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  1. Because of its tractability and straightforward cultivation, the magnetic bacterium Magnetospirillum gryphiswaldense has emerged as a model for the analysis of magnetosome biosynthesis and bioproduction. However,...

    Authors: Theresa Zwiener, Marina Dziuba, Frank Mickoleit, Christian Rückert, Tobias Busche, Jörn Kalinowski, René Uebe and Dirk Schüler

    Citation: Microbial Cell Factories 2021 20:35

    Content type: Research

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  2. Anthranilate is a platform chemical used by the industry in the synthesis of a broad range of high-value products, such as dyes, perfumes and pharmaceutical compounds. Currently anthranilate is produced via ch...

    Authors: Joosu Kuivanen, Matti Kannisto, Dominik Mojzita, Heiko Rischer, Mervi Toivari and Jussi Jäntti

    Citation: Microbial Cell Factories 2021 20:34

    Content type: Research

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  3. The display of recombinant proteins on cell surfaces has a plethora of applications including vaccine development, screening of peptide libraries, whole-cell biocatalysts and biosensor development for diagnost...

    Authors: Sonia Nicchi, Maria Giuliani, Fabiola Giusti, Laura Pancotto, Domenico Maione, Isabel Delany, Cesira L. Galeotti and Cecilia Brettoni

    Citation: Microbial Cell Factories 2021 20:33

    Content type: Research

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  4. Natural glycolysis encounters the decarboxylation of glucose partial oxidation product pyruvate into acetyl-CoA, where one-third of the carbon is lost at CO2. We previously constructed a carbon saving pathway, EP...

    Authors: Ying Li, He Xian, Ya Xu, Yuan Zhu, Zhijie Sun, Qian Wang and Qingsheng Qi

    Citation: Microbial Cell Factories 2021 20:32

    Content type: Research

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  5. Chronic atrophic gastritis (CAG) is well-known related with multiple pathogenic factors and normally therapies comprised by western or Chinese medicines. The present study was designed to identify the bacteria...

    Authors: Minghan Huang, Sihan Li, Youcheng He, Cuili Lin, Yueming Sun, Mingzhu Li, Rong Zheng, Ruoying Xu, Ping Lin and Xiao Ke

    Citation: Microbial Cell Factories 2021 20:31

    Content type: Research

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  6. Protein aggregation is a biological event observed in expression systems in which the recombinant protein is produced under stressful conditions surpassing the homeostasis of the protein quality control system...

    Authors: Jose Vicente Carratalá, Andrés Cisneros, Elijah Hellman, Antonio Villaverde and Neus Ferrer-Miralles

    Citation: Microbial Cell Factories 2021 20:30

    Content type: Research

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  7. Cembranoids are one kind of diterpenoids with multiple biological activities. The tobacco cembratriene-ol (CBT-ol) and cembratriene-diol (CBT-diol) have high anti-insect and anti-fungal activities, which is at...

    Authors: Yu Zhang, Shiquan Bian, Xiaofeng Liu, Ning Fang, Chunkai Wang, Yanhua Liu, Yongmei Du, Michael P. Timko, Zhongfeng Zhang and Hongbo Zhang

    Citation: Microbial Cell Factories 2021 20:29

    Content type: Technical notes

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  8. Norvancomycin has been widely used in clinic to treat against MRSA (Methicillin-resistant Staphylococcus aureus) and MRSE (Methicillin-resistant Staphylococcus epidermidis) infections in China. Amycolatopsis orie...

    Authors: Xingxing Li, Cong Zhang, Ying Zhao, Xuan Lei, Zhibo Jiang, Xuexia Zhang, Zhihui Zheng, Shuyi Si, Lifei Wang and Bin Hong

    Citation: Microbial Cell Factories 2021 20:28

    Content type: Research

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  9. Engine oil used in automobiles is a threat to soil and water due to the recalcitrant properties of its hydrocarbons. It pollutes surrounding environment which affects both flora and fauna. Microbes can degrade...

    Authors: Khem Raj Meena, Rajni Dhiman, Kailash Singh, Sachin Kumar, Abhishek Sharma, Shamsher S. Kanwar, Rittick Mondal, Sandip Das, Octavio L. Franco and Amit Kumar Mandal

    Citation: Microbial Cell Factories 2021 20:26

    Content type: Research

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  10. Alzheimer’s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive...

    Authors: Dana Vigasova, Michal Nemergut, Barbora Liskova and Jiri Damborsky

    Citation: Microbial Cell Factories 2021 20:25

    Content type: Review

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  11. Porcine Parvovirus (PPV) is a Parvovirinae virus that can cause embryonic and fetal loss and death and mummification in affected fetal pigs. Unlike conventional vaccines, virus-like particles (VLPs) inherit the n...

    Authors: Deqiang Yang, Lei Chen, Jinkun Duan, Yao Yu, Jungang Zhou and Hong Lu

    Citation: Microbial Cell Factories 2021 20:24

    Content type: Research

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  12. Lactic acid bacteria can synthesize dextran and oligosaccharides with different functionality, depending on the strain and fermentation conditions. As natural structure-forming agent, dextran has proven useful...

    Authors: Prabin Koirala, Ndegwa Henry Maina, Hanna Nihtilä, Kati Katina and Rossana Coda

    Citation: Microbial Cell Factories 2021 20:23

    Content type: Research

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  13. A considerable challenge in the development of bioprocesses for producing chemicals and fuels has been the high cost of feedstocks relative to oil prices, making it difficult for these processes to compete wit...

    Authors: Aditya Vikram Pandit, Emma Harrison and Radhakrishnan Mahadevan

    Citation: Microbial Cell Factories 2021 20:22

    Content type: Research

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: George Seghal Kiran, Anuj Nishanth Lipton, Sethu Priyadharshini, Kumar Anitha, Lucia Elizabeth Cruz Suárez, Mariadhas Valan Arasu, Ki Choon Choi, Joseph Selvin and Naif Abdullah Al-Dhabi

    Citation: Microbial Cell Factories 2021 20:21

    Content type: Correction

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    The original article was published in Microbial Cell Factories 2014 13:114

  15. Many fungi grow as saprobic organisms and obtain nutrients from a wide range of dead organic materials. Among saprobes, fungal species that grow on wood or in polluted environments have evolved prolific mechan...

    Authors: Michael Dare Asemoloye, Mario Andrea Marchisio, Vijai Kumar Gupta and Lorenzo Pecoraro

    Citation: Microbial Cell Factories 2021 20:20

    Content type: Review

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  16. Eukaryotes use distinct networks of biogenesis factors to synthesize, fold, monitor, traffic, and secrete proteins. During heterologous expression, saturation of any of these networks may bottleneck titer and ...

    Authors: Troy R. Alva, Melanie Riera and Justin W. Chartron

    Citation: Microbial Cell Factories 2021 20:19

    Content type: Research

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  17. To assess the long-term safety and efficacy of monotherapy with a single fresh fecal microbiota transplant (FMT) for recurrent ulcerative colitis (UC).

    Authors: Haiming Fang, Lian Fu, Xuejun Li, Chunxia Lu, Yuan Su, Kangwei Xiong and Lijiu Zhang

    Citation: Microbial Cell Factories 2021 20:18

    Content type: Research

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  18. α,β-Unsaturated aldehydes are widely used in the organic synthesis of fine chemicals for application in products such as flavoring agents, fragrances and pharmaceuticals. In the selective oxidation of α,β-unsa...

    Authors: Yan Qiao, Can Wang, Yin Zeng, Tairan Wang, Jingjing Qiao, Chenze Lu, Zhao Wang and Xiangxian Ying

    Citation: Microbial Cell Factories 2021 20:17

    Content type: Research

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  19. Bifidobacterium spp. are representative probiotics that play an important role in the health of their hosts. Among various Bifidobacterium spp., B. bifidum BGN4 exhibits relatively high cell adhesion to colonic c...

    Authors: Nayoun Hong, Seockmo Ku, Kyungjin Yuk, Tony V. Johnston, Geun Eog Ji and Myeong Soo Park

    Citation: Microbial Cell Factories 2021 20:16

    Content type: Research

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  20. Genetic modification of Rhodococcus jostii RHA1 was carried out in order to optimise the production of pyridine-2,4-dicarboxylic acid and pyridine-2,5-dicarboxylic acid bioproducts from lignin or lignocellulose b...

    Authors: Edward M. Spence, Leonides Calvo-Bado, Paul Mines and Timothy D. H. Bugg

    Citation: Microbial Cell Factories 2021 20:15

    Content type: Research

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  21. Chlorophyllase catalyzes the hydrolysis of chlorophyll and produces chlorophyllide and phytol. Cyanobacterial chlorophyllases are likely to be more highly heterologously expressed than plant chlorophyllases....

    Authors: Sitian Gu, Xiaojun Dai, Zhengjun Xu, Qiwen Niu, Jiang Jiang and Yuanfa Liu

    Citation: Microbial Cell Factories 2021 20:14

    Content type: Research

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  22. The E. coli pET system is the most widely used protein over-expression system worldwide. It relies on the assumption that all cells produce target protein and it is generally believed that integral membrane prote...

    Authors: Jack James, Benjamin Yarnall, Andy Koranteng, Jane Gibson, Tahmina Rahman and Declan A. Doyle

    Citation: Microbial Cell Factories 2021 20:13

    Content type: Research

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  23. Clostridium sp. strain CT7 is a new emerging microbial cell factory with high butanol production ratio owing to its non-traditional butanol fermentation mode with uncoupled acetone and 1,3-propanediol formation....

    Authors: Yujia Jiang, Ruofan Wu, Jiasheng Lu, Weiliang Dong, Jie Zhou, Wenming Zhang, Fengxue Xin and Min Jiang

    Citation: Microbial Cell Factories 2021 20:12

    Content type: Research

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  24. d-Amino acids are increasingly used as building blocks to produce pharmaceuticals and fine chemicals. However, establishing a universal biocatalyst for the general synthesis of d-amino acids from cheap and readil...

    Authors: Dan-Ping Zhang, Xiao-Ran Jing, Lun-Jie Wu, An-Wen Fan, Yao Nie and Yan Xu

    Citation: Microbial Cell Factories 2021 20:11

    Content type: Research

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  25. Freezing stress is the key factor that affecting the cell activity and fermentation performance of baker’s yeast in frozen dough production. Generally, cells protect themselves from injury and maintain metabol...

    Authors: Lu Meng, Xu Yang, Xue Lin, Huan-Yuan Jiang, Xiao-Ping Hu and Si-Xin Liu

    Citation: Microbial Cell Factories 2021 20:10

    Content type: Research

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  26. Growth factors (GFs) are signaling proteins that affect cellular processes such as growth, proliferation, and differentiation. GFs are used as cosmeceuticals, exerting anti-wrinkle, anti-aging, and whitening e...

    Authors: Young Su Kim, Hye-Jeong Lee, Man-ho Han, Nam-kyung Yoon, Yeu-chun Kim and Jungoh Ahn

    Citation: Microbial Cell Factories 2021 20:9

    Content type: Research

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  27. Pichia pastoris (Komagataella phaffii) is an important platform for heterologous protein production due to its growth to high cell density and outstanding secretory capabilities. Recent developments in synthetic ...

    Authors: Laura Navone, Thomas Vogl, Pawarisa Luangthongkam, Jo-Anne Blinco, Carlos Luna-Flores, Xiaojing Chen, Juhani von Hellens and Robert Speight

    Citation: Microbial Cell Factories 2021 20:8

    Content type: Research

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  28. The sesquiterpene germacrene A is a direct precursor of ß-elemene that is a major component of the Chinese medicinal herb Curcuma wenyujin with prominent antitumor activity. The microbial platform for germacrene ...

    Authors: Weixin Zhang, Junqi Guo, Zheng Wang, Yanwei Li, Xiangfeng Meng, Yu Shen and Weifeng Liu

    Citation: Microbial Cell Factories 2021 20:7

    Content type: Research

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  29. The majority of microbial fermentations are currently performed in the batch or fed-batch manner with the high process complexity and huge water consumption. The continuous microbial production can contribute ...

    Authors: Hui Liu, Yujin Cao, Jing Guo, Xin Xu, Qi Long, Lili Song and Mo Xian

    Citation: Microbial Cell Factories 2021 20:6

    Content type: Research

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  30. Phaffia rhodozyma has many desirable properties for astaxanthin production, including rapid heterotrophic metabolism and high cell densities in fermenter culture. The low optimal temperature range (17–21 °C) for...

    Authors: Li-Li Miao, Shuang Chi, Ting-Ting Hou, Zhi-Pei Liu and Ying Li

    Citation: Microbial Cell Factories 2021 20:5

    Content type: Research

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  31. Biosynthesis of l-tert-leucine (l-tle), a significant pharmaceutical intermediate, by a cofactor regeneration system friendly and efficiently is a worthful goal all the time. The cofactor regeneration system of l...

    Authors: Langxing Liao, Yonghui Zhang, Yali Wang, Yousi Fu, Aihui Zhang, Ruodian Qiu, Shuhao Yang and Baishan Fang

    Citation: Microbial Cell Factories 2021 20:3

    Content type: Research

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  32. Cellobiose dehydrogenase from Phanerochaete chrysosporium (PcCDH) is a key enzyme in lignocellulose depolymerization, biosensors and biofuel cells. For these applications, it should retain important molecular and...

    Authors: Lena Wohlschlager, Florian Csarman, Hucheng Chang, Elisabeth Fitz, Bernhard Seiboth and Roland Ludwig

    Citation: Microbial Cell Factories 2021 20:2

    Content type: Research

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  33. Rhamnolipids (RLs) are surface-active compounds and belong to the class of glycolipid biosurfactants, mainly produced from Pseudomonas aeruginosa. Due to their non-toxicity, high biodegradability, low surface ten...

    Authors: Priyanka Thakur, Neeraj K. Saini, Vijay Kumar Thakur, Vijai Kumar Gupta, Reena V. Saini and Adesh K. Saini

    Citation: Microbial Cell Factories 2021 20:1

    Content type: Review

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  34. Nerol (C10H18O), an acyclic monoterpene, naturally presents in plant essential oils, and is used widely in food, cosmetics and pharmaceuticals as the valuable fragrance. Meanwhile, chemical synthesis is the only ...

    Authors: Xueyan Mo, Xinghua Cai, Qinyan Hui, Huijie Sun, Ran Yu, Ru Bu, Bing Yan, Qian Ou, Quanwen Li, Sheng He and Chengjian Jiang

    Citation: Microbial Cell Factories 2021 20:4

    Content type: Research

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  35. PHB (poly-hydroxy-butyrate) represents a promising bioplastic alternative with good biodegradation properties. Furthermore, PHB can be produced in a completely carbon–neutral fashion in the natural producer cy...

    Authors: Moritz Koch, Jonas Bruckmoser, Jörg Scholl, Waldemar Hauf, Bernhard Rieger and Karl Forchhammer

    Citation: Microbial Cell Factories 2020 19:231

    Content type: Research

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  36. Chelocardin (CHD) exhibits a broad-spectrum antibiotic activity and showed promising results in a small phase II clinical study conducted on patients with urinary tract infections. Importantly, CHD was shown t...

    Authors: Tadeja Lukežič, Špela Pikl, Nestor Zaburannyi, Maja Remškar, Hrvoje Petković and Rolf Müller

    Citation: Microbial Cell Factories 2020 19:230

    Content type: Research

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  37. Deactivated Cas9 (dCas9) led to significant improvement of CRISPR/Cas9-based techniques because it can be fused with a variety of functional groups to form diverse molecular devices, which can manipulate or mo...

    Authors: Qianwen Xie, Siwei Li, Dongdong Zhao, Lijun Ye, Qingyan Li, Xueli Zhang, Li Zhu and Changhao Bi

    Citation: Microbial Cell Factories 2020 19:229

    Content type: Research

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  38. CO2 is fixed by all living organisms with an autotrophic metabolism, among which the Calvin–Benson–Bassham (CBB) cycle is the most important and widespread carbon fixation pathway. Thus, studying and engineering ...

    Authors: Zhongkang Li, Xiuqing Xin, Bin Xiong, Dongdong Zhao, Xueli Zhang and Changhao Bi

    Citation: Microbial Cell Factories 2020 19:228

    Content type: Research

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  39. A cellular stress response (CSR) is triggered upon recombinant protein synthesis which acts as a global feedback regulator of protein expression. To remove this key regulatory bottleneck, we had previously pro...

    Authors: Richa Guleria, Priyanka Jain, Madhulika Verma and Krishna J. Mukherjee

    Citation: Microbial Cell Factories 2020 19:227

    Content type: Research

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  40. Saccharomyces cerevisiae is being exploited as a cell factory to produce fatty acids and their derivatives as biofuels. Previous studies found that both precursor supply and fatty acid metabolism deregulation are...

    Authors: Yiming Zhang, Mo Su, Ning Qin, Jens Nielsen and Zihe Liu

    Citation: Microbial Cell Factories 2020 19:226

    Content type: Research

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  41. In bioengineering, growth of microorganisms is limited because of environmental and industrial stresses during fermentation. This study aimed to construct a nisin-producing chassis Lactococcus lactis strain with ...

    Authors: Wanjin Qiao, Yu Qiao, Fulu Liu, Yating Zhang, Ran Li, Zhenzhou Wu, Haijin Xu, Per Erik Joakim Saris and Mingqiang Qiao

    Citation: Microbial Cell Factories 2020 19:225

    Content type: Research

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  42. Monascus azaphilone pigments (MonAzPs), which were produced by Monascus species, have been used as important food colorant and food supplements for more than one billion people during their daily life. Moreover, ...

    Authors: Jiawei Liu, Yun Du, Hongmin Ma, Xiaolin Pei and Mu Li

    Citation: Microbial Cell Factories 2020 19:224

    Content type: Research

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  43. Genome reduction and metabolic engineering have emerged as intensive research hotspots for constructing the promising functional chassis and various microbial cell factories. Surfactin, a lipopeptide-type bios...

    Authors: Fang Zhang, Kaiyue Huo, Xingyi Song, Yufen Quan, Shufang Wang, Zhiling Zhang, Weixia Gao and Chao Yang

    Citation: Microbial Cell Factories 2020 19:223

    Content type: Research

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  44. Dewatering constitutes a major challenge to the production of microalgae, accounting for 20–30% of the product cost. This presents a setback for the applicability of microalgae in the development of several su...

    Authors: Mutah Musa, Andrew Ward, Godwin A. Ayoko, Christine Rösch, Richard Brown and Thomas J. Rainey 

    Citation: Microbial Cell Factories 2020 19:222

    Content type: Research

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  45. Exocrine pancreatic insufficiency (EPI) is characterized by the loss of active pancreatic enzymes and a resulting severely reduced food digestion. EPI therapy requires orally applied pancreatic enzyme replacem...

    Authors: Sabrina Ritz, Daniela Hahn, Haleluya T. Wami, Karin Tegelkamp, Ulrich Dobrindt and Juergen Schnekenburger

    Citation: Microbial Cell Factories 2020 19:221

    Content type: Research

    Published on:

  46. Zeaxanthin, a major xanthophyll pigment, has a significant role as a retinal pigment and antioxidant. Because zeaxanthin helps to prevent age-related macular degeneration, its commercial use in personalized nu...

    Authors: Inhwa Song, Jongrae Kim, Kwangryul Baek, Young Choi, ByongCheol Shin and EonSeon Jin

    Citation: Microbial Cell Factories 2020 19:220

    Content type: Research

    Published on:

  47. Diet, loss of aryl hydrocarbon receptor (AhR) expression and their modification of the gut microbiota community composition and its metabolites affect the development of colorectal cancer (CRC). However, the c...

    Authors: Fang Yang, Jennifer A. A. DeLuca, Rani Menon, Erika Garcia-Vilarato, Evelyn Callaway, Kerstin K. Landrock, Kyongbum Lee, Stephen H. Safe, Robert S. Chapkin, Clinton D. Allred and Arul Jayaraman

    Citation: Microbial Cell Factories 2020 19:219

    Content type: Research

    Published on:

  48. All of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular eukaryotes like helminths, and v...

    Authors: Taha Baghbani, Hossein Nikzad, Javid Azadbakht, Fatemeh Izadpanah and Hamed Haddad Kashani

    Citation: Microbial Cell Factories 2020 19:217

    Content type: Review

    Published on:

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