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  1. Interleukin-15 (IL-15) is a critical cytokine for the development, proliferation, and function of natural killer (NK) cells, NKT cells, and CD8+ memory T cells and has become one of the most promising protein mol...

    Authors: Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, Jing Wu, Yin Yu, Fang Fang, Yugang Guo and Weihua Xiao

    Citation: Microbial Cell Factories 2021 20:115

    Content type: Research

    Published on:

  2. The current shift from a fossil-resource based economy to a more sustainable, bio-based economy requires development of alternative production routes based on utilization of biomass for the many chemicals that...

    Authors: Thomas Nicolaï, Quinten Deparis, María R. Foulquié-Moreno and Johan M. Thevelein

    Citation: Microbial Cell Factories 2021 20:114

    Content type: Research

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  3. Menaquinone (MK-7) is a highly valuable vitamin K2 produced by Bacillus subtilis. Common static metabolic engineering approaches for promoting the production of MK-7 have been studied previously. However, these a...

    Authors: Jing Wu, Wei Li, Shi-guang Zhao, Sen-he Qian, Zhou Wang, Meng-jie Zhou, Wen-song Hu, Jian Wang, Liu-xiu Hu, Yan Liu and Zheng-lian Xue

    Citation: Microbial Cell Factories 2021 20:113

    Content type: Research

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  4. Macro- and microalgae-based foods are becoming popular due to their high nutritious value. The algal biomass is enriched with polysaccharides, protein, polyunsaturated fatty acids, carotenoids, vitamins and mi...

    Authors: Anil Kumar Patel, Reeta Rani Singhania, Mukesh Kumar Awasthi, Sunita Varjani, Shashi Kant Bhatia, Mei-Ling Tsai, Shu-Ling Hsieh, Chiu-Wen Chen and Cheng-Di Dong

    Citation: Microbial Cell Factories 2021 20:112

    Content type: Review

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  5. Pamamycins are macrodiolides of polyketide origin which form a family of differently large homologues with molecular weights between 579 and 663. They offer promising biological activity against pathogenic fun...

    Authors: Lars Gläser, Martin Kuhl, Julian Stegmüller, Christian Rückert, Maksym Myronovskyi, Jörn Kalinowski, Andriy Luzhetskyy and Christoph Wittmann

    Citation: Microbial Cell Factories 2021 20:111

    Content type: Research

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  6. CssR, the product of the Corynebacterium glutamicum ncgl1578 gene cotranscribed with ncgl1579, is a TetR (tetracycline regulator) family repressor. Although many TetR-type regulators in C. glutamicum have been ex...

    Authors: Yang Liu, Wenzhi Yang, Tao Su, Chengchuan Che, Guizhi Li, Can Chen and Meiru Si

    Citation: Microbial Cell Factories 2021 20:110

    Content type: Research

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  7. Plant-based milk alternatives are more popular than ever, and chickpea-based milks are among the most commercially relevant products. Unfortunately, limited nutritional value because of low levels of the essen...

    Authors: Muzi Tangyu, Michel Fritz, Rosa Aragao-Börner, Lijuan Ye, Biljana Bogicevic, Christoph J. Bolten and Christoph Wittmann

    Citation: Microbial Cell Factories 2021 20:109

    Content type: Research

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  8. Human milk is the gold standard for nutrition of infant growth, whose nutritional value is mainly attributed to human milk oligosaccharides (HMOs). HMOs, the third most abundant component of human milk after l...

    Authors: Shunhao Zhang, Tianle Li, Jing Xie, Demao Zhang, Caixia Pi, Lingyun Zhou and Wenbin Yang

    Citation: Microbial Cell Factories 2021 20:108

    Content type: Review

    Published on:

    The Correction to this article has been published in Microbial Cell Factories 2021 20:140

  9. Uprising fossil fuel depletion and deterioration of ecological reserves supply have led to the search for alternative renewable and sustainable energy sources and chemicals. Although first generation biorefine...

    Authors: Gunasekaran Rajeswari, Samuel Jacob, Anuj Kumar Chandel and Vinod Kumar

    Citation: Microbial Cell Factories 2021 20:107

    Content type: Review

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  10. Commercial xylose purification produces xylose mother liquor (XML) as a major byproduct, which has become an inexpensive and abundant carbon source. A portion of this XML has been used to produce low-value-add...

    Authors: Lihua Zhang, Zhen Chen, Junhua Wang, Wei Shen, Qi Li and Xianzhong Chen

    Citation: Microbial Cell Factories 2021 20:105

    Content type: Research

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  11. Protein Glycan Coupling Technology (PGCT) uses purposely modified bacterial cells to produce recombinant glycoconjugate vaccines. This vaccine platform holds great potential in this context, namely due to its ...

    Authors: Jasmin J. Samaras, Marta Mauri, Emily J. Kay, Brendan W. Wren and Martina Micheletti

    Citation: Microbial Cell Factories 2021 20:104

    Content type: Research

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  12. Pseudomonas aeruginosa, the rhamnolipids-producer, is one of dominant bacteria in oil reservoirs. Although P. aeruginosa strains are facultative bacteria, the anaerobic biosynthesis mechanism of rhamnolipids is u...

    Authors: Feng Zhao, Qingzhi Wang, Ying Zhang and Liying Lei

    Citation: Microbial Cell Factories 2021 20:103

    Content type: Research

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  13. As treatment of Staphylococcus aureus (S. aureus) osteomyelitis is often hindered by the development of antibiotic tolerance, novel antibacterial therapeutics are required. Here we found that the cell-free supern...

    Authors: Fan Zhang, Bowei Wang, Shiluan Liu, Yuhui Chen, Yihuang Lin, Zixian Liu, Xianrong Zhang and Bin Yu

    Citation: Microbial Cell Factories 2021 20:102

    Content type: Research

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  14. Pinene is a monoterpene, that is used in the manufacture of fragrances, insecticide, fine chemicals, and renewable fuels. Production of pinene by metabolic-engineered microorganisms is a sustainable method. Pu...

    Authors: Xiaomin Wu, Guang Ma, Chuanyang Liu, Xin-yuan Qiu, Lu Min, Jingyu Kuang and Lingyun Zhu

    Citation: Microbial Cell Factories 2021 20:101

    Content type: Research

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  15. Owing to the excellent properties of photosensitization, cercosporin, one of naturally occurring perylenequinonoid pigments, has been widely used in photodynamic therapy, or as an antimicrobial agent and an or...

    Authors: Tingan Zhou, Shiyu Yu, Yifan Hu, Yan Zhang, Yuechen Song, Jieyu Chu, Changmei Liu and Yijian Rao

    Citation: Microbial Cell Factories 2021 20:100

    Content type: Research

    Published on:

  16. Identifying the regulatory factors that control transcriptional activity is a major challenge of gene expression studies. Here, we describe the application of a novel approach for in vivo identification of reg...

    Authors: Martyna Gongerowska-Jac, Marcin Jan Szafran and Dagmara Jakimowicz

    Citation: Microbial Cell Factories 2021 20:99

    Content type: Research

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  17. Parkinson’s disease (PD) is a neurodegenerative disorder and 70–80% of PD patients suffer from gastrointestinal dysfunction such as constipation. We aimed to assess the efficacy and safety of fecal microbiota ...

    Authors: Xiao-yi Kuai, Xiao-han Yao, Li-juan Xu, Yu-qing Zhou, Li-ping Zhang, Yi Liu, Shao-fang Pei and Chun-li Zhou

    Citation: Microbial Cell Factories 2021 20:98

    Content type: Research

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  18. The demand for biobased polymers is increasing steadily worldwide. Microbial hosts for production of their monomeric precursors such as glutarate are developed. To meet the market demand, production hosts have...

    Authors: Carina Prell, Tobias Busche, Christian Rückert, Lea Nolte, Christoph Brandenbusch and Volker F. Wendisch

    Citation: Microbial Cell Factories 2021 20:97

    Content type: Research

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  19. Surfactin, a representative biosurfactant of lipopeptide mainly produced by Bacillus subtilis, consists of a cyclic heptapeptide linked to a β-hydroxy fatty acid chain. The functional activity of surfactin is clo...

    Authors: Fangxiang Hu, Weijie Cai, Junzhang Lin, Weidong Wang and Shuang Li

    Citation: Microbial Cell Factories 2021 20:96

    Content type: Research

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  20. The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the need to develop safe and effective vaccines with a top priority....

    Authors: Tong Gao, Yi Ren, Shuangqin Li, Xin Lu and Han Lei

    Citation: Microbial Cell Factories 2021 20:95

    Content type: Research

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  21. Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on th...

    Authors: Neil C. Dalvie, Joseph R. Brady, Laura E. Crowell, Mary Kate Tracey, Andrew M. Biedermann, Kawaljit Kaur, John M. Hickey, D. Lee Kristensen II, Alexandra D. Bonnyman, Sergio A. Rodriguez-Aponte, Charles A. Whittaker, Marina Bok, Celina Vega, Tarit K. Mukhopadhyay, Sangeeta B. Joshi, David B. Volkin…

    Citation: Microbial Cell Factories 2021 20:94

    Content type: Research

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  22. Poly(ethylene terephthalate) (PET) is the world’s most abundant polyester plastic, and its ongoing accumulation in nature is causing a global environmental problem. Currently, the main recycling processes u...

    Authors: Sophia A. H. Heyde, Jenny Arnling Bååth, Peter Westh, Morten H. H. Nørholm and Kenneth Jensen

    Citation: Microbial Cell Factories 2021 20:93

    Content type: Research

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  23. Nitric oxide (NO) is a ubiquitous signaling mediator in various physiological processes. However, there are less reports concerning the effects of NO on fungal secondary metabolites. Hypocrellins are effective...

    Authors: Yan Jun Ma, Xin Ping Li, Yue Wang and Jian Wen Wang

    Citation: Microbial Cell Factories 2021 20:92

    Content type: Research

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  24. Protein synthesis is one of the extremely important anabolic pathways in the yeast expression system Pichia pastoris. Codon optimization is a commonly adopted strategy for improved protein expression, although un...

    Authors: Yichun Xu, Kunshan Liu, Yu Han, Yanzi Xing, Yuanxing Zhang, Qiuying Yang and Mian Zhou

    Citation: Microbial Cell Factories 2021 20:91

    Content type: Research

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  25. Currently, the numerous and versatile applications in pharmaceutical and chemical industry make the recombinant production of cytochrome P450 enzymes (CYPs) of great biotechnological interest. Accelerating the...

    Authors: Javier Garrigós-Martínez, Astrid Weninger, José Luis Montesinos-Seguí, Christian Schmid, Francisco Valero, Claudia Rinnofner, Anton Glieder and Xavier Garcia-Ortega

    Citation: Microbial Cell Factories 2021 20:90

    Content type: Research

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  26. SARS-CoV-2 is a novel β-coronavirus that caused the COVID-19 pandemic disease, which spread rapidly, infecting more than 134 million people, and killing almost 2.9 million thus far. Based on the urgent need fo...

    Authors: Norma A. Valdez-Cruz, Enrique García-Hernández, Clara Espitia, Laura Cobos-Marín, Claudia Altamirano, Carlos G. Bando-Campos, Luis F. Cofas-Vargas, Enrique W. Coronado-Aceves, Ricardo A. González-Hernández, Pablo Hernández-Peralta, Daniel Juárez-López, Paola A. Ortega-Portilla, Sara Restrepo-Pineda, Patricio Zelada-Cordero and Mauricio A. Trujillo-Roldán

    Citation: Microbial Cell Factories 2021 20:88

    Content type: Review

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  27. Trans-4-hydroxy-l-proline is an important amino acid that is widely used in medicinal and industrial applications, particularly as a valuable chiral building block for the organic synthesis of pharmaceuticals. Tr...

    Authors: Zhenyu Zhang, Pengfu Liu, Weike Su, Huawei Zhang, Wenqian Xu and Xiaohe Chu

    Citation: Microbial Cell Factories 2021 20:87

    Content type: Review

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  28. Polyketide synthases (PKSs) include ketone synthase (KS), acyltransferase (AT) and acyl carrier protein (ACP) domains to catalyse the elongation of polyketide chains. Some PKSs also contain ketoreductase (KR),...

    Authors: Huimin Wang, Junheng Liang, Qianwen Yue, Long Li, Yan Shi, Guosong Chen, Yue-zhong Li, Xiaoying Bian, Youming Zhang, Guoping Zhao and Xiaoming Ding

    Citation: Microbial Cell Factories 2021 20:86

    Content type: Research

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  29. Lactobacillus (Limosilactobacillus) fermentum D12 is an exopolysaccharide (EPS) producing strain whose genome contains a putative eps operon. Whole-genome analysis of D12 was performed to disclose the essential g...

    Authors: Katarina Butorac, Jasna Novak, Barbara Bellich, Lucrecia C. Terán, Martina Banić, Andreja Leboš Pavunc, Slaven Zjalić, Paola Cescutti, Jagoda Šušković and Blaženka Kos

    Citation: Microbial Cell Factories 2021 20:85

    Content type: Research

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  30. Poly-γ-glutamic acid (γ-PGA) and nattokinase (NK) are the main substances produced by Bacillus subtilis natto in solid-state fermentation and have wide application prospects. We found that our strains had higher ...

    Authors: Min Li, Zilong Zhang, Shenwei Li, Zhengan Tian and Xia Ma

    Citation: Microbial Cell Factories 2021 20:83

    Content type: Research

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  31. Trehalose, an intracellular protective agent reported to mediate defense against many stresses, can alleviate high-temperature-induced damage in Pleurotus ostreatus. In this study, the mechanism by which trehalos...

    Authors: Zhi-Yu Yan, Meng-Ran Zhao, Chen-Yang Huang, Li-Jiao Zhang and Jin-Xia Zhang

    Citation: Microbial Cell Factories 2021 20:82

    Content type: Research

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  32. Phosphonates derivatives are in the area of interests because of their unique chemical-physical features. These compounds manifest variety of biological interactions within the sensitive living cells, includin...

    Authors: Monika Serafin-Lewańczuk, Małgorzata Brzezińska-Rodak, Katarzyna Lubiak-Kozłowska, Paulina Majewska, Magdalena Klimek-Ochab, Tomasz K. Olszewski and Ewa Żymańczyk-Duda

    Citation: Microbial Cell Factories 2021 20:81

    Content type: Review

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  33. Daqu is the most important fermentation starter for Chinese liquor, with large number of microbes and enzymes being openly enriched in the Daqu system over thousands of years. However, only a few enzymes have ...

    Authors: Lanchai Chen, Zhuolin Yi, Yang Fang, Yanling Jin, Kaize He, Yao Xiao, Dong Zhao, Huibo Luo, Hui He, Qun Sun and Hai Zhao

    Citation: Microbial Cell Factories 2021 20:80

    Content type: Research

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  34. Glucosylglycerol (2-O-α-d-glucosyl-sn-glycerol; GG) is a natural osmolyte from bacteria and plants. It has promising applications as cosmetic and food-and-feed ingredient. Due to its natural scarcity, GG must be ...

    Authors: Katharina N. Schwaiger, Monika Cserjan-Puschmann, Gerald Striedner and Bernd Nidetzky

    Citation: Microbial Cell Factories 2021 20:79

    Content type: Research

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  35. Colonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed the ameliorative effect of milk replacer administrat...

    Authors: Aoyun Li, Yan Yang, Songkang Qin, Shenjin Lv, Taihua Jin, Kun Li, Zhaoqing Han and Yongzhu Li

    Citation: Microbial Cell Factories 2021 20:78

    Content type: Research

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  36. Lactobacillus spp. have been researched worldwide and are used in probiotics, but due to difficulties with laboratory cultivation of and experimentation on oral microorganisms, there are few reports of Lactobacil...

    Authors: Soyon Mann, Myeong Soo Park, Tony V. Johnston, Geun Eog Ji, Keum Taek Hwang and Seockmo Ku

    Citation: Microbial Cell Factories 2021 20:75

    Content type: Research

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  37. Pichia pastoris is a powerful and broadly used host for recombinant protein production (RPP), where past bioprocess performance has often been directed with the methanol regulated AOX1 promoter (PAOX1), and the c...

    Authors: Javier Garrigós-Martínez, Kiira Vuoristo, Miguel Angel Nieto-Taype, Juha Tähtiharju, Jaana Uusitalo, Pauliina Tukiainen, Christian Schmid, Ilya Tolstorukov, Knut Madden, Merja Penttilä, José Luis Montesinos-Seguí, Francisco Valero, Anton Glieder and Xavier Garcia-Ortega

    Citation: Microbial Cell Factories 2021 20:74

    Content type: Research

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  38. Escherichia coli is generally used as model bacteria to define microbial cell factories for many products and to investigate regulation mechanisms. E. coli exhibits phospholipids, lipopolysaccharides, colanic aci...

    Authors: Jianli Wang, Wenjian Ma and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2021 20:73

    Content type: Review

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  39. The large-scale application of organic pollutants (OPs) has contaminated the air, soil, and water. Persistent OPs enter the food supply chain and create several hazardous effects on living systems. Thus, there...

    Authors: Pankaj Bhatt, Amit Verma, Saurabh Gangola, Geeta Bhandari and Shaohua Chen

    Citation: Microbial Cell Factories 2021 20:72

    Content type: Review

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  40. The spore-forming lactic acid bacterium Bacillus coagulans MA-13 has been isolated from canned beans manufacturing and successfully employed for the sustainable production of lactic acid from lignocellulosic biom...

    Authors: Martina Aulitto, Andrea Strazzulli, Ferdinando Sansone, Flora Cozzolino, Maria Monti, Marco Moracci, Gabriella Fiorentino, Danila Limauro, Simonetta Bartolucci and Patrizia Contursi

    Citation: Microbial Cell Factories 2021 20:71

    Content type: Research

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  41. Ascomycin is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. As a secondary metabolite, the production of ascomycin is often limited by the shortage of precursors during th...

    Authors: Pan Wang, Ying Yin, Xin Wang and Jianping Wen

    Citation: Microbial Cell Factories 2021 20:70

    Content type: Research

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  42. Myriocin is a natural product with antifungal activity and is derived from Bacillus amyloliquefaciens LZN01. Our previous work demonstrated that myriocin can inhibit the growth of Fusarium oxysporum f. sp. niveum

    Authors: Hengxu Wang, Zhigang Wang, Weihui Xu and Kexin Wang

    Citation: Microbial Cell Factories 2021 20:69

    Content type: Research

    Published on:

  43. Most patients with acute myeloid leukemia (AML) remain uncurable and require novel therapeutic methods. Gain-of-function FMS-like tyrosine kinase 3 (FLT3) mutations are present in 30–40% of AML patients and se...

    Authors: Dengyang Zhang, Yao Guo, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Junbin Huang, Chun Chen, Hongman Xue, Xiaojun Xu, Yihang Pan, Ningning Li, Chengming Zhu, Zhizhuang Joe Zhao, Jian Yu and Yun Chen

    Citation: Microbial Cell Factories 2021 20:67

    Content type: Research

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  44. The alcohol 2,3-butanediol (2,3-BDO) is an important chemical and an Escherichia coli producer strain was recently engineered for bio-based production of 2,3-BDO. However, further improvements are required for re...

    Authors: Simon Boecker, Björn-Johannes Harder, Regina Kutscha, Stefan Pflügl and Steffen Klamt

    Citation: Microbial Cell Factories 2021 20:63

    Content type: Research

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