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  1. Polyhydroxyalkanoates (PHA) are synthesized by many bacteria in the cytoplasm as storage compounds for energy and carbon. The key enzymes for PHA biosynthesis are PHA polymerases, which catalyze the covalent l...

    Authors: Qun Ren, Guy de Roo, Bernard Witholt, Manfred Zinn and Linda Thöny-Meyer
    Citation: Microbial Cell Factories 2009 8:60
  2. Mannans are key components of lignocellulose present in the hemicellulosic fraction of plant primary cell walls. Mannan endo-1,4-β-mannosidases (1,4-β-D-mannanases) catalyze the random hydrolysis of β-1,4-mannosi...

    Authors: Do Bien-Cuong, Dang Thi-Thu, Jean-Guy Berrin, Dietmar Haltrich, To Kim-Anh, Jean-Claude Sigoillot and Montarop Yamabhai
    Citation: Microbial Cell Factories 2009 8:59
  3. Some strains of Bacillus licheniformis have been improved by target-directed screening as well as by classical genetic manipulation and used in commercial thermostable α-amylase and alkaline protease production f...

    Authors: Dandan Niu, Zhirui Zuo, Gui-Yang Shi and Zheng-Xiang Wang
    Citation: Microbial Cell Factories 2009 8:58
  4. Killer yeasts have been used to combat contaminating wild yeasts in food, to control pathogenic fungi in plants, and in the medical field, to develop novel antimycotics for the treatment of human and animal fu...

    Authors: Francesca Comitini, Ilaria Mannazzu and Maurizio Ciani
    Citation: Microbial Cell Factories 2009 8:55
  5. Acetate metabolism in Escherichia coli plays an important role in the control of the central metabolism and in bioprocess performance. The main problems related to the use of E. coli as cellular factory are i) th...

    Authors: Sara Castaño-Cerezo, José M Pastor, Sergio Renilla, Vicente Bernal, José L Iborra and Manuel Cánovas
    Citation: Microbial Cell Factories 2009 8:54
  6. The first genome sequences of the important yeast protein production host Pichia pastoris have been released into the public domain this spring. In order to provide the scientific community easy and versatile acc...

    Authors: Diethard Mattanovich, Nico Callewaert, Pierre Rouzé, Yao-Cheng Lin, Alexandra Graf, Andreas Redl, Petra Tiels, Brigitte Gasser and Kristof De Schutter
    Citation: Microbial Cell Factories 2009 8:53
  7. The presence of terminal, surface-exposed sialic acid moieties can greatly enhance the in vivo half-life of glycosylated biopharmaceuticals and improve their therapeutic efficacy. Complete and homogeneous sialyla...

    Authors: Georgios Skretas, Sean Carroll, Shawn DeFrees, Marc F Schwartz, Karl F Johnson and George Georgiou
    Citation: Microbial Cell Factories 2009 8:50
  8. Fermentation of xylose to ethanol has been achieved in S. cerevisiae by genetic engineering. Xylose utilization is however slow compared to glucose, and during anaerobic conditions addition of glucose has been ne...

    Authors: David Runquist, Bärbel Hahn-Hägerdal and Maurizio Bettiga
    Citation: Microbial Cell Factories 2009 8:49
  9. Previous studies have revealed that the lysin motif (LysM) domains of bacterial cell wall-degrading enzymes are able to bind to peptidoglycan moieties of the cell wall. This suggests an approach for a cell sur...

    Authors: Xiaohu Shao, Mengtian Jiang, Ziniu Yu, Hao Cai and Lin Li
    Citation: Microbial Cell Factories 2009 8:48
  10. Poly-β-hydroxybutyrate (PHB) mobilization in bacteria has been proposed as a mechanism that can benefit their host for survival under stress conditions. Here we reported for the first time that a stress-induced s...

    Authors: Qian Wang, Hongmin Yu, Yongzhen Xia, Zhen Kang and Qingsheng Qi
    Citation: Microbial Cell Factories 2009 8:47
  11. A lot of studies have been carried out on Saccharomyces cerevisiae, an yeast with a predominant fermentative metabolism under aerobic conditions, which allows exploring the complex response induced by oxidative s...

    Authors: M Isabel González-Siso, Ana García-Leiro, Nuria Tarrío and M Esperanza Cerdán
    Citation: Microbial Cell Factories 2009 8:46
  12. Natural products are an important source of drugs and other commercially interesting compounds, however their isolation and production is often difficult. Metabolic engineering, mainly in bacteria and yeast, h...

    Authors: Michael Naesby, Søren VS Nielsen, Curt AF Nielsen, Trine Green, Thomas Ø Tange, Ernesto Simón, Philipp Knechtle, Anders Hansson, Markus S Schwab, Olca Titiz, Christophe Folly, Roberto E Archila, Milena Maver, Stephan van Sint Fiet, Thiamo Boussemghoune, Michael Janes…
    Citation: Microbial Cell Factories 2009 8:45
  13. Upstream bioprocesses are extremely complex since living organisms are used to generate active pharmaceutical ingredients (APIs). Cells in culture behave uniquely in response to their environment, thus culture...

    Authors: Michael A Hanson, Kurt A Brorson, Antonio R Moreira and Govind Rao
    Citation: Microbial Cell Factories 2009 8:44
  14. In silico genome-scale metabolic models enable the analysis of the characteristics of metabolic systems of organisms. In this study, we reconstructed a genome-scale metabolic model of Corynebacterium glutamicum o...

    Authors: Yohei Shinfuku, Natee Sorpitiporn, Masahiro Sono, Chikara Furusawa, Takashi Hirasawa and Hiroshi Shimizu
    Citation: Microbial Cell Factories 2009 8:43
  15. In industry and academic research, there is an increasing demand for flexible automated microfermentation platforms with advanced sensing technology. However, up to now, conventional platforms cannot generate ...

    Authors: Robert Huber, Daniel Ritter, Till Hering, Anne-Kathrin Hillmer, Frank Kensy, Carsten Müller, Le Wang and Jochen Büchs
    Citation: Microbial Cell Factories 2009 8:42
  16. The expression of heterologous proteins in Escherichia coli is strongly affected by codon bias. This phenomenon occurs when the codon usage of the mRNA coding for the foreign protein differs from that of the bact...

    Authors: Germán L Rosano and Eduardo A Ceccarelli
    Citation: Microbial Cell Factories 2009 8:41
  17. Sustainable and economically viable manufacturing of bioethanol from lignocellulose raw material is dependent on the availability of a robust ethanol producing microorganism, able to ferment all sugars present...

    Authors: Maurizio Bettiga, Oskar Bengtsson, Bärbel Hahn-Hägerdal and Marie F Gorwa-Grauslund
    Citation: Microbial Cell Factories 2009 8:40
  18. The synthesis of gold nanoparticles (GNPs) has received considerable attention with their potential applications in various life sciences related applications. Recently, there has been tremendous excitement in...

    Authors: Yogesh Nangia, Nishima Wangoo, Nisha Goyal, G Shekhawat and C Raman Suri
    Citation: Microbial Cell Factories 2009 8:39

    The Retraction Note to this article has been published in Microbial Cell Factories 2009 8:52

  19. Polyhydroxyalkanoates (PHAs) are biodegradable polymers produced by microbes to overcome environmental stress. Commercial production of PHAs is limited by the high cost of production compared to conventional p...

    Authors: Mamtesh Singh, Sanjay KS Patel and Vipin C Kalia
    Citation: Microbial Cell Factories 2009 8:38
  20. Interpretation of comprehensive DNA microarray data sets is a challenging task for biologists and process engineers where scientific assistance of statistics and bioinformatics is essential. Interdisciplinary ...

    Authors: Theresa Scharl, Gerald Striedner, Florentina Pötschacher, Friedrich Leisch and Karl Bayer
    Citation: Microbial Cell Factories 2009 8:37
  21. (+)-Nootkatone (4) is a high added-value compound found in grapefruit juice. Allylic oxidation of the sesquiterpene (+)-valencene (1) provides an attractive route to this sought-after flavoring. So far, chemical ...

    Authors: Marco Girhard, Kazuhiro Machida, Masashi Itoh, Rolf D Schmid, Akira Arisawa and Vlada B Urlacher
    Citation: Microbial Cell Factories 2009 8:36
  22. The optimisation and scale-up of process conditions leading to high yields of recombinant proteins is an enduring bottleneck in the post-genomic sciences. Typical experiments rely on varying selected parameter...

    Authors: William J Holmes, Richard AJ Darby, Martin DB Wilks, Rodney Smith and Roslyn M Bill
    Citation: Microbial Cell Factories 2009 8:35
  23. Polyenes represent a major class of antifungal agents characterised by the presence of a series of conjugated double bonds in their planar hydroxylated macrolide ring structure. Despite their general interest,...

    Authors: Cláudia M Vicente, Javier Santos-Aberturas, Susana M Guerra, Tamara D Payero, Juan F Martín and Jesús F Aparicio
    Citation: Microbial Cell Factories 2009 8:33
  24. Protein over-expression in bacteria is still the easiest, cheapest and therefore preferred way to obtain large amounts of proteins for industrial and laboratory scale preparations. Several studies emphasized t...

    Authors: Riccardo Villa, Marina Lotti and Pietro Gatti-Lafranconi
    Citation: Microbial Cell Factories 2009 8:32
  25. An advanced version of a recently reported high-throughput fermentation system with online measurement, called BioLector, and its validation is presented. The technology combines high-throughput screening and ...

    Authors: Frank Kensy, Emerson Zang, Christian Faulhammer, Rung-Kai Tan and Jochen Büchs
    Citation: Microbial Cell Factories 2009 8:31
  26. Thermostable enzymes from thermophilic microorganisms are playing more and more important roles in molecular biology R&D and industrial applications. However, over-production of recombinant soluble proteins fr...

    Authors: Yiran Wang and Y-H Percival Zhang
    Citation: Microbial Cell Factories 2009 8:30
  27. Pichia pastoris is widely used as a production platform for heterologous proteins and model organism for organelle proliferation. Without a published genome sequence available, strain and process development reli...

    Authors: Diethard Mattanovich, Alexandra Graf, Johannes Stadlmann, Martin Dragosits, Andreas Redl, Michael Maurer, Martin Kleinheinz, Michael Sauer, Friedrich Altmann and Brigitte Gasser
    Citation: Microbial Cell Factories 2009 8:29
  28. For some lactic acid bacteria higher biomass production as a result of aerobic respiration has been reported upon supplementation with heme and menaquinone. In this report, we have studied a large number of sp...

    Authors: Rob Brooijmans, Bart Smit, Filipe Santos, Jan van Riel, Willem M de Vos and Jeroen Hugenholtz
    Citation: Microbial Cell Factories 2009 8:28
  29. Plasmids are being reconsidered as viable vector alternatives to viruses for gene therapies and vaccines because they are safer, non-toxic, and simpler to produce. Accordingly, there has been renewed interest ...

    Authors: Drew S Cunningham, Richard R Koepsel, Mohammad M Ataai and Michael M Domach
    Citation: Microbial Cell Factories 2009 8:27
  30. Colorants derived from natural sources look set to overtake synthetic colorants in market value as manufacturers continue to meet the rising demand for clean label ingredients – particularly in food applicatio...

    Authors: Sameer AS Mapari, Anne S Meyer, Ulf Thrane and Jens C Frisvad
    Citation: Microbial Cell Factories 2009 8:24
  31. Biodegradable plastics can be made from polylactate, which is a polymer made from lactic acid. This compound can be produced from renewable resources as substrates using microorganisms. Bacillus subtilis is a Gra...

    Authors: Susana Romero-Garcia, Claudia Hernández-Bustos, Enrique Merino, Guillermo Gosset and Alfredo Martinez
    Citation: Microbial Cell Factories 2009 8:23
  32. A range of industrial H. polymorpha-based processes exist, most of them for the production of pharmaceuticals. The established industrial processes lean on the use of promoters derived from MOX and FMD, genes of ...

    Authors: Christoph Stöckmann, Marco Scheidle, Barbara Dittrich, Armin Merckelbach, Grit Hehmann, Georg Melmer, Doris Klee, Jochen Büchs, Hyun Ah Kang and Gerd Gellissen
    Citation: Microbial Cell Factories 2009 8:22
  33. Catabolic insufficiency in humans leads to the gradual accumulation of a number of pathogenic compounds associated with age-related diseases, including atherosclerosis, Alzheimer's disease, and macular degener...

    Authors: Jacques M Mathieu, John Schloendorn, Bruce E Rittmann and Pedro JJ Alvarez
    Citation: Microbial Cell Factories 2009 8:21
  34. Many researchers have reported on the optimization of protease production; nevertheless, only a few have reported on the optimization of the production of organic solvent-tolerant proteases. Ironically, none h...

    Authors: Randa A Abusham, Raja Noor Zaliha RA Rahman, Abu Bakar Salleh and Mahiran Basri
    Citation: Microbial Cell Factories 2009 8:20
  35. Anthranilate is an aromatic amine used industrially as an intermediate for the synthesis of dyes, perfumes, pharmaceuticals and other classes of products. Chemical synthesis of anthranilate is an unsustainable...

    Authors: Víctor E Balderas-Hernández, Andrea Sabido-Ramos, Patricia Silva, Natividad Cabrera-Valladares, Georgina Hernández-Chávez, José L Báez-Viveros, Alfredo Martínez, Francisco Bolívar and Guillermo Gosset
    Citation: Microbial Cell Factories 2009 8:19
  36. There is evidence from previous works that bacterial secondary metabolism may be stimulated by genetic manipulation of RNA polymerase (RNAP). In this study we have used rifampicin selection as a strategy to ge...

    Authors: Elisabetta Carata, Clelia Peano, Salvatore M Tredici, Francesco Ferrari, Adelfia Talà, Giorgio Corti, Silvio Bicciato, Gianluca De Bellis and Pietro Alifano
    Citation: Microbial Cell Factories 2009 8:18
  37. Most of the hosts used to produce the 151 recombinant pharmaceuticals so far approved for human use by the Food and Drug Administration (FDA) and/or by the European Medicines Agency (EMEA) are microbial cells,...

    Authors: Neus Ferrer-Miralles, Joan Domingo-Espín, José Luis Corchero, Esther Vázquez and Antonio Villaverde
    Citation: Microbial Cell Factories 2009 8:17
  38. Extensive studies have shown that up-scaling of bioprocesses has a significant impact on the physiology of the microorganisms. Among the factors associated with the fluid dynamics of the bioreactor, concentrat...

    Authors: Frank Delvigne, Mathieu Boxus, Sophie Ingels and Philippe Thonart
    Citation: Microbial Cell Factories 2009 8:15
  39. Lactic acid bacteria of the genus Lactobacillus and Bifidobacterium are one of the most important health promoting groups of the human intestinal microbiota. Their protective role within the gut consists in out c...

    Authors: Cristiana Castaldo, Valeria Vastano, Rosa Anna Siciliano, Marco Candela, Manuela Vici, Lidia Muscariello, Rosangela Marasco and Margherita Sacco
    Citation: Microbial Cell Factories 2009 8:14
  40. Hepatitis B is a serious global public health concern. Though a safe and efficacious recombinant vaccine is available, its use in several resource-poor countries is limited by cost. We have investigated the pr...

    Authors: Chandrasekhar Gurramkonda, Ahmad Adnan, Thomas Gäbel, Heinrich Lünsdorf, Anton Ross, Satish Kumar Nemani, Sathyamangalam Swaminathan, Navin Khanna and Ursula Rinas
    Citation: Microbial Cell Factories 2009 8:13
  41. The cellular proteins Pat1p, Lsm1p, and Dhh1p are required for the replication of some positive-strand viruses and therefore are potential targets for new antiviral drugs. To prioritize host targets for antivi...

    Authors: Konstantin Schneider, Jens Olaf Krömer, Christoph Wittmann, Isabel Alves-Rodrigues, Andreas Meyerhans, Juana Diez and Elmar Heinzle
    Citation: Microbial Cell Factories 2009 8:12
  42. The production of high yields of recombinant proteins is an enduring bottleneck in the post-genomic sciences that has yet to be addressed in a truly rational manner. Typically eukaryotic protein production exp...

    Authors: Nicklas Bonander, Richard AJ Darby, Ljuban Grgic, Nagamani Bora, Jikai Wen, Saverio Brogna, David R Poyner, Michael AA O'Neill and Roslyn M Bill
    Citation: Microbial Cell Factories 2009 8:10

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