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  1. Content type: Research

    Metabolic models are indispensable in guiding cellular engineering and in advancing our understanding of systems biology. As not all enzymatic activities are fully known and/or annotated, metabolic models rema...

    Authors: Sara A. Amin, Elizabeth Chavez, Vladimir Porokhin, Nikhil U. Nair and Soha Hassoun

    Citation: Microbial Cell Factories 2019 18:109

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  2. Content type: Research

    In lactic acid bacteria (LAB), acid stress leads to decreases of cell vitality and fermentation yield. Glutamate decarboxylase (GAD) system is regarded as one of the essential acid-resistance mechanisms in LAB...

    Authors: Luchan Gong, Cong Ren and Yan Xu

    Citation: Microbial Cell Factories 2019 18:108

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  3. Content type: Research

    Late-stage fermentation broth contains high concentrations of target chemicals. Additionally, it contains various cellular metabolites which have leaked from lysed cells, which would exert multifactorial stres...

    Authors: Xiaowei Wang, Qinggang Li, Cunmin Sun, Zhen Cai, Xiaomei Zheng, Xuan Guo, Xiaomeng Ni, Wenjuan Zhou, Yanmei Guo, Ping Zheng, Ning Chen, Jibin Sun, Yin Li and Yanhe Ma

    Citation: Microbial Cell Factories 2019 18:106

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  4. Content type: RESEARCH

    Geraniol, an acyclic monoterpene alcohol, is found as a primary constituent in the essential oils of plants such as geranium, lemongrass and rose. The floral-like scent of geraniol has made it a popular consti...

    Authors: Micaela G. Chacón, Alice Marriott, Emanuele G. Kendrick, Matthew Q. Styles and David J. Leak

    Citation: Microbial Cell Factories 2019 18:105

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  5. Content type: Research

    Methylocystis parvus is a type II methanotroph characterized by its high specific methane degradation rate (compared to other methanotrophs of the same family) and its ability to accumulate up to 50% of its bioma...

    Authors: Sergio Bordel, Antonia Rojas and Raúl Muñoz

    Citation: Microbial Cell Factories 2019 18:104

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  6. Content type: Research

    Pseudorabies caused by pseudorabies virus (PRV) mainly infects the swine and seriously threatens the biosafety of the other animals, including humans. Since 2011, the outbreaks of PRV mutants have caused enorm...

    Authors: Jialu Wang, Yongheng Wang, En Zhang, Mengyun Zhou, Jian Lin and Qian Yang

    Citation: Microbial Cell Factories 2019 18:103

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  7. Content type: Research

    The global prevalence of traditional Chinese medicine stimulates the prosperous development of herb medicines, but the annual generation of massive herb residues becomes big issues about environmental pollutio...

    Authors: Wenping Kong, Chengshuang Huang, Jie Shi, Yu Li, Xinxin Jiang, Quwen Duan, Yong Huang, Yanwen Duan and Xiangcheng Zhu

    Citation: Microbial Cell Factories 2019 18:102

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  8. Content type: Research

    Many fermented foods and beverages are produced through the action of complex microbial communities. Synthetic biology approaches offer the ability to genetically engineer these communities to improve the prop...

    Authors: Rachatida Det-udom, Charlie Gilbert, Long Liu, Cheunjit Prakitchaiwattana, Tom Ellis and Rodrigo Ledesma-Amaro

    Citation: Microbial Cell Factories 2019 18:101

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  9. Content type: Research

    Bacillus subtilis spores have been commonly used for the surface display of various food-related or human antigens or enzymes. For successful display, the target protein needs to be fused with an anchor protein. ...

    Authors: Hongling Liu, Shaojie Yang, Xihui Wang and Tengfei Wang

    Citation: Microbial Cell Factories 2019 18:100

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  10. Content type: Research

    The oleaginous yeast Yarrowia lipolytica is an organism of choice for the tailored production of various compounds such as biofuels or biopolymers. When properly engineered, it is capable of producing medium-chai...

    Authors: Coraline Rigouin, Sophie Lajus, Connie Ocando, Vinciane Borsenberger, Jean Marc Nicaud, Alain Marty, Luc Avérous and Florence Bordes

    Citation: Microbial Cell Factories 2019 18:99

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  11. Content type: Research

    Farnesol is an acyclic sesquiterpene alcohol present in the essential oils of various plants in nature. It has been reported to be valuable in medical applications, such as alleviation of allergic asthma, glio...

    Authors: Xueduan Chen, Xianzhang Jiang, Man Xu, Mingliang Zhang, Runye Huang, Jianzhong Huang and Feng Qi

    Citation: Microbial Cell Factories 2019 18:98

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  12. Content type: Research

    Transglycosylation represents one of the most promising approaches for obtaining novel glycosides, and plant phenols and polyphenols are emerging as one of the best targets for creating new molecules with enha...

    Authors: Juan Antonio Méndez-Líter, Isabel Tundidor, Manuel Nieto-Domínguez, Beatriz Fernández de Toro, Andrés González Santana, Laura Isabel de Eugenio, Alicia Prieto, Juan Luis Asensio, Francisco Javier Cañada, Cristina Sánchez and María Jesús Martínez

    Citation: Microbial Cell Factories 2019 18:97

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  13. Content type: Research

    Promoter evolution by synthetic promoter library (SPL) is a powerful approach to development of functional synthetic promoters to synthetic biology. However, it requires much tedious and time-consuming screeni...

    Authors: Laichuang Han, Wenjing Cui, Feiya Suo, Shengnan Miao, Wenliang Hao, Qiaoqing Chen, Junling Guo, Zhongmei Liu, Li Zhou and Zhemin Zhou

    Citation: Microbial Cell Factories 2019 18:96

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  14. Content type: Research

    Glycyrrhetinic acid (GA) is the most important ingredient in licorice due to its outstanding anti-inflammatory activity and wide application in the medicine and cosmetics industries. Contemporary industrial pr...

    Authors: Caixia Wang, Xinyao Su, Mengchu Sun, Mengting Zhang, Jiajia Wu, Jianmin Xing, Ying Wang, Jianping Xue, Xia Liu, Wei Sun and Shilin Chen

    Citation: Microbial Cell Factories 2019 18:95

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  15. Content type: Research

    Flavone C-glycosides are difficult to be deglycosylated using traditional chemical methods due to their solid carbon–carbon bond between sugar moieties and aglycones; however, some bacteria may easily cleave this...

    Authors: Shiqi Zheng, Di Geng, Shuangyue Liu, Qingqing Wang, Siqi Liu and Rufeng Wang

    Citation: Microbial Cell Factories 2019 18:94

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  16. Content type: Research

    Polyhydroxyalkanoates (PHAs) have attracted much attention in recent years as natural alternatives to petroleum-based synthetic polymers that can be broadly used in many applications. Pseudomonas putida KT2440 is...

    Authors: Justyna Możejko-Ciesielska and Agnieszka Mostek

    Citation: Microbial Cell Factories 2019 18:93

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  17. Content type: Research

    The carboxylate platform is a promising technology for substituting petrochemicals in the provision of specific platform chemicals and liquid fuels. It includes the chain elongation process that exploits rever...

    Authors: Johannes Lambrecht, Nicolas Cichocki, Florian Schattenberg, Sabine Kleinsteuber, Hauke Harms, Susann Müller and Heike Sträuber

    Citation: Microbial Cell Factories 2019 18:92

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  18. Content type: Research

    Surfactin is a cyclic lipopeptide that is of great industrial use owing to its extraordinary surfactant power and antimicrobial, antiviral, and antitumor activities. Surfactin is synthesized by a condensation ...

    Authors: Congya Wang, Yingxiu Cao, Yongping Wang, Liming Sun and Hao Song

    Citation: Microbial Cell Factories 2019 18:90

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  19. Content type: RESEARCH

    Studies carried out with novel 13 strains of Trichoderma, isolated from mangrove sediments (PE, Brazil) using morphophysiological and molecular characterization, followed evaluation of biocontrol using Fusarium s...

    Authors: Patrícia Rego Barros Filizola, Marcos Antônio Cavalcanti Luna, Adriana Ferreira de Souza, Iwanne Lima Coelho, Delson Laranjeira and Galba Maria Campos-Takaki

    Citation: Microbial Cell Factories 2019 18:89

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  20. Content type: Research

    There have been many successful strategies to implement xylose metabolism in Saccharomyces cerevisiae, but no effort has so far enabled xylose utilization at rates comparable to that of glucose (the preferred sug...

    Authors: Karen O. Osiro, Celina Borgström, Daniel P. Brink, Birta Líf Fjölnisdóttir and Marie F. Gorwa-Grauslund

    Citation: Microbial Cell Factories 2019 18:88

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  21. Content type: Research

    Saccharomyces cerevisiae AN120 osw2∆ spores were used as a host with good resistance to unfavorable environment. This work was undertaken to develop a new yeast spore-encapsulation of Candida parapsilosis Glu228S...

    Authors: Jingxin Rao, Rongzhen Zhang, Hongbo Liang, Xiao-Dong Gao, Hideki Nakanishi and Yan Xu

    Citation: Microbial Cell Factories 2019 18:87

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  22. Content type: Research

    The use of chemical herbicides has helped to improve agricultural production, although its intensive use has led to environmental damages. Plant allelochemicals are interesting alternatives due to their divers...

    Authors: Maria Elena de la Calle, Gema Cabrera, Domingo Cantero, Antonio Valle and Jorge Bolivar

    Citation: Microbial Cell Factories 2019 18:86

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  23. Content type: Research

    Cell surface display of recombinant proteins has become a powerful tool for biotechnology and biomedical applications. As a model eukaryotic microorganism, Saccharomyces cerevisiae is an ideal candidate for surfa...

    Authors: Xiaoyu Yang, Hongting Tang, Meihui Song, Yu Shen, Jin Hou and Xiaoming Bao

    Citation: Microbial Cell Factories 2019 18:85

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  24. Content type: Research

    Chicken feather, a byproduct of poultry-processing industries, are considered a potential high-quality protein supplement owing to their crude protein content of more than 85%. Nonetheless, chicken feathers ha...

    Authors: Zheng Peng, Xinzhe Mao, Juan Zhang, Guocheng Du and Jian Chen

    Citation: Microbial Cell Factories 2019 18:84

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  25. Content type: RESEARCH

    Cellulolytic enzymes produced by the filamentous fungus Trichoderma reesei are commonly used in biomass conversion. The high cost of cellulase is still a significant challenge to commercial biofuel production. Im...

    Authors: Pei Liu, Aibo Lin, Guoxiu Zhang, Jiajia Zhang, Yumeng Chen, Tao Shen, Jian Zhao, Dongzhi Wei and Wei Wang

    Citation: Microbial Cell Factories 2019 18:81

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  26. Content type: RESEARCH

    Bacteria are widely used as hosts for recombinant protein production due to their rapid growth, simple media requirement and ability to produce high yields of correctly folded proteins. Overproduction of recom...

    Authors: Agnieszka Gawin, Karl Peebo, Sebastian Hans, Helga Ertesvåg, Marta Irla, Peter Neubauer and Trygve Brautaset

    Citation: Microbial Cell Factories 2019 18:80

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  27. Content type: RESEARCH

    Styrene is a large-volume commodity petrochemical, which has been used in a wide range of polymer industry as the main building block for the construction of various functional polymers. Despite many efforts t...

    Authors: Kyungsoo Lee, Hyun Bae Bang, Yoon Hyeok Lee and Ki Jun Jeong

    Citation: Microbial Cell Factories 2019 18:79

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  28. Content type: RESEARCH

    Production of 2,3-butanediol from renewable resources is a promising measure to decrease the consumption of fossil resources in the chemical industry. One of the most influential parameters on biotechnological...

    Authors: Benedikt Heyman, Robin Lamm, Hannah Tulke, Lars Regestein and Jochen Büchs

    Citation: Microbial Cell Factories 2019 18:78

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  29. Content type: RESEARCH

    Betulinic acid is a pentacyclic lupane-type triterpenoid and a potential antiviral and antitumor drug, but the amount of betulinic acid in plants is low and cannot meet the demand for this compound. Yarrowia lipo...

    Authors: Cong-Cong Jin, Jin-Lai Zhang, Hao Song and Ying-Xiu Cao

    Citation: Microbial Cell Factories 2019 18:77

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  30. Content type: RESEARCH

    Lactic acid bacteria (LAB) are important microorganisms in the food and beverage industry. Due to their food-grade status and probiotic characteristics, several LAB are considered as safe and effective cell-fa...

    Authors: Hoang-Minh Nguyen, Mai-Lan Pham, Elena Maria Stelzer, Esther Plattner, Reingard Grabherr, Geir Mathiesen, Clemens K. Peterbauer, Dietmar Haltrich and Thu-Ha Nguyen

    Citation: Microbial Cell Factories 2019 18:76

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  31. Content type: RESEARCH

    Thermostable enzymes have several advantages over their mesophilic counterparts for industrial applications. However, trade-offs such as thermal instability of enzyme substrates or co-factors exist. Nicotinami...

    Authors: Hironori Taniguchi, Makoto Imura, Kenji Okano and Kohsuke Honda

    Citation: Microbial Cell Factories 2019 18:75

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  32. Content type: RESEARCH

    Production of l-tyrosine is gaining grounds as the market size of 3,4-dihydroxyphenyl-l-alanine (l-DOPA) is expected to increase due to increasing cases of Parkinson’s disease a neurodegenerative disease. Attempt...

    Authors: Eric Fordjour, Frederick Komla Adipah, Shenghu Zhou, Guocheng Du and Jingwen Zhou

    Citation: Microbial Cell Factories 2019 18:74

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  33. Content type: RESEARCH

    Diterpenoids are a large class of natural products with complex structures and broad commercial applications as food additives, important medicines, and fragrances. However, their low abundance in plants and h...

    Authors: Chuanbo Zhang, Haiyan Ju, Chun-Zhe Lu, Fanglong Zhao, Jingjing Liu, Xiaoyan Guo, Yufen Wu, Guang-Rong Zhao and Wenyu Lu

    Citation: Microbial Cell Factories 2019 18:73

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  34. Content type: RESEARCH

    In terms of protein production, the internal environment of the host influences the activity of expression elements, thus affecting the expression level of the target protein. Native expression elements from a...

    Authors: Wei Zhang, Yankun Yang, Xiuxia Liu, Chunli Liu and Zhonghu Bai

    Citation: Microbial Cell Factories 2019 18:72

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  35. Content type: RESEARCH

    In the last years, different biotechnologically relevant microorganisms have been engineered for the synthesis of plant polyphenols such as flavonoids and stilbenes. However, low intracellular availability of ...

    Authors: Lars Milke, Nicolai Kallscheuer, Jannick Kappelmann and Jan Marienhagen

    Citation: Microbial Cell Factories 2019 18:71

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  36. Content type: RESEARCH

    Bacterial surface display systems were developed to surface expose heterologous proteins or peptides for different applications, such as peptide libraries screening and live bacterial vaccine design. Various o...

    Authors: Tingting Chen, Kaihang Wang, Xin Chi, Lizhi Zhou, Jiajia Li, Liqin Liu, Qingbing Zheng, Yingbin Wang, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li and Ningshao Xia

    Citation: Microbial Cell Factories 2019 18:70

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  37. Content type: RESEARCH

    Our laboratory has constructed a Bacillus stearothermophilus α-amylase (AmyS) derivative with excellent enzymatic properties. Bacillus subtilis is generally regarded as safe and has excellent protein secretory ca...

    Authors: Dongbang Yao, Lingqia Su, Na Li and Jing Wu

    Citation: Microbial Cell Factories 2019 18:69

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  38. Content type: RESEARCH

    Iturins, which belong to antibiotic cyclic lipopeptides mainly produced by Bacillus sp., have the potential for application in biomedicine and biocontrol because of their hemolytic and antifungal properties. Baci...

    Authors: Yulei Dang, Fengjie Zhao, Xiangsheng Liu, Xu Fan, Rui Huang, Weixia Gao, Shufang Wang and Chao Yang

    Citation: Microbial Cell Factories 2019 18:68

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  39. Content type: RESEARCH

    O-Methylated phenylpropanoids, which are generally present in small amounts in plants, have improved or distinct biological activities and pharmacological properties as opposed to their unmethylated counterpart.....

    Authors: Heqing Cui, Myoung Chong Song, Yeon Hee Ban, Soo Youn Jun, An Sung Kwon, Ji Young Lee and Yeo Joon Yoon

    Citation: Microbial Cell Factories 2019 18:67

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  40. Content type: RESEARCH

    Oral vaccine is highly desired for infectious disease which is caused by pathogens infection through the mucosal surface. The design of suitable vaccine delivery system is ongoing for the antigen protection fr...

    Authors: Xingmei Qi, Qian Lu, JingPing Hu and Sidong Xiong

    Citation: Microbial Cell Factories 2019 18:66

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  41. Content type: RESEARCH

    NAD(H/+) and NADP(H/+) are the most important redox cofactors in bacteria. However, the intracellular redox balance is in advantage of the cell growth and production of NAD(P)H-dependent products.

    Authors: Jian-Zhong Xu, Hao-Zhe Ruan, Xiu-Lai Chen, Feng Zhang and Weiguo Zhang

    Citation: Microbial Cell Factories 2019 18:65

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  42. Content type: RESEARCH

    Dihomo-gamma linolenic acid (DGLA, 20:3, n-6) is the elongated product of Gamma linolenic acid (GLA, 18:3, n-6) catalyzed by the enzyme delta-6 elongase (D6E) or gamma linolenic acid elongase (GLELO). Construc...

    Authors: Md. Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Li Liang, Victoriano Garre and Yuanda Song

    Citation: Microbial Cell Factories 2019 18:64

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  43. Content type: RESEARCH

    Lactones are highly valuable cyclic esters of hydroxy fatty acids that find application as pure fragrances or as building blocks of speciality chemicals. While chemical synthesis often leads to undesired racem...

    Authors: Rui Silva, Tatiana Q. Aguiar, Eduardo Coelho, Alberto Jiménez, José Luis Revuelta and Lucília Domingues

    Citation: Microbial Cell Factories 2019 18:62

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  44. Content type: Review

    Nature has evolved exquisite sensing mechanisms to detect cellular and environmental signals surrounding living organisms. These biosensors have been widely used to sense small molecules, detect environmental ...

    Authors: Xia Wan, Monireh Marsafari and Peng Xu

    Citation: Microbial Cell Factories 2019 18:61

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  45. Content type: RESEARCH

    A novel d-allulose 3-epimerase from Staphylococcus aureus (SaDAE) has been screened as a d-allulose 3-epimerase family enzyme based on its high specificity for d-allulose. It usually converts both d-fructose and

    Authors: Zhangliang Zhu, Dengke Gao, Chao Li, Ying Chen, Menglu Zhu, Xin Liu, Masaru Tanokura, Hui-Min Qin and Fuping Lu

    Citation: Microbial Cell Factories 2019 18:59

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