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  1. Dietary lignans belong to the group of phytoestrogens together with coumestans, stilbenes and isoflavones, and themselves do not exhibit oestrogen-like properties. Nonetheless, the gut microbiota converts them...

    Authors: Giulia Corona, Anna Kreimes, Monica Barone, Silvia Turroni, Patrizia Brigidi, Enver Keleszade and Adele Costabile

    Citation: Microbial Cell Factories 2020 19:82

    Content type: Research

    Published on:

  2. Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger. Compared to the traditional ways of process optimization, the metabolic engineering strategie...

    Authors: Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang, Ju Chu, Yufei Sui and Yingping Zhuang

    Citation: Microbial Cell Factories 2020 19:81

    Content type: Research

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  3. The bioconversion of phytosterols into high value-added steroidal intermediates, including the 9α-hydroxy-4-androstene-3,17-dione (9-OHAD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), is the cornerstone i...

    Authors: Liang-Bin Xiong, Hao-Hao Liu, Ming Zhao, Yong-Jun Liu, Lu Song, Zhi-Yong Xie, Yi-Xin Xu, Feng-Qing Wang and Dong-Zhi Wei

    Citation: Microbial Cell Factories 2020 19:80

    Content type: Research

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  6. Microbes are rich sources of enzymes and esterases are one of the most important classes of enzymes because of their potential for application in the field of food, agriculture, pharmaceuticals and bioremediat...

    Authors: Jayita Sarkar, Arindam Dutta, Piyali Pal Chowdhury, Joydeep Chakraborty and Tapan K. Dutta

    Citation: Microbial Cell Factories 2020 19:77

    Content type: Research

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  7. Aspergillus niger is a filamentous fungus used for the majority of global citric acid production. Recent developments in genome editing now enable biotechnologists to engineer and optimize A. niger. Currently, ho...

    Authors: Lihui Zhang, Xiaomei Zheng, Timothy C. Cairns, Zhidan Zhang, Depei Wang, Ping Zheng and Jibin Sun

    Citation: Microbial Cell Factories 2020 19:76

    Content type: Research

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  8. Resistance to therapy is one of the major factors that contribute to dismal survival statistics in pancreatic cancer. While there are many tumor intrinsic and tumor microenvironment driven factors that contrib...

    Authors: Kousik Kesh, Roberto Mendez, Leila Abdelrahman, Santanu Banerjee and Sulagna Banerjee

    Citation: Microbial Cell Factories 2020 19:75

    Content type: Research

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  9. In the course of drug discovery and development process, sufficient reference standards of drug metabolites are required, especially for preclinical/clinical or new therapeutic drugs. Whole-cell synthesis of d...

    Authors: Gianluca Catucci, Gianfranco Gilardi and Sheila J. Sadeghi

    Citation: Microbial Cell Factories 2020 19:74

    Content type: Research

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  10. Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial e...

    Authors: Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim and Joong-Hoon Ahn

    Citation: Microbial Cell Factories 2020 19:73

    Content type: Research

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  11. Caffeine, theobromine and theophylline are main purine alkaloid in tea. Theophylline is the downstream metabolite and it remains at a very low level in Camellia sinensis. In our previous study, Aspergillus sydowi...

    Authors: Binxing Zhou, Cunqiang Ma, Tao Xia, Xiaohong Li, Chengqin Zheng, Tingting Wu and Xiaohui Liu

    Citation: Microbial Cell Factories 2020 19:72

    Content type: Research

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  12. Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186. In a high throughput antifungal scr...

    Authors: Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon…

    Citation: Microbial Cell Factories 2020 19:71

    Content type: Research

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  13. Genome streamlining is a feasible strategy for constructing an optimum microbial chassis for synthetic biology applications. Genomic islands (GIs) are usually regarded as foreign DNA sequences, which can be ob...

    Authors: Peixin Liang, Yiting Zhang, Bo Xu, Yuxin Zhao, Xiangsheng Liu, Weixia Gao, Ting Ma, Chao Yang, Shufang Wang and Ruihua Liu

    Citation: Microbial Cell Factories 2020 19:70

    Content type: Research

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  14. Trichoderma species are among the most effective cell factories to produce recombinant proteins, whose productivity relies on the molecular toolkit and promoters available for the expression of the target protein...

    Authors: Nohemí Carreras-Villaseñor, José Guillermo Rico-Ruiz, Ricardo A. Chávez Montes, Lenin Yong-Villalobos, José Fabricio López-Hernández, Pedro Martínez-Hernández, Luis Herrera-Estrella, Alfredo Herrera-Estrella and Damar López-Arredondo

    Citation: Microbial Cell Factories 2020 19:69

    Content type: Research

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  15. Worldwide 3.4 billion tonnes of municipal solid waste (MSW) will be produced annually by 2050, however, current approaches to MSW management predominantly involve unsustainable practices like landfilling and i...

    Authors: Aritha Dornau, James F. Robson, Gavin H. Thomas and Simon J. McQueen-Mason

    Citation: Microbial Cell Factories 2020 19:68

    Content type: Research

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  16. Lupanine is a plant toxin contained in the wastewater of lupine bean processing industries, which could be used for semi-synthesis of various novel high added-value compounds. This paper introduces an environm...

    Authors: Stella Parmaki, Argyro Tsipa, Marlen I. Vasquez, João M. J. Gonçalves, Ioanna Hadjiadamou, Frederico C. Ferreira, Carlos A. M. Afonso, Chrysoulla Drouza and Michalis Koutinas

    Citation: Microbial Cell Factories 2020 19:67

    Content type: Research

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  17. Microbial de novo production of l-serine, which is widely used in a range of cosmetic and pharmaceutical products, has attracted increasing attention due to its environmentally friendly characteristics. Previous ...

    Authors: Chenyang Wang, Junjun Wu, Binchao Shi, Jiping Shi and Zhijun Zhao

    Citation: Microbial Cell Factories 2020 19:66

    Content type: Research

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  18. The ability of some photosynthetic microorganisms, particularly cyanobacteria and microalgae, to produce hydrogen (H2) is a promising alternative for renewable, clean-energy production. However, the most recent, ...

    Authors: Baptiste Roumezi, Luisana Avilan, Véronique Risoul, Myriam Brugna, Sophie Rabouille and Amel Latifi

    Citation: Microbial Cell Factories 2020 19:65

    Content type: Research

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  19. Gamma aminobutyric acid (GABA) is an important platform chemical, which has been used as a food additive and drug. Additionally, GABA is a precursor of 2-pyrrolidone, which is used in nylon synthesis. GABA is ...

    Authors: Sung-ho Park, Yu Jung Sohn, Si Jae Park and Jong-il Choi

    Citation: Microbial Cell Factories 2020 19:64

    Content type: Research

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  20. Co-expression of two distinct guide RNAs (gRNAs) has been used to facilitate the application of CRISPR/Cas9 system in fields such as large genomic deletion. The paired gRNAs are often placed adjacently in the ...

    Authors: Tingting Ding, Chaoyong Huang, Zeyu Liang, Xiaoyan Ma, Ning Wang and Yi-Xin Huo

    Citation: Microbial Cell Factories 2020 19:63

    Content type: Research

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  21. New semi-synthetic aminoglycoside antibiotics generally use chemical modifications to avoid inactivity from pathogens. One of the most used modifications is 3′,4′-di-deoxygenation, which imitates the structure...

    Authors: Xiaotang Chen, Hui Zhang, Shaotong Zhou, Mingjun Bi, Shizhou Qi, Huiyuan Gao, Xianpu Ni and Huanzhang Xia

    Citation: Microbial Cell Factories 2020 19:62

    Content type: Research

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  22. In the last decade, increasing evidence has shown that changes in human gut microbiota are associated with diseases, such as obesity. The excreted/secreted proteins (secretome) of the gut microbiota affect the...

    Authors: Luigui Gallardo-Becerra, Fernanda Cornejo-Granados, Rodrigo García-López, Alejandra Valdez-Lara, Shirley Bikel, Samuel Canizales-Quinteros, Blanca E. López-Contreras, Alfredo Mendoza-Vargas, Henrik Nielsen and Adrián Ochoa-Leyva

    Citation: Microbial Cell Factories 2020 19:61

    Content type: Research

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  23. Heterogeneity of oil-bearing formations is one of major contributors to low oil recovery efficiency globally. Long-term water flooding will aggravate this heterogeneity by resulting in many large channels duri...

    Authors: Ge Gao, Kaihua Ji, Yibo Zhang, Xiaoli Liu, Xuecheng Dai, Bo Zhi, Yiyan Cao, Dan Liu, Mengmeng Wu, Guoqiang Li and Ting Ma

    Citation: Microbial Cell Factories 2020 19:59

    Content type: Research

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  24. The genome-integrated T7 expression system offers significant advantages, in terms of productivity and product quality, even when expressing the gene of interest (GOI) from a single copy. Compared to plasmid-b...

    Authors: Artur Schuller, Monika Cserjan-Puschmann, Christopher Tauer, Johanna Jarmer, Martin Wagenknecht, Daniela Reinisch, Reingard Grabherr and Gerald Striedner

    Citation: Microbial Cell Factories 2020 19:58

    Content type: Research

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  25. The gut microbiota that inhabit our gastrointestinal tract are well known to play an important role in maintaining human health in many aspects, including facilitating the digestion and absorption of nutrients...

    Authors: Zhao Zhou, Xin Chen, Huakang Sheng, Xiaolin Shen, Xinxiao Sun, Yajun Yan, Jia Wang and Qipeng Yuan

    Citation: Microbial Cell Factories 2020 19:56

    Content type: Review

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  26. 5-Ketofructose (5-KF) has recently been identified as a promising non-nutritive natural sweetener. Gluconobacter oxydans strains have been developed that allow efficient production of 5-KF from fructose by plasmi...

    Authors: Svenja Battling, Karen Wohlers, Chika Igwe, Angela Kranz, Matthias Pesch, Astrid Wirtz, Meike Baumgart, Jochen Büchs and Michael Bott

    Citation: Microbial Cell Factories 2020 19:54

    Content type: Research

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  28. Bacillus subtilis is an important industrial workhorse applied in the production of many different commercially relevant proteins, especially enzymes. Virtually all of these proteins are secreted via the general ...

    Authors: Jolanda Neef, Cristina Bongiorni, Brian Schmidt, Vivianne J. Goosens and Jan Maarten van Dijl

    Citation: Microbial Cell Factories 2020 19:52

    Content type: Research

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  29. Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, and in an effort to identify novel therapeutic target for this disease in recent years, human microbiota has attracted much inte...

    Authors: Liang Shen

    Citation: Microbial Cell Factories 2020 19:50

    Content type: Review

    Published on:

  30. The GRAS and oleaginous yeast Yarrowia lipolytica (Y. lipolytica) is an attractive cell factory for the production of chemicals and biofuels. The production of many natural products of commercial interest have be...

    Authors: Yanping Lu, Qingyu Yang, Zhanglin Lin and Xiaofeng Yang

    Citation: Microbial Cell Factories 2020 19:49

    Content type: Research

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  31. Escherichia coli is an important strain for l-threonine production. Genetic switch is a ubiquitous regulatory tool for gene expression in prokaryotic cells. To sense and regulate intracellular or extracellular ch...

    Authors: Lei Zhao, Ying Lu, Jun Yang, Yu Fang, Lifei Zhu, Zhixiang Ding, Chenhui Wang, Wenjian Ma, Xiaoqing Hu and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2020 19:46

    Content type: Research

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  32. Bacillus licheniformis 2709 is extensively applied as a host for the high-level production of heterologous proteins, but Bacillus cells often possess unfavorable wild-type properties, such as production of viscou...

    Authors: Cuixia Zhou, Huiying Zhou, Dengke Li, Huitu Zhang, Hongbin Wang and Fuping Lu

    Citation: Microbial Cell Factories 2020 19:45

    Content type: Research

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  33. Spore-forming bacteria of the Bacillus genus are widely used probiotics known to exert their beneficial effects also through the stimulation of the host immune response. The oral delivery of B. toyonensis spores ...

    Authors: Francisco Denis S. Santos, Arianna Mazzoli, Ana Raquel Maia, Anella Saggese, Rachele Isticato, Fabio Leite, Susanna Iossa, Ezio Ricca and Loredana Baccigalupi

    Citation: Microbial Cell Factories 2020 19:42

    Content type: Research

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  35. The efficiency of industrial fermentation process mainly depends on carbon yield, final titer and productivity. To improve the efficiency of l-lysine production from mixed sugar, we engineered carbohydrate metabo...

    Authors: Jian-Zhong Xu, Hao-Zhe Ruan, Hai-Bo Yu, Li-Ming Liu and Weiguo Zhang

    Citation: Microbial Cell Factories 2020 19:39

    Content type: Research

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  37. Porcine growth hormone (pGH) is a class of peptide hormones secreted from the pituitary gland, which can significantly improve growth and feed utilization of pigs. However, it is unstable and volatile in vitro...

    Authors: Jinbo Deng, Jiaoqing Li, Miaopeng Ma, Peijing Zhao, Feiping Ming, Zhipeng Lu, Juqing Shi, Qin Fan, Qianyi Liang, Junhao Jia, Jiayi Li, Shuxia Zhang and Linghua Zhang

    Citation: Microbial Cell Factories 2020 19:35

    Content type: Research

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  38. Steroid compounds with a 6,19-oxirane bridge possess interesting biological activities including anticonvulsant and analgesic properties, bacteriostatic activity against Gram-positive bacteria and selective an...

    Authors: Ewa Kozłowska, Agata Matera, Jordan Sycz, Anna Kancelista, Edyta Kostrzewa-Susłow and Tomasz Janeczko

    Citation: Microbial Cell Factories 2020 19:37

    Content type: Research

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  39. Biomass growth of Pencillium chrysogenum is characterised by a distinct pellet morphology consisting of compact hyphal agglomerates. Fungal pellets are advantageous in industrial process control due to rheologica...

    Authors: Lukas Veiter, Julian Kager and Christoph Herwig

    Citation: Microbial Cell Factories 2020 19:33

    Content type: Research

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  40. Bleomycin is a broad-spectrum glycopeptide antitumor antibiotic produced by Streptomyces verticillus. Clinically, the mixture of bleomycin A2 and bleomycin B2 is widely used in combination with other drugs for th...

    Authors: Hong Chen, Jiaqi Cui, Pan Wang, Xin Wang and Jianping Wen

    Citation: Microbial Cell Factories 2020 19:32

    Content type: Research

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  42. Lincomycin, produced by Streptomyces lincolnensis, is a lincosamide antibiotic and widely used for the treatment of the infective diseases caused by Gram-positive bacteria. The mechanisms of lincomycin biosynthes...

    Authors: Chun-Yan Lin, Ai-Ping Pang, Yue Zhang, Jianjun Qiao and Guang-Rong Zhao

    Citation: Microbial Cell Factories 2020 19:30

    Content type: Research

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  43. Avian coccidiosis posts a severe threat to poultry production. In addition to commercial attenuated vaccines, other strategies to combat coccidiosis are urgently needed. Lactobacillus plantarum has been frequentl...

    Authors: Qiong Liu, Yanlong Jiang, Wentao Yang, Yongshi Liu, Chunwei Shi, Jing Liu, Xing Gao, Haibin Huang, Tianming Niu, Guilian Yang and Chunfeng Wang

    Citation: Microbial Cell Factories 2020 19:28

    Content type: Research

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  44. Saccharopolyspora pogona is a prominent industrial strain due to its production of butenyl-spinosyn, a high-quality insecticide against a broad spectrum of insect pests. TetR family proteins are diverse in a trem...

    Authors: Haocheng He, Shuangqin Yuan, Jinjuan Hu, Jianming Chen, Jie Rang, Jianli Tang, Zhudong Liu, Ziyuan Xia, Xuezhi Ding, Shengbiao Hu and Liqiu Xia

    Citation: Microbial Cell Factories 2020 19:27

    Content type: Research

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  45. Caffeic acid is industrially recognized for its antioxidant activity and therefore its potential to be used as an anti-inflammatory, anticancer, antiviral, antidiabetic and antidepressive agent. It is traditio...

    Authors: Kristina Haslinger and Kristala L. J. Prather

    Citation: Microbial Cell Factories 2020 19:26

    Content type: Research

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  46. pWB980 derived from pUB110 is a promising expression vector in Bacillus for its high copy number and high stability. However, the low transformation rate of recombinant plasmids to the wild cells limited the appl...

    Authors: XingYa Zhao, JianYong Xu, Ming Tan, Jie Zhen, WenJu Shu, ShiBin Yang, YanHe Ma, HongChen Zheng and Hui Song

    Citation: Microbial Cell Factories 2020 19:25

    Content type: Research

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  47. Rhodosporidium toruloides has emerged as a promising host for the production of bioproducts from lignocellulose, in part due to its ability to grow on lignocellulosic feedstocks, tolerate growth inhibitors, and c...

    Authors: Gina M. Geiselman, Xun Zhuang, James Kirby, Mary B. Tran-Gyamfi, Jan-Philip Prahl, Eric R. Sundstrom, Yuqian Gao, Nathalie Munoz Munoz, Carrie D. Nicora, Derek M. Clay, Gabriella Papa, Kristin E. Burnum-Johnson, Jon K. Magnuson, Deepti Tanjore, Jeffrey M. Skerker and John M. Gladden

    Citation: Microbial Cell Factories 2020 19:24

    Content type: Research

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  48. The gut microbiota can significantly affect the function of the intestinal barrier. Some intestinal probiotics (such as Lactobacillus, Bifidobacteria, a few Escherichia coli strains, and a new generation of probi...

    Authors: Qing Liu, Zhiming Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai and Wei Chen

    Citation: Microbial Cell Factories 2020 19:23

    Content type: Review

    Published on:

  49. Yarrowia lipolytica is an oleaginous yeast that can be genetically engineered to produce lipid and non-lipid biochemicals from a variety of feedstocks. Metabolic engineering of this organism usually requires gene...

    Authors: Maureen Hamilton, Andrew L. Consiglio, Kyle MacEwen, A. Joe Shaw and Vasiliki Tsakraklides

    Citation: Microbial Cell Factories 2020 19:22

    Content type: Research

    Published on:

  50. A possible future shortage of feed protein will force mankind to explore alternative protein sources that can replace conventional soymeal or fishmeal. Several large industrial organic side-streams could poten...

    Authors: David Lapeña, Gergely Kosa, Line D. Hansen, Liv T. Mydland, Volkmar Passoth, Svein J. Horn and Vincent G. H. Eijsink

    Citation: Microbial Cell Factories 2020 19:19

    Content type: Research

    Published on:

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