Austin MB, Noel JP. The chalcone synthase superfamily of type III polyketide synthases. Nat Prod Rep. 2003;20:79–110.
Article
CAS
Google Scholar
Hertweck C. The biosynthetic logic of polyketide diversity. Angew Chem Int Ed Engl. 2009;48:4688–716.
Article
CAS
Google Scholar
Lim YP, Go MK, Yew WS. Exploiting the biosynthetic potential of type III polyketide synthases. Molecules. 2016;21:806.
Article
Google Scholar
Morita H, Wong CP, Abe I. How structural subtleties lead to molecular diversity for the type III polyketide synthases. J Biol Chem. 2019;294:15121–36.
Article
CAS
Google Scholar
Zucko J, Skunca N, Curk T, Zupan B, Long PF, Cullum J, Kessin RH, Hranueli D. Polyketide synthase genes and the natural products potential of Dictyostelium discoideum. Bioinformatics. 2007;23:2543–9.
Article
CAS
Google Scholar
Reimer C, Kufs JE, Rautschek J, Regestein L, Valiante V, Hillmann F. Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides. Nat Biotechnol. 2022;40:751–8.
Article
CAS
Google Scholar
Kufs JE, Reimer C, Stallforth P, Hillmann F, Regestein L. The potential of amoeba-based processes for natural product syntheses. Curr Opin Biotechnol. 2022;77: 102766.
Article
CAS
Google Scholar
Günther M, Reimer C, Herbst R, Kufs JE, Rautschek J, Ueberschaar N, Zhang S, Peschel G, Reimer L, Regestein L, et al. Yellow polyketide pigment suppresses premature hatching in social amoeba. Proc Natl Acad Sci USA. 2022. https://doi.org/10.1073/pnas.2116122119
Luo X, Reiter MA, d’Espaux L, Wong J, Denby CM, Lechner A, Zhang Y, Grzybowski AT, Harth S, Lin W, et al. Complete biosynthesis of cannabinoids and their unnatural analogues in yeast. Nature. 2019;567:123–6.
Article
CAS
Google Scholar
Tan Z, Clomburg JM, Gonzalez R. Synthetic pathway for the production of olivetolic acid in Escherichia coli. ACS Synth Biol. 2018;7:1886–96.
Article
CAS
Google Scholar
Carvalho Â, Hansen EH, Kayser O, Carlsen S, Stehle F. Designing microorganisms for heterologous biosynthesis of cannabinoids. FEMS Yeast Res. 2017;17:fox037.
Article
Google Scholar
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE. Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. Proc Natl Acad Sci USA. 2012;109:12811–6.
Article
CAS
Google Scholar
Okorafor IC, Chen M, Tang Y. High-titer production of olivetolic acid and analogs in engineered fungal host using a nonplant biosynthetic pathway. ACS Synth Biol. 2021;10:2159–66.
Article
CAS
Google Scholar
West CM, Wang ZA, van der Wel H. A cytoplasmic prolyl hydroxylation and glycosylation pathway modifies Skp1 and regulates O2-dependent development in Dictyostelium. Biochim Biophys Acta. 2010;1800:160–71.
Article
CAS
Google Scholar
Bonner JT, Frascella EB. Variations in cell size during the development of the slime mold, Dictyostelium discoideum. Biol Bull. 1953;104:297–300.
Article
Google Scholar
Fey P, Kowal AS, Gaudet P, Pilcher KE, Chisholm RL. Protocols for growth and development of Dictyostelium discoideum. Nat Protoc. 2007;2:1307–16.
Article
CAS
Google Scholar
Han S-I, Friehs K, Flaschel E. Improvement of a synthetic medium for Dictyostelium discoideum. Process Biochem. 2004;39:925–30.
Article
CAS
Google Scholar
Han S-I, Friehs K, Flaschel E. Cultivation of Dictyostelium discoideum on an improved synthetic medium in a conventional bioreactor. Process Biochem. 2004;39:585–9.
Article
CAS
Google Scholar
Lu Y, Knol JC, Linskens MHK, Friehs K, van Haastert PJM, Flaschel E. Production of the soluble human Fas ligand by Dictyostelium discoideum cultivated on a synthetic medium. J Biotechnol. 2004;108:243–51.
Article
CAS
Google Scholar
Stephan M, Beshay U, Friehs K, Flaschel E. Influence of medium composition on growth behaviour of Dictyostelium discoideum for cultivation on axenic media. Process Biochem. 2003;39:333–43.
Article
CAS
Google Scholar
McManamey WJ. Sauter mean and maximum drop diameters of liquid-liquid dispersions in turbulent agitated vessels at low dispersed phase hold-up. Chem Eng Sci. 1979;34:432–4.
Article
CAS
Google Scholar
Okamoto Y, Nishikawa M, Hashimoto K. Energy dissipation rate distribution in mixing vessels and its effects on liquid-liquid dispersion and solid-liquid mass transfer. Int Chem Eng. 1981;21:88–94.
Google Scholar
Daub A, Böhm M, Delueg S, Mühlmann M, Schneider G, Büchs J. Characterization of hydromechanical stress in aerated stirred tanks up to 40 m3 scale by measurement of maximum stable drop size. J Biol Eng. 2014;8:17.
Article
Google Scholar
Daub A, Böhm M, Delueg S, Mühlmann M, Schneider G, Büchs J. Maximum stable drop size measurements indicate turbulence attenuation by aeration in a 3m3 aerated stirred tank. Biochem Eng J. 2014;86:24–32.
Article
CAS
Google Scholar
Van’t Riet K. Review of measuring methods and results in nonviscous gas-liquid mass transfer in stirred vessels. Ind Eng Chem Process Des Dev. 1979;18:357–64.
Article
CAS
Google Scholar
Henzler H-J. Verfahrenstechnische Auslegungsunterlagen für Rührbehälter als Fermenter. Chem Ing Tech. 1982;54:461–76.
Article
CAS
Google Scholar
Milke L, Aschenbrenner J, Marienhagen J, Kallscheuer N. Production of plant-derived polyphenols in microorganisms: current state and perspectives. Appl Microbiol Biotechnol. 2018;102:1575–85.
Article
CAS
Google Scholar
Shah FLA, Ramzi AB, Baharum SN, Noor NM, Goh HH, Leow TC, Oslan SN, Sabri S. Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids. Mol Biol Rep. 2019;46:6647–59.
Article
CAS
Google Scholar
Burdine V, Clarke M. Genetic and physiologic modulation of the prestarvation response in Dictyostelium discoideum. Mol Biol Cell. 1995;6:311–25.
Article
CAS
Google Scholar
Clarke M, Kayman SC, Riley K. Density-dependent induction of discoidin-I synthesis in exponentially growing cells of Dictyostelium discoideum. Differentiation. 1987;34:79–87.
Article
CAS
Google Scholar
Anderlei T, Zang W, Papaspyrou M, Büchs J. Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochem Eng J. 2004;17:187–94.
Article
CAS
Google Scholar
Peña-Ortiz L, Schlembach I, Lackner G, Regestein L. Impact of oxygen supply and scale up on Mycobacterium smegmatis cultivation and mycofactocin formation. Front bioeng biotechnol. 2020;8:593781–593781.
Article
Google Scholar