing bacteria (EPS) in dual chamber microbial fuel cells (DCMFC) is critical which can minimize the chemical oxygen demand (COD) of molasses with bioelectricity produc...

    Authors: Ebtehag A. E. Sakr, Dena Z. Khater, Zeinab M. H. Kheiralla and Kamel M. El‑khatib
    Citation: Microbial Cell Factories 2023 22:202
  19. Xylitol has a wide range of applications in the pharmaceuticals, cosmetic, food and beverage industry. Microbial xylitol production reduces the risk of contamination and is considered as environment friendly a...

    Authors: Anup Kumar Singh, Farha Deeba, Mohit Kumar, Sonam Kumari, Shahid Ali Wani, Tanushree Paul and Naseem A. Gaur
    Citation: Microbial Cell Factories 2023 22:201
  20. Bacillus subtilis has been established as model microorganism for fundamental research in the laboratory on protein production/secretion and sporulation and as model bacterium for controlling spoilage in the food...

    Authors: Taichi Chen, Stanley Brul and Jeroen Hugenholtz
    Citation: Microbial Cell Factories 2023 22:200
  21. Long-chain polyunsaturated fatty acids (LC-PUFAs), such as docosahexaenoic acid (DHA), are essential for human health and have been widely used in the food and pharmaceutical industries. However, the limited a...

    Authors: Demian Dietrich, Sofija Jovanovic-Gasovic, Peng Cao, Michael Kohlstedt and Christoph Wittmann
    Citation: Microbial Cell Factories 2023 22:199
  22. Methanol, synthesized from CO2, is a potentially sustainable one-carbon (C1) resource for biomanufacturing. The use of methanol as a feedstock to produce single cell protein (SCP) has been investigated for decade...

    Authors: Jiao Meng, Shufan Liu, Le Gao, Kai Hong, Shuguang Liu and Xin Wu
    Citation: Microbial Cell Factories 2023 22:198
  23. Ovarian cancer is one of the most frequent and deadly gynaecological cancers, often resistant to platinum-based chemotherapy, the current standard of care. Halophilic microorganisms have been shown to produce ...

    Authors: Magdalena Kowalewicz-Kulbat, Krzysztof T. Krawczyk, Izabela Szulc-Kielbik, Sebastian Rykowski, Marta Denel-Bobrowska, Agnieszka B. Olejniczak, Camille Locht and Magdalena Klink
    Citation: Microbial Cell Factories 2023 22:197
  24. With concerns about depletion of fossil fuel and environmental pollution, synthesis of biofuels such as isobutanol from low-cost substrate by microbial cell factories has attracted more and more attention. As ...

    Authors: Pengfei Gu, Shuo Zhao, Hao Niu, Chengwei Li, Shuixing Jiang, Hao Zhou and Qiang Li
    Citation: Microbial Cell Factories 2023 22:196
  25. In this study, the effect of static magnetic fields (SMFs) on improving the performance of activated sludge process to enhance the higher rate of microbial growth biomass and improve sludge settling characteri...

    Authors: Ghorban Asgari, Abdolmotaleb Seid-Mohammadi, Reza Shokoohi, Mohammad Reza Samarghandi, Glen T. Daigger, Behrooz Malekolkalami and Ramin Khoshniyat
    Citation: Microbial Cell Factories 2023 22:195
  26. Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities. However,...

    Authors: Ying Sun, Yongrong Zhang, Hua Yu, Ashley Saint Fleur, Di Yu, Zhiyong Yang and Hanping Feng
    Citation: Microbial Cell Factories 2023 22:194
  27. Natural and anthropogenic activities, such as weathering of rocks and industrial processes, result in the release of toxic oxyanions such as selenium (Se) and tellurium (Te) into the environment. Due to the hi...

    Authors: Firooz Hosseini, Maryam Hadian, Elham Lashani and Hamid Moghimi
    Citation: Microbial Cell Factories 2023 22:193
  28. Microbial degradation of synthetic dyes is considered a promising green dye detoxification, cost-effective and eco-friendly approach. A detailed study on the decolorization and degradation of malachite green d...

    Authors: Magda A. El-Bendary, Mariam E. Fawzy, Mohamed Abdelraof, Mervat El-Sedik and Mousa A. Allam
    Citation: Microbial Cell Factories 2023 22:192
  29. Fatty acid (FA) is an important platform compound for the further synthesis of high‐value biofuels and oleochemicals, but chemical synthesis of FA has many limitations. One way to meet the future demand for FA...

    Authors: Jin Liu, Mandlaa, Jia Wang, Ziyu Sun and Zhongjun Chen
    Citation: Microbial Cell Factories 2023 22:191
  30. Hydrogen is a promising source of alternative energy. Fermentative production is more feasible because of its high hydrogen generation rate, simple operating conditions, and utilization of various organic wast...

    Authors: Eman S. E. Aldaby, Aya H. A. Mahmoud, Haitham M. El-Bery, Maysa M. Ali, Ahmed A. Shoreit and Asmaa M. M. Mawad
    Citation: Microbial Cell Factories 2023 22:190
  31. Plastics are an indispensable part of our daily life. However, mismanagement at their end-of-life results in severe environmental consequences. The microbial conversion of these polymers into new value-added p...

    Authors: Tom Delmulle, Stijn Bovijn, Sari Deketelaere, Martijn Castelein, Tom Erauw, Matthias D’hooghe and Wim K. Soetaert
    Citation: Microbial Cell Factories 2023 22:188
  32. Enzymes from thermophiles are of great interest for research and bioengineering due to their stability and efficiency. Thermophilic expression hosts such as Thermus thermophilus [T. thermophilus] can overcome spe...

    Authors: Lennart Kirchner, Volker Müller and Beate Averhoff
    Citation: Microbial Cell Factories 2023 22:187
  33. The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eu...

    Authors: Javier Garcia-Pardo, Aleksandra E. Badaczewska-Dawid, Carlos Pintado-Grima, Valentín Iglesias, Aleksander Kuriata, Sebastian Kmiecik and Salvador Ventura
    Citation: Microbial Cell Factories 2023 22:186
  34. In the recombinant protein market with broad economic value, the rapid development of synthetic biology has made it necessary to construct an efficient exocrine expression system for the different heterologous...

    Authors: Siqian Yu, Ge Zhang, Qi Liu, Yingping Zhuang, Zongjie Dai and Jianye Xia
    Citation: Microbial Cell Factories 2023 22:185
  35. Bioplastics are attracting considerable attention, owing to the increase in non-degradable waste. Using microorganisms to degrade bioplastics is a promising strategy for reducing non-degradable plastic waste. ...

    Authors: Su Hyun Kim, Nara Shin, Suk Jin Oh, Jeong Hyeon Hwang, Hyun Jin Kim, Shashi Kant Bhatia, Jeonghee Yun, Jae-Seok Kim and Yung-Hun Yang
    Citation: Microbial Cell Factories 2023 22:184
  36. Microbial fuel cell (MFC) is a bio-electrical energy generator that uses respiring microbes to transform organic matter present in sludge into electrical energy. The primary goal of this work was to introduce ...

    Authors: Amal S. Othman, Nashwa A. Ahmed, Mona S. Elneklawi, Mansour M. Hassan and Mahmoud Abd El-Mongy
    Citation: Microbial Cell Factories 2023 22:183
  37. In the post-genomic era, the demand for faster and more efficient protein production has increased, both in public laboratories and industry. In addition, with the expansion of protein sequences in databases, ...

    Authors: Manman Sun, Alex Xiong Gao, Xiuxia Liu, Yankun Yang, Rodrigo Ledesma-Amaro and Zhonghu Bai
    Citation: Microbial Cell Factories 2023 22:182
  38. The advantages of γ-cyclodextrin (γ-CD) include its high solubility, ability to form inclusion complexes with various poorly water-soluble molecules, and favorable toxicological profile; thus, γ-CD is an attra...

    Authors: Menglu Duan, Yan Wang, Dan Tan, Guowu Yang, Yuan Deng, Ganqiao Ran and Jiao Li
    Citation: Microbial Cell Factories 2023 22:181
  39. Saccharomyces cerevisiae has been used in the biosynthesis of acid products such as organic acids owing to its acid tolerance. Improving the acid tolerance of S. cerevisiae is beneficial for expanding its applica...

    Authors: Xueqin Lv, Ke Jin, Yu Yi, Lingang Song, Xiang Xiu, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen and Long Liu
    Citation: Microbial Cell Factories 2023 22:180
  40. Alginate oligosaccharides (AOs) are the degradation products of alginate, a natural polysaccharide abundant in brown algae. AOs generated by enzymatic hydrolysis have diverse bioactivities and show broad appli...

    Authors: Xiao-Hui Sun, Xiu-Lan Chen, Xiao-Fei Wang, Xin-Ru Zhang, Xiao-Meng Sun, Mei-Ling Sun, Xi-Ying Zhang, Yu-Zhong Zhang, Yu-Qiang Zhang and Fei Xu
    Citation: Microbial Cell Factories 2023 22:179
  41. γ-aminobutyric acid (GABA) is a bioactive compound produced by lactic acid bacteria (LAB). The diversity of GABA production in the Lactococcus genus is poorly understood. Genotypic and phenotypic approaches were ...

    Authors: Valérie Laroute, Nathalie Aubry, Marjorie Audonnet, Muriel Mercier-Bonin, Marie-Line Daveran-Mingot and Muriel Cocaign-Bousquet
    Citation: Microbial Cell Factories 2023 22:178
  42. Avian pathogenic Escherichia coli (APEC) is the major pathogen causing important avian diseases in poultry. As an important subtype of extraintestinal pathogenic E. coli, APEC has zoonotic potential and is consid...

    Authors: Zhongxing Wang, Dongyu Zhu, Yuting Zhang, Fufang Xia, Jiaying Zhu, Jianjun Dai and Xiangkai Zhuge
    Citation: Microbial Cell Factories 2023 22:177
  43. Bioemulsifiers are natural or microbial-based products with the ability to emulsify hydrophobic compounds in water. These compounds are biodegradable, eco-friendly, and find applications in various industries.

    Authors: Yasmina A. Elsaygh, Mona K. Gouda, Yasser Elbahloul, Moustafa Abdel Hakim and Nancy M. El Halfawy
    Citation: Microbial Cell Factories 2023 22:176
  44. Adaptive laboratory evolution (ALE) is known as a powerful tool for untargeted engineering of microbial strains and genomics research. It is particularly well suited for the adaptation of microorganisms to new...

    Authors: Lars Halle, Niels Hollmann, Niklas Tenhaef, Lea Mbengi, Christiane Glitz, Wolfgang Wiechert, Tino Polen, Meike Baumgart, Michael Bott and Stephan Noack
    Citation: Microbial Cell Factories 2023 22:175
  45. Surface display co-opts yeast’s innate ability to embellish its cell wall with mannoproteins, thus converting the yeast’s outer surface into a growing and self-sustaining catalyst. However, the efficient toolb...

    Authors: Tea Martinić Cezar, Mateja Lozančić, Ana Novačić, Ana Matičević, Dominik Matijević, Béatrice Vallée, Vladimir Mrša, Renata Teparić and Bojan Žunar
    Citation: Microbial Cell Factories 2023 22:174
  46. Marine macroalgae have gained interest recently, mostly due to their bioactive components. Polycladia crinita is an example of marine macroalgae from the Phaeophyceae class, also known as brown algae. They are ch...

    Authors: Alanood S. Almurshedi, Thanaa A. El-Masry, Hend Selim, Mostafa M. El-Sheekh, Mofida E. M. Makhlof, Basmah N. Aldosari, Iman M. Alfagih, Bushra T. AlQuadeib, Salma S. Almarshidy and Maisra M. El-Bouseary
    Citation: Microbial Cell Factories 2023 22:173

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