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  1. Raw starch-degrading enzyme (RSDE) is applied in biorefining of starch to produce biofuels efficiently and economically. At present, RSDE is obtained via secretion by filamentous fungi such as Penicillium oxalicu...

    Authors: Shuai Zhao, Ming-Zhu Tan, Rui-Xian Wang, Fa-Ting Ye, Yuan-Peng Chen, Xue-Mei Luo and Jia-Xun Feng
    Citation: Microbial Cell Factories 2022 21:272
  2. α-Humulene is an important biologically active sesquiterpene, whose heterologous production in microorganisms is a promising alternative biotechnological process to plant extraction and chemical synthesis. In ...

    Authors: Qi Guo, Qian-Qian Peng, Ying-Ying Chen, Ping Song, Xiao-Jun Ji, He Huang and Tian-Qiong Shi
    Citation: Microbial Cell Factories 2022 21:271
  3. Resveratrol is a plant-derived phenylpropanoid with diverse biological activities and pharmacological applications. Plant-based extraction could not satisfy ever-increasing market demand, while chemical synthe...

    Authors: Mengyao Zhang, Qidou Gao, Yijuan Liu, Zhumei Fang, Zhiwei Gong, Zongbao K. Zhao and Xiaobing Yang
    Citation: Microbial Cell Factories 2022 21:270
  4. 2-Phenylethanol (2-PE), a higher alcohol with a rose-like odor, inhibits growth of the producer strains. However, the limited knowledge regarding 2-PE tolerance mechanisms renders our current knowledge base in...

    Authors: Huili Xia, Yue Kang, Zilin Ma, Cuiyu Hu, Qiao Yang, Xiaoling Zhang, Shihui Yang, Jun Dai and Xiong Chen
    Citation: Microbial Cell Factories 2022 21:269
  5. The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that ...

    Authors: Ramon Roca-Pinilla, Leszek Lisowski, Anna Arís and Elena Garcia-Fruitós
    Citation: Microbial Cell Factories 2022 21:267
  6. Genetic modifications in Bacillus subtilis have allowed the conversion of myo-inositol into scyllo-inositol, which is proposed as a therapeutic agent for Alzheimer’s disease. This conversion comprises two reactio...

    Authors: Yuzheng Wu, Honami Kawabata, Kyosuke Kita, Shu Ishikawa, Kan Tanaka and Ken-ichi Yoshida
    Citation: Microbial Cell Factories 2022 21:266
  7. Continuous processing with enzyme reuse is a well-known engineering strategy to enhance the efficiency of biocatalytic transformations for chemical synthesis. In one-pot multistep reactions, continuous process...

    Authors: Katharina N. Schwaiger and Bernd Nidetzky
    Citation: Microbial Cell Factories 2022 21:265
  8. The immobilized technology for microbial or cells has the advantages of high microbial activity, high microbial density per unit space, good tolerance, strong shock, load resistance, high processing efficiency...

    Authors: Zhi-Hao Zhong and Yu-Qing Zhang
    Citation: Microbial Cell Factories 2022 21:264
  9. Phospholipase D (PLD) is highly valuable in the food and medicine industries, where it is used to convert low-cost phosphatidylcholine into high-value phospholipids (PLs). Despite being overexpressed in Streptomy...

    Authors: Juntan Wang, Haihua Zhu, Huiyi Shang, Bishan Guo, Mengxue Zhang, Fayun Wang, Lipan Zhang, Jun Xu and Hui Wang
    Citation: Microbial Cell Factories 2022 21:263
  10. Pyocyanin, a specific extracellular secondary metabolite pigment produced by Pseudomonas aeruginosa, exhibits redox activity and has toxic effects on mammalian cells, making it a new and potent alternative for tr...

    Authors: Ahmed A. Abdelaziz, Amal M. Abo Kamer, Khaled B. Al-Monofy and Lamiaa A. Al-Madboly
    Citation: Microbial Cell Factories 2022 21:262
  11. Antarctica has one of the most extreme environments in the world. This region is inhabited by specifically adapted microorganisms that produce various unique secondary metabolites (e.g. pigments) enabling thei...

    Authors: Michal Styczynski, Agata Rogowska, Christine Nyabayo, Przemyslaw Decewicz, Filip Romaniuk, Cezary Pączkowski, Anna Szakiel, Roderich Suessmuth and Lukasz Dziewit
    Citation: Microbial Cell Factories 2022 21:261
  12. Membrane proteins (MPs) are an important class of molecules with a wide array of cellular functions and are part of many metabolic pathways. Despite their great potential—as therapeutic drug targets or in micr...

    Authors: Chiara Guidi, Lien De Wannemaeker, Jasmine De Baets, Wouter Demeester, Jo Maertens, Brecht De Paepe and Marjan De Mey
    Citation: Microbial Cell Factories 2022 21:260
  13. Owing to CRISPR-Cas9 and derivative technologies, genetic studies on microorganisms have dramatically increased. However, the CRISPR-Cas9 system is still difficult to utilize in many wild-type Bacillus strains ow...

    Authors: Man Su Kim, Da-Eun Jeong and Soo-Keun Choi
    Citation: Microbial Cell Factories 2022 21:259
  14. Expression of affinity-tagged recombinant proteins for crystallography, protein–protein interaction, antibody generation, therapeutic applications, etc. mandates the generation of high-yield soluble proteins. ...

    Authors: Amruta A. Shendge and Jacinta S. D’Souza
    Citation: Microbial Cell Factories 2022 21:258
  15. Spray drying is the most cost-effective production method for lactic acid bacteria starters, but heat and oxidative stresses result in low survival rates. The heat stress and oxidative stress tolerance of Lactica...

    Authors: Chenchen Zhang, Haohao Cheng, Yuemei Han, Yunchao Wa, Dawei Chen, Chengran Guan, Yujun Huang and Ruixia Gu
    Citation: Microbial Cell Factories 2022 21:257
  16. The global market for sweeteners is increasing, and the food industry is constantly looking for new low-caloric sweeteners. The natural sweetener 5-keto-d-fructose is one such candidate. 5-Keto-d-fructose has a s...

    Authors: Svenja Battling, Tobias Engel, Elena Herweg, Paul-Joachim Niehoff, Matthias Pesch, Theresa Scholand, Marie Schöpping, Nina Sonntag and Jochen Büchs
    Citation: Microbial Cell Factories 2022 21:255
  17. Rhodosporidium toruloides is capable of co-utilization of complex carbon sources and robust growth from lignocellulosic hydrolysates. This oleaginous yeast is therefore an attractive host for heterologous produc...

    Authors: Peter B. Otoupal, Gina M. Geiselman, Asun M. Oka, Carolina A. Barcelos, Hemant Choudhary, Duy Dinh, Wenqing Zhong, HeeJin Hwang, Jay D. Keasling, Aindrila Mukhopadhyay, Eric Sundstrom, Robert W. Haushalter, Ning Sun, Blake A. Simmons and John M. Gladden
    Citation: Microbial Cell Factories 2022 21:254
  18. Despite decades of engineering efforts, recombinant Saccharomyces cerevisiae are still less efficient at converting d-xylose sugar to ethanol compared to the preferred sugar d-glucose. Using GFP-based biosensors ...

    Authors: Celina Borgström, Viktor C. Persson, Oksana Rogova, Karen O. Osiro, Ester Lundberg, Peter Spégel and Marie Gorwa-Grauslund
    Citation: Microbial Cell Factories 2022 21:253
  19. Cottonseed meal (CSM) is the main by-product of the cottonseed oil extraction process with high protein content, which is an important protein source for feed industry. However, CSM contains free gossypol (FG)...

    Authors: Zhenting Zhang, Danlu Yang, Ling Liu, Zhangbing Chang and Nan Peng
    Citation: Microbial Cell Factories 2022 21:252
  20. The starch in waste bread (WB) from industrial sandwich production was directly converted to ethanol by an amylolytic, ethanologenic thermophile (Parageobacillus thermoglucosidasius strain TM333) under 5 differen...

    Authors: Christopher C. Ibenegbu and David J. Leak
    Citation: Microbial Cell Factories 2022 21:251
  21. Cortisone is a metabolite belonging to the corticosteroid class that is used pharmaceutically directly as a drug or prodrug. In addition to its large consumption, its use is linked to several side effects, so ...

    Authors: Stefania Costa, Paola Tedeschi, Luca Ferraro, Sarah Beggiato, Alessandro Grandini, Stefano Manfredini, Raissa Buzzi, Gianni Sacchetti and Giuseppe Valacchi
    Citation: Microbial Cell Factories 2022 21:250
  22. Genomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have remained enigmatic. The ascomycete genus Epicoccum, belonging to the fami...

    Authors: Tao Zhang, Guowei Cai, Xiaoting Rong, Jingwen Xu, Bingya Jiang, Hao Wang, Xinxin Li, Lu Wang, Ran Zhang, Wenni He and Liyan Yu
    Citation: Microbial Cell Factories 2022 21:249
  23. Polyamide (nylon) is an important material, which has aroused plenty of attention from all aspects. PA 5.4 is one kind of nylon with excellent property, which consists of cadaverine and succinic acid. Due to t...

    Authors: Siyuan Gao, Jiachen Lu, Tongtao Wang, Sheng Xu, Xin Wang, Kequan Chen and Pingkai Ouyang
    Citation: Microbial Cell Factories 2022 21:248
  24. Industrial bioethanol production may involve a low pH environment caused by inorganic acids, improving the tolerance of Saccharomyces cerevisiae to a low pH environment is of industrial importance to increase eth...

    Authors: Yajing Wu, Bo Li, Bu Miao, Caiyun Xie and Yue-Qin Tang
    Citation: Microbial Cell Factories 2022 21:247
  25. α-Ionone is highly valued in cosmetics and perfumery with a global usage of 100–1000 tons per year. Metabolic engineering by microbial fermentation offers a promising way to produce natural (R)-α-ionone in a cost...

    Authors: Ching-Ning Huang, Xiaohui Lim, Leonard Ong, Chinchin Lim, Xixian Chen and Congqiang Zhang
    Citation: Microbial Cell Factories 2022 21:246
  26. The remains of the heart tissue of Thaddeus Kosciuszko have been investigated as the possible cause of disease and death of the hero of Polish and American nations. Three specimens, DNA isolated from scrapping...

    Authors: Michał Witt, Miron Tokarski, Ewa Ziętkiewicz, Arleta Lebioda, Maria Szczypek, Wojciech Falkowski, Przemysław Mrozowski, Teresa Kulak, Małgorzata Sobieszczańska, Magdalena Mrugalska-Banaszak, Tomasz Jurek and Tadeusz Dobosz
    Citation: Microbial Cell Factories 2022 21:245
  27. Due to its high expression capability, recombination of Escherichia coli and pET vector has become the bioengineering preferred expression system. Because β-lactamases mediate bacterial antimicrobial resistance, ...

    Authors: Lele Li, Hui Li, Qingwu Tian, Baosheng Ge, Xiaotong Xu, Yuanyuan Chi, Huaizhi Zhao, Yanfei Liu, Nan Jia, Tingting Zhou, Yuanqi Zhu and Yusun Zhou
    Citation: Microbial Cell Factories 2022 21:244
  28. Ethyl acetate is a bulk chemical traditionally produced via energy intensive chemical esterification. Microbial production of this compound offers promise as a more sustainable alternative process. So far, eff...

    Authors: James C. Dykstra, Jelle van Oort, Ali Tafazoli Yazdi, Eric Vossen, Constantinos Patinios, John van der Oost, Diana Z. Sousa and Servé W. M. Kengen
    Citation: Microbial Cell Factories 2022 21:243
  29. Malic acid, a dicarboxylic acid mainly used in the food industry, is currently produced from fossil resources. The utilization of low-cost substrates derived from biomass could render microbial processes econo...

    Authors: Aline Kövilein, Vera Aschmann, Lena Zadravec and Katrin Ochsenreither
    Citation: Microbial Cell Factories 2022 21:242
  30. Recent studies have demonstrated that gut microbiota plays critical roles in various human diseases. High-throughput technology has been widely applied to characterize the microbial ecosystems, which led to an...

    Authors: Peishun Li, Hao Luo, Boyang Ji and Jens Nielsen
    Citation: Microbial Cell Factories 2022 21:241
  31. Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain. Lack of research on its ...

    Authors: Zhenxin Li, Songbai Yang, Zhengyu Zhang, Yuanjie Wu, Jiawei Tang, Luoju Wang and Shaoxin Chen
    Citation: Microbial Cell Factories 2022 21:240
  32. Caveolae are invaginated plasma membrane domains of 50–100 nm in diameter involved in many important physiological functions in eukaryotic cells. They are composed of different proteins, including the membrane...

    Authors: A. Flourieusse, P. Bourgeois, E. Schenckbecher, J. Palvair, D. Legrand, C. Labbé, T. Bescond, L. Avoscan, S. Orlowski, A. Rouleau and A. Frelet-Barrand
    Citation: Microbial Cell Factories 2022 21:239
  33. Our recent multi-omics analyses of glucoamylase biosynthesis in Aspergillus niger (A. niger) suggested that lipid catabolism was significantly up-regulated during high-yield period under oxygen limitation. Since ...

    Authors: Jie Qi, Xianzun Xiao, Liming Ouyang, Chenghan Yang, Yingping Zhuang and Lixin Zhang
    Citation: Microbial Cell Factories 2022 21:238
  34. Lactobacillus species dominate the vaginal microflora performing a first-line defense against vaginal infections. Extracellular vesicles (EVs) released by lactobacilli are considered mediators of their beneficial...

    Authors: Vanessa Croatti, Carola Parolin, Barbara Giordani, Claudio Foschi, Stefano Fedi and Beatrice Vitali
    Citation: Microbial Cell Factories 2022 21:237
  35. Bacteriocins are ribosomally synthesized antimicrobial peptides, that either kill target bacteria or inhibit their growth. Bacteriocins are used in food preservation and are of increasing interest as potential...

    Authors: Christian K. Desiderato, Katharina M. Hasenauer, Sebastian J. Reich, Oliver Goldbeck, Lalaina Holivololona, Kirill V. Ovchinnikov, Alexander Reiter, Marco Oldiges, Dzung B. Diep, Bernhard J. Eikmanns and Christian U. Riedel
    Citation: Microbial Cell Factories 2022 21:236
  36. Natural life systems can be significantly modified at the genomic scale by human intervention, demonstrating the great innovation capacity of genome engineering. Large epi-chromosomal DNA structures were estab...

    Authors: Junchang Su, Pengju Wang, Ju Li, Dongdong Zhao, Siwei Li, Feiyu Fan, Zhubo Dai, Xiaoping Liao, Zhitao Mao, Chunzhi Zhang, Changhao Bi and Xueli Zhang
    Citation: Microbial Cell Factories 2022 21:235
  37. Trichoderma spp. are important agricultural biocontrol microorganisms that are often used as effective components of microbial fungicides and microbial biofertilizers. However, most of these products are prepared...

    Authors: Dazhi Hao, Bo Lang, Yongkun Wang, Xinhua Wang, Tong Liu and Jie Chen
    Citation: Microbial Cell Factories 2022 21:234
  38. The global market for lactic acid is witnessing growth on the back of increasing applications of lactic acid for manufacturing polylactic acid. Indeed, the lactic acid market is expected to reach 9.8 billion U...

    Authors: Miguel G. Acedos, Paz Gómez-Pérez, Tamara Espinosa, Christian Abarca, Bernat Ibañez and Begoña Ruiz
    Citation: Microbial Cell Factories 2022 21:233
  39. Caprazamycins are liponucleoside antibiotics showing bioactivity against Gram-positive bacteria including clinically relevant Mycobacterium tuberculosis by targeting the bacterial MraY-translocase. Their chemical...

    Authors: Daniel Bär, Benjamin Konetschny, Andreas Kulik, Houchao Xu, Davide Paccagnella, Patrick Beller, Nadine Ziemert, Jeroen S. Dickschat and Bertolt Gust
    Citation: Microbial Cell Factories 2022 21:232
  40. A representative hydrogen-oxidizing bacterium Cupriavidus necator H16 has attracted much attention as hosts to recycle carbon dioxide (CO2) into a biodegradable polymer, poly(R)-3-hydroxybutyrate (PHB). Although

    Authors: Soyoung Kim, Yong Jae Jang, Gyeongtaek Gong, Sun-Mi Lee, Youngsoon Um, Kyoung Heon Kim and Ja Kyong Ko
    Citation: Microbial Cell Factories 2022 21:231
  41. Ginsenosides are Panax plant-derived triterpenoid with wide applications in cardiovascular protection and immunity-boosting. However, the saponins content of Panax plants is fairly low, making it time-consuming a...

    Authors: Yuan Zhu, Jianxiu Li, Longyun Peng, Lijun Meng, Mengxue Diao, Shuiyuan Jiang, Jianbin Li and Nengzhong Xie
    Citation: Microbial Cell Factories 2022 21:230
  42. The production of chemicals via bio-based routes is held back by limited easy-to-use stabilisation systems. A wide range of plasmid stabilisation mechanisms can be found in the literature, however, how these m...

    Authors: James R. Allen, Mario A. Torres-Acosta, Naresh Mohan, Gary J. Lye and John M. Ward
    Citation: Microbial Cell Factories 2022 21:229
  43. The use of palm oil for our current needs is unsustainable. Replacing palm oil with oils produced by microbes through the conversion of sustainable feedstocks is a promising alternative. However, there are maj...

    Authors: Zeynep Efsun Duman-Özdamar, Vitor A. P. Martins dos Santos, Jeroen Hugenholtz and Maria Suarez-Diez
    Citation: Microbial Cell Factories 2022 21:228
  44. PAS biopolymers are recombinant polypeptides comprising the small uncharged l-amino acids Pro, Ala and/or Ser which resemble the widely used poly-ethylene glycol (PEG) in terms of pronounced hydrophilicity. Likew...

    Authors: L. Friedrich, Y. Kikuchi, Y. Matsuda, U. Binder and A. Skerra
    Citation: Microbial Cell Factories 2022 21:227
  45. The utilization of industrial wastes as feedstock in microbial-based processes is a one of the high-potential approach for the development of sustainable, environmentally beneficial and valuable bioproduction,...

    Authors: Katarzyna Drzymała-Kapinos, Aleksandra M. Mirończuk and Adam Dobrowolski
    Citation: Microbial Cell Factories 2022 21:226
  46. Propionibacterium freudenreichii is used in biotechnological applications to produce vitamin B12. Although cultured mainly in anaerobic conditions, microaerobic conditions can greatly enhance biomass formation in...

    Authors: Alexander Dank, Gabriela Biel, Tjakko Abee and Eddy J. Smid
    Citation: Microbial Cell Factories 2022 21:225
  47. ε-poly-l-lysine (ε-PL) is the main secondary metabolite of Streptomyces albulus, and it is widely used in the food industry. Polylysine synthetase (Pls) is the last enzyme in the ε-PL biosynthetic pathway. Our pr...

    Authors: Congcong Lian, Min Zhang, Jiaqi Mao, Yuanyu Liu, Xiuwen Wang, Linghui Kong, Qingshou Yao and Jiayang Qin
    Citation: Microbial Cell Factories 2022 21:224
  48. Adipic acid (AA) is one of the most important industrial chemicals used mainly for the production of Nylon 6,6 but also for making polyurethanes, plasticizers, and unsaturated polyester resins, and more recent...

    Authors: Sang-Hyun Pyo, Mahmoud Sayed, Oliver Englund Örn, Jorge Amorrortu Gallo, Nídia Fernandez Ros and Rajni Hatti-Kaul
    Citation: Microbial Cell Factories 2022 21:223

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