Skip to main content

Articles

Page 1 of 53

  1. Microbial co-cultures and consortia are of interest in cell-based molecular production and even as “smart” therapeutics in that one can take advantage of division of labor and specialization to expand both the...

    Authors: Kayla Chun, Kristina Stephens, Sally Wang, Chen-Yu Tsao, Gregory F. Payne and William E. Bentley

    Citation: Microbial Cell Factories 2021 20:215

    Content type: Research

    Published on:

  2. The intestinal microecological environment is critical to an infant's growth. For those infants consuming milk power, it is very important to improve the intestinal microecological environment to promote the h...

    Authors: Bing Wang, Yang Yang, Xin Bian, Hua-nan Guan, Lin-lin Liu, Xue-xia Li, Qing-qi Guo, Wojciech Piekoszewski, Feng-lian Chen, Na Wu, Zhan-qian Ma, Yan-guo Shi and Na Zhang

    Citation: Microbial Cell Factories 2021 20:213

    Content type: Research

    Published on:

  3. Protein A (SpA) is one of the most important Staphylococcus aureus cell wall proteins. It includes five immunoglobulin (Ig)-binding domains which can bind to immune complexes through the Fc region of immunoglobul...

    Authors: Samira Ghaedmohammadi and Gholamreza Ahmadian

    Citation: Microbial Cell Factories 2021 20:212

    Content type: Research

    Published on:

  4. Many applications of microbial synthetic biology, such as metabolic engineering and biocomputing, are increasing in design complexity. Implementing complex tasks in single populations can be a challenge becaus...

    Authors: Katherine E. Duncker, Zachary A. Holmes and Lingchong You

    Citation: Microbial Cell Factories 2021 20:211

    Content type: Review

    Published on:

  5. Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias. However, codon...

    Authors: Yide Huang, Ting Lin, Lingfang Lu, Fan Cai, Jie Lin, Yu′e Jiang and Yao Lin

    Citation: Microbial Cell Factories 2021 20:209

    Content type: Research

    Published on:

  6. Recombinant enzyme expression in Escherichia coli is one of the most popular methods to produce bulk concentrations of protein product. However, this method is often limited by the inadvertent formation of inclus...

    Authors: Suraj Mital, Graham Christie and Duygu Dikicioglu

    Citation: Microbial Cell Factories 2021 20:208

    Content type: Review

    Published on:

  7. Several Rhodobacter sphaeroides have been widely applied in commercial CoQ10 production, but they have poor glucose use. Strategies for enhancing glucose use have been widely exploited in R. sphaeroides. Neverthe...

    Authors: Yuying Yang, Lu Li, Haoyu Sun, Zhen Li, Zhengliang Qi and Xinli Liu

    Citation: Microbial Cell Factories 2021 20:207

    Content type: Research

    Published on:

  8. Fluorinases play a unique role in the production of fluorine-containing organic molecules by biological methods. Whole-cell catalysis is a better choice in the large-scale fermentation processes, and over 60% ...

    Authors: Xinming Feng, Miaomiao Jin, Wei Huang, Wei Liu and Mo Xian

    Citation: Microbial Cell Factories 2021 20:206

    Content type: Research

    Published on:

  9. The oleaginous yeast Cutaneotrichosporon oleaginosus represents one of the most promising microbial platforms for resource-efficient and scalable lipid production, with the capacity to accept a wide range of carb...

    Authors: Tobias Fuchs, Felix Melcher, Zora Selina Rerop, Jan Lorenzen, Pariya Shaigani, Dania Awad, Martina Haack, Sophia Alice Prem, Mahmoud Masri, Norbert Mehlmer and Thomas B. Brueck

    Citation: Microbial Cell Factories 2021 20:205

    Content type: Research

    Published on:

  10. Metabolomics coupled with genome-scale metabolic modeling approaches have been employed recently to quantitatively analyze the physiological states of various organisms, including Saccharomyces cerevisiae. Althou...

    Authors: William T. Scott Jr., Eddy J. Smid, David E. Block and Richard A. Notebaart

    Citation: Microbial Cell Factories 2021 20:204

    Content type: Research

    Published on:

  11. Corynebacterium glutamicum is used in the industrial production of amino acids and nucleotides. During the course of fermentation, C. glutamicum cells face various stresses and employ multiple regulatory genes to...

    Authors: Haeri Jeong, Younhee Kim and Heung-Shick Lee

    Citation: Microbial Cell Factories 2021 20:203

    Content type: Research

    Published on:

  12. Saccharomyces cerevisiae is an important synthetic biology chassis for microbial production of valuable molecules. Promoter engineering has been frequently applied to generate more synthetic promoters with a vari...

    Authors: Jiliang Deng, Yanling Wu, Zhaohui Zheng, Nanzhu Chen, Xiaozhou Luo, Hongting Tang and Jay D. Keasling

    Citation: Microbial Cell Factories 2021 20:202

    Content type: Research

    Published on:

  13. Autoinduction systems can regulate protein production in Escherichia coli without the need to monitor cell growth or add inducer at the proper time following culture growth. Compared to classical IPTG induction, ...

    Authors: Qin Fan, Peter Neubauer and Matthias Gimpel

    Citation: Microbial Cell Factories 2021 20:201

    Content type: Research

    Published on:

  14. Plants produce a variety of specialized metabolites, many of which are used in pharmaceutical industries as raw materials. However, certain metabolites may be produced at markedly low concentrations in plants....

    Authors: Miya Urui, Yasuyuki Yamada, Yoshito Ikeda, Akira Nakagawa, Fumihiko Sato, Hiromichi Minami and Nobukazu Shitan

    Citation: Microbial Cell Factories 2021 20:200

    Content type: Research

    Published on:

  15. Quantification of individual species in microbial co-cultures and consortia is critical to understanding and designing communities with prescribed functions. However, it is difficult to physically separate spe...

    Authors: Patrick A. Leggieri, Corey Kerdman-Andrade, Thomas S. Lankiewicz, Megan T. Valentine and Michelle A. O’Malley

    Citation: Microbial Cell Factories 2021 20:199

    Content type: Research

    Published on:

  16. The production of N-linked glycoproteins in genetically amenable bacterial hosts offers great potential for reduced cost, faster/simpler bioprocesses, greater customisation, and utility for distributed manufac...

    Authors: Fenryco Pratama, Dennis Linton and Neil Dixon

    Citation: Microbial Cell Factories 2021 20:198

    Content type: Research

    Published on:

    The Correction to this article has been published in Microbial Cell Factories 2021 20:210

  17. Herbaspirillum camelliae is a gram-negative endophyte isolated from the tea plant. Both strains WT00C and WT00F were found to hydrolyze epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) to release...

    Authors: Jia Lei, Yong Zhang, Xuechen Ni, Xuejing Yu and Xingguo Wang

    Citation: Microbial Cell Factories 2021 20:197

    Content type: Research

    Published on:

  18. Glycerol is a desirable alternative substrate for 2,3-butanediol (2,3-BD) production for sustainable development in biotechnological industries and non-food competitive feedstock. B. subtilis, a “generally recogn...

    Authors: Nunthaphan Vikromvarasiri, Tomokazu Shirai and Akihiko Kondo

    Citation: Microbial Cell Factories 2021 20:196

    Content type: Research

    Published on:

  19. Contemporary biotechnology focuses on many problems related to the functioning of developed societies. Many of these problems are related to health, especially with the rapidly rising numbers of people sufferi...

    Authors: Magdalena Rakicka-Pustułka, Joanna Miedzianka, Dominika Jama, Sylwia Kawalec, Kamila Liman, Tomasz Janek, Grzegorz Skaradziński, Waldemar Rymowicz and Zbigniew Lazar

    Citation: Microbial Cell Factories 2021 20:195

    Content type: Research

    Published on:

  20. Members of the genus Planococcus have been revealed to utilize and degrade solvents such as aromatic hydrocarbons and alkanes, and likely to acquire tolerance to solvents. A yellow marine bacterium Planococcus ma...

    Authors: Miho Takemura, Chiharu Takagi, Mayuri Aikawa, Kanaho Araki, Seon-Kang Choi, Mitsuhiro Itaya, Kazutoshi Shindo and Norihiko Misawa

    Citation: Microbial Cell Factories 2021 20:194

    Content type: Research

    Published on:

  21. Poultry is the world's most popular animal-based food and global production has tripled in the past 20 years alone. Low-cost vaccines that can be combined to protect poultry against multiple infections are a c...

    Authors: Marta Mauri, Thippeswamy H. Sannasiddappa, Prerna Vohra, Ricardo Corona-Torres, Alexander A. Smith, Cosmin Chintoan-Uta, Abi Bremner, Vanessa S. Terra, Sherif Abouelhadid, Mark P. Stevens, Andrew J. Grant, Jon Cuccui and Brendan W. Wren

    Citation: Microbial Cell Factories 2021 20:193

    Content type: Research

    Published on:

  22. Rubiginones belong to the angucycline family of aromatic polyketides, and they have been shown to potentiate the vincristine (VCR)-induced cytotoxicity against VCR-resistant cancer cell lines. However, the bio...

    Authors: Jingyan Zhang, Ying Sun, Yeji Wang, Xin Chen, Lu Xue, Jingjing Zhang, Xiangcheng Zhu, Yanwen Duan and Xiaohui Yan

    Citation: Microbial Cell Factories 2021 20:192

    Content type: Research

    Published on:

  23. The split GFP assay is a well-known technology for activity-independent screening of target proteins. A superfolder GFP is split into two non-fluorescent parts, GFP11 which is fused to the target protein and G...

    Authors: Carolin Müller, Chika L. Igwe, Wolfgang Wiechert and Marco Oldiges

    Citation: Microbial Cell Factories 2021 20:191

    Content type: Technical Notes

    Published on:

  24. Escherichia coli is the most widely used bacterium in prokaryotic expression system for the production of recombinant proteins. In BL21 (DE3), the gene encoding the T7 RNA polymerase (T7 RNAP) is under control of...

    Authors: Fei Du, Yun-Qi Liu, Ying-Shuang Xu, Zi-Jia Li, Yu-Zhou Wang, Zi-Xu Zhang and Xiao-Man Sun

    Citation: Microbial Cell Factories 2021 20:189

    Content type: Research

    Published on:

  25. Bacillus subtilis is a well-established host for a variety of bioproduction processes, with much interest focused on the production of biosurfactants such as the cyclic lipopeptide surfactin. Surfactin production...

    Authors: Peter Klausmann, Lars Lilge, Moritz Aschern, Katja Hennemann, Marius Henkel, Rudolf Hausmann and Kambiz Morabbi Heravi

    Citation: Microbial Cell Factories 2021 20:188

    Content type: Research

    Published on:

  26. The objective of this work was to engineer Deinococcus radiodurans R1 as a microbial cell factory for the production of pinene, a monoterpene molecule prominently used for the production of fragrances, pharmaceut...

    Authors: Seyed Hossein Helalat, Carsten Jers, Mandana Bebahani, Hassan Mohabatkar and Ivan Mijakovic

    Citation: Microbial Cell Factories 2021 20:187

    Content type: Research

    Published on:

  27. Noroviruses are a major cause of epidemic and sporadic acute non-bacterial gastroenteritis worldwide. Unfortunately, the development of an effective norovirus vaccine has proven difficult and no prophylactic v...

    Authors: Mirosława Panasiuk, Karolina Zimmer, Anna Czarnota, Katarzyna Grzyb, Magdalena Narajczyk, Grażyna Peszyńska-Sularz, Sabina Żołędowska, Dawid Nidzworski, Lilit Hovhannisyan and Beata Gromadzka

    Citation: Microbial Cell Factories 2021 20:186

    Content type: Research

    Published on:

  28. The anaerobic production of rhamnolipids is significant in research and application, such as foamless fermentation and in situ production of rhamnolipids in the anoxic environments. Although a few studies reporte...

    Authors: Feng Zhao, Yuting Wu, Qingzhi Wang, Mengyao Zheng and Qingfeng Cui

    Citation: Microbial Cell Factories 2021 20:185

    Content type: Research

    Published on:

  29. Microorganisms can be metabolically engineered to produce a wide range of commercially important chemicals. Advancements in computational strategies for strain design and synthetic biological techniques to con...

    Authors: Kaushik Raj, Naveen Venayak, Patrick Diep, Sai Akhil Golla, Alexander F. Yakunin and Radhakrishnan Mahadevan

    Citation: Microbial Cell Factories 2021 20:184

    Content type: Technical Notes

    Published on:

  30. The aryltetralin lignan (−)−podophyllotoxin is a potent antiviral and anti-neoplastic compound that is mainly found in Podophyllum plant species. Over the years, the commercial demand for this compound rose notab...

    Authors: Davide Decembrino, Alessandra Raffaele, Ronja Knöfel, Marco Girhard and Vlada B. Urlacher

    Citation: Microbial Cell Factories 2021 20:183

    Content type: Research

    Published on:

  31. β-amylase (EC 3.2.1.2) is an exo-enzyme that shows high specificity for cleaving the α-1,4-glucosidic linkage of starch from the non-reducing end, thereby liberating maltose. In this study, we heterologously e...

    Authors: Xuguo Duan, Qiuyu Zhu, Xinyi Zhang, Zhenyan Shen and Yue Huang

    Citation: Microbial Cell Factories 2021 20:182

    Content type: Research

    Published on:

  32. Hydroxycinnamic acids such as p-coumaric acid (CA) are chemically linked to lignin in grassy biomass with fairly labile ester bonds and therefore represent a straightforward opportunity to extract and valorize li...

    Authors: Alberto Rodriguez, Jamie A. Meadows, Ning Sun, Blake A. Simmons and John M. Gladden

    Citation: Microbial Cell Factories 2021 20:181

    Content type: Research

    Published on:

  33. 2,5-Furandicarboxylic acid (FDCA) is a precursor for green plastics due to its structural similarity to terephthalic acid, a common precursor of oil-derived polymers, and its potential production from sugars o...

    Authors: María Isabel Sánchez-Ruiz, Angel T. Martínez and Ana Serrano

    Citation: Microbial Cell Factories 2021 20:180

    Content type: Research

    Published on:

  34. Oleaginous microorganisms are sustainable alternatives for the production of biodiesel. Among them, oleaginous fungi are known for their rapid growth, short life cycles, no light requirement, easy scalability,...

    Authors: Naganandhini Srinivasan, Kiruthika Thangavelu, Ashika Sekar, B. Sanjeev and Sivakumar Uthandi

    Citation: Microbial Cell Factories 2021 20:179

    Content type: Research

    Published on:

  35. Lignocellulose biomass has been investigated as a feedstock for second generation biofuels and other value-added products. Some of the processes for biofuel production utilize cellulases and hemicellulases to ...

    Authors: Sami Havukainen, Jonai Pujol-Giménez, Mari Valkonen, Matthias A. Hediger and Christopher P. Landowski

    Citation: Microbial Cell Factories 2021 20:177

    Content type: Research

    Published on:

  36. Monomeric autotransporters have been used extensively to transport recombinant proteins or protein domains to the cell surface of Gram-negative bacteria amongst others for antigen display. Genetic fusion of su...

    Authors: Trang H. Phan, Coen Kuijl, Dung T. Huynh, Wouter S. P. Jong, Joen Luirink and Peter van Ulsen

    Citation: Microbial Cell Factories 2021 20:176

    Content type: Research

    Published on:

  37. Astaxanthin is a carotenoid with a number of assets useful for the food, cosmetic and pharmaceutical industries. Nowadays, it is mainly produced by chemical synthesis. However, the process leads to an enantiom...

    Authors: Alejandro Torres-Haro, Jorge Verdín, Manuel R. Kirchmayr and Melchor Arellano-Plaza

    Citation: Microbial Cell Factories 2021 20:175

    Content type: Review

    Published on:

  38. Bacillus subtilis is one of the most important microorganisms for recombinant protein production. It possesses the GRAS (generally recognized as safe) status and a potent protein secretion capacity. Secretory pro...

    Authors: Patrick Lenz, Fabienne Hilgers, Alina Burmeister, Leonie Zimmermann, Kristina Volkenborn, Alexander Grünberger, Dietrich Kohlheyer, Thomas Drepper, Karl-Erich Jaeger and Andreas Knapp

    Citation: Microbial Cell Factories 2021 20:174

    Content type: Research

    Published on:

  39. Of the many neurotransmitters in humans, gamma-aminobutyric acid (GABA) shows potential for improving several mental health indications such as stress and anxiety. The microbiota-gut-brain axis is an important...

    Authors: Sagarika Banerjee, Matthew Poore, Svetlana Gerdes, Derek Nedveck, Lene Lauridsen, Heidi Thomsen Kristensen, Henrik Max Jensen, Phillip M. Byrd, Arthur C. Ouwehand, Elaine Patterson and Wesley Morovic

    Citation: Microbial Cell Factories 2021 20:173

    Content type: Research

    Published on:

  40. L-valine is an essential amino acid that has wide and expanding applications with a suspected growing market demand. Its applicability ranges from animal feed additive, ingredient in cosmetic and special nutri...

    Authors: Hui Gao, Philibert Tuyishime, Xian Zhang, Taowei Yang, Meijuan Xu and Zhiming Rao

    Citation: Microbial Cell Factories 2021 20:172

    Content type: Review

    Published on:

  41. The use of bovine-origin ribonucleases has been part of the standard protocol for plasmid DNA purification. As the field of gene therapy now enters the clinical stage, such enzymes need to be phased out or alt...

    Authors: Ram Shankar, Nina Schäffer, Marco Schmeer, Joe Max Risse, Karl Friehs and Martin Schleef

    Citation: Microbial Cell Factories 2021 20:171

    Content type: Research

    Published on:

    The Correction to this article has been published in Microbial Cell Factories 2021 20:190

  42. Melatonin has attracted substantial attention because of its excellent prospects for both medical applications and crop improvement. The microbial production of melatonin is a safer and more promising alternat...

    Authors: Yanfeng Zhang, Yongzhi He, Nan Zhang, JiaJia Gan, Shan Zhang and Zhiyang Dong

    Citation: Microbial Cell Factories 2021 20:170

    Content type: Research

    Published on:

  43. Recently it was shown that production of recombinant proteins in E. coli BL21(DE3) using pET based expression vectors leads to metabolic stress comparable to a carbon overfeeding response. Opposite to original ex...

    Authors: Jan Weber, Zhaopeng Li and Ursula Rinas

    Citation: Microbial Cell Factories 2021 20:169

    Content type: Research

    Published on:

  44. Glucose transporters play an important role in the fermentation of citric acid. In this study, a high-affinity glucose transporter (HGT1) was identified and overexpressed in the industrial strain A. niger CGMCC 1...

    Authors: Xianli Xue, Futi Bi, Boya Liu, Jie Li, Lan Zhang, Jian Zhang, Qiang Gao and Depei Wang

    Citation: Microbial Cell Factories 2021 20:168

    Content type: Research

    Published on:

  45. Biodiesel is an eco-friendly and renewable energy source and a valuable substitute for petro-diesel. Sago processing wastewater (SWW), a by-product of the cassava processing industry, has starch content rangin...

    Authors: Kiruthika Thangavelu, Pugalendhi Sundararaju, Naganandhini Srinivasan and Sivakumar Uthandi

    Citation: Microbial Cell Factories 2021 20:167

    Content type: Research

    Published on:

  46. FK506, a macrolide mainly with immunosuppressive activity, can be produced by various Streptomyces strains. However, one of the major challenges in the fermentation of FK506 is its insufficient production, result...

    Authors: Qing-Bin Wu, Xiao-Ying Zhang, Xin-Ai Chen and Yong-Quan Li

    Citation: Microbial Cell Factories 2021 20:166

    Content type: Research

    Published on:

Annual Journal Metrics