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  1. Content type: RESEARCH

    Cancer and infectious diseases are problematic because of continuous emergence of drug resistance. One way to address this enormous global health threat is bioprospecting the unlikeliest environments, such as ...

    Authors: Laila Ziko, Al-Hussein A. Saqr, Amged Ouf, Matthias Gimpel, Ramy K. Aziz, Peter Neubauer and Rania Siam

    Citation: Microbial Cell Factories 2019 18:56

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  2. Content type: Review

    Naturally occurring carotenoids have been isolated and used as colorants, antioxidants, nutrients, etc. in many fields. There is an ever-growing demand for carotenoids production. To comfort this, microbial pr...

    Authors: Chonglong Wang, Shuli Zhao, Xixi Shao, Ji-Bin Park, Seong-Hee Jeong, Hyo-Jin Park, Won-Ju Kwak, Gongyuan Wei and Seon-Won Kim

    Citation: Microbial Cell Factories 2019 18:55

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  3. Content type: RESEARCH

    Due to their high energy density and compatible physical properties, several monoterpenes have been investigated as potential renewable transportation fuels, either as blendstocks with petroleum or as drop-in ...

    Authors: Xun Zhuang, Oliver Kilian, Eric Monroe, Masakazu Ito, Mary Bao Tran-Gymfi, Fang Liu, Ryan W. Davis, Mona Mirsiaghi, Eric Sundstrom, Todd Pray, Jeffrey M. Skerker, Anthe George and John M. Gladden

    Citation: Microbial Cell Factories 2019 18:54

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  4. Content type: RESEARCH

    Microalgae are promising sources of lipid triacylglycerol (TAG) for sustainable production of natural edible oils and biofuels. Nevertheless, products derived from microalgal TAG are not yet economically feasi...

    Authors: Wipa Chungjatupornchai, Kanchanaporn Areerat and Sirirat Fa-Aroonsawat

    Citation: Microbial Cell Factories 2019 18:53

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  5. Content type: RESEARCH

    Strains with increased alkali tolerance have a broad application in industrial, especially for bioremediation, biodegradation, biocontrol and production of bio-based chemicals. A novel synthetic chromosome rec...

    Authors: Lu Ma, Yunxiang Li, Xinyu Chen, Mingzhu Ding, Yi Wu and Ying-Jin Yuan

    Citation: Microbial Cell Factories 2019 18:52

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  6. Content type: RESEARCH

    Delactosed whey permeate (DWP) is a side stream of whey processing, which often is discarded as waste, despite of its high residual content of lactose, typically 10–20%. Microbial fermentation is one of the mo...

    Authors: Jing Shen, Jun Chen, Peter Ruhdal Jensen and Christian Solem

    Citation: Microbial Cell Factories 2019 18:51

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  7. Content type: RESEARCH

    The physiological characterization of microorganisms provides valuable information for bioprocess development. Chemostat cultivations are a powerful tool for this purpose, as they allow defined changes to one ...

    Authors: Alicia V. Lis, Konstantin Schneider, Jost Weber, Jay D. Keasling, Michael Krogh Jensen and Tobias Klein

    Citation: Microbial Cell Factories 2019 18:50

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  8. Content type: RESEARCH

    Fatty acids (FAs) with a chain length of more than 18 carbon atoms (> C18) are interesting for the production of specialty compounds derived from these FAs. These compounds include free FAs, like erucic acid (...

    Authors: Leonie Wenning, Christer S. Ejsing, Florian David, Richard R. Sprenger, Jens Nielsen and Verena Siewers

    Citation: Microbial Cell Factories 2019 18:49

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  9. Content type: RESEARCH

    Integration of synthetic metabolic pathways to catabolically diverse chassis provides new opportunities for sustainable production. One attractive scenario is the use of abundant waste material to produce a re...

    Authors: Jin Luo, Tapio Lehtinen, Elena Efimova, Ville Santala and Suvi Santala

    Citation: Microbial Cell Factories 2019 18:48

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  10. Content type: RESEARCH

    The hemolysin (Hly) secretion system of E. coli allows the one-step translocation of hemolysin A (HlyA) from the bacterial cytoplasm to the extracellular medium, without a periplasmic intermediate. In this work, ...

    Authors: David Ruano-Gallego, Sofía Fraile, Carlos Gutierrez and Luis Ángel Fernández

    Citation: Microbial Cell Factories 2019 18:47

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  11. Content type: RESEARCH

    Pectinolytic enzymes, which are used in several industries, especially in the clarification process during wine and fruit juice production, represent approximately 10% of the global enzyme market. To prevent t...

    Authors: Mario Carrasco, Juan Manuel Rozas, Jennifer Alcaíno, Víctor Cifuentes and Marcelo Baeza

    Citation: Microbial Cell Factories 2019 18:45

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  12. Content type: RESEARCH

    Mycobacterium bovis Bacille Calmette-Guérin (BCG) is not only used as a vaccine against tuberculosis but also protects against leprosy and is used as part of bladder cancer treatment to induce a protective immune...

    Authors: Maroeska J. Burggraaf, Louis S. Ates, Alexander Speer, Kim van der Kuij, Coen Kuijl and Wilbert Bitter

    Citation: Microbial Cell Factories 2019 18:44

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  13. Content type: RESEARCH

    l-2-aminobutyric acid (l-ABA) is an unnatural amino acid that is a key intermediate for the synthesis of several important pharmaceuticals. To make the biosynthesis of l-ABA environmental friendly and more suitab...

    Authors: Jian-Miao Xu, Jian-Qiang Li, Bo Zhang, Zhi-Qiang Liu and Yu-Guo Zheng

    Citation: Microbial Cell Factories 2019 18:43

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  14. Content type: RESEARCH

    Due to various environmental problems, biodegradable polymers such as poly (3-hydroxybutyrate) (PHB) have gained much attention in recent years. Purple non-sulfur (PNS) bacteria have various attractive charact...

    Authors: Jyumpei Kobayashi and Akihiko Kondo

    Citation: Microbial Cell Factories 2019 18:40

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  15. Content type: Review

    Microbial fuel cell (MFC) is an environmentally friendly technology for electricity harvesting from a variety of substrates. Microorganisms used as catalysts in the anodic chamber, which are termed as electric...

    Authors: Yujin Cao, Hui Mu, Wei Liu, Rubing Zhang, Jing Guo, Mo Xian and Huizhou Liu

    Citation: Microbial Cell Factories 2019 18:39

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  16. Content type: RESEARCH

    Bitespiramycin (BT) is produced by recombinant spiramycin (SP) producing strain Streptomyces spiramyceticus harboring a heterologous 4″-O-isovaleryltransferase gene (ist). Exogenous l-Leucine (l-Leu) could improv...

    Authors: Zhili Lu, Xiaoting Zhang, Jianlu Dai, Yiguang Wang and Weiqing He

    Citation: Microbial Cell Factories 2019 18:38

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  17. Content type: Correction

    After publication of the original article [1], the authors flagged that one of the co-authors' names was erroneously deleted during the review process and, as a result, the name is missing from the published a...

    Authors: Gunjan Singh, Sweta Sinha, K. K. Bandyopadhyay, Mark Lawrence, Ram Prasad and Debarati Paul

    Citation: Microbial Cell Factories 2019 18:37

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    The original article was published in Microbial Cell Factories 2018 17:182

  18. Content type: RESEARCH

    Interactions between microorganisms during specific steps of anaerobic digestion determine metabolic pathways in bioreactors and consequently the efficiency of fermentation processes. This study focuses on con...

    Authors: Anna Detman, Damian Mielecki, Aleksandra Chojnacka, Agnieszka Salamon, Mieczysław K. Błaszczyk and Anna Sikora

    Citation: Microbial Cell Factories 2019 18:36

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  19. Content type: REVIEW

    During microbial applications, metabolic burdens can lead to a significant drop in cell performance. Novel synthetic biology tools or multi-step bioprocessing (e.g., fermentation followed by chemical conversio...

    Authors: Garrett W. Roell, Jian Zha, Rhiannon R. Carr, Mattheos A. Koffas, Stephen S. Fong and Yinjie J. Tang

    Citation: Microbial Cell Factories 2019 18:35

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  20. Content type: RESEARCH

    Bear bile powder is a valuable medicinal material characterized by high content of tauroursodeoxycholic acid (TUDCA) at a certain ratio to taurochenodeoxycholic acid (TCDCA). We had created an engineered E. coli ...

    Authors: Yingpeng Xu, Li Yang, Shujuan Zhao and Zhengtao Wang

    Citation: Microbial Cell Factories 2019 18:34

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  21. Content type: RESEARCH

    Immobilization is an appropriate tool to ease the handling and recycling of enzymes in biocatalytic processes and to increase their stability. Most of the established immobilization methods require case-to-cas...

    Authors: V. D. Jäger, R. Kloss, A. Grünberger, S. Seide, D. Hahn, T. Karmainski, M. Piqueray, J. Embruch, S. Longerich, U. Mackfeld, K.-E. Jaeger, W. Wiechert, M. Pohl and U. Krauss

    Citation: Microbial Cell Factories 2019 18:33

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  22. Content type: RESEARCH

    Serratia plymuthica WS3236 was selected for whole genome sequencing based on preliminary genetic and chemical screening indicating the presence of multiple natural product pathways. This led to the identification...

    Authors: Elke R. Duell, Paul M. D’Agostino, Nicole Shapiro, Tanja Woyke, Thilo M. Fuchs and Tobias A. M. Gulder

    Citation: Microbial Cell Factories 2019 18:32

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  23. Content type: RESEARCH

    Heterologous gene expression is well established for various prokaryotic model systems. However, low yield, incorrect folding and instability still impede the production of soluble, bioactive proteins. To impr...

    Authors: Janine Heinrich, Chris Drewniok, Eva Neugebauer, Harald Kellner and Thomas Wiegert

    Citation: Microbial Cell Factories 2019 18:31

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  24. Content type: RESEARCH

    Isobutanol, a C4 branched-chain higher alcohol, is regarded as an attractive next-generation transport fuel. Metabolic engineering for efficient isobutanol production has been achieved in many studies. BmoR, a...

    Authors: Huan Yu, Ning Wang, Wenbo Huo, Yuhong Zhang, Wei Zhang, Yu Yang, Zhenya Chen and Yi-Xin Huo

    Citation: Microbial Cell Factories 2019 18:30

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  25. Content type: Review

    Citric acid is the world’s largest consumed organic acid and is widely used in beverage, food and pharmaceutical industries. Aspergillus niger is the main industrial workhorse for citric acid production. Since th...

    Authors: Zhenyu Tong, Xiaomei Zheng, Yi Tong, Yong-Cheng Shi and Jibin Sun

    Citation: Microbial Cell Factories 2019 18:28

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  26. Content type: RESEARCH

    l-Alanyl-l-glutamine (Ala-Gln) represents the great application potential in clinic due to the unique physicochemical properties. A new approach was developed to synthesize Ala-Gln by recombinant Escherichia coli

    Authors: Yi-Min Li, Jiao-Qi Gao, Xu-Ze Pei, Cong Du, Chao Fan, Wen-Jie Yuan and Feng-Wu Bai

    Citation: Microbial Cell Factories 2019 18:27

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  27. Content type: RESEARCH

    Escherichia coli W3110 and a group of six isogenic derivatives, each displaying distinct specific rates of glucose consumption were characterized to determine levels of GFP production and population heterogeneity...

    Authors: Juan Carlos Fragoso-Jiménez, Jonathan Baert, Thai Minh Nguyen, Wenzheng Liu, Hosni Sassi, Frédéric Goormaghtigh, Laurence Van Melderen, Paul Gaytán, Georgina Hernández-Chávez, Alfredo Martinez, Frank Delvigne and Guillermo Gosset

    Citation: Microbial Cell Factories 2019 18:26

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  28. Content type: RESEARCH

    Phosphoketolases (Xfpk) are a non-native group of enzymes in yeast, which can be expressed in combination with other metabolic enzymes to positively influence the yield of acetyl-CoA derived products by reduci...

    Authors: Alexandra Bergman, John Hellgren, Thomas Moritz, Verena Siewers, Jens Nielsen and Yun Chen

    Citation: Microbial Cell Factories 2019 18:25

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  29. Content type: RESEARCH

    Lignocellulosic biomass is one of the most abundant materials for biochemicals production. However, efficient co-utilization of glucose and xylose from the lignocellulosic biomass is a challenge due to the glu...

    Authors: Yan Hua, Jichao Wang, Yelin Zhu, Biao Zhang, Xin Kong, Wenjie Li, Dongmei Wang and Jiong Hong

    Citation: Microbial Cell Factories 2019 18:24

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  30. Content type: RESEARCH

    Terpenes are industrially relevant natural compounds the biosynthesis of which relies on two well-established—mevalonic acid (MVA) and methyl erythritol phosphate (MEP)-pathways. Both pathways are widely distr...

    Authors: Juan Rico, Katia Duquesne, Jean-Louis Petit, Aline Mariage, Ekaterina Darii, Frédéric Peruch, Véronique de Berardinis and Gilles Iacazio

    Citation: Microbial Cell Factories 2019 18:23

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  31. Content type: RESEARCH

    Infectious bursal disease (IBD) is an acute contagious immunosuppressive disease which lead to acute bursal injury and immune dysfunction in poultry. It has caused heavy economic losses in the commercial poult...

    Authors: Wenqian Wang, Yuxin Song, Linlin Liu, Yuan Zhang, Tingting Wang, Wang Zhang, Kai Li, Xiaole Qi, Yulong Gao, Li Gao, Changjun Liu, Yanping Zhang, Yongqiang Wang, Qing Pan, Gaoming He, Xiaomei Wang…

    Citation: Microbial Cell Factories 2019 18:21

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  32. Content type: RESEARCH

    Long-chain free fatty acids (FFAs) are a type of backbone molecule that can react with alcohol to produce biodiesels. Various microorganisms have become potent producers of FFAs. Efforts have focused on increa...

    Authors: Xiaomeng Tong, Eun Kyoung Oh, Byeong-ha Lee and Jeong K. Lee

    Citation: Microbial Cell Factories 2019 18:20

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  33. Content type: RESEARCH

    The Twin-arginine translocation (Tat) pathway of Escherichia coli has great potential for the export of biopharmaceuticals to the periplasm due to its ability to transport folded proteins, and its proofreading me...

    Authors: Isabel Guerrero Montero, Katarzyna Magdalena Dolata, Rabea Schlüter, Gilles Malherbe, Susanne Sievers, Daniela Zühlke, Thomas Sura, Emma Dave, Katharina Riedel and Colin Robinson

    Citation: Microbial Cell Factories 2019 18:19

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  34. Content type: RESEARCH

    Recombinant human Fibroblast growth factor 21 (rhFGF21) is an endocrine hormone that has profound effects on treatment of metabolic diseases. However, rhFGF21 is prone to form inclusion body when expressed in ...

    Authors: Dandan Li, Gang Fu, Ran Tu, Zhaoxia Jin and Dawei Zhang

    Citation: Microbial Cell Factories 2019 18:17

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  35. Content type: RESEARCH

    Streptomyces chattanoogensis L10 is the industrial producer of natamycin and has been proved a highly efficient host for diverse natural products. It has an enormous potential to be developed as a versatile cell ...

    Authors: Qing-Ting Bu, Pin Yu, Jue Wang, Zi-Yue Li, Xin-Ai Chen, Xu-Ming Mao and Yong-Quan Li

    Citation: Microbial Cell Factories 2019 18:16

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  36. Content type: RESEARCH

    Electrochemical energy is a key factor of biosynthesis, and is necessary for the reduction or assimilation of substrates such as CO2. Previous microbial electrosynthesis (MES) research mainly utilized naturally e...

    Authors: Zaiqiang Wu, Junsong Wang, Jun Liu, Yan Wang, Changhao Bi and Xueli Zhang

    Citation: Microbial Cell Factories 2019 18:15

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  37. Content type: RESEARCH

    Research on filamentous fungi emphasized the remarkable redundancy in genes encoding hydrolytic enzymes, the similarities but also the large differences in their expression, especially through the role of the ...

    Authors: Agustina Llanos, Sébastien Déjean, Virginie Neugnot-Roux, Jean M. François and Jean-Luc Parrou

    Citation: Microbial Cell Factories 2019 18:14

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  38. Content type: RESEARCH

    Alternaria sp. MG1, an endophytic fungus isolated from grape, is a native producer of resveratrol, which has important application potential. However, the metabolic characteristics and physiological behavior of M...

    Authors: Yao Lu, Chao Ye, Jinxin Che, Xiaoguang Xu, Dongyan Shao, Chunmei Jiang, Yanlin Liu and Junling Shi

    Citation: Microbial Cell Factories 2019 18:13

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  39. Content type: RESEARCH

    Styrene monooxygenase (SMO) catalyzes the first step of aromatic alkene degradation yielding the corresponding epoxides. Because of its broad spectrum of substrates, the enzyme harbors a great potential for an...

    Authors: Chunlin Tan, Xian Zhang, Zhijing Zhu, Meijuan Xu, Taowei Yang, Tolbert Osire, Shangtian Yang and Zhiming Rao

    Citation: Microbial Cell Factories 2019 18:12

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  40. Content type: RESEARCH

    Pichia pastoris (syn. Komagataella phaffii) is one of the most highly utilized eukaryotic expression systems for the production of heterologous glycoproteins, being able to perform both N- and O-mannosylation. In...

    Authors: Giroshi Bando-Campos, Daniel Juárez-López, Sergio A. Román-González, Antonia I. Castillo-Rodal, Clarita Olvera, Yolanda López-Vidal, Roberto Arreguín-Espinosa, Clara Espitia, Mauricio A. Trujillo-Roldán and Norma A. Valdez-Cruz

    Citation: Microbial Cell Factories 2019 18:11

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  41. Content type: RESEARCH

    Many valuable biopharmaceutical and biotechnological proteins have been produced in Escherichia coli, however these proteins are almost exclusively localised in the cytoplasm or periplasm. This presents challenge...

    Authors: Charlotte A. Green, Nitin S. Kamble, Elizabeth K. Court, Owain J. Bryant, Matthew G. Hicks, Christopher Lennon, Gillian M. Fraser, Phillip C. Wright and Graham P. Stafford

    Citation: Microbial Cell Factories 2019 18:10

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  42. Content type: RESEARCH

    Cellulase is the one of the largest contributors to the high production costs of the lignocellulose-based biorefineries. As the most widely used cellulase producer, Trichoderma reesei has two weaknesses, deficien...

    Authors: Hao Fang, Runze Zhao, Chaofeng Li and Chen Zhao

    Citation: Microbial Cell Factories 2019 18:9

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  43. Content type: RESEARCH

    In vivo protein formation is a crucial part of cellular life. The process needs to adapt to growth conditions and is exploited for the production of technical and pharmaceutical proteins in microbes such as Esche...

    Authors: Alexander Nieß, Martin Siemann-Herzberg and Ralf Takors

    Citation: Microbial Cell Factories 2019 18:8

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  44. Content type: RESEARCH

    Multi-monocistronic and multi-variate vectors were designed, built, and tested for the improved production of cyanidin 3-O-glucoside (C3G) in Escherichia coli BL21 (DE3). The synthetic bio-parts were designed in ...

    Authors: Biplav Shrestha, Ramesh Prasad Pandey, Sumangala Darsandhari, Prakash Parajuli and Jae Kyung Sohng

    Citation: Microbial Cell Factories 2019 18:7

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