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  1. Content type: RESEARCH

    Thermostable enzymes have several advantages over their mesophilic counterparts for industrial applications. However, trade-offs such as thermal instability of enzyme substrates or co-factors exist. Nicotinami...

    Authors: Hironori Taniguchi, Makoto Imura, Kenji Okano and Kohsuke Honda

    Citation: Microbial Cell Factories 2019 18:75

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  2. Content type: RESEARCH

    Diterpenoids are a large class of natural products with complex structures and broad commercial applications as food additives, important medicines, and fragrances. However, their low abundance in plants and h...

    Authors: Chuanbo Zhang, Haiyan Ju, Chun-Zhe Lu, Fanglong Zhao, Jingjing Liu, Xiaoyan Guo, Yufen Wu, Guang-Rong Zhao and Wenyu Lu

    Citation: Microbial Cell Factories 2019 18:73

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  3. Content type: RESEARCH

    In terms of protein production, the internal environment of the host influences the activity of expression elements, thus affecting the expression level of the target protein. Native expression elements from a...

    Authors: Wei Zhang, Yankun Yang, Xiuxia Liu, Chunli Liu and Zhonghu Bai

    Citation: Microbial Cell Factories 2019 18:72

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  4. Content type: RESEARCH

    In the last years, different biotechnologically relevant microorganisms have been engineered for the synthesis of plant polyphenols such as flavonoids and stilbenes. However, low intracellular availability of ...

    Authors: Lars Milke, Nicolai Kallscheuer, Jannick Kappelmann and Jan Marienhagen

    Citation: Microbial Cell Factories 2019 18:71

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  5. Content type: RESEARCH

    Bacterial surface display systems were developed to surface expose heterologous proteins or peptides for different applications, such as peptide libraries screening and live bacterial vaccine design. Various o...

    Authors: Tingting Chen, Kaihang Wang, Xin Chi, Lizhi Zhou, Jiajia Li, Liqin Liu, Qingbing Zheng, Yingbin Wang, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li and Ningshao Xia

    Citation: Microbial Cell Factories 2019 18:70

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  6. Content type: RESEARCH

    Our laboratory has constructed a Bacillus stearothermophilus α-amylase (AmyS) derivative with excellent enzymatic properties. Bacillus subtilis is generally regarded as safe and has excellent protein secretory ca...

    Authors: Dongbang Yao, Lingqia Su, Na Li and Jing Wu

    Citation: Microbial Cell Factories 2019 18:69

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  7. Content type: RESEARCH

    Iturins, which belong to antibiotic cyclic lipopeptides mainly produced by Bacillus sp., have the potential for application in biomedicine and biocontrol because of their hemolytic and antifungal properties. Baci...

    Authors: Yulei Dang, Fengjie Zhao, Xiangsheng Liu, Xu Fan, Rui Huang, Weixia Gao, Shufang Wang and Chao Yang

    Citation: Microbial Cell Factories 2019 18:68

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  8. Content type: RESEARCH

    O-Methylated phenylpropanoids, which are generally present in small amounts in plants, have improved or distinct biological activities and pharmacological properties as opposed to their unmethylated counterpart.....

    Authors: Heqing Cui, Myoung Chong Song, Yeon Hee Ban, Soo Youn Jun, An Sung Kwon, Ji Young Lee and Yeo Joon Yoon

    Citation: Microbial Cell Factories 2019 18:67

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  9. Content type: RESEARCH

    Oral vaccine is highly desired for infectious disease which is caused by pathogens infection through the mucosal surface. The design of suitable vaccine delivery system is ongoing for the antigen protection fr...

    Authors: Xingmei Qi, Qian Lu, JingPing Hu and Sidong Xiong

    Citation: Microbial Cell Factories 2019 18:66

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  10. Content type: RESEARCH

    NAD(H/+) and NADP(H/+) are the most important redox cofactors in bacteria. However, the intracellular redox balance is in advantage of the cell growth and production of NAD(P)H-dependent products.

    Authors: Jian-Zhong Xu, Hao-Zhe Ruan, Xiu-Lai Chen, Feng Zhang and Weiguo Zhang

    Citation: Microbial Cell Factories 2019 18:65

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  11. Content type: RESEARCH

    Dihomo-gamma linolenic acid (DGLA, 20:3, n-6) is the elongated product of Gamma linolenic acid (GLA, 18:3, n-6) catalyzed by the enzyme delta-6 elongase (D6E) or gamma linolenic acid elongase (GLELO). Construc...

    Authors: Md. Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Li Liang, Victoriano Garre and Yuanda Song

    Citation: Microbial Cell Factories 2019 18:64

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  12. Content type: RESEARCH

    Lactones are highly valuable cyclic esters of hydroxy fatty acids that find application as pure fragrances or as building blocks of speciality chemicals. While chemical synthesis often leads to undesired racem...

    Authors: Rui Silva, Tatiana Q. Aguiar, Eduardo Coelho, Alberto Jiménez, José Luis Revuelta and Lucília Domingues

    Citation: Microbial Cell Factories 2019 18:62

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  13. Content type: Review

    Nature has evolved exquisite sensing mechanisms to detect cellular and environmental signals surrounding living organisms. These biosensors have been widely used to sense small molecules, detect environmental ...

    Authors: Xia Wan, Monireh Marsafari and Peng Xu

    Citation: Microbial Cell Factories 2019 18:61

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  14. Content type: RESEARCH

    A novel d-allulose 3-epimerase from Staphylococcus aureus (SaDAE) has been screened as a d-allulose 3-epimerase family enzyme based on its high specificity for d-allulose. It usually converts both d-fructose and

    Authors: Zhangliang Zhu, Dengke Gao, Chao Li, Ying Chen, Menglu Zhu, Xin Liu, Masaru Tanokura, Hui-Min Qin and Fuping Lu

    Citation: Microbial Cell Factories 2019 18:59

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  15. Content type: RESEARCH

    Acetate is one of promising feedstocks owing to its cheap price and great abundance. Considering that tyrosine production is gradually shifting to microbial production method, its production from acetate can b...

    Authors: Minji Jo, Myung Hyun Noh, Hyun Gyu Lim, Chae Won Kang, Dae-Kyun Im, Min-Kyu Oh and Gyoo Yeol Jung

    Citation: Microbial Cell Factories 2019 18:57

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  16. Content type: RESEARCH

    Cancer and infectious diseases are problematic because of continuous emergence of drug resistance. One way to address this enormous global health threat is bioprospecting the unlikeliest environments, such as ...

    Authors: Laila Ziko, Al-Hussein A. Saqr, Amged Ouf, Matthias Gimpel, Ramy K. Aziz, Peter Neubauer and Rania Siam

    Citation: Microbial Cell Factories 2019 18:56

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  17. Content type: Review

    Naturally occurring carotenoids have been isolated and used as colorants, antioxidants, nutrients, etc. in many fields. There is an ever-growing demand for carotenoids production. To comfort this, microbial pr...

    Authors: Chonglong Wang, Shuli Zhao, Xixi Shao, Ji-Bin Park, Seong-Hee Jeong, Hyo-Jin Park, Won-Ju Kwak, Gongyuan Wei and Seon-Won Kim

    Citation: Microbial Cell Factories 2019 18:55

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  18. Content type: RESEARCH

    Due to their high energy density and compatible physical properties, several monoterpenes have been investigated as potential renewable transportation fuels, either as blendstocks with petroleum or as drop-in ...

    Authors: Xun Zhuang, Oliver Kilian, Eric Monroe, Masakazu Ito, Mary Bao Tran-Gymfi, Fang Liu, Ryan W. Davis, Mona Mirsiaghi, Eric Sundstrom, Todd Pray, Jeffrey M. Skerker, Anthe George and John M. Gladden

    Citation: Microbial Cell Factories 2019 18:54

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  19. Content type: RESEARCH

    Microalgae are promising sources of lipid triacylglycerol (TAG) for sustainable production of natural edible oils and biofuels. Nevertheless, products derived from microalgal TAG are not yet economically feasi...

    Authors: Wipa Chungjatupornchai, Kanchanaporn Areerat and Sirirat Fa-Aroonsawat

    Citation: Microbial Cell Factories 2019 18:53

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  20. Content type: RESEARCH

    Strains with increased alkali tolerance have a broad application in industrial, especially for bioremediation, biodegradation, biocontrol and production of bio-based chemicals. A novel synthetic chromosome rec...

    Authors: Lu Ma, Yunxiang Li, Xinyu Chen, Mingzhu Ding, Yi Wu and Ying-Jin Yuan

    Citation: Microbial Cell Factories 2019 18:52

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  21. Content type: RESEARCH

    Delactosed whey permeate (DWP) is a side stream of whey processing, which often is discarded as waste, despite of its high residual content of lactose, typically 10–20%. Microbial fermentation is one of the mo...

    Authors: Jing Shen, Jun Chen, Peter Ruhdal Jensen and Christian Solem

    Citation: Microbial Cell Factories 2019 18:51

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  22. Content type: RESEARCH

    The physiological characterization of microorganisms provides valuable information for bioprocess development. Chemostat cultivations are a powerful tool for this purpose, as they allow defined changes to one ...

    Authors: Alicia V. Lis, Konstantin Schneider, Jost Weber, Jay D. Keasling, Michael Krogh Jensen and Tobias Klein

    Citation: Microbial Cell Factories 2019 18:50

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  23. Content type: RESEARCH

    Fatty acids (FAs) with a chain length of more than 18 carbon atoms (> C18) are interesting for the production of specialty compounds derived from these FAs. These compounds include free FAs, like erucic acid (...

    Authors: Leonie Wenning, Christer S. Ejsing, Florian David, Richard R. Sprenger, Jens Nielsen and Verena Siewers

    Citation: Microbial Cell Factories 2019 18:49

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  24. Content type: RESEARCH

    Integration of synthetic metabolic pathways to catabolically diverse chassis provides new opportunities for sustainable production. One attractive scenario is the use of abundant waste material to produce a re...

    Authors: Jin Luo, Tapio Lehtinen, Elena Efimova, Ville Santala and Suvi Santala

    Citation: Microbial Cell Factories 2019 18:48

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  25. Content type: RESEARCH

    The hemolysin (Hly) secretion system of E. coli allows the one-step translocation of hemolysin A (HlyA) from the bacterial cytoplasm to the extracellular medium, without a periplasmic intermediate. In this work, ...

    Authors: David Ruano-Gallego, Sofía Fraile, Carlos Gutierrez and Luis Ángel Fernández

    Citation: Microbial Cell Factories 2019 18:47

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  26. Content type: RESEARCH

    Pectinolytic enzymes, which are used in several industries, especially in the clarification process during wine and fruit juice production, represent approximately 10% of the global enzyme market. To prevent t...

    Authors: Mario Carrasco, Juan Manuel Rozas, Jennifer Alcaíno, Víctor Cifuentes and Marcelo Baeza

    Citation: Microbial Cell Factories 2019 18:45

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  27. Content type: RESEARCH

    Mycobacterium bovis Bacille Calmette-Guérin (BCG) is not only used as a vaccine against tuberculosis but also protects against leprosy and is used as part of bladder cancer treatment to induce a protective immune...

    Authors: Maroeska J. Burggraaf, Louis S. Ates, Alexander Speer, Kim van der Kuij, Coen Kuijl and Wilbert Bitter

    Citation: Microbial Cell Factories 2019 18:44

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  28. Content type: RESEARCH

    l-2-aminobutyric acid (l-ABA) is an unnatural amino acid that is a key intermediate for the synthesis of several important pharmaceuticals. To make the biosynthesis of l-ABA environmental friendly and more suitab...

    Authors: Jian-Miao Xu, Jian-Qiang Li, Bo Zhang, Zhi-Qiang Liu and Yu-Guo Zheng

    Citation: Microbial Cell Factories 2019 18:43

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  29. Content type: RESEARCH

    Due to various environmental problems, biodegradable polymers such as poly (3-hydroxybutyrate) (PHB) have gained much attention in recent years. Purple non-sulfur (PNS) bacteria have various attractive charact...

    Authors: Jyumpei Kobayashi and Akihiko Kondo

    Citation: Microbial Cell Factories 2019 18:40

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  30. Content type: Review

    Microbial fuel cell (MFC) is an environmentally friendly technology for electricity harvesting from a variety of substrates. Microorganisms used as catalysts in the anodic chamber, which are termed as electric...

    Authors: Yujin Cao, Hui Mu, Wei Liu, Rubing Zhang, Jing Guo, Mo Xian and Huizhou Liu

    Citation: Microbial Cell Factories 2019 18:39

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  31. Content type: RESEARCH

    Bitespiramycin (BT) is produced by recombinant spiramycin (SP) producing strain Streptomyces spiramyceticus harboring a heterologous 4″-O-isovaleryltransferase gene (ist). Exogenous l-Leucine (l-Leu) could improv...

    Authors: Zhili Lu, Xiaoting Zhang, Jianlu Dai, Yiguang Wang and Weiqing He

    Citation: Microbial Cell Factories 2019 18:38

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  32. Content type: Correction

    After publication of the original article [1], the authors flagged that one of the co-authors' names was erroneously deleted during the review process and, as a result, the name is missing from the published a...

    Authors: Gunjan Singh, Sweta Sinha, K. K. Bandyopadhyay, Mark Lawrence, Ram Prasad and Debarati Paul

    Citation: Microbial Cell Factories 2019 18:37

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    The original article was published in Microbial Cell Factories 2018 17:182

  33. Content type: RESEARCH

    Interactions between microorganisms during specific steps of anaerobic digestion determine metabolic pathways in bioreactors and consequently the efficiency of fermentation processes. This study focuses on con...

    Authors: Anna Detman, Damian Mielecki, Aleksandra Chojnacka, Agnieszka Salamon, Mieczysław K. Błaszczyk and Anna Sikora

    Citation: Microbial Cell Factories 2019 18:36

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  34. Content type: REVIEW

    During microbial applications, metabolic burdens can lead to a significant drop in cell performance. Novel synthetic biology tools or multi-step bioprocessing (e.g., fermentation followed by chemical conversio...

    Authors: Garrett W. Roell, Jian Zha, Rhiannon R. Carr, Mattheos A. Koffas, Stephen S. Fong and Yinjie J. Tang

    Citation: Microbial Cell Factories 2019 18:35

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  35. Content type: RESEARCH

    Bear bile powder is a valuable medicinal material characterized by high content of tauroursodeoxycholic acid (TUDCA) at a certain ratio to taurochenodeoxycholic acid (TCDCA). We had created an engineered E. coli ...

    Authors: Yingpeng Xu, Li Yang, Shujuan Zhao and Zhengtao Wang

    Citation: Microbial Cell Factories 2019 18:34

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  36. Content type: RESEARCH

    Immobilization is an appropriate tool to ease the handling and recycling of enzymes in biocatalytic processes and to increase their stability. Most of the established immobilization methods require case-to-cas...

    Authors: V. D. Jäger, R. Kloss, A. Grünberger, S. Seide, D. Hahn, T. Karmainski, M. Piqueray, J. Embruch, S. Longerich, U. Mackfeld, K.-E. Jaeger, W. Wiechert, M. Pohl and U. Krauss

    Citation: Microbial Cell Factories 2019 18:33

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  37. Content type: RESEARCH

    Serratia plymuthica WS3236 was selected for whole genome sequencing based on preliminary genetic and chemical screening indicating the presence of multiple natural product pathways. This led to the identification...

    Authors: Elke R. Duell, Paul M. D’Agostino, Nicole Shapiro, Tanja Woyke, Thilo M. Fuchs and Tobias A. M. Gulder

    Citation: Microbial Cell Factories 2019 18:32

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  38. Content type: RESEARCH

    Heterologous gene expression is well established for various prokaryotic model systems. However, low yield, incorrect folding and instability still impede the production of soluble, bioactive proteins. To impr...

    Authors: Janine Heinrich, Chris Drewniok, Eva Neugebauer, Harald Kellner and Thomas Wiegert

    Citation: Microbial Cell Factories 2019 18:31

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  39. Content type: RESEARCH

    Isobutanol, a C4 branched-chain higher alcohol, is regarded as an attractive next-generation transport fuel. Metabolic engineering for efficient isobutanol production has been achieved in many studies. BmoR, a...

    Authors: Huan Yu, Ning Wang, Wenbo Huo, Yuhong Zhang, Wei Zhang, Yu Yang, Zhenya Chen and Yi-Xin Huo

    Citation: Microbial Cell Factories 2019 18:30

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  40. Content type: Review

    Citric acid is the world’s largest consumed organic acid and is widely used in beverage, food and pharmaceutical industries. Aspergillus niger is the main industrial workhorse for citric acid production. Since th...

    Authors: Zhenyu Tong, Xiaomei Zheng, Yi Tong, Yong-Cheng Shi and Jibin Sun

    Citation: Microbial Cell Factories 2019 18:28

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  41. Content type: RESEARCH

    l-Alanyl-l-glutamine (Ala-Gln) represents the great application potential in clinic due to the unique physicochemical properties. A new approach was developed to synthesize Ala-Gln by recombinant Escherichia coli

    Authors: Yi-Min Li, Jiao-Qi Gao, Xu-Ze Pei, Cong Du, Chao Fan, Wen-Jie Yuan and Feng-Wu Bai

    Citation: Microbial Cell Factories 2019 18:27

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  42. Content type: RESEARCH

    Escherichia coli W3110 and a group of six isogenic derivatives, each displaying distinct specific rates of glucose consumption were characterized to determine levels of GFP production and population heterogeneity...

    Authors: Juan Carlos Fragoso-Jiménez, Jonathan Baert, Thai Minh Nguyen, Wenzheng Liu, Hosni Sassi, Frédéric Goormaghtigh, Laurence Van Melderen, Paul Gaytán, Georgina Hernández-Chávez, Alfredo Martinez, Frank Delvigne and Guillermo Gosset

    Citation: Microbial Cell Factories 2019 18:26

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  43. Content type: RESEARCH

    Lignocellulosic biomass is one of the most abundant materials for biochemicals production. However, efficient co-utilization of glucose and xylose from the lignocellulosic biomass is a challenge due to the glu...

    Authors: Yan Hua, Jichao Wang, Yelin Zhu, Biao Zhang, Xin Kong, Wenjie Li, Dongmei Wang and Jiong Hong

    Citation: Microbial Cell Factories 2019 18:24

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