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  1. (+)-Nootkatone is a highly valued sesquiterpenoid compound, exhibiting a typical grapefruit aroma and various desired biological activities for use as aromatics and pharmaceuticals. The high commercial demand ...

    Authors: Xiangfeng Meng, Hui Liu, Wenqiang Xu, Weixin Zhang, Zheng Wang and Weifeng Liu

    Citation: Microbial Cell Factories 2020 19:21

    Content type: Research

    Published on:

  2. Steviol glycosides such as stevioside have attracted the attention of the food and beverage industry. Recently, efforts were made to produce these natural sweeteners in microorganisms using metabolic engineeri...

    Authors: Jun Ho Moon, Kunjoong Lee, Jun Ho Lee and Pyung Cheon Lee

    Citation: Microbial Cell Factories 2020 19:20

    Content type: Research

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  3. Amphotericin B (AmB) is widely used against fungal infection and produced mainly by Streptomyces nodosus. Various intracellular metabolites of S. nodosus were identified during AmB fermentation, and the key compo...

    Authors: Bo Zhang, Yi-Teng Zhou, Sheng-Xian Jiang, Yu-Han Zhang, Kai Huang, Zhi-Qiang Liu and Yu-Guo Zheng

    Citation: Microbial Cell Factories 2020 19:18

    Content type: Research

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  4. Citric acid, a commodity product of industrial biotechnology, is produced by fermentation of the filamentous fungus Aspergillus niger. A requirement for high-yield citric acid production is keeping the concentrat...

    Authors: Balázs Fejes, Jean-Paul Ouedraogo, Erzsébet Fekete, Erzsébet Sándor, Michel Flipphi, Áron Soós, Ákos P. Molnár, Béla Kovács, Christian P. Kubicek, Adrian Tsang and Levente Karaffa

    Citation: Microbial Cell Factories 2020 19:17

    Content type: Research

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  5. Cell-based experimentation in microfluidic droplets is becoming increasingly popular among biotechnologists and microbiologists, since inherent characteristics of droplets allow high throughput at low cost and...

    Authors: Miguel Tovar, Lisa Mahler, Stefanie Buchheim, Martin Roth and Miriam A. Rosenbaum

    Citation: Microbial Cell Factories 2020 19:16

    Content type: Technical notes

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  6. Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmac...

    Authors: Nikolaj L. Hansen, Karel Miettinen, Yong Zhao, Codruta Ignea, Aggeliki Andreadelli, Morten H. Raadam, Antonios M. Makris, Birger L. Møller, Dan Stærk, Søren Bak and Sotirios C. Kampranis

    Citation: Microbial Cell Factories 2020 19:15

    Content type: Research

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  7. Today there is an increasing demand for high yielding robust and cost efficient biotechnological production processes. Although cells in these processes originate from isogenic cultures, heterogeneity induced ...

    Authors: Anna-Lena Heins, Jan Reyelt, Marlen Schmidt, Harald Kranz and Dirk Weuster-Botz

    Citation: Microbial Cell Factories 2020 19:14

    Content type: Research

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  8. Androstenedione (AD) is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of AD is mainly the degradation of the phytostero...

    Authors: Yang Zhang, Xiuling Zhou, Xuemei Wang, Lu Wang, Menglei Xia, Jianmei Luo, Yanbing Shen and Min Wang

    Citation: Microbial Cell Factories 2020 19:13

    Content type: Research

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  9. The ureolytic bacterium Sporosarcina pasteurii is well-known for its capability of microbially induced calcite precipitation (MICP), representing a great potential in constructional engineering and material appli...

    Authors: Liang Ma, Ai-Ping Pang, Yongsheng Luo, Xiaolin Lu and Fengming Lin

    Citation: Microbial Cell Factories 2020 19:12

    Content type: Research

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  10. In recent years, the industrial workhorse Corynebacterium glutamicum has gained increasing interest as a host organism for the secretory production of heterologous proteins. Generally, the yield of a target prote...

    Authors: Sarah Jurischka, Astrid Bida, Doris Dohmen-Olma, Britta Kleine, Janko Potzkei, Stephan Binder, Georg Schaumann, Patrick J. Bakkes and Roland Freudl

    Citation: Microbial Cell Factories 2020 19:11

    Content type: Research

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  11. The use of microorganisms in the biosynthesis of zinc oxide nanoparticles (ZnO NPs) has recently emerged as an alternative to chemical and physical methods due to its low-cost and eco-friendly method. Several ...

    Authors: Hidayat Mohd Yusof, Rosfarizan Mohamad, Uswatun Hasanah Zaidan and Nor’Aini Abdul Rahman

    Citation: Microbial Cell Factories 2020 19:10

    Content type: Research

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  12. Aerobic growth provides benefits in biomass yield and stress tolerance of Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus). Catabolite control protein A (CcpA) is a master regulator involved in the aer...

    Authors: Guofang Zhang, Libo Liu and Chun Li

    Citation: Microbial Cell Factories 2020 19:9

    Content type: Research

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  13. The authors of this article [1] wish to draw the readers’ attention to their closely related paper, published in RSC Advances [2] which should have been cited in this article. The authors regret that there is ...

    Authors: Hailin Chen, Meijie Li, Changqing Liu, Haibo Zhang, Mo Xian and Huizhou Liu

    Citation: Microbial Cell Factories 2020 19:8

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2018 17:65

  14. Therapeutic glycoproteins have occupied an extremely important position in the market of biopharmaceuticals. N-Glycosylation of protein drugs facilitates them to maintain optimal conformations and affect their st...

    Authors: Shengjun Wang, Yongheng Rong, Yaoguang Wang, Decai Kong, Peng George Wang, Min Chen and Yun Kong

    Citation: Microbial Cell Factories 2020 19:7

    Content type: Research

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  15. 1,3-propanediol (1,3-PDO) is the most widely studied value-added product that can be produced by feeding glycerol to bacteria, including Lactobacillus sp. However, previous research reported that L. reuteri only ...

    Authors: Jung-Hyun Ju, Dexin Wang, Sun-Yeon Heo, Min-Soo Kim, Jeong-Woo Seo, Young-Min Kim, Dae-Hyuk Kim, Soon-Ah Kang, Chul-Ho Kim and Baek-Rock Oh

    Citation: Microbial Cell Factories 2020 19:6

    Content type: Research

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  16. Heterologous expression of secondary metabolite gene clusters is used to achieve increased production of desired compounds, activate cryptic gene clusters, manipulate clusters from genetically unamenable strai...

    Authors: Yousra Ahmed, Yuriy Rebets, Marta Rodríguez Estévez, Josef Zapp, Maksym Myronovskyi and Andriy Luzhetskyy

    Citation: Microbial Cell Factories 2020 19:5

    Content type: Research

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  17. Swep is an excellent carbamate herbicide that kills weeds by interfering with metabolic processes and inhibiting cell division at the growth point. Due to the large amount of use, swep residues in soil and wat...

    Authors: Long Zhang, Ping Hang, Xiyi Zhou, Chen Dai, Ziyi He and Jiandong Jiang

    Citation: Microbial Cell Factories 2020 19:4

    Content type: Research

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  18. Using an established CRISPR-Cas mediated genome editing technique for streptomycetes, we explored the combinatorial biosynthesis potential of the auroramycin biosynthetic gene cluster in Streptomyces roseosporous...

    Authors: Wan Lin Yeo, Elena Heng, Lee Ling Tan, Yi Wee Lim, Kuan Chieh Ching, De-Juin Tsai, Yi Wun Jhang, Tsai-Ling Lauderdale, Kak-Shan Shia, Huimin Zhao, Ee Lui Ang, Mingzi M. Zhang, Yee Hwee Lim and Fong T. Wong

    Citation: Microbial Cell Factories 2020 19:3

    Content type: Research

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  19. l-ornithine is a valuable amino acid with a wide range of applications in the pharmaceutical and food industries. However, the production of l-ornithine by fermentation cannot compete with other methods, because ...

    Authors: Yan Jiang, Ming-Zhu Huang, Xue-Lan Chen and Bin Zhang

    Citation: Microbial Cell Factories 2020 19:2

    Content type: Research

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  20. The author’s middle name is missed out in the original publication of the article [1]. The correct coauthor’s name is Tobias J. Erb.

    Authors: Daniel Moog, Johanna Schmitt, Jana Senger, Jan Zarzycki, Karl-Heinz Rexer, Uwe Linne, Tobias J. Erb and Uwe G. Maier

    Citation: Microbial Cell Factories 2020 19:1

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2019 18:171

  21. Following publication of the original article [1], the authors have noted that the standard curve in Additional file 1: Figure S7 is incorrect.

    Authors: Maren Wehrs, Jan-Philip Prahl, Jadie Moon, Yuchen Li, Deepti Tanjore, Jay D. Keasling, Todd Pray and Aindrila Mukhopadhyay

    Citation: Microbial Cell Factories 2019 18:218

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2018 17:193

  22. Diacetyl provides the buttery aroma in products such as butter and margarine. It can be made via a harsh set of chemical reactions from sugarcane bagasse, however, in dairy products it is normally formed spont...

    Authors: Robin Dorau, Lin Chen, Jianming Liu, Peter Ruhdal Jensen and Christian Solem

    Citation: Microbial Cell Factories 2019 18:217

    Content type: Research

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  23. This study reveals that it is possible to secrete truncated versions of outer membrane cytochromes into the culture supernatant and that these proteins can provide a basis for the export of heterologously prod...

    Authors: Helge M. Dietrich, Miriam Edel, Thea Bursac, Manfred Meier, Katrin Sturm-Richter and Johannes Gescher

    Citation: Microbial Cell Factories 2019 18:216

    Content type: Research

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  24. Serratia marcescens, a Gram-negative nosocomial pathogen secretes a 50 kDa multi-domain zinc metalloprotease called serratiopeptidase. Broad substrate specificity of serratiopeptidase makes it suitable for deterg...

    Authors: Vishal Srivastava, Shivam Mishra and Tapan K. Chaudhuri

    Citation: Microbial Cell Factories 2019 18:215

    Content type: Research

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  25. Increased inclusion of plant proteins in aquafeeds has become a common practice due to the high cost and limited supply of fish meal but generally leads to inferior growth performance and health problems of fi...

    Authors: Chaoqun Li, Beili Zhang, Xin Wang, Xionge Pi, Xuan Wang, Huihui Zhou, Kangsen Mai and Gen He

    Citation: Microbial Cell Factories 2019 18:214

    Content type: Research

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  26. Ustilago cynodontis ranks among the relatively unknown itaconate production organisms. In comparison to the well-known and established organisms like Aspergillus terreus and Ustilago maydis, genetic engineering a...

    Authors: Hamed Hosseinpour Tehrani, Katharina Saur, Apilaasha Tharmasothirajan, Lars M. Blank and Nick Wierckx

    Citation: Microbial Cell Factories 2019 18:213

    Content type: Research

    Published on:

  27. Histamine is a key mediator of the anti-inflammatory activity conferred by the probiotic organism Lactobacillus reuteri ATCC PTA 6475 in animal models of colitis and colorectal cancer. In L. reuteri, histamine sy...

    Authors: Anne E. Hall, Melinda A. Engevik, Numan Oezguen, Anthony Haag and James Versalovic

    Citation: Microbial Cell Factories 2019 18:212

    Content type: Research

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  28. Komagataella phaffii is a yeast widely used in the pharmaceutical and biotechnology industries, and is one of the two species that were previously called Pichia pastoris. However, almost all laboratory work on K....

    Authors: Stephanie Braun-Galleani, Julie A. Dias, Aisling Y. Coughlan, Adam P. Ryan, Kevin P. Byrne and Kenneth H. Wolfe

    Citation: Microbial Cell Factories 2019 18:211

    Content type: Research

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  29. Synthesis of nanoparticles (NPs) and their incorporation in materials are amongst the most studied topics in chemistry, physics and material science. Gold NPs have applications in medicine due to their antibac...

    Authors: Imen Ben Tahar, Patrick Fickers, Andrzej Dziedzic, Dariusz Płoch, Bartosz Skóra and Małgorzata Kus-Liśkiewicz

    Citation: Microbial Cell Factories 2019 18:210

    Content type: Research

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  30. Diatoms, which can accumulate large amounts of carotenoids, are a major group of microalgae and the dominant primary producer in marine environments. Phaeodactylum tricornutum, a model diatom species, acquires li...

    Authors: Zhiqian Yi, Yixi Su, Paulina Cherek, David R. Nelson, Jianping Lin, Ottar Rolfsson, Hua Wu, Kourosh Salehi-Ashtiani, Sigurdur Brynjolfsson and Weiqi Fu

    Citation: Microbial Cell Factories 2019 18:209

    Content type: Research

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  31. Yarrowia lipolytica has emerged as a biomanufacturing platform for a variety of industrial applications. It has been demonstrated to be a robust cell factory for the production of renewable chemicals and enzymes ...

    Authors: Vijaydev Ganesan, Michael Spagnuolo, Ayushi Agrawal, Spencer Smith, Difeng Gao and Mark Blenner

    Citation: Microbial Cell Factories 2019 18:208

    Content type: Review

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  32. The methylotrophic yeast Pichia pastoris is well-known for the production of a broad spectrum of functional types of heterologous proteins including enzymes, antigens, engineered antibody fragments, and next gen ...

    Authors: Xueyun Zheng, Yimin Zhang, Xinying Zhang, Cheng Li, Xiaoxiao Liu, Ying Lin and Shuli Liang

    Citation: Microbial Cell Factories 2019 18:207

    Content type: Research

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  33. The choice of phosphate/nitrogen source and their concentrations have been shown to have great influences on antibiotic production. However, the underlying mechanisms responsible for this remain poorly underst...

    Authors: Ya Xu, Di You, Li-li Yao, Xiaohe Chu and Bang-Ce Ye

    Citation: Microbial Cell Factories 2019 18:206

    Content type: Research

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  34. The sesquiterpenoid abscisic acid (ABA) is mostly known for regulating developmental processes and abiotic stress responses in higher plants. Recent studies show that ABA also exhibits a variety of pharmacolog...

    Authors: Maximilian Otto, Paulo Gonçalves Teixeira, Maria Isabel Vizcaino, Florian David and Verena Siewers

    Citation: Microbial Cell Factories 2019 18:205

    Content type: Research

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  35. Rhodobacter sphaeroides is a metabolically versatile bacterium that serves as a model for analysis of photosynthesis, hydrogen production and terpene biosynthesis. The elimination of by-products formation, such a...

    Authors: Ioannis Mougiakos, Enrico Orsi, Mohammad Rifqi Ghiffary, Wilbert Post, Alberto de Maria, Belén Adiego-Perez, Servé W. M. Kengen, Ruud A. Weusthuis and John van der Oost

    Citation: Microbial Cell Factories 2019 18:204

    Content type: Research

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  36. Orthogonal, synthetic control devices were developed for Penicillium chrysogenum, a model filamentous fungus and industrially relevant cell factory. In the synthetic transcription factor, the QF DNA-binding domai...

    Authors: László Mózsik, Zsófia Büttel, Roel A. L. Bovenberg, Arnold J. M. Driessen and Yvonne Nygård

    Citation: Microbial Cell Factories 2019 18:203

    Content type: Research

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  37. Epoxide hydrolase can regioselectively catalyze the oxirane ring-opening hydrolysis of rac-epoxides producing the corresponding chiral diols. In our laboratory, a gene named pveh1 encoding an EH from Phaseolus vu...

    Authors: Xun-Cheng Zong, Chuang Li, Yao-Hui Xu, Die Hu, Bo-Chun Hu, Jia Zang and Min-Chen Wu

    Citation: Microbial Cell Factories 2019 18:202

    Content type: Research

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  38. The chemolithoautotrophic β-proteobacterium Ralstonia eutropha H16 (Cupriavidus necator) is one of the most studied model organisms for growth on H2 and CO2. R. eutropha H16 is also a biologically significant bac...

    Authors: Anna Poladyan, Syuzanna Blbulyan, Mayramik Sahakyan, Oliver Lenz and Armen Trchounian

    Citation: Microbial Cell Factories 2019 18:201

    Content type: Research

    Published on:

  39. The global rise in urbanization and industrial activity has led to the production and incorporation of foreign contaminant molecules into ecosystems, distorting them and impacting human and animal health. Phys...

    Authors: Leticia Arregui, Marcela Ayala, Ximena Gómez-Gil, Guadalupe Gutiérrez-Soto, Carlos Eduardo Hernández-Luna, Mayra Herrera de los Santos, Laura Levin, Arturo Rojo-Domínguez, Daniel Romero-Martínez, Mario C. N. Saparrat, Mauricio A. Trujillo-Roldán and Norma A. Valdez-Cruz

    Citation: Microbial Cell Factories 2019 18:200

    Content type: Review

    Published on:

  40. Oleaginous yeasts are able to accumulate very high levels of neutral lipids especially under condition of excess of carbon and nitrogen limitation (medium with high C/N ratio). This makes necessary the use of ...

    Authors: Silvia Donzella, Daniela Cucchetti, Claudia Capusoni, Aurora Rizzi, Silvia Galafassi, Gambaro Chiara and Concetta Compagno

    Citation: Microbial Cell Factories 2019 18:199

    Content type: Research

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  41. After 2.83% genome reduction in Lactococcus lactis NZ9000, a good candidate host for proteins production was obtained in our previous work. However, the gene deletion process was time consuming and laborious. Her...

    Authors: Fulu Liu, Yating Zhang, Wanjin Qiao, Duolong Zhu, Haijin Xu, Per Erik Joakim Saris and Mingqiang Qiao

    Citation: Microbial Cell Factories 2019 18:198

    Content type: Research

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  42. Heterologous production of cold-adapted proteins currently represents one of the greatest bottlenecks in the ongoing bioprospecting efforts to find new enzymes from low-temperature environments, such as, the p...

    Authors: Jenny Johansson Söderberg, Miriam Grgic, Erik Hjerde and Peik Haugen

    Citation: Microbial Cell Factories 2019 18:197

    Content type: Research

    Published on:

  43. The thermostable serine protease pernisine originates from the hyperthermophilic Archaeaon Aeropyrum pernix and has valuable industrial applications. Due to its properties, A. pernix cannot be cultivated in stand...

    Authors: Marko Šnajder, Andrés Felipe Carrillo Rincón, Vasilka Magdevska, Miha Bahun, Luka Kranjc, Maja Paš, Polona Juntes, Hrvoje Petković and Nataša Poklar Ulrih

    Citation: Microbial Cell Factories 2019 18:196

    Content type: Research

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  44. The biological synthesis of high value compounds in industry through metabolically engineered microorganism factories has received increasing attention in recent years. Valencene is a high value ingredient in ...

    Authors: Hefeng Chen, Chaoyi Zhu, Muzi Zhu, Jinghui Xiong, Hao Ma, Min Zhuo and Shuang Li

    Citation: Microbial Cell Factories 2019 18:195

    Content type: Research

    Published on:

  45. 5′-Aminolevulinic acid (ALA) is widely used in the pharmaceutical industry, healthcare, and food production, and is a substrate for the biosynthesis of heme, which is required for respiration and photosynthesi...

    Authors: Kiyotaka Y. Hara, Masaru Saito, Hiroko Kato, Kana Morikawa, Hiroshi Kikukawa, Hironari Nomura, Takanori Fujimoto, Yoko Hirono-Hara, Shigeyuki Watanabe, Kengo Kanamaru and Akihiko Kondo

    Citation: Microbial Cell Factories 2019 18:194

    Content type: Research

    Published on:

  46. Biomass contains cellulose (C6-sugars), hemicellulose (C5-sugars) and lignin. Biomass ranks amongst the most abundant hydrocarbon resources on earth. However, biomass is recalcitrant to enzymatic digestion by ...

    Authors: Patrick Ballmann, Jorge Lightfoot, Michael Müller, Stephan Dröge and Rolf Prade

    Citation: Microbial Cell Factories 2019 18:193

    Content type: Research

    Published on:

  47. Terpenoids are of high interest as chemical building blocks and pharmaceuticals. In microbes, terpenoids can be synthesized via the methylerythritol phosphate (MEP) or mevalonate (MVA) pathways. Although the M...

    Authors: Daniel Christoph Volke, Johann Rohwer, Rainer Fischer and Stefan Jennewein

    Citation: Microbial Cell Factories 2019 18:192

    Content type: Research

    Published on:

  48. The focus of this study is online estimation of biomass concentration in fed-batch cultures. It describes a bioengineering software solution, which is explored for Escherichia coli and Saccharomyces cerevisiae fe...

    Authors: Renaldas Urniezius, Arnas Survyla, Dziugas Paulauskas, Vladas Algirdas Bumelis and Vytautas Galvanauskas

    Citation: Microbial Cell Factories 2019 18:190

    Content type: Research

    Published on:

  49. Oxygen-evolving photoautotrophic organisms, like cyanobacteria, protect their photosynthetic machinery by a number of regulatory mechanisms, including alternative electron transfer pathways. Despite the import...

    Authors: Kati Thiel, Pekka Patrikainen, Csaba Nagy, Duncan Fitzpatrick, Nicolas Pope, Eva-Mari Aro and Pauli Kallio

    Citation: Microbial Cell Factories 2019 18:189

    Content type: Research

    Published on:

  50. Probiotic bacteria can provide health benefits when delivered in functional foods. This study involved isolation of lactic acid bacteria (LAB) from traditionally dried and salted anchovy fish and characterizat...

    Authors: Nadia S. AlKalbani, Mark S. Turner and Mutamed M. Ayyash

    Citation: Microbial Cell Factories 2019 18:188

    Content type: Research

    Published on:

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