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  1. Content type: RESEARCH

    Lactic acid bacteria (LAB) are one of the microorganisms of choice for the development of protein delivery systems for therapeutic purposes. Although there are numerous tools to facilitate genome engineering o...

    Authors: Laura Ortiz-Velez, Javiera Ortiz-Villalobos, Abby Schulman, Jee-Hwan Oh, Jan-Peter van Pijkeren and Robert A. Britton

    Citation: Microbial Cell Factories 2018 17:138

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  2. Content type: RESEARCH

    β-Ionone is a fragrant terpenoid that generates a pleasant floral scent and is used in diverse applications as a cosmetic and flavoring ingredient. A growing consumer desire for natural products has increased ...

    Authors: Jeffrey J. Czajka, Justin A. Nathenson, Veronica T. Benites, Edward E. K. Baidoo, Qianshun Cheng, Yechun Wang and Yinjie J. Tang

    Citation: Microbial Cell Factories 2018 17:136

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  3. Content type: Review

    Biotechnological processes use microbes to convert abundant molecules, such as glucose, into high-value products, such as pharmaceuticals, commodity and fine chemicals, and energy. However, from the outset of ...

    Authors: Kevin James Metcalf, Marilyn F. Slininger Lee, Christopher Matthew Jakobson and Danielle Tullman-Ercek

    Citation: Microbial Cell Factories 2018 17:135

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  4. Content type: RESEARCH

    Gram-positive bacterium Bacillus subtilis has been extensively studied as a microbial cell factory for high-level producing a wide range of interesting products. Green fluorescent protein (GFP) is commonly used a...

    Authors: Haojie Cao and Oscar P. Kuipers

    Citation: Microbial Cell Factories 2018 17:134

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  5. Content type: RESEARCH

    Erythritol is a four-carbon sugar alcohol with sweetening properties that is used by the agro-food industry as a food additive. In the yeast Yarrowia lipolytica, the last step of erythritol synthesis involves the...

    Authors: Huiling Cheng, Siqi Wang, Muhammad Bilal, Xuemei Ge, Can Zhang, Patrick Fickers and Hairong Cheng

    Citation: Microbial Cell Factories 2018 17:133

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  6. Content type: RESEARCH

    Tubercidin (TBN), an adenosine analog with potent antimycobacteria and antitumor bioactivities, highlights an intriguing structure, in which a 7-deazapurine core is linked to the ribose moiety by an N-glycosidic ...

    Authors: Yan Liu, Rong Gong, Xiaoqin Liu, Peichao Zhang, Qi Zhang, You-Sheng Cai, Zixin Deng, Margit Winkler, Jianguo Wu and Wenqing Chen

    Citation: Microbial Cell Factories 2018 17:131

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  7. Content type: RESEARCH

    Flavonoid glycosides have many beneficial effects on health, but these bioactivities tend to decrease after oral administration owing to their poor lipophilicity. In this study, a facile whole-cell-based metho...

    Authors: Xuan Xin, Mengmeng Zhang, Xiaofeng Li, Furao Lai and Guanglei Zhao

    Citation: Microbial Cell Factories 2018 17:130

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  8. Content type: Technical Notes

    Filamentous fungi including Aspergillus niger are cell factories for the production of organic acids, proteins and bioactive compounds. Traditionally, stirred-tank reactors (STRs) are used to cultivate them under...

    Authors: Tutku Kurt, Anna-Maria Marbà-Ardébol, Zeynep Turan, Peter Neubauer, Stefan Junne and Vera Meyer

    Citation: Microbial Cell Factories 2018 17:128

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  9. Content type: RESEARCH

    Recent interest has been focused on the production of platform chemicals from renewable biomass due to increasing concerns on global warming and depletion of fossil fuel reserves. Microbial production of platf...

    Authors: Kei-Anne Baritugo, Hee Taek Kim, Yokimiko David, Tae Uk Khang, Sung Min Hyun, Kyoung Hee Kang, Ju Hyun Yu, Jong Hyun Choi, Jae Jun Song, Jeong Chan Joo and Si Jae Park

    Citation: Microbial Cell Factories 2018 17:129

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  10. Content type: RESEARCH

    Bacterial strains of the genus Geobacillus grow at high temperatures of 50–75 °C and could thus be useful for biotechnological applications. However, genetic manipulation of these species is difficult because the...

    Authors: Megumi Miyano, Kosei Tanaka, Shu Ishikawa, Kotaro Mori, Andrés Miguel-Arribas, Wilfried J. J. Meijer and Ken-ichi Yoshida

    Citation: Microbial Cell Factories 2018 17:127

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  11. Content type: RESEARCH

    Recent biotechnological advancements have allowed for the adoption of Lactococcus lactis, a typical component of starter cultures used in food industry, as the host for the production of food-grade recombinant ta...

    Authors: Mohamed Boumaiza, Andrea Colarusso, Ermenegilda Parrilli, Elena Garcia-Fruitós, Angela Casillo, Anna Arís, Maria Michela Corsaro, Delia Picone, Serena Leone and Maria Luisa Tutino

    Citation: Microbial Cell Factories 2018 17:126

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  12. Content type: RESEARCH

    Emergence of antibiotic resistance and growing consumer trend towards foods containing biopreservatives stimulated the search for alternative antimicrobials. This research is aimed at characterizing, investiga...

    Authors: Samson Baranzan Wayah and Koshy Philip

    Citation: Microbial Cell Factories 2018 17:125

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  13. Content type: RESEARCH

    β-Mannanase catalyzes the cleavage of β-1,4-linked internal linkages of mannan backbone randomly to produce new chain ends. Alkaline and thermostable β-mannanases provide obvious advantages for many applicatio...

    Authors: Cheng Zhou, Yanfen Xue and Yanhe Ma

    Citation: Microbial Cell Factories 2018 17:124

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  14. Content type: RESEARCH

    Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response (UPR) usually apparent through increased intracellular l...

    Authors: Gustavo Roth, Ana Letícia Vanz, Heinrich Lünsdorf, Manfred Nimtz and Ursula Rinas

    Citation: Microbial Cell Factories 2018 17:123

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  15. Content type: RESEARCH

    Lipopeptides are a promising group of surface-active compounds of microbial origin (biosurfactants). These diverse molecules are produced mainly by Bacillus and Pseudomonas strains. Because of their attractive ph...

    Authors: Piotr Biniarz, François Coutte, Frédérique Gancel and Marcin Łukaszewicz

    Citation: Microbial Cell Factories 2018 17:121

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  16. Content type: Review

    For years, microbes have been widely applied as chassis in the construction of synthetic metabolic pathways. However, the lack of in vivo enzyme clustering of heterologous metabolic pathways in these organisms...

    Authors: Xin-yuan Qiu, Si-Si Xie, Lu Min, Xiao-Min Wu, Lv-Yun Zhu and Lingyun Zhu

    Citation: Microbial Cell Factories 2018 17:120

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  17. Content type: Correction

    Upon publication of this article [1], it was brought to our attention that revised Fig. 1 supplied by the author during proof correction was unfortunately not presented in the original version of the article. ...

    Authors: Katherina Garcia Vanegas, Arésu Bondrup Larsen, Michael Eichenberger, David Fischer, Uffe Hasbro Mortensen and Michael Naesby

    Citation: Microbial Cell Factories 2018 17:119

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    The original article was published in Microbial Cell Factories 2018 17:107

  18. Content type: RESEARCH

    Acid stress is often encountered during industrial fermentation as a result of the accumulation of acidic metabolites. Acid stress increases the intracellular acidity and can cause DNA damage and denaturation ...

    Authors: Xianxing Gao, Xiaofeng Yang, Jiahui Li, Yan Zhang, Ping Chen and Zhanglin Lin

    Citation: Microbial Cell Factories 2018 17:118

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  19. Content type: RESEARCH

    Phenazine-1-carboxamide (PCN), a phenazine derivative, is strongly antagonistic to fungal phytopathogens. The high PCN biocontrol activity fascinated researcher’s attention in isolating and identifying novel b...

    Authors: Huasong Peng, Pingyuan Zhang, Muhammad Bilal, Wei Wang, Hongbo Hu and Xuehong Zhang

    Citation: Microbial Cell Factories 2018 17:117

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  20. Content type: RESEARCH

    Pine wilt disease, caused by the pinewood nematode Bursaphelenchus xylophilus (PWN), is an important destructive disease of pine forests worldwide. In addition to behaving as a plant-parasitic nematode that feeds...

    Authors: Chihang Cheng, Jialing Qin, Choufei Wu, Mengying Lei, Yongjun Wang and Liqin Zhang

    Citation: Microbial Cell Factories 2018 17:116

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  21. Content type: RESEARCH

    Cis, cis-muconic acid (MA) is a dicarboxylic acid of recognized industrial value. It provides direct access to adipic acid and terephthalic acid, prominent monomers of commercial plastics.

    Authors: Judith Becker, Martin Kuhl, Michael Kohlstedt, Sören Starck and Christoph Wittmann

    Citation: Microbial Cell Factories 2018 17:115

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  22. Content type: RESEARCH

    Malate is a C4-dicarboxylic acid widely used as an acidulant in the food and beverage industry. Rational engineering has been performed in the past for the development of microbial strains capable of efficient...

    Authors: Debora Trichez, Clément Auriol, Audrey Baylac, Romain Irague, Clémentine Dressaire, Marc Carnicer-Heras, Stéphanie Heux, Jean Marie François and Thomas Walther

    Citation: Microbial Cell Factories 2018 17:113

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  23. Content type: RESEARCH

    The yeast Komagataella phaffii, better known as Pichia pastoris, is a commonly used host for recombinant protein production. Here expression vectors are reported that address the different steps of the transcript...

    Authors: Loknath Gidijala, Stefan Uthoff, Sebastiaan J. van Kampen, Alexander Steinbüchel and Raymond M. D. Verhaert

    Citation: Microbial Cell Factories 2018 17:112

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  24. Content type: RESEARCH

    C-glycosylated flavones have recently attracted increased attention due to their possible benefits in human health. These biologically active compounds are part of the human diet, and the C-linkage makes them mor...

    Authors: Katherina Garcia Vanegas, Arésu Bondrup Larsen, Michael Eichenberger, David Fischer, Uffe Hasbro Mortensen and Michael Naesby

    Citation: Microbial Cell Factories 2018 17:107

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    The Correction to this article has been published in Microbial Cell Factories 2018 17:119

  25. Content type: RESEARCH

    Marine diatoms have a higher fucoxanthin content in comparison to macroalgae. Fucoxanthin features many potent bioactive properties, particularly anti-obesity properties. Despite the great potential for harves...

    Authors: Song Wang, Sujit K. Verma, Inamullah Hakeem Said, Laurenz Thomsen, Matthias S. Ullrich and Nikolai Kuhnert

    Citation: Microbial Cell Factories 2018 17:110

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  26. Content type: RESEARCH

    The overreliance on dwindling fossil fuel reserves and the negative climatic effects of using such fuels are driving the development of new clean energy sources. One such alternative source is hydrogen (H2), whic...

    Authors: Teresa Mohr, Habibu Aliyu, Raphael Küchlin, Shamara Polliack, Michaela Zwick, Anke Neumann, Don Cowan and Pieter de Maayer

    Citation: Microbial Cell Factories 2018 17:108

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  27. Content type: RESEARCH

    Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is prone to significant variations from batch to batch an...

    Authors: Janina Müller, Mario Beckers, Nina Mußmann, Johannes Bongaerts and Jochen Büchs

    Citation: Microbial Cell Factories 2018 17:106

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  28. Content type: RESEARCH

    Low concentration NaHCO3 (ca. 12 mM) had been demonstrated to be an excellent carbon source for industrially important green alga Chlorella vulgaris and high concentration NaHCO3 (e.g. 160 mM) had been shown to b...

    Authors: Jingya Li, Changhao Li, Christopher Q. Lan and Dankui Liao

    Citation: Microbial Cell Factories 2018 17:111

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  29. Content type: RESEARCH

    Due to its high stress tolerance and low acetate secretion, Escherichia coli W is reported to be a good production host for several metabolites and recombinant proteins. However, simultaneous co-utilization of gl...

    Authors: Katharina Novak, Lukas Flöckner, Anna Maria Erian, Philipp Freitag, Christoph Herwig and Stefan Pflügl

    Citation: Microbial Cell Factories 2018 17:109

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  30. Content type: RESEARCH

    Oxaloacetate (OAA) and l-glutamate are essential precursors for the biosynthesis of l-lysine. Reasonable control of all potentially rate-limiting steps, including the precursors supply rate, is of vital importanc...

    Authors: Jian-Zhong Xu, Ze-Hua Wu, Shi-Jun Gao and Weiguo Zhang

    Citation: Microbial Cell Factories 2018 17:105

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  31. Content type: RESEARCH

    Cheese ripening is a complex, time consuming and expensive process, which involves the generation of precursors from carbohydrates, proteins and fats and their subsequent conversion into a wide range of compou...

    Authors: Oscar van Mastrigt, Diego Gallegos Tejeda, Mette N. Kristensen, Tjakko Abee and Eddy J. Smid

    Citation: Microbial Cell Factories 2018 17:104

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  32. Content type: RESEARCH

    Anthocyanins are polyphenolic pigments which provide pink to blue colours in fruits and flowers. There is an increasing demand for anthocyanins, as food colorants and as health-promoting substances. Plant prod...

    Authors: Mark Levisson, Constantinos Patinios, Sascha Hein, Philip A. de Groot, Jean-Marc Daran, Robert D. Hall, Stefan Martens and Jules Beekwilder

    Citation: Microbial Cell Factories 2018 17:103

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  33. Content type: RESEARCH

    High production cost of bioplastics polyhydroxyalkanoates (PHA) is a major obstacle to replace traditional petro-based plastics. To address the challenges, strategies towards upstream metabolic engineering and...

    Authors: Jing Chen, Wei Li, Zhao-Zhou Zhang, Tian-Wei Tan and Zheng-Jun Li

    Citation: Microbial Cell Factories 2018 17:102

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  34. Content type: RESEARCH

    2′-Fucosyllactose (2-FL), one of the most abundant oligosaccharides in human milk, has potential applications in foods due to its health benefits such as the selective promotion of bifidobacterial growth and t...

    Authors: Sora Yu, Jing-Jing Liu, Eun Ju Yun, Suryang Kwak, Kyoung Heon Kim and Yong-Su Jin

    Citation: Microbial Cell Factories 2018 17:101

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  35. Content type: RESEARCH

    Metabolic activities of microorganisms to modify the chemical structures of organic compounds became an effective tool for the production of high-valued steroidal drugs or their precursors. Currently research ...

    Authors: Alina Świzdor, Anna Panek and Paulina Ostrowska

    Citation: Microbial Cell Factories 2018 17:100

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  36. Content type: RESEARCH

    Global energy and resource shortages make it necessary to quest for renewable resources. n-Caproic acid (CA) production based on carboxylate platform by anaerobic fermentation is booming. Recently, a novel Rumino...

    Authors: Han Wang, Xiangzhen Li, Yi Wang, Yong Tao, Shaowen Lu, Xiaoyu Zhu and Daping Li

    Citation: Microbial Cell Factories 2018 17:99

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  37. Content type: RESEARCH

    Polyene antibiotics are important as antifungal medicines albeit with serious side effects such as nephrotoxicity. Reedsmycin (RDM) A (1), produced by marine-derived Streptomyces youssoufiensis OUC6819, is a non-...

    Authors: Tingting Yao, Zengzhi Liu, Tong Li, Hui Zhang, Jing Liu, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li and Wenli Li

    Citation: Microbial Cell Factories 2018 17:98

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  38. Content type: Review

    The goal of this research is the investigation of a way to maximize the production of docosahexaenoic acid (DHA) and β-carotene by optimizing the culture conditions of their sources, microalgae Schizochytrium lim...

    Authors: Maria Bindea, Bogdan Rusu, Alexandru Rusu, Monica Trif, Loredana Florina Leopold, Francisc Dulf and Dan Cristian Vodnar

    Citation: Microbial Cell Factories 2018 17:97

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  39. Content type: RESEARCH

    The cellulolytic fungus Neurospora crassa is considered a potential host for enzyme and bioethanol production. However, large scale applications are hindered by its filamentous growth. Although previous investiga...

    Authors: Liangcai Lin, Zhiyong Sun, Jingen Li, Yong Chen, Qian Liu, Wenliang Sun and Chaoguang Tian

    Citation: Microbial Cell Factories 2018 17:96

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  40. Content type: RESEARCH

    The lifestyle of filamentous fungi depends on the secretion of hydrolytic enzymes into the surrounding medium, which degrade polymeric substances into monomers that are then taken up to sustain metabolism. Thi...

    Authors: Markus R. M. Fiedler, Lars Barthel, Christin Kubisch, Corrado Nai and Vera Meyer

    Citation: Microbial Cell Factories 2018 17:95

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  41. Content type: RESEARCH

    α-d-Glucosylglycerol (αGG) has beneficial functions as a moisturizing agent in cosmetics and potential as a health food material, and therapeutic agent. αGG serves as compatible solute in various halotolerant cya...

    Authors: Benjamin Roenneke, Natalie Rosenfeldt, Sami M. Derya, Jens F. Novak, Kay Marin, Reinhard Krämer and Gerd M. Seibold

    Citation: Microbial Cell Factories 2018 17:94

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  42. Content type: RESEARCH

    Co-production of polyhydroxyalkanoate (PHA) and amino acids makes bacteria effective microbial cell factories by secreting amino acids outside while accumulating PHA granules inside. Poly(3-hydroxybutyrate-co-...

    Authors: Wenjian Ma, Jianli Wang, Ye Li, Lianghong Yin and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2018 17:93

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  43. Content type: RESEARCH

    1,3-Propanediol (1,3-PDO) is important building blocks for the bio-based chemical industry, Klebsiella pneumoniae can be an attractive candidate for their production. However, 1,3-PDO production is high but produ...

    Authors: Baek-Rock Oh, Sung-Mok Lee, Sun-Yeon Heo, Jeong-Woo Seo and Chul Ho Kim

    Citation: Microbial Cell Factories 2018 17:92

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  44. Content type: RESEARCH

    A future bioeconomy relies on the development of technologies to convert waste into valuable compounds. We present here an attempt to design a biotechnological cascade for the conversion of vegetable waste int...

    Authors: Annemarie Schmidt, Gunnar Sturm, Christian Jonas Lapp, Daniel Siebert, Florencia Saravia, Harald Horn, Padma Priya Ravi, Andreas Lemmer and Johannes Gescher

    Citation: Microbial Cell Factories 2018 17:90

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  45. Content type: RESEARCH

    ʟ-Ornithine is an important amino acid with broad applications in pharmaceutical and food industries. Despite lagging ʟ-ornithine productivity and cost reduction, microbial fermentation is a promising route fo...

    Authors: Bin Zhang, Miao Yu, Wen-Ping Wei and Bang-Ce Ye

    Citation: Microbial Cell Factories 2018 17:91

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  46. Content type: RESEARCH

    Some marine bacteria, such as Moritella marina, produce the nutraceutical docosahexaenoic acid (DHA) thanks to a specific enzymatic complex called Pfa synthase. Escherichia coli heterologously expressing the pfa ...

    Authors: Laura Giner-Robles, Beatriz Lázaro, Fernando de la Cruz and Gabriel Moncalián

    Citation: Microbial Cell Factories 2018 17:88

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