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  1. Acetic acid and furfural (AF) are two major inhibitors of microorganisms during lignocellulosic ethanol production. In our previous study, we successfully engineered Zymomonas mobilis 532 (ZM532) strain by genome...

    Authors: Samina Shabbir, Weiting Wang, Mohsin Nawaz, Prerona Boruah, Muhammad Fakhar-e-Alam Kulyar, Mao Chen, Bo Wu, Panting Liu, Yonghua Dai, Lingling Sun, Qiyu Gou, Renbin Liu, Guoquan Hu, Tahira Younis and Mingxiong He
    Citation: Microbial Cell Factories 2023 22:88
    Content type: Research Published on:

  2. Expression systems for lactic acid bacteria have been developed for metabolic engineering applications as well as for food-grade recombinant protein production. But the industrial applications of lactic acid b...

    Authors: Nisit Watthanasakphuban, Pimsiriya Srila, Phitsanu Pinmanee, Kamonwan Sompinit, Kittipong Rattanaporn and Clemens Peterbauer
    Citation: Microbial Cell Factories 2023 22:86
    Content type: Research Published on:

  3. Bacterial siderophores are chelating compounds with the potential of application in agriculture, due to their plant growth-promoting (PGP) properties, however, high production and purification costs are limiti...

    Authors: M. Musialowski, Ł. Kowalewska, R. Stasiuk, T. Krucoń and K. Debiec-Andrzejewska
    Citation: Microbial Cell Factories 2023 22:85
    Content type: Research Published on:

  4. Nature has provided unique molecular scaffolds for applications including therapeutics, agriculture, and food. Due to differences in ecological environments and laboratory conditions, engineering is often nece...

    Authors: Elena Heng, Yi Wee Lim, Chung Yan Leong, Veronica W. P. Ng, Siew Bee Ng, Yee Hwee Lim and Fong Tian Wong
    Citation: Microbial Cell Factories 2023 22:84
    Content type: Research Published on:

  5. Various factors contribute to the development of the acute inflammation process, like the pro-inflammatory cytokines, certain enzymes as well as oxidative stress mediators. The anti-inflammatory potential of t...

    Authors: Asmaa Saleh, Walaa A. Negm, Thanaa A. El-Masry, Duaa Eliwa, Badriyah Alotaibi, Manal E. Alosaimi, Khalid Nijr Alotaibi, Sameh Magdeldin, Sebaey Mahgoub and Engy Elekhnawy
    Citation: Microbial Cell Factories 2023 22:83
    Content type: Research Published on:

  6. Di(2-ethylhexyl) phthalate (DEHP) is a widely detected plasticizer and a priority pollutant of utmost concern for its adverse impact on humans, wildlife and the environment. To eliminate such toxic burden, bio...

    Authors: Mousumi Bhattacharyya, Rinita Dhar, Suman Basu, Avijit Das, Darren M. Reynolds and Tapan K. Dutta
    Citation: Microbial Cell Factories 2023 22:82
    Content type: Research Published on:

  7. Recombinant proteins cover a wide range of biomedical, biotechnological, and industrial needs. Although there are diverse available protocols for their purification from cell extracts or from culture media, ma...

    Authors: Jose Vicente Carratalá, Jan Atienza-Garriga, Hèctor López-Laguna, Esther Vázquez, Antonio Villaverde, Julieta M. Sánchez and Neus Ferrer-Miralles
    Citation: Microbial Cell Factories 2023 22:81
    Content type: Research Published on:

  8. In spite of the fact that recombinant enzymes are preferably biotechnologically obtained using recombinant clones, the purification of proteins from native microorganisms, including those encoded by bacterioph...

    Authors: Beata Łubkowska, Edyta Czajkowska, Aleksandra Stodolna, Michał Sroczyński, Agnieszka Zylicz-Stachula, Ireneusz Sobolewski and Piotr M. Skowron
    Citation: Microbial Cell Factories 2023 22:80
    Content type: Research Published on:

    The Correction to this article has been published in Microbial Cell Factories 2023 22:146

  9. Mucormycosis disease, which has recently expanded with the Covid 19 pandemic in many countries, endangers patients' lives, and treatment with common drugs is fraught with unfavorable side effects.

    Authors: Amr S. Al-kashef, Mohamed U. Nooman, Mona M. Rashad, Amr H. Hashem and Mohamed Abdelraof
    Citation: Microbial Cell Factories 2023 22:79
    Content type: Research Published on:

  10. Metal oxide nanoparticles (NPs) are becoming valuable due to their novel applications. The green synthesis of TiO2 NPs is more popular as a flexible and eco-friendly method compared to traditional chemical synthe...

    Authors: Rasha A. Metwally, Jehan El Nady, Shaker Ebrahim, Amany El Sikaily, Nermeen A. El-Sersy, Soraya A. Sabry and Hanan A. Ghozlan
    Citation: Microbial Cell Factories 2023 22:78
    Content type: Research Published on:

  11. Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as str...

    Authors: Gerrit Haeger, Jessika Wirges, Nicole Tanzmann, Sven Oyen, Tristan Jolmes, Karl-Erich Jaeger, Ulrich Schörken, Johannes Bongaerts and Petra Siegert
    Citation: Microbial Cell Factories 2023 22:77
    Content type: Research Published on:

  12. Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains...

    Authors: Zhenke Wu, Xiqin Liang, Mingkai Li, Mengyu Ma, Qiusheng Zheng, Defang Li, Tianyue An and Guoli Wang
    Citation: Microbial Cell Factories 2023 22:76
    Content type: Review Published on:

  13. Coenzyme A (CoA) is a carrier of acyl groups. This cofactor is synthesized from pantothenic acid in five steps. The phosphorylation of pantothenate is catalyzed by pantothenate kinase (CoaA), which is a key st...

    Authors: Hirotaka Kudo, Sho Ono, Kenta Abe, Mami Matsuda, Tomohisa Hasunuma, Tomoyasu Nishizawa, Munehiko Asayama, Hirofumi Nishihara and Shigeru Chohnan
    Citation: Microbial Cell Factories 2023 22:75
    Content type: Research Published on:

  14. Two important flavonoids, kaempferol and quercetin possess remarkably potent biological impacts on human health. However, their structural complexity and low abundance in nature make both bulk chemical synthes...

    Authors: Musa Tartik, Juan Liu, Marta Tous Mohedano, Jiwei Mao and Yun Chen
    Citation: Microbial Cell Factories 2023 22:74
    Content type: Research Published on:

  15. Algae are prominent producers of carotenoids and polyunsaturated fatty acids which are greatly prized in the food and pharmaceutic industry. Fucoxanthin represents a notable high-value carotenoid produced excl...

    Authors: Antonín Střížek, Pavel Přibyl, Martin Lukeš, Tomáš Grivalský, Jiří Kopecký, Tomáš Galica and Pavel Hrouzek
    Citation: Microbial Cell Factories 2023 22:73
    Content type: Research Published on:

  16. Laccases are multicopper enzymes that oxidize a wide range of aromatic and non-aromatic compounds in the presence of oxygen. The majority of industrially relevant laccases are derived from fungi and are produc...

    Authors: Silja Välimets, Patricia Pedetti, Ludovika Jessica Virginia, Mai Ngoc Hoang, Michael Sauer and Clemens Peterbauer
    Citation: Microbial Cell Factories 2023 22:72
    Content type: Research Published on:

  17. Amino acid production features of Corynebacterium glutamicum were extensively studied in the last two decades. Many metabolic pathways, regulatory and transport principles are known, but purely rational approache...

    Authors: Rico Zuchowski, Simone Schito, Friederike Neuheuser, Philipp Menke, Daniel Berger, Niels Hollmann, Srushti Gujar, Lea Sundermeyer, Christina Mack, Astrid Wirtz, Oliver H. Weiergräber, Tino Polen, Michael Bott, Stephan Noack and Meike Baumgart
    Citation: Microbial Cell Factories 2023 22:71
    Content type: Research Published on:

  18. Alternaria alternata that threatens pepper production and causes major economic harm is responsible for the leaf spot/blight disease. Chemical fungicides have been widely employed; unfortunately, fungicidal resis...

    Authors: Shereen A. Soliman, Reda E. Abdelhameed and Rabab A. Metwally
    Citation: Microbial Cell Factories 2023 22:70
    Content type: Research Published on:

  19. Intracellular biomacromolecules, such as industrial enzymes and biopolymers, represent an important class of bio-derived products obtained from bacterial hosts. A common key step in the downstream separation o...

    Authors: Jeremy David Adams, Kyle B. Sander, Craig S. Criddle, Adam P. Arkin and Douglas S. Clark
    Citation: Microbial Cell Factories 2023 22:69
    Content type: Research Published on:

  20. This study aimed to isolate a novel thermotolerant bacterium that is capable of synthesizing polyhydroxyalkanoate from glycerol under high temperature conditions.

    Authors: Anuyut Yootoum, Kittisak Jantanasakulwong, Pornchai Rachtanapun, Churairat Moukamnerd, Thanongsak Chaiyaso, Chayakorn Pumas, Nuttapol Tanadchangsaeng, Masanori Watanabe, Toshiaki Fukui and Chayatip Insomphun
    Citation: Microbial Cell Factories 2023 22:68
    Content type: Research Published on:

  21. Natural killer (NK) cell-based immunotherapies have demonstrated substantial potential for the treatment of hematologic malignancies. However, its application is limited due to the difficulty in the production...

    Authors: Yangyang Li, Siqi Xie, Minhua Chen, Hao Li, Yehai Wang, Yan Fan, Kang An, Yu Wu and Weihua Xiao
    Citation: Microbial Cell Factories 2023 22:67
    Content type: Research Published on:

  22. Cycloartane-type triterpenoids possess important biological activities, including immunostimulant, wound healing, and telomerase activation. Biotransformation is one of the derivatization strategies of natural...

    Authors: Melis Küçüksolak, Sinem Yılmaz, Petek Ballar-Kırmızıbayrak and Erdal Bedir
    Citation: Microbial Cell Factories 2023 22:66
    Content type: Research Published on:

  23. Highly efficient production of L-phenylalanine (L-Phe) in E. coli has been achieved by multiple rounds of random mutagenesis and modification of key genes of the shikimate (SHIK) and L-Phe branch pathways. In thi...

    Authors: Wei Sun, Dongqin Ding, Danyang Bai, Yang Lin, Yaru Zhu, Cuiying Zhang and Dawei Zhang
    Citation: Microbial Cell Factories 2023 22:65
    Content type: Research Published on:

  24. Icaritin is an aglycone of flavonoid glycosides from Herba Epimedii. It has good performance in the treatment of hepatocellular carcinoma in clinical trials. However, the natural icaritin content of Herba Epimedi...

    Authors: Yu Lin, Wen-wen Chen, Bo Ding, Man Guo, Meng Liang, Hao Pang, Yu-tuo Wei, Ri-bo Huang and Li-qin Du
    Citation: Microbial Cell Factories 2023 22:64
    Content type: Research Published on:

  25. Adaptation to alkalinization of the medium in fungi involves an extensive remodeling of gene expression. Komagataella phaffii is an ascomycetous yeast that has become an organism widely used for heterologous prot...

    Authors: Marcel Albacar, Abdelghani Zekhnini, Jorge Pérez-Valle, José L. Martínez, Antonio Casamayor and Joaquín Ariño
    Citation: Microbial Cell Factories 2023 22:63
    Content type: Research Published on:

    The Correction to this article has been published in Microbial Cell Factories 2023 22:210

  26. Yarrowia lipolytica is a well-studied oleaginous yeast known for its ability to accumulate and store intracellular lipids, while growing on diverse, non-conventional substrates. Amongst them, crude glycerol, a lo...

    Authors: Asimina Tsirigka, Eleni Theodosiou, Sotiris I. Patsios, Antiopi Tsoureki, Aggeliki Andreadelli, Elisavet Papa, Amalia Aggeli, Anastasios J. Karabelas and Antonios M. Makris
    Citation: Microbial Cell Factories 2023 22:62
    Content type: Research Published on:

  27. Research development in the precise control of gene expression in plant cells is an emerging necessity that would lead to the elucidation of gene function in these biological systems. Conventional gene-interfe...

    Authors: Hossein Alishah Aratboni, Nahid Rafiei, Ashanti Concepción Uscanga-Palomeque, Itza Eloisa Luna Cruz, Roberto Parra-Saldivar and Jose Ruben Morones-Ramirez
    Citation: Microbial Cell Factories 2023 22:61
    Content type: Research Published on:

  28. Orsellinic acid (2,4-dihydroxy-6-methylbenzoic acid, OA) and its structural analog o-Orsellinaldehyde, have become widely used intermediates in clinical drugs synthesis. Although the research on the biosynthesis ...

    Authors: Haiyan Han, Chunyan Yu, Jianzhao Qi, Pengchao Wang, Peipei Zhao, Wenbing Gong, Chunliang Xie, Xuekui Xia and Chengwei Liu
    Citation: Microbial Cell Factories 2023 22:60
    Content type: Research Published on:

  29. Heme proteins, such as hemoglobin, horseradish peroxidase and cytochrome P450 (CYP) enzyme, are highly versatile and have widespread applications in the fields of food, healthcare, medical and biological analy...

    Authors: Jianzhong Ge, Xiaolu Wang, Yingguo Bai, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huiying Luo, Bin Yao, Huoqing Huang and Jie Zhang
    Citation: Microbial Cell Factories 2023 22:59
    Content type: Research Published on:

  31. Perylenequinones from Shiraia fruiting bodies are excellent photosensitizers and widely used for anti-cancer photodynamic therapy (PDT). The lower yield of Shiraia perylenequinones becomes a significant bottlenec...

    Authors: Wen Hao Shen, Rui Peng Cong, Xin Ping Li, Qun Yan Huang, Li Ping Zheng and Jian Wen Wang
    Citation: Microbial Cell Factories 2023 22:57
    Content type: Research Published on:

  32. l‑Fucose is a rare sugar that has beneficial biological activities, and its industrial production is mainly achieved with brown algae through acidic/enzymatic fucoidan hydrolysis and a cumbersome purification p.....

    Authors: Cong Fu, Xuexia Xu, Yukang Xie, Yufei Liu, Min Liu, Ai Chen, Jenny M. Blamey, Jiping Shi, Suwen Zhao and Junsong Sun
    Citation: Microbial Cell Factories 2023 22:56
    Content type: Research Published on:

  33. Escherichia coli heat labile toxin B subunit (LTB) is one of the most popular oral vaccine adjuvants and intestine adsorption enhancers. It is often expressed as a fusion partner with target antigens to enhance t...

    Authors: Kum-Kang So, Ngoc My Tieu Le, Ngoc-Luong Nguyen and Dae-Hyuk Kim
    Citation: Microbial Cell Factories 2023 22:55
    Content type: Research Published on:

  34. The strain Lsc-8 can produce a current density of 33.08 µA cm−2 using carboxymethylcellulose (CMC) as a carbon source in a three-electrode configuration. A co-culture system of strain Lsc-8 and Geobacter sulfurre...

    Authors: Lianbin Cao, Hongmei Sun, Yamei Ma, Mingguo Lu, Mengrui Zhao, Enzhong Li and Ying Liu
    Citation: Microbial Cell Factories 2023 22:54
    Content type: Research Published on:

  35. 9α-hydroxyandrost-4-ene-3,17-dione (9-OHAD) is a significant intermediate for the synthesis of glucocorticoid drugs. However, in the process of phytosterol biotransformation to manufacture 9-OHAD, product degr...

    Authors: Xiangcen Liu, Jingxian Zhang, Chenyang Yuan, Guilin Du, Suwan Han, Jiping Shi, Junsong Sun and Baoguo Zhang
    Citation: Microbial Cell Factories 2023 22:53
    Content type: Research Published on:

  36. Thraustochytrids accumulate lipids with a high content of docosahexaenoic acid (DHA). Although their growth and DHA content are significantly affected by the dissolved oxygen (DO) supply, the role of DO on the...

    Authors: Lu Liu, Xingyu Zhu, Huike Ye, Yingying Wen, Biswarup Sen and Guangyi Wang
    Citation: Microbial Cell Factories 2023 22:52
    Content type: Research Published on:

  37. ε-Poly-L-lysine (ε-PL) is a natural and safe food preservative that is mainly produced by filamentous and aerobic bacteria Streptomyces albulus. During ε-PL biosynthesis, a large amount of ATP is used for the pol...

    Authors: Hao Yang, Daojun Zhu, Lang Kai, Liang Wang, Hongjian Zhang, Jianhua Zhang and Xusheng Chen
    Citation: Microbial Cell Factories 2023 22:51
    Content type: Research Published on:

  38. The lipopeptide herbicolin A (HA) secreted by the biocontrol agent Pantoea agglomerans ZJU23 is a promising antifungal drug to combat fungal pathogens by targeting lipid rafts, both in agricultural and clinical s...

    Authors: Hongkai Wang, Yaqi Zhou, Sunde Xu, Boyan Zhang, Tomislav Cernava, Zhonghua Ma and Yun Chen
    Citation: Microbial Cell Factories 2023 22:50
    Content type: Research Published on:

  40. Improving the resistance of Saccharomyces cerevisiae to vanillin, derived from lignin, will benefit the design of robust cell factories for lignocellulosic biorefining. The transcription factor Yrr1p mediates S. ...

    Authors: Weiquan Zhao, Xinning Wang, Bolun Yang, Ying Wang, Zailu Li and Xiaoming Bao
    Citation: Microbial Cell Factories 2023 22:48
    Content type: Research Published on:

  41. Microbially produced bioplastics are specially promising materials since they can be naturally synthesized and degraded, making its end-of-life management more amenable to the environment. A prominent example ...

    Authors: Manuel S. Godoy, Santiago R. de Miguel and M. Auxiliadora Prieto
    Citation: Microbial Cell Factories 2023 22:47
    Content type: Research Published on:

  42. Resveratrol is a commercially available stilbenoid widely used as dietary supplements, functional food ingredients, and cosmetic ingredients due to its diverse physiological activities. The production of resve...

    Authors: Lijun Meng, Mengxue Diao, Qingyan Wang, Longyun Peng, Jianxiu Li and Nengzhong Xie
    Citation: Microbial Cell Factories 2023 22:46
    Content type: Research Published on:

  43. Exopolysaccharides (EPS) secreted by beneficial lactobacilli exert a plethora of positive activities, but little is known about their effects on biofilms of opportunistic vaginal pathogens and especially on bi...

    Authors: Barbara Giordani, Marina Naldi, Vanessa Croatti, Carola Parolin, Ülfet Erdoğan, Manuela Bartolini and Beatrice Vitali
    Citation: Microbial Cell Factories 2023 22:45
    Content type: Research Published on:

  44. Micafungin is an echinocandin-type antifungal agent used for the clinical treatment of invasive fungal infections. It is semisynthesized from the sulfonated lipohexapeptide FR901379, a nonribosomal peptide pro...

    Authors: Ping Men, Yu Zhou, Li Xie, Xuan Zhang, Wei Zhang, Xuenian Huang and Xuefeng Lu
    Citation: Microbial Cell Factories 2023 22:44
    Content type: Research Published on:

  45. Microbial production of propionic acid (PA) from renewable resources is limited by the slow growth of the producer bacteria and product-mediated inhibition. The present study evaluates high cell density contin...

    Authors: Victor Hugo Cavero-Olguin, Tarek Dishisha and Rajni Hatti-Kaul
    Citation: Microbial Cell Factories 2023 22:43
    Content type: Research Published on:

  46. Adding acid protease to feed can enhance protein digestibility, boost feed utilization, and stimulate the growth of animals in breading industry. In order to obtain an acid protease with high hydrolysis effici...

    Authors: Mengyuan Wei, Pengcheng Chen, Pu Zheng, Xiumei Tao, Xiaowei Yu and Dan Wu
    Citation: Microbial Cell Factories 2023 22:42
    Content type: Research Published on:

  47. Pediocin PA-1 is a bacteriocin of recognized value with applications in food bio-preservation and the medical sector for the prevention of infection. To date, industrial manufacturing of pediocin PA-1 is limit...

    Authors: Jens Christmann, Peng Cao, Judith Becker, Christian K. Desiderato, Oliver Goldbeck, Christian U. Riedel, Michael Kohlstedt and Christoph Wittmann
    Citation: Microbial Cell Factories 2023 22:41
    Content type: Research Published on:

  48. Kojic acid (KA) is a widely used compound in the cosmetic, medical, and food industries, and is typically produced by Aspergillus oryzae. To meet increasing market demand, it is important to optimize KA productio...

    Authors: Liu Wu, Licheng Zhang, Xiaojie Li, Ruitong Lv, Wei Cao, Weixia Gao, Jiao Liu, Zhoujie Xie and Hao Liu
    Citation: Microbial Cell Factories 2023 22:40
    Content type: Research Published on:

  49. Virus-like particles are an interesting vector platform for vaccine development. Particularly, Hepatitis B virus core antigen has been used as a promising VLP platform. It is highly expressed in different reco...

    Authors: Sima Sazegari, Malihe Akbarzadeh Niaki, Alireza Afsharifar, Ali Niazi, Abdollah Derakhshandeh, Maryam Moradi Vahdat, Farshad Hemmati and Mohammad Hadi Eskandari
    Citation: Microbial Cell Factories 2023 22:39
    Content type: Research Published on:

  50. Trichoderma reesei (T. reesei) is well-known for its excellent ability to secret a large quantity of cellulase. However, unlike the endogenous proteins, little is known about the molecular mechanisms governing he...

    Authors: Wangli Ji, Xiaolu Wang, Xiaoqing Liu, Yuan Wang, Fangui Liu, Bo Xu, Huiying Luo, Tao Tu, Wei Zhang, Xinxin Xu and Xiaoyun Su
    Citation: Microbial Cell Factories 2023 22:38
    Content type: Research Published on:
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Companion Journals

Microbial Cell Factories is a companion journal to:

Biotechnology for Biofuels and Bioproducts

Biotechnology for the Environment

Blue Biotechnology

Biotechnology for Sustainable Materials

Fungal Biology and Biotechnology


Microbial Cell Factories

ISSN: 1475-2859

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