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  1. Intracellular hyperaccumulation of phycocyanin (PC) and its high susceptibility to degradation at higher temperatures are major challenging problems associated with its production from cyanobacteria. The prese...

    Authors: Mohamed Gomaa, Shimaa Abdelmohsen Ali and Awatief F. Hifney
    Citation: Microbial Cell Factories 2023 22:248
  2. Photosynthetic cyanobacterial components are gaining great economic importance as prospective low-cost biostimulants for the green synthesis of metal nanoparticles with valuable medical and industrial applicat...

    Authors: Asmaa H. Al-Badwy, Ahmed M. Khalil, Ali H. Bashal and Rashad Kebeish
    Citation: Microbial Cell Factories 2023 22:247
  3. Biodiesel, unlike to its fossil-based homologue (diesel), is renewable. Its use contributes to greater sustainability in the energy sector, mainly by reducing greenhouse gas emissions. Current biodiesel produc...

    Authors: María Gallego-García, Ana Susmozas, María José Negro and Antonio D. Moreno
    Citation: Microbial Cell Factories 2023 22:246
  4. Removal of trace organic chemicals (TOrCs) in aquatic environments has been intensively studied. Some members of natural microbial communities play a vital role in transforming chemical contaminants, however, ...

    Authors: Lijia Cao, Sarahi L. Garcia and Christian Wurzbacher
    Citation: Microbial Cell Factories 2023 22:245
  5. Protein complex assembly facilitates the combination of individual protein subunits into functional entities, and thus plays a crucial role in biology and biotechnology. Recently, we developed quasi-twodimensi...

    Authors: Stefanie Förste, Ohad Vonshak, Shirley S. Daube, Roy H. Bar-Ziv, Reinhard Lipowsky and Sophia Rudorf
    Citation: Microbial Cell Factories 2023 22:244
  6. Integrated metabolic engineering approaches that combine system and synthetic biology tools enable the efficient design of microbial cell factories for synthesizing high-value products. In this study, we utili...

    Authors: Koray Malcı, Rodrigo Santibáñez, Nestor Jonguitud-Borrego, Jorge H. Santoyo-Garcia, Eduard J. Kerkhoven and Leonardo Rios-Solis
    Citation: Microbial Cell Factories 2023 22:243
  7. Plasmid DNA (pDNA) is a key biotechnological product whose importance became apparent in the last years due to its role as a raw material in the messenger ribonucleic acid (mRNA) vaccine manufacturing process....

    Authors: Mathias Gotsmy, Florian Strobl, Florian Weiß, Petra Gruber, Barbara Kraus, Juergen Mairhofer and Jürgen Zanghellini
    Citation: Microbial Cell Factories 2023 22:242
  8. In whole-cell bio-catalysis, the biosystems engineering paradigm shifts from the global reconfiguration of cellular metabolism as in fermentation to a more focused, and more easily modularized, optimization of...

    Authors: Sabine Schelch, Manuel Eibinger, Jasmin Zuson, Jürgen Kuballa and Bernd Nidetzky
    Citation: Microbial Cell Factories 2023 22:241
  9. trans-4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production remains challenging due to the low production efficiency of T-4-HYP. This stud...

    Authors: Yu Gong, Ruiqi Wang, Ling Ma, Shuo Wang, Changgeng Li and Qingyang Xu
    Citation: Microbial Cell Factories 2023 22:240
  10. (Hydroxy)cinnamyl alcohols and allylphenols, including coniferyl alcohol and eugenol, are naturally occurring aromatic compounds widely utilised in pharmaceuticals, flavours, and fragrances. Traditionally, the...

    Authors: Erik K. R. Hanko, Kris Niño G. Valdehuesa, Koen J. A. Verhagen, Jakub Chromy, Ruth A. Stoney, Jeremy Chua, Cunyu Yan, Johannes A. Roubos, Joep Schmitz and Rainer Breitling
    Citation: Microbial Cell Factories 2023 22:238
  11. Methanol is increasingly gaining attraction as renewable carbon source to produce specialty and commodity chemicals, as it can be generated from renewable sources such as carbon dioxide (CO2). In this context, na...

    Authors: Sílvia Àvila-Cabré, Míriam Pérez-Trujillo, Joan Albiol and Pau Ferrer
    Citation: Microbial Cell Factories 2023 22:237
  12. Thermophilic fungus Myceliophthora thermophila has been widely used in industrial applications due to its ability to produce various enzymes. However, the lack of an efficient protein expression system has limite...

    Authors: Jinyang Li, Yidi Wang, Kun Yang, Xiaolu Wang, Yuan Wang, Honglian Zhang, Huoqing Huang, Xiaoyun Su, Bin Yao, Huiying Luo and Xing Qin
    Citation: Microbial Cell Factories 2023 22:236
  13. Emerging evidence has shown that extracellular vesicles (EVs) derived from gut bacteria play a crucial role in microbiota-host interactions. Here, we aimed to evaluate the attenuating effect of EVs derived fro...

    Authors: Lin Ye, Yizhong Wang, Fangfei Xiao, Xufei Wang, Xiaolu Li, Rong Cao, Jiayue Zhang and Ting Zhang
    Citation: Microbial Cell Factories 2023 22:235
  14. Flavonoids are important plant secondary metabolites showing antioxidant, antitumor, anti-inflammatory, and antiviral activities, among others. Methylated flavonoids are particularly interesting compared to no...

    Authors: Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J. Villar and Felipe Lombó
    Citation: Microbial Cell Factories 2023 22:234
  15. Pamamycins are a family of highly bioactive macrodiolide polyketides produced by Streptomyces alboniger as a complex mixture of derivatives with molecular weights ranging from 579 to 705 Daltons. The large deriva...

    Authors: Nikolas Eckert, Yuriy Rebets, Lilya Horbal, Josef Zapp, Jennifer Herrmann, Tobias Busche, Rolf Müller, Jörn Kalinowski and Andriy Luzhetskyy
    Citation: Microbial Cell Factories 2023 22:233
  16. Several reports demonstrated anti-inflammatory properties of minocycline in various inflammatory disorders including colitis. We have experimental evidence suggesting synergistic anti-inflammatory effect of mi...

    Authors: Maitham A. Khajah and Sanaa Hawai
    Citation: Microbial Cell Factories 2023 22:232
  17. The physical states and chemical components of bulk sludge determine the occurrence and development of membrane fouling in membrane bioreactors. Thus, regulation of sludge suspensions can provide new strategie...

    Authors: Ji Qi, Qicheng Zhou, Danlei Huang, Zhong Yu and Fangang Meng
    Citation: Microbial Cell Factories 2023 22:230
  18. Cyanobacteria are a potential source of promising secondary metabolites with different biological activities, including antibacterial, antiviral, antifungal, antiprotozoal, and anticancer activities. To combat...

    Authors: Mabroka H. Saad, Nagwa M. Sidkey and Esmail M. El-Fakharany
    Citation: Microbial Cell Factories 2023 22:229
  19. Mycosynthesis of silver nanoparticles (SNPs) offers a safe, eco-friendly, and promising alternative technique for large-scale manufacturing. Our study might be the first report that uses mycelial filtrate of a...

    Authors: Nessma A. EL-Zawawy, Alaa M. Abou-Zeid, Doha M. Beltagy, Nada H. Hantera and Hoda S. Nouh
    Citation: Microbial Cell Factories 2023 22:228
  20. Not changing the native constitution of genes prior to their expression by a heterologous host can affect the amount of proteins synthesized as well as their folding, hampering their activity and even cell via...

    Authors: Thomas Willems, Wim Hectors, Jeltien Rombaut, Anne-Sofie De Rop, Stijn Goegebeur, Tom Delmulle, Maarten L. De Mol, Sofie L. De Maeseneire and Wim K. Soetaert
    Citation: Microbial Cell Factories 2023 22:227
  21. Many plants possess immense pharmacological properties because of the presence of various therapeutic bioactive secondary metabolites that are of great importance in many pharmaceutical industries. Therefore, ...

    Authors: Poonam Kumari, Nikky Deepa, Prabodh Kumar Trivedi, Brajesh K. Singh, Vaibhav Srivastava and Akanksha Singh
    Citation: Microbial Cell Factories 2023 22:226
  22. Lacticaseibacillus is one of the predominant microorganisms in gut from human and animal, and the lacticaseibacillus have effective applications against the viral diarrhea of piglets in the farm. However, the fun...

    Authors: Shaojun Chen, Zida Nai, Ziliang Qin, Gang Li, Xinmiao He, Wentao Wang, Yaguang Tian, Di Liu and Xinpeng Jiang
    Citation: Microbial Cell Factories 2023 22:225
  23. Protein purification remains a critical need for biosciences and biotechnology. It frequently requires multiple rounds of chromatographic steps that are expensive and time-consuming. Our lab previously reporte...

    Authors: Guang Zeng, Yinzhen Zheng, Ya Xiang, Run Liu, Xiaofeng Yang and Zhanglin Lin
    Citation: Microbial Cell Factories 2023 22:224
  24. Lactic acid is one of the most important organic acids, with various applications in the food, beverage, pharmaceutical, cosmetic, and chemical industries. Optically pure forms of L- and D-lactic acid produced...

    Authors: Ernesta Augustiniene, Ilona Jonuskiene, Jurgita Kailiuviene, Edita Mazoniene, Kestutis Baltakys and Naglis Malys
    Citation: Microbial Cell Factories 2023 22:223
  25. Oxytetracycline which is derived from Streptomyces rimosus, inhibits a wide range of bacteria and is industrially important. The underlying biosynthetic processes are complex and hinder rational engineering, so i...

    Authors: Selma Beganovic, Christian Rückert-Reed, Hilda Sucipto, Wei Shu, Lars Gläser, Thomas Patschkowski, Ben Struck, Jörn Kalinowski, Andriy Luzhetskyy and Christoph Wittmann
    Citation: Microbial Cell Factories 2023 22:222
  26. Normally, a salt amount greater than 3.5% (w/v) is defined as hypersaline. Large amounts of hypersaline wastewater containing organic pollutants need to be treated before it can be discharged into the environm...

    Authors: Jie Zheng, Zhengzhi Zhang, Juan An, Yubin Xue and Bo Yu
    Citation: Microbial Cell Factories 2023 22:220
  27. Production of plant secondary metabolites in engineered microorganisms provides a scalable and sustainable alternative to their sourcing from nature or through chemical synthesis. However, the biosynthesis of ...

    Authors: Michal Poborsky, Christoph Crocoll, Mohammed Saddik Motawie and Barbara Ann Halkier
    Citation: Microbial Cell Factories 2023 22:219
  28. Identification and characterization of novel, faithful and processive DNA polymerases is a driving force in the development of DNA amplification methods. Purification of proteins from natural phages is often t...

    Authors: Pengjun Han, Huahao Fan and Yigang Tong
    Citation: Microbial Cell Factories 2023 22:217
  29. Lignocellulosic biomass plays a crucial role in creating a circular bioeconomy and minimizing environmental impact. Enset biomass is a byproduct of traditional Ethiopian Enset food processing that is thrown aw...

    Authors: Nebyat Seid, Katrin Ochsenreither and Anke Neumann
    Citation: Microbial Cell Factories 2023 22:216
  30. Seleno-methylselenocysteine (SeMCys) is an effective component of selenium supplementation with anti-carcinogenic potential that can ameliorate neuropathology and cognitive deficits. In a previous study, a SeM...

    Authors: Xian Yin, Meiyi Zhao, Yu Zhou, Hulin Yang, Yonghong Liao and Fenghuan Wang
    Citation: Microbial Cell Factories 2023 22:215
  31. The increasing prevalence of plastic waste combined with the inefficiencies of mechanical recycling has inspired interest in processes that can convert these waste streams into value-added biomaterials. To dat...

    Authors: Alexander Connor, Jessica V. Lamb, Massimiliano Delferro, Mattheos Koffas and R. Helen Zha
    Citation: Microbial Cell Factories 2023 22:214
  32. Enantio-pure α-hydroxy amides are valuable intermediates for the synthesis of chiral pharmaceuticals. The asymmetric reduction of α-keto amides to generate chiral α-hydroxy amides is a difficult and challengin...

    Authors: Ruixuan Bai, Baoling Chen and Liangyu Zheng
    Citation: Microbial Cell Factories 2023 22:213
  33. Oviedomycin is one among several polyketides known for their potential as anticancer agents. The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in Streptomyces antibioticus. However, because t...

    Authors: Boncheol Gu, Duck Gyun Kim, Do-Kyung Kim, Minji Kim, Hyun Uk Kim and Min-Kyu Oh
    Citation: Microbial Cell Factories 2023 22:212
  34. Halophiles possess several unique properties and have broad biotechnological applications including industrial biotechnology production. Halomonas spp., especially Halomonas bluephagenesis, have been engineered t...

    Authors: Chunyan Liu, Yaxin Yue, Yanfen Xue, Cheng Zhou and Yanhe Ma
    Citation: Microbial Cell Factories 2023 22:211
  35. Phenylpropanoids such as p-coumaric acid represent important precursors for the synthesis of a broad range of plant secondary metabolites including stilbenoids, flavonoids, and lignans, which are of pharmacologic...

    Authors: Mario Mutz, Dominic Kösters, Benedikt Wynands, Nick Wierckx and Jan Marienhagen
    Citation: Microbial Cell Factories 2023 22:209
  36. Zymomonas mobilis is an important industrial bacterium ideal for biorefinery and synthetic biology studies. High-throughput CRISPR-based genome editing technologies have been developed to enable targeted engineer...

    Authors: Yanli Zheng, Hongmei Fu, Jue Chen, Jie Li, Yuejie Bian, Ping Hu, Lei Lei, Yihan Liu, Jiangke Yang and Wenfang Peng
    Citation: Microbial Cell Factories 2023 22:208
  37. Providing sufficient and usable energy for the cell factory has long been a heated issue in biosynthesis as solar energy has never been rooted out from the strategy for improvement, and turning Escherichia coli (...

    Authors: Chao-Yu Lee, Kai-Wen Chen, Chih-Lu Chiang, Hsuan-Yu Kao, Hao-Cheng Yu, Hsiao-Ching Lee and Wen-Liang Chen
    Citation: Microbial Cell Factories 2023 22:207
  38. Coenzyme Q10 (CoQ10) is crucial for human beings, especially in the fields of biology and medicine. The aim of this experiment was to investigate the conditions for increasing CoQ10 production. At present, microb...

    Authors: Yujun Xiao, Yi Zheng, Yong Zhou, Chaofan Yu and Ting-E Ye
    Citation: Microbial Cell Factories 2023 22:206
  39. Edible mushrooms are delicious in flavour and rich in high-quality protein and amino acids required by humans. A transcription factor, general control nonderepressible 4 (GCN4), can regulate the expression of ...

    Authors: Lingdan Lian, Jinjin Qiao, Xiaoyu Guo, Zhenzhen Xing, Ang Ren, Mingwen Zhao and Jing Zhu
    Citation: Microbial Cell Factories 2023 22:205
  40. “ATP wasting” has been observed in 13C metabolic flux analyses of Saccharomyces cerevisiae, a yeast strain commonly used to produce ethanol. Some strains of S. cerevisiae, such as the sake strain Kyokai 7, consum...

    Authors: Futa Yatabe, Taisuke Seike, Nobuyuki Okahashi, Jun Ishii and Fumio Matsuda
    Citation: Microbial Cell Factories 2023 22:204
  41. Bacillus subtilis is one of the workhorses in industrial biotechnology and well known for its secretion potential. Efficient secretion of recombinant proteins still requires extensive optimization campaigns and s...

    Authors: Patrick Lenz, Patrick J. Bakkes, Carolin Müller, Marzena Malek, Roland Freudl, Marco Oldiges, Thomas Drepper, Karl-Erich Jaeger and Andreas Knapp
    Citation: Microbial Cell Factories 2023 22:203
  42. The application of exopolysaccharide-producing bacteria (EPS) in dual chamber microbial fuel cells (DCMFC) is critical which can minimize the chemical oxygen demand (COD) of molasses with bioelectricity produc...

    Authors: Ebtehag A. E. Sakr, Dena Z. Khater, Zeinab M. H. Kheiralla and Kamel M. El‑khatib
    Citation: Microbial Cell Factories 2023 22:202
  43. Xylitol has a wide range of applications in the pharmaceuticals, cosmetic, food and beverage industry. Microbial xylitol production reduces the risk of contamination and is considered as environment friendly a...

    Authors: Anup Kumar Singh, Farha Deeba, Mohit Kumar, Sonam Kumari, Shahid Ali Wani, Tanushree Paul and Naseem A. Gaur
    Citation: Microbial Cell Factories 2023 22:201
  44. Bacillus subtilis has been established as model microorganism for fundamental research in the laboratory on protein production/secretion and sporulation and as model bacterium for controlling spoilage in the food...

    Authors: Taichi Chen, Stanley Brul and Jeroen Hugenholtz
    Citation: Microbial Cell Factories 2023 22:200
  45. Long-chain polyunsaturated fatty acids (LC-PUFAs), such as docosahexaenoic acid (DHA), are essential for human health and have been widely used in the food and pharmaceutical industries. However, the limited a...

    Authors: Demian Dietrich, Sofija Jovanovic-Gasovic, Peng Cao, Michael Kohlstedt and Christoph Wittmann
    Citation: Microbial Cell Factories 2023 22:199

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