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  1. Plipastatin is a potent Bacillus antimicrobial lipopeptide with the prospect to replace conventional antifungal chemicals for controlling plant pathogens. However, the application of this lipopeptide has so far b...

    Authors: Maliheh Vahidinasab, Lars Lilge, Aline Reinfurt, Jens Pfannstiel, Marius Henkel, Kambiz Morabbi Heravi and Rudolf Hausmann

    Citation: Microbial Cell Factories 2020 19:205

    Content type: Research

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  2. Lipids from oleaginous yeasts emerged as a sustainable alternative to vegetable oils and animal fat to produce biodiesel, the biodegradable and environmentally friendly counterpart of petro-diesel fuel. To dev...

    Authors: Francesca Martani, Letizia Maestroni, Mattia Torchio, Diletta Ami, Antonino Natalello, Marina Lotti, Danilo Porro and Paola Branduardi

    Citation: Microbial Cell Factories 2020 19:204

    Content type: Research

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  3. Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this inc...

    Authors: Wallace Jeng Yang Chee, Shu Yih Chew and Leslie Thian Lung Than

    Citation: Microbial Cell Factories 2020 19:203

    Content type: Review

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  4. In industrial fermentation, pH fluctuation resulted from microbial metabolism influences the strain performance and the final production. The common way to control pH is adding acid or alkali after probe detec...

    Authors: Chenyi Li, Xiaopeng Gao, Xiao Peng, Jinlin Li, Wenxin Bai, Jiadong Zhong, Mengchao He, Ke Xu, Ying Wang and Chun Li

    Citation: Microbial Cell Factories 2020 19:202

    Content type: Research

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  5. Vitamins’ deficiency in humans is an important threat worldwide and requires solutions. In the concept of natural biofactory for bioactive compounds production, microalgae represent one of the most promising t...

    Authors: Angelo Del Mondo, Arianna Smerilli, Elisabet Sané, Clementina Sansone and Christophe Brunet

    Citation: Microbial Cell Factories 2020 19:201

    Content type: Review

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  6. Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol®), remains limited despite growing global demands. Low yields of the critical taxadiene precursor remains a key bottleneck in ...

    Authors: Behnaz Nowrouzi, Rachel A. Li, Laura E. Walls, Leo d’Espaux, Koray Malcı, Lungang Liang, Nestor Jonguitud-Borrego, Albert I. Lerma-Escalera, Jose R. Morones-Ramirez, Jay D. Keasling and Leonardo Rios-Solis

    Citation: Microbial Cell Factories 2020 19:200

    Content type: Research

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  7. The methylotrophic yeast, Pichia pastoris has been widely used for the production of human therapeutics, but production of granulocyte colony-stimulating factor (G-CSF) in this yeast is low.The work reported here...

    Authors: Sakshi Aggarwal and Saroj Mishra

    Citation: Microbial Cell Factories 2020 19:199

    Content type: Research

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  8. Nicotinamide adenine dinucleotide phosphate (NADPH) is an important cofactor ensuring intracellular redox balance, anabolism and cell growth in all living systems. Our recent multi-omics analyses of glucoamyla...

    Authors: Yu-fei Sui, Tabea Schütze, Li-ming Ouyang, Hongzhong Lu, Peng Liu, Xianzun Xiao, Jie Qi, Ying-Ping Zhuang and Vera Meyer

    Citation: Microbial Cell Factories 2020 19:198

    Content type: Research

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  9. In Saccharomyces cerevisiae, alpha-glucosidase (maltase) is a key enzyme in maltose metabolism. In addition, the overexpression of the alpha-glucosidase-encoding gene MAL62 has been shown to increase the freezing...

    Authors: Xi Sun, Jun Zhang, Zhi-Hua Fan, Ping Xiao, Feng Li, Hai-Qing Liu and Wen-Bi Zhu

    Citation: Microbial Cell Factories 2020 19:196

    Content type: Research

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  10. A new Bacillus thuringiensis X023 (BtX023) with high insecticidal activity was isolated in Hunan Province, China. The addition of metals (Cu, Fe, Mg and Mn) to the medium could influence the formation of spores a...

    Authors: Zhuolin Liu, Junyan Xie, Ziru Deng, Mulan Wang, Dandan Dang, Sha Luo, Yunfeng Wang, Yunjun Sun, Liqiu Xia and Xuezhi Ding

    Citation: Microbial Cell Factories 2020 19:195

    Content type: Research

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  11. Enzymatic quantification of creatinine has become an essential method for clinical evaluation of renal function. Although creatinase (CR) is frequently used for this purpose, its poor thermostability severely ...

    Authors: Xue Bai, Daixi Li, Fuqiang Ma, Xi Deng, Manjie Luo, Yan Feng and Guangyu Yang

    Citation: Microbial Cell Factories 2020 19:194

    Content type: Research

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  12. The highly pathogenic avian influenza (HPAI) H5N1 virus poses a potential threat to the poultry industry. The currently available avian influenza H5N1 vaccines for poultry are clade-specific. Therefore, an eff...

    Authors: Han Lei, Tong Gao, Qianhong Cen and Xiaojue Peng

    Citation: Microbial Cell Factories 2020 19:193

    Content type: Research

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  13. Nowadays, microbial infections have caused increasing economic losses in aquaculture industry and deteriorated worldwide environments. Many of these infections are caused by opportunistic pathogens through cel...

    Authors: Weiwei Dong, Yuyuan Cai, Zhilong Xu, Biao Fu, Qitong Chen, Yuxin Cui, Zhiyong Ruan, Yunxiang Liang, Nan Peng and Shumiao Zhao

    Citation: Microbial Cell Factories 2020 19:191

    Content type: Research

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  14. Heme proteins and heme-derived molecules are essential in numerous cellular processes. Research into their in vitro functionality requires the production of large amounts of protein. Unfortunately, high yield ...

    Authors: Kerstin Fiege and Nicole Frankenberg-Dinkel

    Citation: Microbial Cell Factories 2020 19:190

    Content type: Technical notes

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  15. Corynebacterium glutamicum thrives under oxidative stress caused by the inevitably extreme environment during fermentation as it harbors antioxidative stress genes. Antioxidant genes are controlled by pathway-spe...

    Authors: Meiru Si, Can Chen, Jingyi Zhong, Xiaona Li, Yang Liu, Tao Su and Ge Yang

    Citation: Microbial Cell Factories 2020 19:189

    Content type: Research

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  16. l-rhamnose (6-deoxy-mannose) occurs in nature mainly as a component of certain plant structural polysaccharides and bioactive metabolites but has also been found in some microorganisms and animals. The release of...

    Authors: Andrew P. MacCabe, Elpinickie I. Ninou, Ester Pardo and Margarita Orejas

    Citation: Microbial Cell Factories 2020 19:188

    Content type: Research

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  17. Mycobacterium neoaurum strains can transform phytosterols to 4-androstene-3,17-dione (4-AD), a key intermediate for the synthesis of advanced steroidal medicines. In this work, we presented the complete genome se...

    Authors: Hongwei Wang, Shikui Song, Fei Peng, Fei Yang, Tian Chen, Xin Li, Xiyao Cheng, Yijun He, Yongqi Huang and Zhengding Su

    Citation: Microbial Cell Factories 2020 19:187

    Content type: Research

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  18. Bovine viral diarrhea virus (BVDV) is one of the main causes of infectious diseases in cattle and causes large financial losses to the cattle industry worldwide. In this study, Lactobacillus casei strain W56 (Lc ...

    Authors: Shuo Jia, Xinning Huang, Hua Li, Dianzhong Zheng, Li Wang, Xinyuan Qiao, Yanping Jiang, Wen Cui, Lijie Tang, Yijing Li and Yigang Xu

    Citation: Microbial Cell Factories 2020 19:186

    Content type: Research

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  19. Bacterial spores displaying heterologous antigens or enzymes have long been proposed as mucosal vaccines, functionalized probiotics or biocatalysts. Two main strategies have been developed to display heterolog...

    Authors: Claudia Petrillo, Stefany Castaldi, Mariamichela Lanzilli, Anella Saggese, Giuliana Donadio, Loredana Baccigalupi, Ezio Ricca and Rachele Isticato

    Citation: Microbial Cell Factories 2020 19:185

    Content type: Research

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  20. Marine fungi are an important repository of bioactive molecules with great potential in different technological fields, the annual number of new compounds isolated from marine fungi is impressive and the gener...

    Authors: Lorenzo Botta, Raffaele Saladino, Paolo Barghini, Massimiliano Fenice and Marcella Pasqualetti

    Citation: Microbial Cell Factories 2020 19:184

    Content type: Research

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  21. Resistance towards known antimalarial drugs poses a significant problem, urging for novel drugs that target vital proteins in the malaria parasite Plasmodium falciparum. However, recombinant production of malaria...

    Authors: Karen Molbaek, Maria Tejada, Christina Hoeier Ricke, Peter Scharff-Poulsen, Peter Ellekvist, Claus Helix-Nielsen, Nirbhay Kumar, Dan A. Klaerke and Per Amstrup Pedersen

    Citation: Microbial Cell Factories 2020 19:183

    Content type: Research

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  22. FODMAPs (Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) intake is associated with the onset of irritable bowel syndrome symptoms. FODMAPs in wheat-derived baked goods may be reduced...

    Authors: Marta Acín Albiac, Raffaella Di Cagno, Pasquale Filannino, Vincenzo Cantatore and Marco Gobbetti

    Citation: Microbial Cell Factories 2020 19:182

    Content type: Research

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  23. Chitinase and chitin-oligosaccaride can be used in multiple field, so it is important to develop a high-yield chitinase producing strain. Here, a recombinant Pichia pastoris with 4 copies of ChiA gene from Bacill...

    Authors: Wen Song, Nuo Zhang, Mo Yang, Yuling Zhou, Nisha He and Guimin Zhang

    Citation: Microbial Cell Factories 2020 19:181

    Content type: Research

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  24. Epothilone B is a natural product that stabilizes microtubules, similar to paclitaxel (Taxol); therefore, epothilone B and several derivatives have shown obvious antitumour activities. Some of these products a...

    Authors: Junheng Liang, Huimin Wang, Xiaoying Bian, Youming Zhang, Guoping Zhao and Xiaoming Ding

    Citation: Microbial Cell Factories 2020 19:180

    Content type: Research

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  25. Sugars and triglycerides are common carbon sources for microorganisms. Nonetheless, a systematic comparative interpretation of metabolic changes upon vegetable oil or glucose as sole carbon source is still lac...

    Authors: Arief Izzairy Zamani, Susann Barig, Sarah Ibrahim, Hirzun Mohd. Yusof, Julia Ibrahim, Jaime Yoke Sum Low, Shwu Fun Kua, Syarul Nataqain Baharum, Klaus-Peter Stahmann and Chyan Leong Ng

    Citation: Microbial Cell Factories 2020 19:179

    Content type: Research

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  26. Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclod...

    Authors: Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, Nicolas Canu, Muriel Gondry, Olivier Lequin and Pascal Belin

    Citation: Microbial Cell Factories 2020 19:178

    Content type: Research

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  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yunchang Xie, Jiawen Chen, Bo Wang, Tai Chen, Junyu Chen, Yuan Zhang, Xiaoying Liu and Qi Chen

    Citation: Microbial Cell Factories 2020 19:177

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2020 19:159

  28. Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape and function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de...

    Authors: Jorge Royes, Valérie Biou, Nathalie Dautin, Christophe Tribet and Bruno Miroux

    Citation: Microbial Cell Factories 2020 19:176

    Content type: Review

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  29. Inclusion bodies (IBs) are biologically active protein aggregates forming natural nanoparticles with a high stability and a slow-release behavior. Because of their nature, IBs have been explored to be used as ...

    Authors: Ramon Roca-Pinilla, Sara Fortuna, Antonino Natalello, Alejandro Sánchez-Chardi, Diletta Ami, Anna Arís and Elena Garcia-Fruitós

    Citation: Microbial Cell Factories 2020 19:175

    Content type: Research

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  30. One major mission of microbial breeding is high-level production of desired metabolites. Overproduction of intermediate metabolites in core pathways is challenging as it may impair cell growth and viability.

    Authors: Qingyang Li, Peng Zhao, Hang Yin, Zhaonan Liu, Haifeng Zhao and Pingfang Tian

    Citation: Microbial Cell Factories 2020 19:174

    Content type: Research

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  31. Although recent studies have indicated that intestinal microbiota dweller are involved in the pathogenesis of allergy rhinitis (AR), the influence of gut microbiota on AR adult has not been fully elucidated ye...

    Authors: Libing Zhu, Feng Xu, Wenrong Wan, Bin Yu, Lin Tang, Yimin Yang, Yanling Du, Zhangran Chen and Hongzhi Xu

    Citation: Microbial Cell Factories 2020 19:171

    Content type: Research

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    The Correction to this article has been published in Microbial Cell Factories 2020 19:192

  32. Miniaturization of biochemical reaction volumes within artificial microcompartments has been the key driver for directed evolution of several catalysts in the past two decades. Typically, single cells are co-c...

    Authors: Salvatore Di Girolamo, Chasper Puorger and Georg Lipps

    Citation: Microbial Cell Factories 2020 19:170

    Content type: Technical notes

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  33. Probiotics have several health benefits by modulating gut microbiome; however, techno-functional limitations such as viability controls have hampered their full potential applications in the food and pharmaceu...

    Authors: Basavaprabhu H. Nataraj, Syed Azmal Ali, Pradip V. Behare and Hariom Yadav

    Citation: Microbial Cell Factories 2020 19:168

    Content type: Review

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  34. Despite the latest advancements in metabolic engineering for genome editing and characterization of host performance, the successful development of robust cell factories used for industrial bioprocesses and ac...

    Authors: Maren Wehrs, Mitchell G. Thompson, Deepanwita Banerjee, Jan-Philip Prahl, Norma M. Morella, Carolina A. Barcelos, Jadie Moon, Zak Costello, Jay D. Keasling, Patrick M. Shih, Deepti Tanjore and Aindrila Mukhopadhyay

    Citation: Microbial Cell Factories 2020 19:167

    Content type: Research

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  35. The biotechnology production of enzymes is often troubled by the toxicity of the recombinant products of cloned and expressed genes, which interferes with the recombinant hosts’ metabolism. Various approaches ...

    Authors: Natalia Krawczun, Marta Bielawa, Kasjan Szemiako, Beata Łubkowska, Ireneusz Sobolewski, Agnieszka Zylicz-Stachula and Piotr M. Skowron

    Citation: Microbial Cell Factories 2020 19:166

    Content type: Research

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  36. l-malate is one of the most important platform chemicals widely used in food, metal cleaning, textile finishing, pharmaceuticals, and synthesis of various fine chemicals. Recently, the development of biotechnol.....

    Authors: Youming Jiang, Tianwen Zheng, Xiaohan Ye, Fengxue Xin, Wenming Zhang, Weiliang Dong, Jiangfeng Ma and Min Jiang

    Citation: Microbial Cell Factories 2020 19:165

    Content type: Research

    Published on:

  37. Ergothioneine (EGT) has a unique antioxidant ability and diverse beneficial effects on human health. But the content of EGT is very low in its natural producing organisms such as Mycobacterium smegmatis and mushr...

    Authors: Ying-Hao Yu, Hong-Yu Pan, Li-Qiong Guo, Jun-Fang Lin, Han-Lu Liao and Hao-Ying Li

    Citation: Microbial Cell Factories 2020 19:164

    Content type: Research

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  38. Cinnamyl alcohol is not only a kind of flavoring agent and fragrance, but also a versatile chemical applied in the production of various compounds. At present, the preparation of cinnamyl alcohol depends on pl...

    Authors: Chen Zhang, Qian Xu, Hongliang Hou, Jiawei Wu, Zhaojuan Zheng and Jia Ouyang

    Citation: Microbial Cell Factories 2020 19:163

    Content type: Research

    Published on:

  39. Whey is a major pollutant generated by the dairy industry. To decrease environmental pollution caused by the industrial release of whey, new prospects for its utilization need to be urgently explored. Here, we...

    Authors: Wensi Meng, Yongjia Zhang, Menghao Cao, Wen Zhang, Chuanjuan Lü, Chunyu Yang, Chao Gao, Ping Xu and Cuiqing Ma

    Citation: Microbial Cell Factories 2020 19:162

    Content type: Research

    Published on:

  40. In Lactobacillus plantarum, fructooligosaccharides (FOS) metabolism is controlled by both global and local regulatory mechanisms. Although catabolite control protein A has been identified as a global regulator of...

    Authors: Chen Chen, Linlin Wang, Haiyan Yu and Huaixiang Tian

    Citation: Microbial Cell Factories 2020 19:161

    Content type: Research

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  41. Thioesters of coenzyme A participate in 5% of all enzymatic reactions. In microbial cell factories, they function as building blocks for products of recognized commercial value, including natural products such...

    Authors: Lars Gläser, Martin Kuhl, Sofija Jovanovic, Michel Fritz, Bastian Vögeli, Tobias J. Erb, Judith Becker and Christoph Wittmann

    Citation: Microbial Cell Factories 2020 19:160

    Content type: Research

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  42. Activation of silent biosynthetic gene clusters (BGCs) in marine-derived actinomycete strains is a feasible strategy to discover bioactive natural products. Actinoalloteichus sp. AHMU CJ021, isolated from the sea...

    Authors: Yunchang Xie, Jiawen Chen, Bo Wang, Tai Chen, Junyu Chen, Yuan Zhang, Xiaoying Liu and Qi Chen

    Citation: Microbial Cell Factories 2020 19:159

    Content type: Research

    Published on:

    The Correction to this article has been published in Microbial Cell Factories 2020 19:177

  43. The goal of the present study was to investigate the effects of TAK-242 on the gut microbiota and the TLR4/JAK2/STAT3 signaling pathway in mice with dextran sulfate sodium (DSS)-induced colitis.

    Authors: Jiajia Wang, Guannan Zhu, Cheng Sun, Kangwei Xiong, Tingting Yao, Yuan Su and Haiming Fang

    Citation: Microbial Cell Factories 2020 19:158

    Content type: Research

    Published on:

  44. Maltoheptaose as malto-oligosaccharides with specific degree of polymerization, has wide applications in food, medicine and cosmetics industries. Currently, cyclodextrinase have been applied as prepared enzyme...

    Authors: Lei Wang, Quan Wu, Kang Zhang, Sheng Chen, Zhengfei Yan and Jing Wu

    Citation: Microbial Cell Factories 2020 19:157

    Content type: Research

    Published on:

  45. Two marine fungi, a Trichoderma sp. and a Coniochaeta sp., which can grow on d-galacturonic acid and pectin, were selected as hosts to engineer for mucic acid production, assessing the suitability of marine fungi...

    Authors: Virve Vidgren, Satu Halinen, Anu Tamminen, Susanna Olenius and Marilyn G. Wiebe

    Citation: Microbial Cell Factories 2020 19:156

    Content type: Research

    Published on:

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