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  1. Biobased 5-(hydroxymethyl)furfural (5-HMF) is an important platform that offers numerous possibilities for upgrading to a range of chemical, material and fuel products. One reaction of special interest is the ...

    Authors: Sara Jonsdottir Glaser, Sang-Hyun Pyo, Nicola Rehnberg, Dörte Rother and Rajni Hatti-Kaul
    Citation: Microbial Cell Factories 2023 22:120
  2. A processing methodology of raw starch extraction from avocado seeds (ASs) and a sequential hydrolysis and fermentation bioprocess in just a few steps was successfully obtained for the bioethanol production by...

    Authors: Luis Caballero-Sanchez, Pedro E. Lázaro-Mixteco, Alejandra Vargas-Tah and Agustín J. Castro-Montoya
    Citation: Microbial Cell Factories 2023 22:119
  3. Raw starch-degrading α-amylase (RSDA) can hydrolyze raw starch at moderate temperatures, thus contributing to savings in starch processing costs. However, the low production level of RSDA limits its industrial...

    Authors: Dongbang Yao, Xudong Han, Huanhuan Gao, Bin Wang, Zemin Fang, He Li, Wei Fang and Yazhong Xiao
    Citation: Microbial Cell Factories 2023 22:118
  4. Production of 3-hydroxypropionic acid (3-HP) through the malonyl-CoA pathway has yielded promising results in Pichia pastoris (Komagataella phaffii), demonstrating the potential of this cell factory to produce th...

    Authors: Albert Fina, Pierre Millard, Joan Albiol, Pau Ferrer and Stephanie Heux
    Citation: Microbial Cell Factories 2023 22:117
  5. 17β-estradiol (E2) residues exhibit harmful effects both for human and animals and have got global attention of the scientific community. Microbial enzymes are considered as one of the effective strategies hav...

    Authors: Peng Hao, Hanyu Pan, Zongshuo Lv, Jingyi Zhang, Lixia Wang, Yanbin Zhu, Wangdui Basang and Yunhang Gao
    Citation: Microbial Cell Factories 2023 22:116
  6. Chinese Nong-favor daqu, the presentative liquor starter of Baijiu, has been enriched with huge amounts of enzymes in degrading various biological macromolecules by openly man-made process for thousand years. ...

    Authors: Zhuolin Yi, Lanchai Chen, Yanling Jin, Yi Shen, Nian Liu, Yang Fang, Yao Xiao, Xi Wang, Kui Peng, Kaize He and Hai Zhao
    Citation: Microbial Cell Factories 2023 22:114
  7. Compared with steviol glycosides, the taste of glucosylated steviol glycosides is better and more similar to that of sucrose. At present, cyclodextrin glucanotransferase (CGTase) is primarily used to catalyze ...

    Authors: Ruiqin Zhang, Ruiqi Tang, Wei Wang, Jiahua Bi, Xianrui Xu, Qiuling Fan, Yanjun Li and Qihe Chen
    Citation: Microbial Cell Factories 2023 22:113
  8. Bifidobacteria are representative intestinal probiotics that have extremely high application value in the food and medical fields. However, the lack of molecular biology tools limits the research on functional ge...

    Authors: Jiao Li, Xin Song, Zhiqiang Xiong, Guangqiang Wang, Yongjun Xia, Yijin Yang and Lianzhong Ai
    Citation: Microbial Cell Factories 2023 22:112
  9. Lactic Acid Bacteria such as Lactococcus lactis, Latilactobacillus sakei (basonym: Lactobacillus sakei) and Lactiplantibacillus plantarum (basonym: Lactobacillus plantarum) have gained importance as recombinant c...

    Authors: Ricardo Baltà-Foix, Caterina Serrano-Adrover, Adrià López-Cano, Laia Gifre-Renom, Alejandro Sanchez-Chardi, Anna Arís and Elena Garcia-Fruitós
    Citation: Microbial Cell Factories 2023 22:111
  10. A subject of great interest is the bioprospecting of microorganisms and their bioactive byproducts, such as pigments. Microbial pigments have various benefits, including being safe to use due to their natural ...

    Authors: Ahmed A. Abdelaziz, Amal M. Abo Kamer, Khaled B. Al-Monofy and Lamiaa A. Al-Madboly
    Citation: Microbial Cell Factories 2023 22:110
  11. The probiotic yeast Saccharomyces boulardii (Sb) is a promising chassis to deliver therapeutic proteins to the gut due to Sb’s innate therapeutic properties, resistance to phage and antibiotics, and high protein ...

    Authors: Deniz Durmusoglu, Ibrahim Al’Abri, Zidan Li, Taufika Islam Williams, Leonard B. Collins, José L. Martínez and Nathan Crook
    Citation: Microbial Cell Factories 2023 22:109
  12. With the dramatic decrease in fossil fuel stocks and their detrimental effects on the environment, renewable energy sources have gained imminent importance in the mitigation of emissions. As lipid-enriched ene...

    Authors: Yavuz S. Yalcin, Busra Aydin, Huan Chen, Samson Gichuki and Viji Sitther
    Citation: Microbial Cell Factories 2023 22:108
  13. Human life has been significantly impacted by the creation and spread of novel species of antibiotic-resistant bacteria and virus strains that are difficult to manage. Scientists and researchers have recently ...

    Authors: Amr H. Hashem, Mohamed S. Attia, Eslam K. Kandil, Mahmoud M. Fawzi, Ahmed S. Abdelrahman, Mohamed S. Khader, Mohamed A. Khodaira, Abdallah E. Emam, Mohamed A. Goma and Amer M. Abdelaziz
    Citation: Microbial Cell Factories 2023 22:107

    The Correction to this article has been published in Microbial Cell Factories 2023 22:122

  14. Biofloc technology aims to maximize fish farming productivity by effectively breaking down ammonia and nitrite, promoting healthy flocculation, and enhancing the growth and immunity of cultured animals. Howeve...

    Authors: Vikash Kumar, Himanshu Sekhar Swain, Paton Vuong, Suvra Roy, Aurobinda Upadhyay, Ramesh Chandra Malick, Kampan Bisai, Parwinder Kaur and Basanta Kumar Das
    Citation: Microbial Cell Factories 2023 22:106
  15. Previously, we isolated a riboflavin-overproducing Ashbya gossypii mutant (MT strain) and discovered some mutations in genes encoding flavoproteins. Here, we analyzed the riboflavin production in the MT strain, i...

    Authors: Tatsuya Kato, Mai Kano, Ami Yokomori, Junya Azegami, Hesham A. El Enshasy and Enoch Y. Park
    Citation: Microbial Cell Factories 2023 22:105
  16. In the biopharmaceutical industry, Escherichia coli is one of the preferred expression hosts for large-scale production of therapeutic proteins. Although increasing the product yield is important, product quality...

    Authors: Klaudia Arauzo-Aguilera, Luisa Buscajoni, Karin Koch, Gary Thompson, Colin Robinson and Matthias Berkemeyer
    Citation: Microbial Cell Factories 2023 22:104
  17. The filamentous fungus Trichoderma reesei has been used as a host organism for the production of lignocellulosic biomass-degrading enzymes. Although this microorganism has high potential for protein production, i...

    Authors: Toshiharu Arai, Mayumi Wada, Hiroki Nishiguchi, Yasushi Takimura and Jun Ishii
    Citation: Microbial Cell Factories 2023 22:103
  18. Heme is an iron/porphyrin complex compound, widely used in the health care, food, and pharmaceutical industries. It is more advantageous and attractive to develop microbial cell factories to produce heme by fe...

    Authors: Shaomei Yang, Anlong Wang, Jiachang Li, Yunhang Shao, Fengjie Sun, Shucheng Li, Kai Cao, Hongliang Liu, Peng Xiong and Zhengquan Gao
    Citation: Microbial Cell Factories 2023 22:102
  19. The nanoparticles (NPs) formed by Enterococcus thailandicus, Pseudomonas putida, Marinobacter hydrocarbonoclasticus, and P. geniculate were tested against soft rot/blackleg genera. The effects of NPs recorded on ...

    Authors: Alia A. Shoeib, Nader A. Ashmawy, Ayman Kamal and Sahar Abd El Fatah Zaki
    Citation: Microbial Cell Factories 2023 22:101
  20. Human epidermal growth factor receptor 2 (HER2) positive breast cancer is an aggressive subtype, accounting for around 20% of all breast cancers. The development of HER2-targeted therapy has substantially impr...

    Authors: Yanjie Peng, Zhengli Wu, Zheng Pang, Lin Zhang, Dandan Song, Fang Liu, Yanhong Li and Tongjun Lin
    Citation: Microbial Cell Factories 2023 22:100
  21. In research and production, reproducibility is a key factor, to meet high quality and safety standards and maintain productivity. For microbial fermentations, complex substrates and media components are often ...

    Authors: Sarah Sparviero, Max Daniel Dicke, Tobias M. Rosch, Tania Castillo, Holjes Salgado-Lugo, Enrique Galindo, Carlos Peña and Jochen Büchs
    Citation: Microbial Cell Factories 2023 22:99
  22. Palifermin (trade name Kepivance®) is an amino-terminally truncated recombinant human keratinocyte growth factor 1 (KGF-1) with 140 residues that has been produced using Escherichia coli to prevent and treat oral...

    Authors: Young Su Kim, Hye-Jeong Lee, Gabriella Aphrodita Handoko, Jaehui Kim, Seong-Bo Kim, Minho Won, Jung-Ho Park and Jungoh Ahn
    Citation: Microbial Cell Factories 2023 22:98
  23. The filamentous fungus Trichoderma reesei (teleomorph Hypocrea jecorina, Ascomycota) is a well-known lignocellulolytic enzymes-producing strain in industry. To increase the fermentation titer of lignocellulolytic...

    Authors: Chixiang Ma, Jialong Liu, Jiaxin Tang, Yuanlu Sun, Xiaojie Jiang, Tongtong Zhang, Yan Feng, Qinghua Liu and Lei Wang
    Citation: Microbial Cell Factories 2023 22:97
  24. The use of probiotic lactic acid bacteria as a mucosal vaccine vector is considered a promising alternative compared to the use of other microorganisms because of its “Generally Regarded as Safe” status, its p...

    Authors: In-Chan Hwang, Valerie Diane Valeriano, Ji Hoon Song, Marcela Pereira, Ju Kyoung Oh, Kyudong Han, Lars Engstrand and Dae-Kyung Kang
    Citation: Microbial Cell Factories 2023 22:96
  25. Engineered strains of Escherichia coli have been used to produce bioconjugate vaccines using Protein Glycan Coupling Technology (PGCT). Nanovaccines have also entered the vaccine development arena with advances i...

    Authors: Yan Liu, Chao Pan, Kangfeng Wang, Yan Guo, YanGe Sun, Xiang Li, Peng Sun, Jun Wu, Hengliang Wang and Li Zhu
    Citation: Microbial Cell Factories 2023 22:95
  26. Due to the therapeutic importance of microbial pigments, these pigments are receiving the attention of researchers. In this present study 60 isolates were isolated from sediments of Abu-Qir coast of the Medite...

    Authors: Walaa M. Ibrahim, Zakia A. Olama, G. M. Abou-elela, Heba S. Ramadan, Ghada E. Hegazy and Dalia El S. El Badan
    Citation: Microbial Cell Factories 2023 22:94
  27. Prolyl endopeptidase from Aspergillus niger (AN-PEP) is a prominent serine proteinase with various potential applications in the food and pharmaceutical industries. However, the availability of efficient and low-...

    Authors: Minglu Liu, Meng Hu, Hui Zhou, Zhiyang Dong and Xiuzhen Chen
    Citation: Microbial Cell Factories 2023 22:93
  28. Pichia pastoris (Komagataella phaffii) is widely used for industrial production of heterologous proteins due to high secretory capabilities but selection of highly productive engineered strains remains a limiting...

    Authors: Laura Navone, Kaylee Moffitt, James Behrendorff, Pawel Sadowski, Carol Hartley and Robert Speight
    Citation: Microbial Cell Factories 2023 22:92
  29. Biological nitrogen fixation converting atmospheric dinitrogen to ammonia is an important way to provide nitrogen for plants. Pseudomonas stutzeri DSM4166 is a diazotrophic Gram-negative bacterium isolated from t...

    Authors: Guangle Yu, Xiaochen Li, Qiuyue Duan, Jun Fu, Youming Zhang, Hailong Wang and Ji Luan
    Citation: Microbial Cell Factories 2023 22:91
  30. Although microalgae and plants are traditionally used for obtaining natural pigments, overexploitation and overharvesting threaten them. Bacteria represent a superior alternative for the production of pigments...

    Authors: Noura Sh. A. Hagaggi and Usama M. Abdul-Raouf
    Citation: Microbial Cell Factories 2023 22:90
  31. Aromatic α-hydroxy ketones, such as S-2-hydroxypropiophenone (2-HPP), are highly valuable chiral building blocks useful for the synthesis of various pharmaceuticals and natural products. In the present study, ena...

    Authors: Reihaneh Kordesedehi, Mohammad Ali Asadollahi, Azar Shahpiri, Davoud Biria and Pablo Iván Nikel
    Citation: Microbial Cell Factories 2023 22:89
  32. Acetic acid and furfural (AF) are two major inhibitors of microorganisms during lignocellulosic ethanol production. In our previous study, we successfully engineered Zymomonas mobilis 532 (ZM532) strain by genome...

    Authors: Samina Shabbir, Weiting Wang, Mohsin Nawaz, Prerona Boruah, Muhammad Fakhar-e-Alam Kulyar, Mao Chen, Bo Wu, Panting Liu, Yonghua Dai, Lingling Sun, Qiyu Gou, Renbin Liu, Guoquan Hu, Tahira Younis and Mingxiong He
    Citation: Microbial Cell Factories 2023 22:88
  33. Expression systems for lactic acid bacteria have been developed for metabolic engineering applications as well as for food-grade recombinant protein production. But the industrial applications of lactic acid b...

    Authors: Nisit Watthanasakphuban, Pimsiriya Srila, Phitsanu Pinmanee, Kamonwan Sompinit, Kittipong Rattanaporn and Clemens Peterbauer
    Citation: Microbial Cell Factories 2023 22:86
  34. Bacterial siderophores are chelating compounds with the potential of application in agriculture, due to their plant growth-promoting (PGP) properties, however, high production and purification costs are limiti...

    Authors: M. Musialowski, Ł. Kowalewska, R. Stasiuk, T. Krucoń and K. Debiec-Andrzejewska
    Citation: Microbial Cell Factories 2023 22:85
  35. Nature has provided unique molecular scaffolds for applications including therapeutics, agriculture, and food. Due to differences in ecological environments and laboratory conditions, engineering is often nece...

    Authors: Elena Heng, Yi Wee Lim, Chung Yan Leong, Veronica W. P. Ng, Siew Bee Ng, Yee Hwee Lim and Fong Tian Wong
    Citation: Microbial Cell Factories 2023 22:84
  36. Various factors contribute to the development of the acute inflammation process, like the pro-inflammatory cytokines, certain enzymes as well as oxidative stress mediators. The anti-inflammatory potential of t...

    Authors: Asmaa Saleh, Walaa A. Negm, Thanaa A. El-Masry, Duaa Eliwa, Badriyah Alotaibi, Manal E. Alosaimi, Khalid Nijr Alotaibi, Sameh Magdeldin, Sebaey Mahgoub and Engy Elekhnawy
    Citation: Microbial Cell Factories 2023 22:83
  37. Di(2-ethylhexyl) phthalate (DEHP) is a widely detected plasticizer and a priority pollutant of utmost concern for its adverse impact on humans, wildlife and the environment. To eliminate such toxic burden, bio...

    Authors: Mousumi Bhattacharyya, Rinita Dhar, Suman Basu, Avijit Das, Darren M. Reynolds and Tapan K. Dutta
    Citation: Microbial Cell Factories 2023 22:82
  38. Recombinant proteins cover a wide range of biomedical, biotechnological, and industrial needs. Although there are diverse available protocols for their purification from cell extracts or from culture media, ma...

    Authors: Jose Vicente Carratalá, Jan Atienza-Garriga, Hèctor López-Laguna, Esther Vázquez, Antonio Villaverde, Julieta M. Sánchez and Neus Ferrer-Miralles
    Citation: Microbial Cell Factories 2023 22:81
  39. In spite of the fact that recombinant enzymes are preferably biotechnologically obtained using recombinant clones, the purification of proteins from native microorganisms, including those encoded by bacterioph...

    Authors: Beata Łubkowska, Edyta Czajkowska, Aleksandra Stodolna, Michał Sroczyński, Agnieszka Zylicz-Stachula, Ireneusz Sobolewski and Piotr M. Skowron
    Citation: Microbial Cell Factories 2023 22:80

    The Correction to this article has been published in Microbial Cell Factories 2023 22:146

  40. Mucormycosis disease, which has recently expanded with the Covid 19 pandemic in many countries, endangers patients' lives, and treatment with common drugs is fraught with unfavorable side effects.

    Authors: Amr S. Al-kashef, Mohamed U. Nooman, Mona M. Rashad, Amr H. Hashem and Mohamed Abdelraof
    Citation: Microbial Cell Factories 2023 22:79
  41. Metal oxide nanoparticles (NPs) are becoming valuable due to their novel applications. The green synthesis of TiO2 NPs is more popular as a flexible and eco-friendly method compared to traditional chemical synthe...

    Authors: Rasha A. Metwally, Jehan El Nady, Shaker Ebrahim, Amany El Sikaily, Nermeen A. El-Sersy, Soraya A. Sabry and Hanan A. Ghozlan
    Citation: Microbial Cell Factories 2023 22:78
  42. Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as str...

    Authors: Gerrit Haeger, Jessika Wirges, Nicole Tanzmann, Sven Oyen, Tristan Jolmes, Karl-Erich Jaeger, Ulrich Schörken, Johannes Bongaerts and Petra Siegert
    Citation: Microbial Cell Factories 2023 22:77
  43. Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains...

    Authors: Zhenke Wu, Xiqin Liang, Mingkai Li, Mengyu Ma, Qiusheng Zheng, Defang Li, Tianyue An and Guoli Wang
    Citation: Microbial Cell Factories 2023 22:76
  44. Coenzyme A (CoA) is a carrier of acyl groups. This cofactor is synthesized from pantothenic acid in five steps. The phosphorylation of pantothenate is catalyzed by pantothenate kinase (CoaA), which is a key st...

    Authors: Hirotaka Kudo, Sho Ono, Kenta Abe, Mami Matsuda, Tomohisa Hasunuma, Tomoyasu Nishizawa, Munehiko Asayama, Hirofumi Nishihara and Shigeru Chohnan
    Citation: Microbial Cell Factories 2023 22:75
  45. Two important flavonoids, kaempferol and quercetin possess remarkably potent biological impacts on human health. However, their structural complexity and low abundance in nature make both bulk chemical synthes...

    Authors: Musa Tartik, Juan Liu, Marta Tous Mohedano, Jiwei Mao and Yun Chen
    Citation: Microbial Cell Factories 2023 22:74
  46. Algae are prominent producers of carotenoids and polyunsaturated fatty acids which are greatly prized in the food and pharmaceutic industry. Fucoxanthin represents a notable high-value carotenoid produced excl...

    Authors: Antonín Střížek, Pavel Přibyl, Martin Lukeš, Tomáš Grivalský, Jiří Kopecký, Tomáš Galica and Pavel Hrouzek
    Citation: Microbial Cell Factories 2023 22:73
  47. Laccases are multicopper enzymes that oxidize a wide range of aromatic and non-aromatic compounds in the presence of oxygen. The majority of industrially relevant laccases are derived from fungi and are produc...

    Authors: Silja Välimets, Patricia Pedetti, Ludovika Jessica Virginia, Mai Ngoc Hoang, Michael Sauer and Clemens Peterbauer
    Citation: Microbial Cell Factories 2023 22:72
  48. Amino acid production features of Corynebacterium glutamicum were extensively studied in the last two decades. Many metabolic pathways, regulatory and transport principles are known, but purely rational approache...

    Authors: Rico Zuchowski, Simone Schito, Friederike Neuheuser, Philipp Menke, Daniel Berger, Niels Hollmann, Srushti Gujar, Lea Sundermeyer, Christina Mack, Astrid Wirtz, Oliver H. Weiergräber, Tino Polen, Michael Bott, Stephan Noack and Meike Baumgart
    Citation: Microbial Cell Factories 2023 22:71

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