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  1. Aromatic amino acids and their derivatives are valuable chemicals and are precursors for different industrially compounds. p-Coumaric acid is the main building block for complex secondary metabolites in commercia...

    Authors: Gheorghe M. Borja, Angelica Rodriguez, Kate Campbell, Irina Borodina, Yun Chen and Jens Nielsen

    Citation: Microbial Cell Factories 2019 18:191

    Content type: Research

    Published on:

  2. The focus of this study is online estimation of biomass concentration in fed-batch cultures. It describes a bioengineering software solution, which is explored for Escherichia coli and Saccharomyces cerevisiae fe...

    Authors: Renaldas Urniezius, Arnas Survyla, Dziugas Paulauskas, Vladas Algirdas Bumelis and Vytautas Galvanauskas

    Citation: Microbial Cell Factories 2019 18:190

    Content type: Research

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  3. Probiotic bacteria can provide health benefits when delivered in functional foods. This study involved isolation of lactic acid bacteria (LAB) from traditionally dried and salted anchovy fish and characterizat...

    Authors: Nadia S. AlKalbani, Mark S. Turner and Mutamed M. Ayyash

    Citation: Microbial Cell Factories 2019 18:188

    Content type: Research

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  4. The PAOX1-based expression system is the most widely used for producing recombinant proteins in the methylotrophic yeast Pichia pastoris (Komagataella phaffii). Despite relevant recent advances in regulation of t...

    Authors: Javier Garrigós-Martínez, Miguel Angel Nieto-Taype, Arnau Gasset-Franch, José Luis Montesinos-Seguí, Xavier Garcia-Ortega and Francisco Valero

    Citation: Microbial Cell Factories 2019 18:187

    Content type: Research

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  5. Lactobacillus reuteri is a heterofermentative Lactic Acid Bacterium (LAB) that is commonly used for food fermentations and probiotic purposes. Due to its robust properties, it is also increasingly considered for ...

    Authors: Thordis Kristjansdottir, Elleke F. Bosma, Filipe Branco dos Santos, Emre Özdemir, Markus J. Herrgård, Lucas França, Bruno Ferreira, Alex T. Nielsen and Steinn Gudmundsson

    Citation: Microbial Cell Factories 2019 18:186

    Content type: Research

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  6. The consequence of simultaneous and sequential inoculation of T. asperellum and B. amyloliquefaciens cultures with respect to growth rate, differential expression of vital genes and metabolites were examined.

    Authors: Valliappan Karuppiah, Murugappan Vallikkannu, Tingting Li and Jie Chen

    Citation: Microbial Cell Factories 2019 18:185

    Content type: Research

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  7. As an attracted compatible solute, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid (ectoine) showed great potentials in various field. However, lower productivity and high saline medium seriously hinde...

    Authors: Qi Zhao, Shannan Li, Peiwen Lv, Simian Sun, Cuiqing Ma, Ping Xu, Haijun Su and Chunyu Yang

    Citation: Microbial Cell Factories 2019 18:184

    Content type: Research

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  8. α-Amylases specifically catalyse the hydrolysis of the internal α-1, 4-glucosidic linkages of starch. Glycoside hydrolase (GH) family 13 is the main α-amylase family in the carbohydrate-active database. Lactobaci...

    Authors: Laura Plaza-Vinuesa, Oswaldo Hernandez-Hernandez, F. Javier Moreno, Blanca de las Rivas and Rosario Muñoz

    Citation: Microbial Cell Factories 2019 18:183

    Content type: Research

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  9. Oxidative stress caused by inevitable hostile conditions during fermentative process was the most serious threat to the survival of the well-known industrial microorganism Corynebacterium glutamicum. To survive,

    Authors: Meiru Si, Chengchuan Che, Guanxi Li, Xiaona Li, Zhijin Gong, Jinfeng Liu, Ge Yang and Can Chen

    Citation: Microbial Cell Factories 2019 18:182

    Content type: Research

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  10. There has been in increasing interest in evaluating research production by means of “objective parameters” which should score the scientific impact of single articles and researchers’ career. In contrast, the ...

    Authors: Ario de Marco

    Citation: Microbial Cell Factories 2019 18:181

    Content type: Commentary

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  11. Structurally stable α-galactosidases are of great interest for various biotechnological applications. More thermophilic α-galactosidases with high activity and structural stability have therefore to be mined a...

    Authors: Jian-Lu An, Wei-Xin Zhang, Wei-Ping Wu, Guan-Jun Chen and Wei-Feng Liu

    Citation: Microbial Cell Factories 2019 18:180

    Content type: Research

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  12. Pseudomonas putida is a metabolically versatile, genetically accessible, and stress-robust species with outstanding potential to be used as a workhorse for industrial applications. While industry recognises the i...

    Authors: Linde F. C. Kampers, Ruben G. A. van Heck, Stefano Donati, Edoardo Saccenti, Rita J. M. Volkers, Peter J. Schaap, Maria Suarez-Diez, Pablo I. Nikel and Vitor A. P. Martins dos Santos

    Citation: Microbial Cell Factories 2019 18:179

    Content type: Research

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  13. The use of fossil fuels has been strongly related to critical problems currently affecting society, such as: global warming, global greenhouse effects and pollution. These problems have affected the homeostasi...

    Authors: Hossein Alishah Aratboni, Nahid Rafiei, Raul Garcia-Granados, Abbas Alemzadeh and José Rubén Morones-Ramírez

    Citation: Microbial Cell Factories 2019 18:178

    Content type: Review

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  14. Saccharomyces cerevisiae is a suitable host for the industrial production of pyruvate-derived chemicals such as ethanol and 2,3-butanediol (23BD). For the improvement of the productivity of these chemicals, it is...

    Authors: Keisuke Morita, Fumio Matsuda, Koji Okamoto, Jun Ishii, Akihiko Kondo and Hiroshi Shimizu

    Citation: Microbial Cell Factories 2019 18:177

    Content type: Research

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  15. Yarrowia lipolytica is an unconventional yeast with a huge industrial potential. Despite many advantages for biotechnological applications, it possesses enormous demand for oxygen, which is a bottleneck in large ...

    Authors: Aleksandra M. Mirończuk, Katarzyna E. Kosiorowska, Anna Biegalska, Magdalena Rakicka-Pustułka, Mateusz Szczepańczyk and Adam Dobrowolski

    Citation: Microbial Cell Factories 2019 18:176

    Content type: Research

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  16. Herbicidin F has an undecose tricyclic furano-pyrano-pyran structure with post-decorations. It was detected from Streptomyces mobaraensis US-43 fermentation broth as a trace component by HPLC–MS analysis. As herb...

    Authors: Yuanyuan Shi, Renjie Gu, Yihong Li, Xinwei Wang, Weicong Ren, Xingxing Li, Lifei Wang, Yunying Xie and Bin Hong

    Citation: Microbial Cell Factories 2019 18:175

    Content type: Research

    Published on:

  17. Currently, industrial societies are seeking for green alternatives to conventional chemical synthesis. This demand has merged with the efforts to convert lignocellulosic biomass into value-added products. In t...

    Authors: Manuel Nieto-Domínguez, José Alberto Martínez-Fernández, Beatriz Fernández de Toro, Juan A. Méndez-Líter, Francisco Javier Cañada, Alicia Prieto, Laura I. de Eugenio and María Jesús Martínez

    Citation: Microbial Cell Factories 2019 18:174

    Content type: Research

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  18. Bioemulsifiers are surface-active compounds, which exhibit advantages including low toxicity, higher biodegradability and biocompatibility over synthetic chemical surfactants. Despite their potential benefits,...

    Authors: Weiyi Tao, Junzhang Lin, Weidong Wang, He Huang and Shuang Li

    Citation: Microbial Cell Factories 2019 18:173

    Content type: Research

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  19. α-Galactosidases are enzymes that act on galactosides present in many vegetables, mainly legumes and cereals, have growing importance with respect to our diet. For this reason, the use of their catalytic activ...

    Authors: María-Efigenia Álvarez-Cao, María-Esperanza Cerdán, María-Isabel González-Siso and Manuel Becerra

    Citation: Microbial Cell Factories 2019 18:172

    Content type: Research

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  20. The biological degradation of plastics is a promising method to counter the increasing pollution of our planet with artificial polymers and to develop eco-friendly recycling strategies. Polyethylene terephthal...

    Authors: Daniel Moog, Johanna Schmitt, Jana Senger, Jan Zarzycki, Karl-Heinz Rexer, Uwe Linne, Tobias Erb and Uwe G. Maier

    Citation: Microbial Cell Factories 2019 18:171

    Content type: Research

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    The Correction to this article has been published in Microbial Cell Factories 2020 19:1

  21. Most microorganisms have evolved to maximize growth rate, with rapid consumption of carbon sources from the surroundings. However, fast growing phenotypes usually feature secretion of organic compounds. For ex...

    Authors: Hwi-Min Jung, Dae-Kyun Im, Jae Hyung Lim, Gyoo Yeol Jung and Min-Kyu Oh

    Citation: Microbial Cell Factories 2019 18:170

    Content type: Research

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  22. With a variety of physiological and pharmacological functions, menaquinone is an essential prenylated product that can be endogenously converted from phylloquinone (VK1) or menadione (VK3) via the expression of H...

    Authors: Xiaowen Sun, Hui Liu, Peng Wang, Li wang, Wenfeng Ni, Qiang Yang, Han Wang, Hengfang Tang, Genhai Zhao and Zhiming Zheng

    Citation: Microbial Cell Factories 2019 18:169

    Content type: Research

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  23. Bioethanol is one of the most representative eco-friendly fuels developed to replace the non-renewable fossil fuels and is the most successful commercially available bio-conversion technology till date. With t...

    Authors: Jeongmo Yang, Ji Hee Son, Hyeonsoo Kim, Sukhyeong Cho, Jeong-geol Na, Young Joo Yeon and Jinwon Lee

    Citation: Microbial Cell Factories 2019 18:168

    Content type: Research

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  24. The oleaginous yeast Yarrowia lipolytica is increasingly used as an alternative cell factory for the production of recombinant proteins. Recently, regulated promoters from genes EYK1 and EYD1, encoding an erythru...

    Authors: Young-Kyoung Park, Marie Vandermies, Paul Soudier, Samuel Telek, Stéphane Thomas, Jean-Marc Nicaud and Patrick Fickers

    Citation: Microbial Cell Factories 2019 18:167

    Content type: Research

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  25. Polyhydroxyalkanoate (PHA) are nano-granules naturally produced by bacteria. Two types of proteins, PHA synthase (PhaC) and phasins (PhaPs), are attached to the PHA surface by covalent and hydrophobic interact...

    Authors: Ru Li, Jian Yang, Yunzhu Xiao and Lijuan Long

    Citation: Microbial Cell Factories 2019 18:166

    Content type: Research

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  26. In comparison to synthetically derived surfactants, biosurfactants produced from microbial culture are generally regarded by industry as being more sustainable and possess lower toxicity. One major class of bi...

    Authors: Lakshmi Tripathi, Matthew S. Twigg, Aikaterini Zompra, Karina Salek, Victor U. Irorere, Tony Gutierrez, Georgios A. Spyroulias, Roger Marchant and Ibrahim M. Banat

    Citation: Microbial Cell Factories 2019 18:164

    Content type: Research

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  27. Sustainable production of microbial fatty acids derivatives has the potential to replace petroleum based equivalents in the chemical, cosmetic and pharmaceutical industry. Most fatty acid sources for productio...

    Authors: Elias Kassab, Monika Fuchs, Martina Haack, Norbert Mehlmer and Thomas B. Brueck

    Citation: Microbial Cell Factories 2019 18:163

    Content type: Research

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  28. Efficient and convenient genome-editing toolkits can expedite genomic research and strain improvement for desirable phenotypes. Zymomonas mobilis is a highly efficient ethanol-producing bacterium with a small gen...

    Authors: Wei Shen, Jun Zhang, Binan Geng, Mengyue Qiu, Mimi Hu, Qing Yang, Weiwei Bao, Yubei Xiao, Yanli Zheng, Wenfang Peng, Guimin Zhang, Lixin Ma and Shihui Yang

    Citation: Microbial Cell Factories 2019 18:162

    Content type: Research

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  29. Numerous studies have shown that stress induction and genetic engineering can effectively increase lipid accumulation, but lead to a decrease of growth in the majority of microalgae. We previously found that e...

    Authors: Songcui Wu, Wenhui Gu, Aiyou Huang, Yuanxiang Li, Manoj Kumar, Phaik Eem Lim, Li Huan, Shan Gao and Guangce Wang

    Citation: Microbial Cell Factories 2019 18:161

    Content type: Research

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  30. Xylanases randomly cleave the internal β-1,4-glycosidic bonds in the xylan backbone and are grouped into different families in the carbohydrate-active enzyme (CAZy) database. Although multiple xylanases are de...

    Authors: Yi Yang, Jinshui Yang, Ruonan Wang, Jiawen Liu, Yu Zhang, Liang Liu, Fengqin Wang and Hongli Yuan

    Citation: Microbial Cell Factories 2019 18:159

    Content type: Research

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  31. PrsA is an extracytoplasmic folding catalyst essential in Bacillus subtilis. Overexpression of the native PrsA from B. subtilis has repeatedly lead to increased amylase yields. Nevertheless, little is known about...

    Authors: Ane Quesada-Ganuza, Minia Antelo-Varela, Jeppe C. Mouritzen, Jürgen Bartel, Dörte Becher, Morten Gjermansen, Peter F. Hallin, Karen F. Appel, Mogens Kilstrup, Michael D. Rasmussen and Allan K. Nielsen

    Citation: Microbial Cell Factories 2019 18:158

    Content type: Research

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  32. Bifidobacterium inhabiting the human and animal intestinal tract is known for its health-promoting effect. Tolerance to acid stress is crucial for bifidobacteria to survive and then exert their beneficial effects...

    Authors: Yanxia Wei, Jing Gao, Dianbin Liu, Yang Li and Wenli Liu

    Citation: Microbial Cell Factories 2019 18:156

    Content type: Research

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  33. A microorganism engineered for non-native tasks may suffer stresses it never met before. Therefore, we examined whether a Kluyveromyces marxianus strain engineered with a carotenoid biosynthesis pathway can serve...

    Authors: Hsien-Lin Liu, Jui-Jen Chang, Caroline Thia, Yu-Ju Lin, Shou-Chen Lo, Chieh-Chen Huang and Wen-Hsiung Li

    Citation: Microbial Cell Factories 2019 18:155

    Content type: Research

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  34. Mitochondrial and cytoplasmic malate transporter proteins are responsible for transmembrane transport of malate, thereby linking malate metabolism in various subcellular regions of the cell. These transporters...

    Authors: Lu Wang, Huaiyuan Zhang, Yao Zhang and Yuanda Song

    Citation: Microbial Cell Factories 2019 18:154

    Content type: Research

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  35. Dextransucrases are extracellular enzymes, which catalyze the formation of α-1→6-linked glucose polymers from sucrose. These enzymes are exclusively expressed by lactic acid bacteria, which commonly acidify th...

    Authors: Jonas Schmid, Julia Bechtner, Rudi F. Vogel and Frank Jakob

    Citation: Microbial Cell Factories 2019 18:153

    Content type: Research

    Published on:

  36. The soil bacterium Pseudomonas putida is a promising platform for the production of industrially valuable natural compounds. In the case of isoprenoids, the availability of biosynthetic precursors is a major limi...

    Authors: Sofía Hernandez-Arranz, Jordi Perez-Gil, Dominic Marshall-Sabey and Manuel Rodriguez-Concepcion

    Citation: Microbial Cell Factories 2019 18:152

    Content type: Research

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  37. Escherichia coli (E. coli) is a bacteria that is widely employed in many industries for the production of high interest bio-products such as recombinant proteins. Nevertheless, the use of E. coli for recombinant ...

    Authors: Gema Lozano Terol, Julia Gallego-Jara, Rosa Alba Sola Martínez, Manuel Cánovas Díaz and Teresa de Diego Puente

    Citation: Microbial Cell Factories 2019 18:151

    Content type: Research

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  38. Fine-tuning the aeration for cultivations when oxygen-limited conditions are demanded (such as the production of vaccines, isobutanol, 2–3 butanediol, acetone, and bioethanol) is still a challenge in the area ...

    Authors: Thiago José Barbosa Mesquita, Cíntia Regina Sargo, José Roberto Fuzer Neto, Sheyla Alexandra Hidalgo Paredes, Roberto de Campos Giordano, Antonio Carlos Luperni Horta and Teresa Cristina Zangirolami

    Citation: Microbial Cell Factories 2019 18:150

    Content type: Research

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  39. Polyol esters of fatty acids (PEFA) are a kind of promising biosurfactants and mainly secreted by Rhodotorula strains. In addition, some strains of Rhodotorula are reliable producers of microbial lipid. Therefore...

    Authors: Mengqi Wang, Weian Mao, Xiaoxiang Wang, Fengyi Li, Jiming Wang, Zhe Chi, Zhenming Chi and Guanglei Liu

    Citation: Microbial Cell Factories 2019 18:149

    Content type: Research

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  40. Colonization of Trichoderma spp. is essential for exerting their beneficial functions on the plant. However, the interactions between Trichoderma spp. and plant roots are still not completely understood. The aim ...

    Authors: Xiaohui Meng, Youzhi Miao, Qiumei Liu, Lei Ma, Kai Guo, Dongyang Liu, Wei Ran and Qirong Shen

    Citation: Microbial Cell Factories 2019 18:148

    Content type: Research

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  41. Poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) [P(3HB-co-3HHx)] is a bacterial polyester with high biodegradability, even in marine environments. Ralstonia eutropha has been engineered for the biosynthesis...

    Authors: Mengxiao Zhang, Shunsuke Kurita, Izumi Orita, Satoshi Nakamura and Toshiaki Fukui

    Citation: Microbial Cell Factories 2019 18:147

    Content type: Research

    Published on:

  42. Roseoflavin, a promising broad-spectrum antibiotic, is naturally produced by the bacteria Streptomyces davaonensis and Streptomyces cinnabarinus. The key enzymes responsible for roseoflavin biosynthesis and the c...

    Authors: Rodrigo Mora-Lugo, Julian Stegmüller and Matthias Mack

    Citation: Microbial Cell Factories 2019 18:146

    Content type: Research

    Published on:

  43. Simultaneous co-fermentation of mixed sugars is an important feature to consider in the production of ethanol from lignocellulosic biomass hydrolysates because it enhances the overall ethanol yield and volumet...

    Authors: Marco T. Fernández-Sandoval, Juvencio Galíndez-Mayer, Francisco Bolívar, Guillermo Gosset, Octavio T. Ramírez and Alfredo Martinez

    Citation: Microbial Cell Factories 2019 18:145

    Content type: Research

    Published on:

  44. Pichia pastoris (syn. Komagataella phaffii) is a widely used generally recognized as safe host for heterologous expression of proteins in both industry and academia. Recently, it has been shown to be a potentiall...

    Authors: Qi Liu, Xiaona Shi, Lili Song, Haifeng Liu, Xiangshan Zhou, Qiyao Wang, Yuanxing Zhang and Menghao Cai

    Citation: Microbial Cell Factories 2019 18:144

    Content type: Research

    Published on:

  45. In most microbial cultivations d-glucose is the main carbon and energy source. However, quantification of d-glucose especially in small scale is still challenging. Therefore, we developed a FRET-based glucose bio...

    Authors: Julia Otten, Niklas Tenhaef, Roman P. Jansen, Johannes Döbber, Lisa Jungbluth, Stephan Noack, Marco Oldiges, Wolfgang Wiechert and Martina Pohl

    Citation: Microbial Cell Factories 2019 18:143

    Content type: Research

    Published on:

  46. Hirame novirhabdovirus (HIRRV) can infect a wide range of marine and freshwater fish, causing huge economic losses to aquaculture industry. Vaccine development, especially oral vaccine, has become an effective...

    Authors: Lining Zhao, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing and Wenbin Zhan

    Citation: Microbial Cell Factories 2019 18:142

    Content type: Research

    Published on:

  47. Bacillus subtilis 916 has been identified as an effective biocontrol agent against Rhizoctonia solani, the causal pathogen of rice sheath blight, under greenhouse and field conditions. HPLC analysis showed that s...

    Authors: Xiaoyu Wang, Zhiyi Chen, Hui Feng, Xi Chen and Lihui Wei

    Citation: Microbial Cell Factories 2019 18:141

    Content type: Research

    Published on:

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