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  1. Anthraquinone-fused enediynes (AFEs) are excellent payloads for antibody-drug conjugates (ADCs). The yields of AFEs in the original bacterial hosts are extremely low. Multiple traditional methods had been adop...

    Authors: Zhoukang Zhuang, Wenping Kong, Zhongqing Wen, Nian Tong, Jing Lin, Fan Zhang, Zhiying Fan, Liwei Yi, Yong Huang, Yanwen Duan, Xiaohui Yan and Xiangcheng Zhu
    Citation: Microbial Cell Factories 2024 23:128
  2. Methane is a greenhouse gas with a significant potential to contribute to global warming. The biological conversion of methane to ectoine using methanotrophs represents an environmentally and economically bene...

    Authors: Sang Eun Lim, Sukhyeong Cho, Yejin Choi, Jeong-Geol Na and Jinwon Lee
    Citation: Microbial Cell Factories 2024 23:127
  3. Hydrocarbon pollution stemming from petrochemical activities is a significant global environmental concern. Bioremediation, employing microbial chitinase-based bioproducts to detoxify or remove contaminants, p...

    Authors: Shaimaa A. Nour, Maha T. H. Emam, Ghada M. El-Sayed and Ebtehag A. E. Sakr
    Citation: Microbial Cell Factories 2024 23:126
  4. The facultatively anaerobic thermophile Parageobacillus thermoglucosidasius is able to produce hydrogen gas (H2) through the water–gas shift (WGS) reaction. To date this process has been evaluated under controlle...

    Authors: Michael Mol, Magda Stephania Ardila, Bronwyn Ashleigh Mol, Habibu Aliyu, Anke Neumann and Pieter de Maayer
    Citation: Microbial Cell Factories 2024 23:125
  5. Having a simple and fast dividing organism capable of producing and exposing at its surface or secreting functional complex biomolecules with disulphide bridges is of great interest. The mycoplasma bacterial g...

    Authors: Javier Gonzalez-de-Miguel, Ariadna Montero-Blay, Ludovica Ciampi, Irene Rodriguez-Arce and Luis Serrano
    Citation: Microbial Cell Factories 2024 23:124
  6. Industrial biomanufacturing of value-added products using CO2 as a carbon source is considered more sustainable, cost-effective and resource-efficient than using common carbohydrate feedstocks. Cupriavidus necato...

    Authors: Yongjae Jang, Yeon Ji Lee, Gyeongtaek Gong, Sun-Mi Lee, Youngsoon Um, Kyoung Heon Kim and Ja Kyong Ko
    Citation: Microbial Cell Factories 2024 23:122
  7. The conversion of plant biomass into biochemicals is a promising way to alleviate energy shortage, which depends on efficient microbial saccharification and cellular metabolism. Trichoderma spp. have plentiful CA...

    Authors: Yang Liu, Tuo Li, Han Zhu, Linhua Cao, Lebin Liang, Dongyang Liu and Qirong Shen
    Citation: Microbial Cell Factories 2024 23:120
  8. Clostridium spp. has demonstrated therapeutic potential in cancer treatment through intravenous or intratumoral administration. This approach has expanded to include non-pathogenic clostridia for the treatment of...

    Authors: Yanchao Zhang, Tom S. Bailey, Philip Hittmeyer, Ludwig J. Dubois, Jan Theys and Philippe Lambin
    Citation: Microbial Cell Factories 2024 23:119
  9. Excessive alcohol consumption has been consistently linked to serious adverse health effects, particularly affecting the liver. One natural defense against the detrimental impacts of alcohol is provided by alc...

    Authors: Sini Kang, Jing Long, Myeong Soo Park, Geun Eog Ji, Ying Ju and Seockmo Ku
    Citation: Microbial Cell Factories 2024 23:118
  10. Several antiviral agents lost their efficacy due to their severe side effects and virus mutations. This study aimed to identify and optimize the conditions for exopolysaccharide (EPS) production from a newly i...

    Authors: Mabroka H. Saad, Nagwa M. Sidkey and Esmail M. El-Fakharany
    Citation: Microbial Cell Factories 2024 23:117
  11. Most recombinant Komagataella phaffii (Pichia pastoris) strains for protein production are generated by genomic integration of expression cassettes. The clonal variability in gene copy numbers, integration loci a...

    Authors: Florian Weiss, Guillermo Requena-Moreno, Carsten Pichler, Francisco Valero, Anton Glieder and Xavier Garcia-Ortega
    Citation: Microbial Cell Factories 2024 23:116
  12. The process of producing proteins in bacterial systems and secreting them through ATP-binding cassette (ABC) transporters is an area that has been actively researched and used due to its high protein productio...

    Authors: Yerin Kim, Danny Kim, Nguyen-Mihn Hieu, Hyunjong Byun and Jung Hoon Ahn
    Citation: Microbial Cell Factories 2024 23:115
  13. Isoquercitrin (quercetin-3-O-β-D-glucopyranoside) has exhibited promising therapeutic potentials as cardioprotective, anti-diabetic, anti-cancer, and anti-viral agents. However, its structural complexity and l...

    Authors: Tengfei Niu, Chaokang Huang, Rufeng Wang, Li Yang, Shujuan Zhao and Zhengtao Wang
    Citation: Microbial Cell Factories 2024 23:114
  14. Isatropolone A and C, produced by Streptomyces sp. CPCC 204095, belong to an unusual class of non-benzenoid aromatic compounds and contain a rare seven-membered ring structure. Isatropolone A exhibits potent acti...

    Authors: Cong Zhang, Qianqian Xu, Jie Fu, Linzhuan Wu, Yihong Li, Yuan Lu, Yuanyuan Shi, Hongmin Sun, Xingxing Li, Lifei Wang and Bin Hong
    Citation: Microbial Cell Factories 2024 23:113
  15. Filamentous fungi have long been recognized for their exceptional enzyme production capabilities. Among these, Trichoderma reesei has emerged as a key producer of various industrially relevant enzymes and is part...

    Authors: Katja Rohr, Lisa Gremm, Bertram Geinitz, Etienne Jourdier, Wolfgang Wiechert, Fadhel Ben Chaabane and Marco Oldiges
    Citation: Microbial Cell Factories 2024 23:112
  16. Ascomycetous budding yeasts are ubiquitous environmental microorganisms important in food production and medicine. Due to recent intensive genomic research, the taxonomy of yeast is becoming more organized bas...

    Authors: Damian Mielecki, Anna Detman, Tamara Aleksandrzak-Piekarczyk, Małgorzata Widomska, Aleksandra Chojnacka, Anna Stachurska-Skrodzka, Paulina Walczak, Elżbieta Grzesiuk and Anna Sikora
    Citation: Microbial Cell Factories 2024 23:111
  17. The wasabi receptor, also known as the Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel, is a potential target for development of repellents for insects, like the pine weevil (Hylobius abietis) feeding ...

    Authors: Balder Werin, Wilhelm Hansson Wennersten, Robin Olsson, Oliwia Kołodziejczyk, Martin N. Andersson, Magnus Carlquist and Urban Johanson
    Citation: Microbial Cell Factories 2024 23:110
  18. Cellulase is considered a group member of the hydrolytic enzymes, responsible for catalyzing the hydrolysis of cellulose and has various industrial applications. Agricultural wastes are used as an inexpensive ...

    Authors: Mohamed A.A. Abdella, Nehad E. Ahmed and Mohamed S. Hasanin
    Citation: Microbial Cell Factories 2024 23:109
  19. Microbial cell surface display technology allows immobilizing proteins on the cell surface by fusing them to anchoring motifs, thereby endowing the cells with diverse functionalities. However, the assessment o...

    Authors: Li Zhang, Ling Tan, Meizi Liu, Yunhong Chen, Yu Yang, Yanfei Zhang and Guoping Zhao
    Citation: Microbial Cell Factories 2024 23:108
  20. Cryptococcus neoformans has been designated as critical fungal pathogens by the World Health Organization, mainly due to limited treatment options and the prevalence of antifungal resistance. Consequently, the ut...

    Authors: Weidong Qian, Jiaxing Lu, Chang Gao, Qiming Liu, Yongdong Li, Qiao Zeng, Jian Zhang, Ting Wang and Si Chen
    Citation: Microbial Cell Factories 2024 23:107
  21. The textile industry has several negative impacts, mainly because it is based on a linear business model that depletes natural resources and produces excessive amounts of waste. Globally, about 75% of textile ...

    Authors: Marta Simonetti, Pietro Butti, Raffaella Desiré Di Lorenzo, Valeria Mapelli and Paola Branduardi
    Citation: Microbial Cell Factories 2024 23:106
  22. Pregnenolone and progesterone are the life-important steroid hormones regulating essential vital functions in mammals, and widely used in different fields of medicine. Microbiological production of these compo...

    Authors: Mikhail Karpov, Nicolai Strizhov, Ludmila Novikova, Tatyana Lobastova, Sergey Khomutov, Andrei Shutov, Alexey Kazantsev and Marina Donova
    Citation: Microbial Cell Factories 2024 23:105
  23. Single-cell droplet microfluidics is an important platform for high-throughput analyses and screening because it provides an independent and compartmentalized microenvironment for reaction or cultivation by co...

    Authors: Ririka Asama, Cher J. S. Liu, Masahiro Tominaga, Yu-Ru Cheng, Yasuyuki Nakamura, Akihiko Kondo, Hsiang-Yu Wang and Jun Ishii
    Citation: Microbial Cell Factories 2024 23:104
  24. The macrolide antibiotic avermectin, a natural product derived from Streptomyces avermitilis, finds extensive applications in agriculture, animal husbandry and medicine. The mtrA (sav_5063) gene functions as a tr...

    Authors: Jinpin Tian, Yue Li, Chuanbo Zhang, Jianyu Su and Wenyu Lu
    Citation: Microbial Cell Factories 2024 23:103
  25. Poultry feather waste has a potential for bioenergy production because of its high protein content. This research explored the use of chicken feather hydrolysate for methane and hydrogen production via anaerob...

    Authors: Dina Hassan El Salamony, Mohamed Salah Eldin Hassouna, Taha Ibrahim Zaghloul, Zhen He and Hanan Moustafa Abdallah
    Citation: Microbial Cell Factories 2024 23:102
  26. Short-chain fatty acids (SCFAs) are cost-effective carbon sources for an affordable production of lipids. Hexanoic acid, the acid with the longest carbon chain in the SCFAs pool, is produced in anaerobic ferme...

    Authors: Sergio Morales-Palomo, Clara Navarrete, José Luis Martínez, Cristina González-Fernández and Elia Tomás-Pejó
    Citation: Microbial Cell Factories 2024 23:101
  27. Surfactin is a cyclic hexalipopeptide compound, nonribosomal synthesized by representatives of the Bacillus subtilis species complex which includes B. subtilis group and its closely related species, such as B. su...

    Authors: Junqing Qiao, Rainer Borriss, Kai Sun, Rongsheng Zhang, Xijun Chen, Youzhou Liu and Yongfeng Liu
    Citation: Microbial Cell Factories 2024 23:100
  28. The yeast Komagataella phaffii has become a very popular host for heterologous protein expression, very often based on the use of the AOX1 promoter, which becomes activated when cells are grown with methanol as a...

    Authors: Marcel Albacar, Antonio Casamayor and Joaquín Ariño
    Citation: Microbial Cell Factories 2024 23:99
  29. Bacteria of the genus Photorhabdus and Xenorhabdus are motile, Gram-negative bacteria that live in symbiosis with entomopathogenic nematodes. Due to their complex life cycle, they produce a large number of specia...

    Authors: Alexander Rill, Lei Zhao and Helge B. Bode
    Citation: Microbial Cell Factories 2024 23:98
  30. Biotransformation of waste oil into value-added nutraceuticals provides a sustainable strategy. Thraustochytrids are heterotrophic marine protists and promising producers of omega (ω) fatty acids. Although the...

    Authors: Iqra Mariam, Eleni Krikigianni, Chloe Rantzos, Maurizio Bettiga, Paul Christakopoulos, Ulrika Rova, Leonidas Matsakas and Alok Patel
    Citation: Microbial Cell Factories 2024 23:97
  31. Engineering bacterial strains to redirect the metabolism towards the production of a specific product has enabled the development of industrial biotechnology. However, rewiring the metabolism can have severe i...

    Authors: Sofie Snoeck, Chiara Guidi and Marjan De Mey
    Citation: Microbial Cell Factories 2024 23:96
  32. Surfactin, a green lipopeptide bio-surfactant, exhibits excellent surface, hemolytic, antibacterial, and emulsifying activities. However, a lack of clear understanding of the synthesis regulation mechanism of ...

    Authors: Yumeng Su, Ling Gao, Chenyu Li, Liang Wang, Huimin Zhou, Chenhao Zhang and Xiaole Xia
    Citation: Microbial Cell Factories 2024 23:94
  33. Fungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium, one of the most common filamentous fungi, is well-known for its biosynthetic potential of NR...

    Authors: Ziwei Huang, Wangjie Zhu, Yifan Bai, Xuelian Bai and Huawei Zhang
    Citation: Microbial Cell Factories 2024 23:93
  34. Propionic acid fermentation from renewable feedstock suffers from low volumetric productivity and final product concentration, which limits the industrial feasibility of the microbial route. High cell density ...

    Authors: Tarek Dishisha, Mridul Jain and Rajni Hatti-Kaul
    Citation: Microbial Cell Factories 2024 23:91
  35. Cellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral...

    Authors: Khursheed Muzammil, Mohammad Hosseini Hooshiar, Shirin Varmazyar, Thabit Moath Omar, Manal Morad Karim, Sadeq Aadi, Shaylan Kalavi and Saman Yasamineh
    Citation: Microbial Cell Factories 2024 23:90
  36. Staphylococcus aureus and its single or mixed biofilm infections seriously threaten global public health. Phage therapy, which uses active phage particles or phage-derived endolysins, has emerged as a promising a...

    Authors: He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu and Xiancai Rao
    Citation: Microbial Cell Factories 2024 23:89
  37. The halophilic bacterium Halomonas elongata is an industrially important strain for ectoine production, with high value and intense research focus. While existing studies primarily delve into the adaptive mechani...

    Authors: Junxiong Yu, Yue Zhang, Hao Liu, Yuxuan Liu, Ali Mohsin, Zebo Liu, Yanning Zheng, Jianmin Xing, Jing Han, Yingping Zhuang, Meijin Guo and Zejian Wang
    Citation: Microbial Cell Factories 2024 23:88
  38. Natural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of bioactivities. Biosynthesis of tetramates in microorganisms is normally di...

    Authors: Haixia Zang, Yijia Cheng, Mengjia Li, Lin Zhou, Li-Li Hong, Hai Deng, Hou-Wen Lin and Yongjun Zhou
    Citation: Microbial Cell Factories 2024 23:87
  39. Escherichia coli is one of the most commonly used host organisms for the production of biopharmaceuticals, as it allows for cost-efficient and fast recombinant protein expression. However, challenging proteins ar...

    Authors: Christoph Köppl, Wolfgang Buchinger, Gerald Striedner and Monika Cserjan-Puschmann
    Citation: Microbial Cell Factories 2024 23:86
  40. The abundance of glucuronoxylan (GX) in agricultural and forestry residual side streams positions it as a promising feedstock for microbial conversion into valuable compounds. By engineering strains of the wid...

    Authors: Jonas L. Ravn, João H.C. Manfrão-Netto, Jana B. Schaubeder, Luca Torello Pianale, Stefan Spirk, Iván F. Ciklic and Cecilia Geijer
    Citation: Microbial Cell Factories 2024 23:85
  41. Extreme halophilic archaea that can live in high saline environments can offer potential applications in different biotechnological fields. This study delves into the fascinating field of halophilic archaea an...

    Authors: Basma T. Alghamrawy, Ghada E. Hegazy, Soraya A. Sabry and Hanan Ghozlan
    Citation: Microbial Cell Factories 2024 23:84
  42. Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the most abundant soluble protein in nature. Extensive studies have been conducted for improving its activity in photosynthesis through approaches l...

    Authors: Muhammad Faisal, Aditya P. Sarnaik, Nandini Kannoju, Nima Hajinajaf, Muhammad Javaid Asad, Ryan W. Davis and Arul M. Varman
    Citation: Microbial Cell Factories 2024 23:83
  43. Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, posing a serious public health challenge that necessitates the development of new therapeutics, therapies, and prevention methods. Among t...

    Authors: Rafał Jastrząb, Rafał Tomecki, Aneta Jurkiewicz, Damian Graczyk, Agnieszka K. Szczepankowska, Jennifer Mytych, Damian Wolman and Pawel Siedlecki
    Citation: Microbial Cell Factories 2024 23:82
  44. One of the leading current trends in technology is the miniaturization of devices to the microscale and nanoscale. The highly advanced approaches are based on biological systems, subjected to bioengineering us...

    Authors: Joanna Żebrowska, Piotr Mucha, Maciej Prusinowski, Daria Krefft, Agnieszka Żylicz-Stachula, Milena Deptuła, Aneta Skoniecka, Agata Tymińska, Małgorzata Zawrzykraj, Jacek Zieliński, Michał Pikuła and Piotr M. Skowron
    Citation: Microbial Cell Factories 2024 23:81
  45. Spathaspora passalidarum is a yeast with the highly effective capability of fermenting several monosaccharides in lignocellulosic hydrolysates, especially xylose. However, this yeast was shown to be sensitive to ...

    Authors: Thanyalak Saengphing, Pachara Sattayawat, Thitisuda Kalawil, Nakarin Suwannarach, Jaturong Kumla, Mamoru Yamada, Watanalai Panbangred and Nadchanok Rodrussamee
    Citation: Microbial Cell Factories 2024 23:80
  46. The current study aimed to evaluate the effects of biogenic silver nanoparticles (AgNPs) on growth behavior and leaf anatomy of in vitro growing shoots of ‘Picual’ and ‘Dolce’ olive cultivars. Biosynthesis of ...

    Authors: Mohamed S. Hasanin, Sayed A.M. Hassan, A. M. AbdAllatif and Osama M. Darwesh
    Citation: Microbial Cell Factories 2024 23:79
  47. The biosynthetic potency of Taxol by fungi raises their prospective to be a platform for commercial production of Taxol, nevertheless, the attenuation of its productivity with the fungal storage, is the challe...

    Authors: Asmaa Gamal, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Ashraf S. A. El-Sayed and Maher M. El-Domiaty
    Citation: Microbial Cell Factories 2024 23:78
  48. Erythritol is a four-carbon polyol with an unclear role in metabolism of some unconventional yeasts. Its production has been linked to the osmotic stress response, but the mechanism of stress protection remain...

    Authors: DA. Rzechonek, M. Szczepańczyk, I. Borodina, C. Neuvéglise and AM. Mirończuk
    Citation: Microbial Cell Factories 2024 23:77

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