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  1. Content type: RESEARCH

    β-Mannanase catalyzes the cleavage of β-1,4-linked internal linkages of mannan backbone randomly to produce new chain ends. Alkaline and thermostable β-mannanases provide obvious advantages for many applicatio...

    Authors: Cheng Zhou, Yanfen Xue and Yanhe Ma

    Citation: Microbial Cell Factories 2018 17:124

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  2. Content type: RESEARCH

    Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response (UPR) usually apparent through increased intracellular l...

    Authors: Gustavo Roth, Ana Letícia Vanz, Heinrich Lünsdorf, Manfred Nimtz and Ursula Rinas

    Citation: Microbial Cell Factories 2018 17:123

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  3. Content type: RESEARCH

    Lipopeptides are a promising group of surface-active compounds of microbial origin (biosurfactants). These diverse molecules are produced mainly by Bacillus and Pseudomonas strains. Because of their attractive ph...

    Authors: Piotr Biniarz, François Coutte, Frédérique Gancel and Marcin Łukaszewicz

    Citation: Microbial Cell Factories 2018 17:121

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  4. Content type: Review

    For years, microbes have been widely applied as chassis in the construction of synthetic metabolic pathways. However, the lack of in vivo enzyme clustering of heterologous metabolic pathways in these organisms...

    Authors: Xin-yuan Qiu, Si-Si Xie, Lu Min, Xiao-Min Wu, Lv-Yun Zhu and Lingyun Zhu

    Citation: Microbial Cell Factories 2018 17:120

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  5. Content type: Correction

    Upon publication of this article [1], it was brought to our attention that revised Fig. 1 supplied by the author during proof correction was unfortunately not presented in the original version of the article. ...

    Authors: Katherina Garcia Vanegas, Arésu Bondrup Larsen, Michael Eichenberger, David Fischer, Uffe Hasbro Mortensen and Michael Naesby

    Citation: Microbial Cell Factories 2018 17:119

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    The original article was published in Microbial Cell Factories 2018 17:107

  6. Content type: RESEARCH

    Acid stress is often encountered during industrial fermentation as a result of the accumulation of acidic metabolites. Acid stress increases the intracellular acidity and can cause DNA damage and denaturation ...

    Authors: Xianxing Gao, Xiaofeng Yang, Jiahui Li, Yan Zhang, Ping Chen and Zhanglin Lin

    Citation: Microbial Cell Factories 2018 17:118

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  7. Content type: RESEARCH

    Phenazine-1-carboxamide (PCN), a phenazine derivative, is strongly antagonistic to fungal phytopathogens. The high PCN biocontrol activity fascinated researcher’s attention in isolating and identifying novel b...

    Authors: Huasong Peng, Pingyuan Zhang, Muhammad Bilal, Wei Wang, Hongbo Hu and Xuehong Zhang

    Citation: Microbial Cell Factories 2018 17:117

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  8. Content type: RESEARCH

    Pine wilt disease, caused by the pinewood nematode Bursaphelenchus xylophilus (PWN), is an important destructive disease of pine forests worldwide. In addition to behaving as a plant-parasitic nematode that feeds...

    Authors: Chihang Cheng, Jialing Qin, Choufei Wu, Mengying Lei, Yongjun Wang and Liqin Zhang

    Citation: Microbial Cell Factories 2018 17:116

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  9. Content type: RESEARCH

    Cis, cis-muconic acid (MA) is a dicarboxylic acid of recognized industrial value. It provides direct access to adipic acid and terephthalic acid, prominent monomers of commercial plastics.

    Authors: Judith Becker, Martin Kuhl, Michael Kohlstedt, Sören Starck and Christoph Wittmann

    Citation: Microbial Cell Factories 2018 17:115

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  10. Content type: RESEARCH

    Malate is a C4-dicarboxylic acid widely used as an acidulant in the food and beverage industry. Rational engineering has been performed in the past for the development of microbial strains capable of efficient...

    Authors: Debora Trichez, Clément Auriol, Audrey Baylac, Romain Irague, Clémentine Dressaire, Marc Carnicer-Heras, Stéphanie Heux, Jean Marie François and Thomas Walther

    Citation: Microbial Cell Factories 2018 17:113

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  11. Content type: RESEARCH

    The yeast Komagataella phaffii, better known as Pichia pastoris, is a commonly used host for recombinant protein production. Here expression vectors are reported that address the different steps of the transcript...

    Authors: Loknath Gidijala, Stefan Uthoff, Sebastiaan J. van Kampen, Alexander Steinbüchel and Raymond M. D. Verhaert

    Citation: Microbial Cell Factories 2018 17:112

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  12. Content type: RESEARCH

    Low concentration NaHCO3 (ca. 12 mM) had been demonstrated to be an excellent carbon source for industrially important green alga Chlorella vulgaris and high concentration NaHCO3 (e.g. 160 mM) had been shown to b...

    Authors: Jingya Li, Changhao Li, Christopher Q. Lan and Dankui Liao

    Citation: Microbial Cell Factories 2018 17:111

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  13. Content type: RESEARCH

    Marine diatoms have a higher fucoxanthin content in comparison to macroalgae. Fucoxanthin features many potent bioactive properties, particularly anti-obesity properties. Despite the great potential for harves...

    Authors: Song Wang, Sujit K. Verma, Inamullah Hakeem Said, Laurenz Thomsen, Matthias S. Ullrich and Nikolai Kuhnert

    Citation: Microbial Cell Factories 2018 17:110

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  14. Content type: RESEARCH

    Due to its high stress tolerance and low acetate secretion, Escherichia coli W is reported to be a good production host for several metabolites and recombinant proteins. However, simultaneous co-utilization of gl...

    Authors: Katharina Novak, Lukas Flöckner, Anna Maria Erian, Philipp Freitag, Christoph Herwig and Stefan Pflügl

    Citation: Microbial Cell Factories 2018 17:109

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  15. Content type: RESEARCH

    The overreliance on dwindling fossil fuel reserves and the negative climatic effects of using such fuels are driving the development of new clean energy sources. One such alternative source is hydrogen (H2), whic...

    Authors: Teresa Mohr, Habibu Aliyu, Raphael Küchlin, Shamara Polliack, Michaela Zwick, Anke Neumann, Don Cowan and Pieter de Maayer

    Citation: Microbial Cell Factories 2018 17:108

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  16. Content type: RESEARCH

    C-glycosylated flavones have recently attracted increased attention due to their possible benefits in human health. These biologically active compounds are part of the human diet, and the C-linkage makes them mor...

    Authors: Katherina Garcia Vanegas, Arésu Bondrup Larsen, Michael Eichenberger, David Fischer, Uffe Hasbro Mortensen and Michael Naesby

    Citation: Microbial Cell Factories 2018 17:107

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    The Correction to this article has been published in Microbial Cell Factories 2018 17:119

  17. Content type: RESEARCH

    Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is prone to significant variations from batch to batch an...

    Authors: Janina Müller, Mario Beckers, Nina Mußmann, Johannes Bongaerts and Jochen Büchs

    Citation: Microbial Cell Factories 2018 17:106

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  18. Content type: RESEARCH

    Oxaloacetate (OAA) and l-glutamate are essential precursors for the biosynthesis of l-lysine. Reasonable control of all potentially rate-limiting steps, including the precursors supply rate, is of vital importanc...

    Authors: Jian-Zhong Xu, Ze-Hua Wu, Shi-Jun Gao and Weiguo Zhang

    Citation: Microbial Cell Factories 2018 17:105

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  19. Content type: RESEARCH

    Cheese ripening is a complex, time consuming and expensive process, which involves the generation of precursors from carbohydrates, proteins and fats and their subsequent conversion into a wide range of compou...

    Authors: Oscar van Mastrigt, Diego Gallegos Tejeda, Mette N. Kristensen, Tjakko Abee and Eddy J. Smid

    Citation: Microbial Cell Factories 2018 17:104

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  20. Content type: RESEARCH

    Anthocyanins are polyphenolic pigments which provide pink to blue colours in fruits and flowers. There is an increasing demand for anthocyanins, as food colorants and as health-promoting substances. Plant prod...

    Authors: Mark Levisson, Constantinos Patinios, Sascha Hein, Philip A. de Groot, Jean-Marc Daran, Robert D. Hall, Stefan Martens and Jules Beekwilder

    Citation: Microbial Cell Factories 2018 17:103

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  21. Content type: RESEARCH

    High production cost of bioplastics polyhydroxyalkanoates (PHA) is a major obstacle to replace traditional petro-based plastics. To address the challenges, strategies towards upstream metabolic engineering and...

    Authors: Jing Chen, Wei Li, Zhao-Zhou Zhang, Tian-Wei Tan and Zheng-Jun Li

    Citation: Microbial Cell Factories 2018 17:102

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  22. Content type: RESEARCH

    2′-Fucosyllactose (2-FL), one of the most abundant oligosaccharides in human milk, has potential applications in foods due to its health benefits such as the selective promotion of bifidobacterial growth and t...

    Authors: Sora Yu, Jing-Jing Liu, Eun Ju Yun, Suryang Kwak, Kyoung Heon Kim and Yong-Su Jin

    Citation: Microbial Cell Factories 2018 17:101

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  23. Content type: RESEARCH

    Metabolic activities of microorganisms to modify the chemical structures of organic compounds became an effective tool for the production of high-valued steroidal drugs or their precursors. Currently research ...

    Authors: Alina Świzdor, Anna Panek and Paulina Ostrowska

    Citation: Microbial Cell Factories 2018 17:100

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  24. Content type: RESEARCH

    Global energy and resource shortages make it necessary to quest for renewable resources. n-Caproic acid (CA) production based on carboxylate platform by anaerobic fermentation is booming. Recently, a novel Rumino...

    Authors: Han Wang, Xiangzhen Li, Yi Wang, Yong Tao, Shaowen Lu, Xiaoyu Zhu and Daping Li

    Citation: Microbial Cell Factories 2018 17:99

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  25. Content type: RESEARCH

    Polyene antibiotics are important as antifungal medicines albeit with serious side effects such as nephrotoxicity. Reedsmycin (RDM) A (1), produced by marine-derived Streptomyces youssoufiensis OUC6819, is a non-...

    Authors: Tingting Yao, Zengzhi Liu, Tong Li, Hui Zhang, Jing Liu, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li and Wenli Li

    Citation: Microbial Cell Factories 2018 17:98

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  26. Content type: Review

    The goal of this research is the investigation of a way to maximize the production of docosahexaenoic acid (DHA) and β-carotene by optimizing the culture conditions of their sources, microalgae Schizochytrium lim...

    Authors: Maria Bindea, Bogdan Rusu, Alexandru Rusu, Monica Trif, Loredana Florina Leopold, Francisc Dulf and Dan Cristian Vodnar

    Citation: Microbial Cell Factories 2018 17:97

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  27. Content type: RESEARCH

    The cellulolytic fungus Neurospora crassa is considered a potential host for enzyme and bioethanol production. However, large scale applications are hindered by its filamentous growth. Although previous investiga...

    Authors: Liangcai Lin, Zhiyong Sun, Jingen Li, Yong Chen, Qian Liu, Wenliang Sun and Chaoguang Tian

    Citation: Microbial Cell Factories 2018 17:96

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  28. Content type: RESEARCH

    The lifestyle of filamentous fungi depends on the secretion of hydrolytic enzymes into the surrounding medium, which degrade polymeric substances into monomers that are then taken up to sustain metabolism. Thi...

    Authors: Markus R. M. Fiedler, Lars Barthel, Christin Kubisch, Corrado Nai and Vera Meyer

    Citation: Microbial Cell Factories 2018 17:95

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  29. Content type: RESEARCH

    α-d-Glucosylglycerol (αGG) has beneficial functions as a moisturizing agent in cosmetics and potential as a health food material, and therapeutic agent. αGG serves as compatible solute in various halotolerant cya...

    Authors: Benjamin Roenneke, Natalie Rosenfeldt, Sami M. Derya, Jens F. Novak, Kay Marin, Reinhard Krämer and Gerd M. Seibold

    Citation: Microbial Cell Factories 2018 17:94

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  30. Content type: RESEARCH

    Co-production of polyhydroxyalkanoate (PHA) and amino acids makes bacteria effective microbial cell factories by secreting amino acids outside while accumulating PHA granules inside. Poly(3-hydroxybutyrate-co-...

    Authors: Wenjian Ma, Jianli Wang, Ye Li, Lianghong Yin and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2018 17:93

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  31. Content type: RESEARCH

    1,3-Propanediol (1,3-PDO) is important building blocks for the bio-based chemical industry, Klebsiella pneumoniae can be an attractive candidate for their production. However, 1,3-PDO production is high but produ...

    Authors: Baek-Rock Oh, Sung-Mok Lee, Sun-Yeon Heo, Jeong-Woo Seo and Chul Ho Kim

    Citation: Microbial Cell Factories 2018 17:92

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  32. Content type: RESEARCH

    ʟ-Ornithine is an important amino acid with broad applications in pharmaceutical and food industries. Despite lagging ʟ-ornithine productivity and cost reduction, microbial fermentation is a promising route fo...

    Authors: Bin Zhang, Miao Yu, Wen-Ping Wei and Bang-Ce Ye

    Citation: Microbial Cell Factories 2018 17:91

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  33. Content type: RESEARCH

    A future bioeconomy relies on the development of technologies to convert waste into valuable compounds. We present here an attempt to design a biotechnological cascade for the conversion of vegetable waste int...

    Authors: Annemarie Schmidt, Gunnar Sturm, Christian Jonas Lapp, Daniel Siebert, Florencia Saravia, Harald Horn, Padma Priya Ravi, Andreas Lemmer and Johannes Gescher

    Citation: Microbial Cell Factories 2018 17:90

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  34. Content type: RESEARCH

    Some marine bacteria, such as Moritella marina, produce the nutraceutical docosahexaenoic acid (DHA) thanks to a specific enzymatic complex called Pfa synthase. Escherichia coli heterologously expressing the pfa ...

    Authors: Laura Giner-Robles, Beatriz Lázaro, Fernando de la Cruz and Gabriel Moncalián

    Citation: Microbial Cell Factories 2018 17:88

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  35. Content type: Research

    Cephalosporin C (CPC) produced by Acremonium chrysogenum is one of the most important drugs for treatment of bacterial infectious diseases. As the major stimulant, methionine is widely used in the industrial prod...

    Authors: Jiajia Liu, Wenyan Gao, Yuanyuan Pan and Gang Liu

    Citation: Microbial Cell Factories 2018 17:87

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  36. Content type: Correction

    Upon publication of this article [1], it was brought to our attention that Figs. 3, 4 and 5 are incorrectly presented in the original version of the article. The figures were inadvertently swapped in the origi...

    Authors: Zothanpuia, Ajit Kumar Passari, Vincent Vineeth Leo, Preeti Chandra, Brijesh Kumar, Chandra Nayak, Abeer Hashem, Elsayed Fathi Abd_Allah, Abdulaziz A. Alqarawi and Bhim Pratap Singh

    Citation: Microbial Cell Factories 2018 17:86

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    The original article was published in Microbial Cell Factories 2018 17:68

  37. Content type: RESEARCH

    Geranyl acetate is widely used in the fragrance and cosmetic industries, and thus has great economic value. However, plants naturally produce a mixture of hundreds of esters, and geranyl acetate is usually onl...

    Authors: Tao Wu, Siwei Li, Bolin Zhang, Changhao Bi and Xueli Zhang

    Citation: Microbial Cell Factories 2018 17:85

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  38. Content type: RESEARCH

    Plipastatin, an antifungal lipopeptide, is synthesized by a non-ribosomal peptide synthetase (NRPS) in Bacillus subtilis. However, little information is available on the combinatorial biosynthesis strategies appl...

    Authors: Ling Gao, Jianping Guo, Yun Fan, Zhi Ma, Zhaoxin Lu, Chong Zhang, Haizhen Zhao and Xiaomei Bie

    Citation: Microbial Cell Factories 2018 17:84

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  39. Content type: RESEARCH

    Water stress is a critical issue for plant growth in arid sandy soils. Here, we aimed to select bacteria producing polyextremotolerant surface-active compounds capable of improving water retention and humidity...

    Authors: Noura Raddadi, Lucia Giacomucci, Ramona Marasco, Daniele Daffonchio, Ameur Cherif and Fabio Fava

    Citation: Microbial Cell Factories 2018 17:83

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  40. Content type: RESEARCH

    Saccharomyces cerevisiae is a host for the industrial production of S-adenosyl-l-methionine (SAM), which has been widely used in pharmaceutical and nutritional supplement industries. It has been reported that the...

    Authors: Kenshi Hayakawa, Fumio Matsuda and Hiroshi Shimizu

    Citation: Microbial Cell Factories 2018 17:82

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  41. Content type: RESEARCH

    2-Keto-l-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, l-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicig...

    Authors: Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu and Yi-Xuan Zhang

    Citation: Microbial Cell Factories 2018 17:81

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  42. Content type: RESEARCH

    Gamma-aminobutyric acid (GABA) plays a significant role in the food and drug industries. Our previous study established an efficient fed-batch fermentation process for Lactobacillus brevis NCL912 production of GA...

    Authors: Qiong Wang, Xiaohua Liu, Jinheng Fu, Shuixing Wang, Yuanhong Chen, Kunpeng Chang and Haixing Li

    Citation: Microbial Cell Factories 2018 17:80

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  43. Content type: RESEARCH

    Utilization of cocoa pod husks (CPH) in animal feed is hindered by the presence of theobromine, which is variably toxic to animals. Treatment of this agro-waste to remove theobromine, while preserving its nutr...

    Authors: Daniel Oduro-Mensah, Augustine Ocloo, Sammy T. Lowor, Cheetham Mingle, Laud K. N.-A. Okine and Naa Ayikailey Adamafio

    Citation: Microbial Cell Factories 2018 17:79

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  44. Content type: RESEARCH

    The characterization of the molecular determinants of metal resistance has potential biotechnological application in biosensing and bioremediation. In this context, the bacterium Thermus thermophilus HB27 is a me...

    Authors: Immacolata Antonucci, Giovanni Gallo, Danila Limauro, Patrizia Contursi, Ana Luisa Ribeiro, Alba Blesa, José Berenguer, Simonetta Bartolucci and Gabriella Fiorentino

    Citation: Microbial Cell Factories 2018 17:78

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  45. Content type: RESEARCH

    3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only a few KstDs have thus far been characterized biochemically and applied for th...

    Authors: Ruijie Zhang, Xiangcen Liu, Yushi Wang, Yuchang Han, Junsong Sun, Jiping Shi and Baoguo Zhang

    Citation: Microbial Cell Factories 2018 17:77

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  46. Content type: RESEARCH

    l-Arabinose is the second most abundant component of hemicellulose in lignocellulosic biomass, next to d-xylose. However, few microorganisms are capable of utilizing pentoses, and catabolic genes and operons enab...

    Authors: Hideo Kawaguchi, Kumiko Yoshihara, Kiyotaka Y. Hara, Tomohisa Hasunuma, Chiaki Ogino and Akihiko Kondo

    Citation: Microbial Cell Factories 2018 17:76

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  47. Content type: RESEARCH

    Cellulase can convert lignocellulosic feedstocks into fermentable sugars, which can be used for the industrial production of biofuels and chemicals. The high cost of cellulase production remains a challenge fo...

    Authors: Jiajia Zhang, Guoxiu Zhang, Wei Wang, Wei Wang and Dongzhi Wei

    Citation: Microbial Cell Factories 2018 17:75

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