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  1. Lactobacillus (Limosilactobacillus) fermentum D12 is an exopolysaccharide (EPS) producing strain whose genome contains a putative eps operon. Whole-genome analysis of D12 was performed to disclose the essential g...

    Authors: Katarina Butorac, Jasna Novak, Barbara Bellich, Lucrecia C. Terán, Martina Banić, Andreja Leboš Pavunc, Slaven Zjalić, Paola Cescutti, Jagoda Šušković and Blaženka Kos

    Citation: Microbial Cell Factories 2021 20:85

    Content type: Research

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  2. Poly-γ-glutamic acid (γ-PGA) and nattokinase (NK) are the main substances produced by Bacillus subtilis natto in solid-state fermentation and have wide application prospects. We found that our strains had higher ...

    Authors: Min Li, Zilong Zhang, Shenwei Li, Zhengan Tian and Xia Ma

    Citation: Microbial Cell Factories 2021 20:83

    Content type: Research

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  3. Trehalose, an intracellular protective agent reported to mediate defense against many stresses, can alleviate high-temperature-induced damage in Pleurotus ostreatus. In this study, the mechanism by which trehalos...

    Authors: Zhi-Yu Yan, Meng-Ran Zhao, Chen-Yang Huang, Li-Jiao Zhang and Jin-Xia Zhang

    Citation: Microbial Cell Factories 2021 20:82

    Content type: Research

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  4. Phosphonates derivatives are in the area of interests because of their unique chemical-physical features. These compounds manifest variety of biological interactions within the sensitive living cells, includin...

    Authors: Monika Serafin-Lewańczuk, Małgorzata Brzezińska-Rodak, Katarzyna Lubiak-Kozłowska, Paulina Majewska, Magdalena Klimek-Ochab, Tomasz K. Olszewski and Ewa Żymańczyk-Duda

    Citation: Microbial Cell Factories 2021 20:81

    Content type: Review

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  5. Daqu is the most important fermentation starter for Chinese liquor, with large number of microbes and enzymes being openly enriched in the Daqu system over thousands of years. However, only a few enzymes have ...

    Authors: Lanchai Chen, Zhuolin Yi, Yang Fang, Yanling Jin, Kaize He, Yao Xiao, Dong Zhao, Huibo Luo, Hui He, Qun Sun and Hai Zhao

    Citation: Microbial Cell Factories 2021 20:80

    Content type: Research

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  6. Glucosylglycerol (2-O-α-d-glucosyl-sn-glycerol; GG) is a natural osmolyte from bacteria and plants. It has promising applications as cosmetic and food-and-feed ingredient. Due to its natural scarcity, GG must be ...

    Authors: Katharina N. Schwaiger, Monika Cserjan-Puschmann, Gerald Striedner and Bernd Nidetzky

    Citation: Microbial Cell Factories 2021 20:79

    Content type: Research

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  7. Colonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed the ameliorative effect of milk replacer administrat...

    Authors: Aoyun Li, Yan Yang, Songkang Qin, Shenjin Lv, Taihua Jin, Kun Li, Zhaoqing Han and Yongzhu Li

    Citation: Microbial Cell Factories 2021 20:78

    Content type: Research

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  8. Lactobacillus spp. have been researched worldwide and are used in probiotics, but due to difficulties with laboratory cultivation of and experimentation on oral microorganisms, there are few reports of Lactobacil...

    Authors: Soyon Mann, Myeong Soo Park, Tony V. Johnston, Geun Eog Ji, Keum Taek Hwang and Seockmo Ku

    Citation: Microbial Cell Factories 2021 20:75

    Content type: Research

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  9. Pichia pastoris is a powerful and broadly used host for recombinant protein production (RPP), where past bioprocess performance has often been directed with the methanol regulated AOX1 promoter (PAOX1), and the c...

    Authors: Javier Garrigós-Martínez, Kiira Vuoristo, Miguel Angel Nieto-Taype, Juha Tähtiharju, Jaana Uusitalo, Pauliina Tukiainen, Christian Schmid, Ilya Tolstorukov, Knut Madden, Merja Penttilä, José Luis Montesinos-Seguí, Francisco Valero, Anton Glieder and Xavier Garcia-Ortega

    Citation: Microbial Cell Factories 2021 20:74

    Content type: Research

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  10. Escherichia coli is generally used as model bacteria to define microbial cell factories for many products and to investigate regulation mechanisms. E. coli exhibits phospholipids, lipopolysaccharides, colanic aci...

    Authors: Jianli Wang, Wenjian Ma and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2021 20:73

    Content type: Review

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  11. The large-scale application of organic pollutants (OPs) has contaminated the air, soil, and water. Persistent OPs enter the food supply chain and create several hazardous effects on living systems. Thus, there...

    Authors: Pankaj Bhatt, Amit Verma, Saurabh Gangola, Geeta Bhandari and Shaohua Chen

    Citation: Microbial Cell Factories 2021 20:72

    Content type: Review

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  12. The spore-forming lactic acid bacterium Bacillus coagulans MA-13 has been isolated from canned beans manufacturing and successfully employed for the sustainable production of lactic acid from lignocellulosic biom...

    Authors: Martina Aulitto, Andrea Strazzulli, Ferdinando Sansone, Flora Cozzolino, Maria Monti, Marco Moracci, Gabriella Fiorentino, Danila Limauro, Simonetta Bartolucci and Patrizia Contursi

    Citation: Microbial Cell Factories 2021 20:71

    Content type: Research

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  13. Ascomycin is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. As a secondary metabolite, the production of ascomycin is often limited by the shortage of precursors during th...

    Authors: Pan Wang, Ying Yin, Xin Wang and Jianping Wen

    Citation: Microbial Cell Factories 2021 20:70

    Content type: Research

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  14. Myriocin is a natural product with antifungal activity and is derived from Bacillus amyloliquefaciens LZN01. Our previous work demonstrated that myriocin can inhibit the growth of Fusarium oxysporum f. sp. niveum

    Authors: Hengxu Wang, Zhigang Wang, Weihui Xu and Kexin Wang

    Citation: Microbial Cell Factories 2021 20:69

    Content type: Research

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  15. Most patients with acute myeloid leukemia (AML) remain uncurable and require novel therapeutic methods. Gain-of-function FMS-like tyrosine kinase 3 (FLT3) mutations are present in 30–40% of AML patients and se...

    Authors: Dengyang Zhang, Yao Guo, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Junbin Huang, Chun Chen, Hongman Xue, Xiaojun Xu, Yihang Pan, Ningning Li, Chengming Zhu, Zhizhuang Joe Zhao, Jian Yu and Yun Chen

    Citation: Microbial Cell Factories 2021 20:67

    Content type: Research

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  16. The polyene macrocyclic compound amphotericin B (AmB) is an important antifungal antibiotic for the clinical treatment of invasive fungal infections. To rationally guide the improvement of AmB production in th...

    Authors: Bo Zhang, Yu Chen, Sheng-Xian Jiang, Xue Cai, Kai Huang, Zhi-Qiang Liu and Yu-Guo Zheng

    Citation: Microbial Cell Factories 2021 20:66

    Content type: Research

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  17. The C-3′,4′-dideoxygenation structure in gentamicin can prevent deactivation by aminoglycoside 3′-phosphotransferase (APH(3′)) in drug-resistant pathogens. However, the enzyme catalyzing the dideoxygenation st...

    Authors: Shaotong Zhou, Xiaotang Chen, Xianpu Ni, Yu Liu, Hui Zhang, Min Dong and Huanzhang Xia

    Citation: Microbial Cell Factories 2021 20:65

    Content type: Research

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  18. Saccharomyces cerevisiae is a well-known popular model system for basic biological studies and serves as a host organism for the heterologous production of commercially interesting small molecules and proteins. T...

    Authors: Kanhaiya Kumar, Vishwesh Venkatraman and Per Bruheim

    Citation: Microbial Cell Factories 2021 20:64

    Content type: Research

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  19. The alcohol 2,3-butanediol (2,3-BDO) is an important chemical and an Escherichia coli producer strain was recently engineered for bio-based production of 2,3-BDO. However, further improvements are required for re...

    Authors: Simon Boecker, Björn-Johannes Harder, Regina Kutscha, Stefan Pflügl and Steffen Klamt

    Citation: Microbial Cell Factories 2021 20:63

    Content type: Research

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  20. Valuable polysaccharides are usually produced using wild-type or metabolically-engineered host microbial strains through fermentation. These hosts act as cell factories that convert carbohydrates, such as mono...

    Authors: Zi-Xu Liu, Si-Ling Huang, Jin Hou, Xue-Ping Guo, Feng-Shan Wang and Ju-Zheng Sheng

    Citation: Microbial Cell Factories 2021 20:62

    Content type: Review

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  21. The chloroacetamide herbicides pretilachlor is an emerging pollutant. Due to the large amount of use, its presence in the environment threatens human health. However, the molecular mechanism of pretilachlor de...

    Authors: Hong-ming Liu, Meng Yuan, Ai-min Liu, Lei Ren, Guo-ping Zhu and Li-na Sun

    Citation: Microbial Cell Factories 2021 20:61

    Content type: Research

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  22. d-Allulose is an ultra-low calorie sugar of multifarious health benefits, including anti-diabetic and anti-obesity potential. d-Allulose 3-epimerase family enzymes catalyze biosynthesis of d-allulose via epimeriz...

    Authors: Satya Narayan Patel, Girija Kaushal and Sudhir P. Singh

    Citation: Microbial Cell Factories 2021 20:60

    Content type: Research

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  23. Oleaginous filamentous fungi can accumulate large amount of cellular lipids and potentially serve as a major source of oleochemicals for food, feed, chemical, pharmaceutical, and transport industries. Transest...

    Authors: Anne Marie Langseter, Simona Dzurendova, Volha Shapaval, Achim Kohler, Dag Ekeberg and Boris Zimmermann

    Citation: Microbial Cell Factories 2021 20:59

    Content type: Research

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  24. Betaine, an osmoprotective compatible solute, has been used to improve l-threonine production in engineered Escherichia coli l-threonine producer. Betaine supplementation upregulates the expression of zwf encodin...

    Authors: Shuaiwen Wang, Yu Fang, Zhen Wang, Shuyan Zhang, Liangjia Wang, Yong Guo and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2021 20:58

    Content type: Research

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  25. Retention of agricultural bio-mass residues without proper treatment could affect the subsequent plant growth. In the present investigation, the co-cultivation of genetically engineered T. asperellum and B. amylo...

    Authors: Valliappan Karuppiah, Lu Zhixiang, Hongyi Liu, Murugappan Vallikkannu and Jie Chen

    Citation: Microbial Cell Factories 2021 20:57

    Content type: Research

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  26. Antibiotic-resistant bacteria have emerged as a serious problem; bacteriophages have, therefore, been proposed as a therapeutic alternative to antibiotics. Several authorities, such as pharmacopeia, FDA, have ...

    Authors: Sang Guen Kim, Jun Kwon, Sib Sankar Giri, Saekil Yun, Hyoun Joong Kim, Sang Wha Kim, Jung Woo Kang, Sung Bin Lee, Won Joon Jung and Se Chang Park

    Citation: Microbial Cell Factories 2021 20:56

    Content type: Research

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  27. The accelerating energy demands of the increasing global population and industrialization has become a matter of great concern all over the globe. In the present scenario, the world is witnessing a considerabl...

    Authors: Praveen C. Ramamurthy, Simranjeet Singh, Dhriti Kapoor, Parul Parihar, Jastin Samuel, Ram Prasad, Alok Kumar and Joginder Singh

    Citation: Microbial Cell Factories 2021 20:55

    Content type: Review

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  28. Linalool, an acyclic monoterpene alcohol, is extensively used in the flavor and fragrance industries and exists as two enantiomers, (S)- and (R)-linalool, which have different odors and biological properties. Lin...

    Authors: Nobuhisa Nitta, Yoshinori Tajima, Yoko Yamamoto, Mika Moriya, Akiko Matsudaira, Yasushi Hoshino, Yousuke Nishio and Yoshihiro Usuda

    Citation: Microbial Cell Factories 2021 20:54

    Content type: Research

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  29. The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microb...

    Authors: Xin Yuan, Ruimin Chen, Kenneth L. McCormick, Ying Zhang, Xiangquan Lin and Xiaohong Yang

    Citation: Microbial Cell Factories 2021 20:53

    Content type: Research

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  30. Mucor circinelloides WJ11 is a high-lipid producing strain and an excellent producer of γ-linolenic acid (GLA) which is crucial for human health. We have previously identified genes that encode for AMP-activated...

    Authors: Shaista Nosheen, Tahira Naz, Junhuan Yang, Syed Ammar Hussain, Abu Bakr Ahmad Fazili, Yusuf Nazir, Shaoqi Li, Hassan Mohamed, Wu Yang, Kiren Mustafa and Yuanda Song

    Citation: Microbial Cell Factories 2021 20:52

    Content type: Research

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  31. Substrate-limited fed-batch conditions have the favorable effect of preventing overflow metabolism, catabolite repression, oxygen limitation or inhibition caused by elevated substrate or osmotic concentrations...

    Authors: Tobias Habicher, Tobias Klein, Jacqueline Becker, Andreas Daub and Jochen Büchs

    Citation: Microbial Cell Factories 2021 20:51

    Content type: Research

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  32. Xylitol is a five-carbon sugar alcohol that has numerous beneficial health properties. It has almost the same sweetness as sucrose but has lower energy value compared to the sucrose. Metabolism of xylitol is i...

    Authors: Tai Man Louie, Kailin Louie, Samuel DenHartog, Sridhar Gopishetty, Mani Subramanian, Mark Arnold and Shuvendu Das

    Citation: Microbial Cell Factories 2021 20:50

    Content type: Research

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  33. In recent years, the production of inclusion bodies that retained substantial catalytic activity was demonstrated. These catalytically active inclusion bodies (CatIBs) were formed by genetic fusion of an ag...

    Authors: Kira Küsters, Martina Pohl, Ulrich Krauss, Gizem Ölçücü, Sandor Albert, Karl-Erich Jaeger, Wolfgang Wiechert and Marco Oldiges

    Citation: Microbial Cell Factories 2021 20:49

    Content type: Research

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  34. Humic substances (HS) form the largest proportion among all the constituents of soil organic matter and are a key component of the terrestrial ecosystem. HS plays a multifunctional role in the environment by c...

    Authors: Iniyakumar Muniraj, Syed Shameer, Priyadharshini Ramachandran and Sivakumar Uthandi

    Citation: Microbial Cell Factories 2021 20:48

    Content type: Research

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  35. Natural products are a valuable source of biologically active compounds that have applications in medicine and agriculture. One disadvantage with natural products is the slow, time-consuming strain improvement...

    Authors: Špela Pikl, Andrés Felipe Carrillo Rincón, Lucija Slemc, Dušan Goranovič, Martina Avbelj, Krešimir Gjuračić, Hilda Sucipto, Katja Stare, Špela Baebler, Martin Šala, Meijin Guo, Andriy Luzhetskyy, Hrvoje Petković and Vasilka Magdevska

    Citation: Microbial Cell Factories 2021 20:47

    Content type: Research

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  36. With the long-term goal of developing an ultra-sensitive microcantilever-based biosensor for versatile biomarker detection, new controlled bioreceptor-analytes systems are being explored to overcome the disadv...

    Authors: Nurul Akmal Che Lah, Robert Gray and Sonia Trigueros

    Citation: Microbial Cell Factories 2021 20:46

    Content type: Research

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  37. Pediococcus pentosaceus, a promising strain of lactic acid bacteria (LAB), is gradually attracting attention, leading to a rapid increase in experimental research. Due to increased demand for practical applicatio...

    Authors: Shiman Jiang, Lingzhi Cai, Longxian Lv and Lanjuan Li

    Citation: Microbial Cell Factories 2021 20:45

    Content type: Review

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  38. Protein secretion in bacteria is an attractive strategy for heterologous protein production because it retains the high titers and tractability of bacterial hosts while simplifying downstream processing. Tradi...

    Authors: Lisa Ann Burdette, Han Teng Wong and Danielle Tullman-Ercek

    Citation: Microbial Cell Factories 2021 20:44

    Content type: Research

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  39. Nannochloropsis is a marine microalga that has been extensively studied. The major carotenoid produced by this group of microalgae is violaxanthin, which exhibits anti-inflammatory, anti-photoaging, and antiprol...

    Authors: Su-Bin Park, Jin-Ho Yun, Ae Jin Ryu, Joohyun Yun, Ji Won Kim, Sujin Lee, Saehae Choi, Dae-Hyun Cho, Dong-Yun Choi, Yong Jae Lee and Hee-Sik Kim

    Citation: Microbial Cell Factories 2021 20:43

    Content type: Research

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  40. The co-culture strategy which mimics natural ecology by constructing an artificial microbial community is a useful tool to activate the biosynthetic gene clusters to generate new metabolites. However, the conv...

    Authors: Yu Sun, Wen-Cai Liu, Xuan Shi, Hai-Zhou Zheng, Zhi-Hui Zheng, Xin-Hua Lu, Yan Xing, Kai Ji, Mei Liu and Yue-Sheng Dong

    Citation: Microbial Cell Factories 2021 20:42

    Content type: Research

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  41. Microbes are present in almost every environment on Earth, even in those with extreme environmental conditions such as Antarctica, where rocks may represent the main refuge for life. Lithobiontic communities a...

    Authors: V. Carrasco, V. Amarelle, S. Lagos-Moraga, C. P. Quezada, R. Espinoza-González, R. Faccio, E. Fabiano and J. M. Pérez-Donoso

    Citation: Microbial Cell Factories 2021 20:41

    Content type: Research

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  42. Microbial surfactants called biosurfactants, thanks to their high biodegradability, low toxicity and stability can be used not only in bioremediation and oil processing, but also in the food and cosmetic indus...

    Authors: Olga Marchut-Mikołajczyk, Piotr Drożdżyński, Arkadiusz Polewczyk, Wojciech Smułek and Tadeusz Antczak

    Citation: Microbial Cell Factories 2021 20:40

    Content type: Research

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  43. Cyanobacteria are promising hosts for the production of various industrially important compounds such as succinate. This study focuses on introduction of the glyoxylate shunt, which is naturally present in onl...

    Authors: Claudia Durall, Kateryna Kukil, Jeffrey A. Hawkes, Alessia Albergati, Peter Lindblad and Pia Lindberg

    Citation: Microbial Cell Factories 2021 20:39

    Content type: Research

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  44. Violaceins have attracted much attention as potential targets used in medicines, food additives, insecticides, cosmetics and textiles, but low productivity was the key factor to limit their large-scale applica...

    Authors: Yuyang Zhang, Hongping Chen, Yao Zhang, Huifang Yin, Chenyan Zhou and Yan Wang

    Citation: Microbial Cell Factories 2021 20:38

    Content type: Research

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  45. Exploring a simple and versatile technique for direct immobilization of target enzymes from cell lysate without prior purification is urgently needed. Thus, a novel all-in-one strategy for purification and imm...

    Authors: Lixi Cai, Yunmen Chu, Xin Liu, Yue Qiu, Zhongqi Ge and Guangya Zhang

    Citation: Microbial Cell Factories 2021 20:37

    Content type: Research

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  46. Extracellular metabolites of short chain fatty acids (SCFA) excreted by gut microbiota have been reported to play an important role in the regulation of intestinal homeostasis. Apart from supplying energy, SCF...

    Authors: Atchareeya Nakkarach, Hooi Ling Foo, Adelene Ai-Lian Song, Nur Elina Abdul Mutalib, Sunee Nitisinprasert and Ulaiwan Withayagiat

    Citation: Microbial Cell Factories 2021 20:36

    Content type: Research

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