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  1. Filamentous fungi have long been used as hosts for the production of proteins, enzymes and valuable products in various biotechnological applications. However, recombinant proteins are expressed with highly se...

    Authors: Changyu Pi, Zhe Zhang, Boyu Xiang, Hongwei Tian, Qinzhen Liao, Yu Chen, Liqiu Xia, Yibo Hu and Shengbiao Hu

    Citation: Microbial Cell Factories 2020 19:155

    Content type: Research

    Published on:

  2. Bacillus subtilis is widely used for the industrial production of recombinant proteins, mainly due to its high secretion capacity, but higher production yields can be achieved only if bottlenecks are removed. To ...

    Authors: Kristina Volkenborn, Laura Kuschmierz, Nuka Benz, Patrick Lenz, Andreas Knapp and Karl-Erich Jaeger

    Citation: Microbial Cell Factories 2020 19:154

    Content type: Research

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  3. Furfural and 5-hydroxymethyl furfural (5-HMF) are key furan inhibitors that are generated due to breakdown of lignocellulosic sugars at high temperature and acidic treatment conditions. Both furfural and 5-HMF...

    Authors: Syed Bilal Jilani, Chandra Dev, Danish Eqbal, Kamran Jawed, Rajendra Prasad and Syed Shams Yazdani

    Citation: Microbial Cell Factories 2020 19:153

    Content type: Research

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  4. Accumulating evidence infer that gut microbiome-host relations are key mediators or modulators driving the observed sexual dimorphism in some disease onset and progression. To date, the sex-differences of gut ...

    Authors: Xin Yuan, Ruimin Chen, Ying Zhang, Xiangquan Lin and Xiaohong Yang

    Citation: Microbial Cell Factories 2020 19:152

    Content type: Research

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  5. The suitability of bacteria as microbial cell factories is dependent on several factors such as price of feedstock, product range, production yield and ease of downstream processing. The facultative methylotroph

    Authors: Marta Irla, Eivind B. Drejer, Trygve Brautaset and Sigrid Hakvåg

    Citation: Microbial Cell Factories 2020 19:151

    Content type: Research

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  6. Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. Howeve...

    Authors: William B. Black, Derek Aspacio, Danielle Bever, Edward King, Linyue Zhang and Han Li

    Citation: Microbial Cell Factories 2020 19:150

    Content type: Research

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  7. Enzymatic hydrolysis is a key step in the conversion of lignocellulosic polysaccharides to fermentable sugars for the production of biofuels and high-value chemicals. However, current enzyme preparations from ...

    Authors: Ning Zhu, Hongmei Jin, Xiangping Kong, Yanyun Zhu, Xiaomei Ye, Yonglan Xi, Jing Du, Bingqing Li, Menghan Lou and Ghulam Mustafa Shah

    Citation: Microbial Cell Factories 2020 19:149

    Content type: Research

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  8. The expression of recombinant proteins triggers a stress response which downregulates key metabolic pathway genes leading to a decline in cellular health and feedback inhibition of both growth and protein expr...

    Authors: Ashish K. Sharma, Esha Shukla, Deepak S. Janoti, Krishna J. Mukherjee and Joseph Shiloach

    Citation: Microbial Cell Factories 2020 19:148

    Content type: Research

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  9. With the development of engineering the microbial cell factories, biosensors have been used widely for regulation of cellular metabolism and high-throughput screening. However, most of the biosensors construct...

    Authors: Chenxi Qiu, Xiaoxu Chen, Reheman Rexida, Yu Shen, Qingsheng Qi, Xiaoming Bao and Jin Hou

    Citation: Microbial Cell Factories 2020 19:146

    Content type: Research

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  10. Biosurfactants, being highly biodegradable, ecofriendly and multifunctional compounds have wide applications in various industrial sectors including environmental bioremediation. Surfactin, a member of lipopep...

    Authors: Irfan Ali Phulpoto, Zhisheng Yu, Bowen Hu, Yanfen Wang, Fabrice Ndayisenga, Jinmei Li, Hongxia Liang and Muneer Ahmed Qazi

    Citation: Microbial Cell Factories 2020 19:145

    Content type: Research

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  11. Resveratrol is a plant secondary metabolite with diverse, potential health-promoting benefits. Due to its nutraceutical merit, bioproduction of resveratrol via microbial engineering has gained increasing atten...

    Authors: Shuo-Fu Yuan, Xiunan Yi, Trevor G. Johnston and Hal S. Alper

    Citation: Microbial Cell Factories 2020 19:143

    Content type: Research

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  12. β-mannanase can hydrolyze β-1,4 glycosidic bond of mannan by the manner of endoglycosidase to generate mannan-oligosaccharides. Currently, β-mannanase has been widely applied in food, medicine, textile, paper ...

    Authors: Siyu Liu, Tangbing Cui and Yan Song

    Citation: Microbial Cell Factories 2020 19:142

    Content type: Research

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  13. Carotenoids are natural tetraterpene pigments widely utilized in the food, pharmaceutical and cosmetic industries. Currently, chemical synthesis of these compounds outperforms their production in Escherichia coli

    Authors: Anna Maj, Lukasz Dziewit, Lukasz Drewniak, Maciej Garstka, Tomasz Krucon, Katarzyna Piatkowska, Katarzyna Gieczewska, Jakub Czarnecki, Ewa Furmanczyk, Robert Lasek, Jadwiga Baj and Dariusz Bartosik

    Citation: Microbial Cell Factories 2020 19:141

    Content type: Research

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  14. α-Glucosidases are widely distributed enzymes with a varied substrate specificity that are traditionally used in biotechnological industries based on oligo- and polysaccharides as starting materials. According...

    Authors: Martin Garcia-Gonzalez, Marina Minguet-Lobato, Francisco J. Plou and Maria Fernandez-Lobato

    Citation: Microbial Cell Factories 2020 19:140

    Content type: Research

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  15. Zoonotic hepatitis E virus (HEV) infection emerged as a serious threat in the industrialized countries. The aim of this study is exploring a new approach for the control of zoonotic HEV in its main host (swine...

    Authors: Nouredine Behloul, Sarra Baha, Zhenzhen Liu, Wenjuan Wei, Yuanyuan Zhu, Yuliang Rao, Ruihua Shi and Jihong Meng

    Citation: Microbial Cell Factories 2020 19:137

    Content type: Research

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  16. Escherichia coli BL21 is arguably the most popular host for industrial production of proteins, and industrial fermentations are often plagued by phage infections. The CRISPR/Cas system is guided by a gRNA to clea...

    Authors: Li Liu, Dongdong Zhao, Lijun Ye, Tao Zhan, Bin Xiong, Muzi Hu, Changhao Bi and Xueli Zhang

    Citation: Microbial Cell Factories 2020 19:136

    Content type: Research

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  17. A neutral, heat-sensitive serine protease (NHSSP) originating from the feather-degrading fungus Onygena corvina (O. corvina) was described and defined as an alkaline serine protease of the subtilisin type S8 fami...

    Authors: Piotr M. Skowron, Daria Krefft, Robert Brodzik, Paulina Kasperkiewicz, Marcin Drag and Klaus-Peter Koller

    Citation: Microbial Cell Factories 2020 19:135

    Content type: Research

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  18. The Saccharomyces cerevisiae Snf1 complex is a member of the AMP-activated protein kinase family and plays an important role in response to environmental stress. The α catalytic subunit Snf1 regulates the activit...

    Authors: Lu Meng, Hui-Ling Liu, Xue Lin, Xiao-Ping Hu, Kun-Ru Teng and Si-Xin Liu

    Citation: Microbial Cell Factories 2020 19:134

    Content type: Research

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  19. Lactobacillus spp. dominating the vaginal microbiota of healthy women contribute to the prevention of urogenital and sexually transmitted infections. Their protective role in the vagina can be mediated by Lactoba...

    Authors: Priscilla Romina De Gregorio, Carola Parolin, Angela Abruzzo, Barbara Luppi, Michele Protti, Laura Mercolini, Jessica Alejandra Silva, Barbara Giordani, Antonella Marangoni, María Elena Fátima Nader-Macías and Beatrice Vitali

    Citation: Microbial Cell Factories 2020 19:133

    Content type: Research

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  20. Streptococcus thermophilus is an important food starter and receiving more attention to serve as cell factories for production of high-valued metabolites. However, the low yields of intracellular or extracellular...

    Authors: Yingli Mu, Yongping Xin, Tingting Guo and Jian Kong

    Citation: Microbial Cell Factories 2020 19:132

    Content type: Research

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  21. Methanotrophs is a promising biocatalyst in biotechnological applications with their ability to utilize single carbon (C1) feedstock to produce high-value compounds. Understanding the behavior of biological ne...

    Authors: Anh Duc Nguyen, Gayoung Nam, Donghyuk Kim and Eun Yeol Lee

    Citation: Microbial Cell Factories 2020 19:131

    Content type: Research

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  22. Celiac disease is an intestinal chronic disorder with multifactorial etiology resulting in small intestinal mucosal injuries and malabsorption. In genetically predisposed individuals with HLA DQ2/DQ8 molecules...

    Authors: Bennur Somashekharaiah Rashmi, Devaraja Gayathri, Mahanthesh Vasudha, Chakra Siddappa Prashantkumar, Chidanandamurthy Thippeswamy Swamy, Kumar S. Sunil, Palegar Krishnappa Somaraja and Patil Prakash

    Citation: Microbial Cell Factories 2020 19:130

    Content type: Research

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  23. l-Alanyl-l-glutamine (AQ) is a functional dipeptide with high water solubility, good thermal stability and high bioavailability. It is widely used in clinical treatment, post-operative rehabilitation, sports heal...

    Authors: Jiangming Zhu, Wei Yang, Bohua Wang, Qun Liu, Xiaotong Zhong, Quanxiu Gao, Jiezheng Liu, Jianzhong Huang, Baixue Lin and Yong Tao

    Citation: Microbial Cell Factories 2020 19:129

    Content type: Research

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  24. As cell engineering technology advances, more complex synthetically designed cells and metabolically engineered cells are being developed. Engineered cells are important resources in industry. Similar to image...

    Authors: Dokyun Na

    Citation: Microbial Cell Factories 2020 19:128

    Content type: Technical notes

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  25. The interest for finding novel β-glucosidases that can improve the yields to produce second-generation (2G) biofuels is still very high. One of the most desired features for these enzymes is glucose tolerance,...

    Authors: Juan Antonio Méndez-Líter, Manuel Nieto-Domínguez, Beatriz Fernández de Toro, Andrés González Santana, Alicia Prieto, Juan Luis Asensio, Francisco Javier Cañada, Laura Isabel de Eugenio and María Jesús Martínez

    Citation: Microbial Cell Factories 2020 19:127

    Content type: Review

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  26. Thermostable enzymes are commonly produced in mesophilic hosts for research and bioengineering purposes. However, these hosts do not overexpress the active forms of some biologically functional thermoenzymes. ...

    Authors: Yasuhiro Fujino, Shuichiro Goda, Yuri Suematsu and Katsumi Doi

    Citation: Microbial Cell Factories 2020 19:126

    Content type: Research

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  27. Deracemization, the transformation of the racemate into a single stereoisomeric product in 100% theoretical yield, is an appealing but challenging option for the asymmetric synthesis of optically pure chiral c...

    Authors: Han Zu, Jie Gu, Hui Zhang, Anwen Fan, Yao Nie and Yan Xu

    Citation: Microbial Cell Factories 2020 19:125

    Content type: Research

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  28. Saccharomyces cerevisiae wine strains can develop stuck or sluggish fermentations when nutrients are scarce or suboptimal. Nutrient sensing and signaling pathways, such as PKA, TORC1 and Snf1, work coordinately t...

    Authors: Beatriz Vallejo, Emilia Matallana and Agustín Aranda

    Citation: Microbial Cell Factories 2020 19:124

    Content type: Research

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  29. The gut microbiota is a complex ecosystem, which is essential for the metabolism, health and immunity of host. Many diseases have been shown to be closely related to the alteration of intestinal flora. Aeromonas ...

    Authors: Zhigang Liu, Aoyun Li, Yaping Wang, Mudassar Iqbal, Aifang Zheng, Mengmeng Zhao, Zhongkai Li, Nuo Wang, Chao Wu and Daoping Yu

    Citation: Microbial Cell Factories 2020 19:123

    Content type: Research

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  30. Although most of antimicrobial peptides (AMPs), being relatively short, are produced by chemical synthesis, several AMPs have been produced using recombinant technology. However, AMPs could be cytotoxic to the...

    Authors: Ramon Roca-Pinilla, Adrià López-Cano, Cristina Saubi, Elena Garcia-Fruitós and Anna Arís

    Citation: Microbial Cell Factories 2020 19:122

    Content type: Research

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  31. Xylitol is a commercially important chemical with multiple applications in the food and pharmaceutical industries. According to the US Department of Energy, xylitol is one of the top twelve platform chemicals ...

    Authors: Ashish A. Prabhu, Dominic J. Thomas, Rodrigo Ledesma-Amaro, Gary A. Leeke, Angel Medina, Carol Verheecke-Vaessen, Frederic Coulon, Deepti Agrawal and Vinod Kumar

    Citation: Microbial Cell Factories 2020 19:121

    Content type: Research

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  32. The well-known fact that avian pathogenic Escherichia coli (APEC) is harder to prevent due to its numerous serogroups has promoted the development of biological immunostimulatory materials as new vaccine candidat...

    Authors: Rujiu Hu, Jing Li, Yuezhen Zhao, Hua Lin, Liu Liang, Mimi Wang, Haojing Liu, Yuna Min, Yupeng Gao and Mingming Yang

    Citation: Microbial Cell Factories 2020 19:119

    Content type: Research

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  33. Hydrogenobyrinic acid is a key intermediate of the de-novo aerobic biosynthesis pathway of vitamin B12. The introduction of a heterologous de novo vitamin B12 biosynthesis pathway in Escherichia coli offers an al...

    Authors: Pingtao Jiang, Huan Fang, Jing Zhao, Huina Dong, Zhaoxia Jin and Dawei Zhang

    Citation: Microbial Cell Factories 2020 19:118

    Content type: Research

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  34. Recombinant protein expression in bacteria often leads to the formation of intracellular insoluble protein deposits, a major bottleneck for the production of soluble and active products. However, in recent yea...

    Authors: Marcos Gil-Garcia, Susanna Navarro and Salvador Ventura

    Citation: Microbial Cell Factories 2020 19:117

    Content type: Research

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  35. Microbial metabolism is highly dependent on the environmental conditions. Especially, the substrate concentration, as well as oxygen availability, determine the metabolic rates. In large-scale bioreactors, mic...

    Authors: Eleni Vasilakou, Mark C. M. van Loosdrecht and S. Aljoscha Wahl

    Citation: Microbial Cell Factories 2020 19:116

    Content type: Research

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  36. l-Serine has wide and increasing applications in industries with fast-growing market demand. Although strategies for achieving and improving l-serine production in Corynebacterium glutamicum (C. glutamicum) have ...

    Authors: Xiaomei Zhang, Yujie Gao, Ziwei Chen, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Mattheos A. G. Koffas and Zhenghong Xu

    Citation: Microbial Cell Factories 2020 19:115

    Content type: Research

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  37. Phthalic acid esters (PAEs) are widely used as plasticizers or additives during the industrial manufacturing of plastic products. PAEs have been detected in both aquatic and terrestrial environments due to the...

    Authors: Junmei Ding, Yang Zhou, Chaofan Wang, Zheng Peng, Yuelin Mu, Xianghua Tang and Zunxi Huang

    Citation: Microbial Cell Factories 2020 19:114

    Content type: Research

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  38. Corynebacterium glutamicum is a traditional food-grade industrial microorganism, in which an efficient endotoxin-free recombinant protein expression factory is under developing in recent years. However, the intri...

    Authors: Manman Sun, Xiong Gao, Zihao Zhao, An Li, Yali Wang, Yankun Yang, Xiuxia Liu and Zhonghu Bai

    Citation: Microbial Cell Factories 2020 19:113

    Content type: Research

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  39. The signal peptides (SPs) of secretory proteins are frequently used or modified to guide recombinant proteins outside the cytoplasm of prokaryotic cells. In the periplasmic space and extracellular environment,...

    Authors: Jianhua Gao, Hongmei Qian, Xiaoqin Guo, Yi Mi, Junpei Guo, Juanli Zhao, Chao Xu, Ting Zheng, Ming Duan, Zhongwei Tang, Chaoyang Lin, Zhicheng Shen, Yiwei Jiang and Xingchun Wang

    Citation: Microbial Cell Factories 2020 19:112

    Content type: Research

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  40. Mithramycin is an anti-tumor compound of the aureolic acid family produced by Streptomyces argillaceus. Its biosynthesis gene cluster has been cloned and characterized, and several new analogs with improved pharm...

    Authors: Daniel Zabala, Lijiang Song, Yousef Dashti, Gregory L. Challis, José A. Salas and Carmen Méndez

    Citation: Microbial Cell Factories 2020 19:111

    Content type: Research

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  41. Aromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are characterized by their polycyclic aromatic structure. The b...

    Authors: Jia Wang, Ruihua Zhang, Xin Chen, Xinxiao Sun, Yajun Yan, Xiaolin Shen and Qipeng Yuan

    Citation: Microbial Cell Factories 2020 19:110

    Content type: Review

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  42. The biosynthesis of high value-added compounds using metabolically engineered strains has received wide attention in recent years. Myo-inositol (inositol), an important compound in the pharmaceutics, cosmetics...

    Authors: Ran You, Lei Wang, Congrong Shi, Hao Chen, Shasha Zhang, Meirong Hu and Yong Tao

    Citation: Microbial Cell Factories 2020 19:109

    Content type: Research

    Published on:

  43. Metabolic engineering frequently needs genomic integration of many heterologous genes for biosynthetic pathway assembly. Despite great progresses in genome editing for the model microorganism Escherichia coli, th...

    Authors: Buli Su, Dandan Song and Honghui Zhu

    Citation: Microbial Cell Factories 2020 19:108

    Content type: Research

    Published on:

  44. The obligate aerobe Azotobacter vinelandii is a model organism for the study of biological nitrogen fixation (BNF). This bacterium regulates the process of BNF through the two component NifL and NifA system, wher...

    Authors: Mary H. Plunkett, Carolann M. Knutson and Brett M. Barney

    Citation: Microbial Cell Factories 2020 19:107

    Content type: Research

    Published on:

  45. We evaluated the functional capacity of plantaricin-producing Lactobacillus plantarum SF9C and S-layer-carrying Lactobacillus brevis SF9B to withstand gastrointestinal transit and to compete among the gut microbi...

    Authors: Katarina Butorac, Martina Banić, Jasna Novak, Andreja Leboš Pavunc, Ksenija Uroić, Ksenija Durgo, Nada Oršolić, Marina Kukolj, Slobodanka Radović, Simone Scalabrin, Jurica Žučko, Antonio Starčević, Jagoda Šušković and Blaženka Kos

    Citation: Microbial Cell Factories 2020 19:106

    Content type: Research

    Published on:

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