Skip to content



Page 5 of 40

  1. Content type: Technical Notes

    To optimize the production of membrane and secretory proteins in Escherichia coli, it is critical to harmonize the expression rates of the genes encoding these proteins with the capacity of their biogenesis machi...

    Authors: Grietje Kuipers, Alexandros Karyolaimos, Zhe Zhang, Nurzian Ismail, Gianluca Trinco, David Vikström, Dirk Jan Slotboom and Jan-Willem de Gier

    Citation: Microbial Cell Factories 2017 16:226

    Published on:

  2. Content type: RESEARCH

    Rhamnolipids are biosurfactants featuring surface-active properties that render them suitable for a broad range of industrial applications. These properties include their emulsification and foaming capacity, c...

    Authors: Till Tiso, Rabea Zauter, Hannah Tulke, Bernd Leuchtle, Wing-Jin Li, Beate Behrens, Andreas Wittgens, Frank Rosenau, Heiko Hayen and Lars Mathias Blank

    Citation: Microbial Cell Factories 2017 16:225

    Published on:

  3. Content type: RESEARCH

    A key advantage of recombinant antibody technology is the ability to optimize and tailor reagents. Single domain antibodies (sdAbs), the recombinantly produced variable domains derived from camelid and shark h...

    Authors: Jinny L. Liu, Lisa C. Shriver-Lake, George P. Anderson, Dan Zabetakis and Ellen R. Goldman

    Citation: Microbial Cell Factories 2017 16:223

    Published on:

  4. Content type: RESEARCH

    Lactulose, a synthetic disaccharide, has received increasing interest due to its role as a prebiotic, specifically proliferating Bifidobacilli and Lactobacilli and enhancing absorption of calcium and magnesium. T...

    Authors: Ah-Reum Park, Jin-Sook Kim, Seung-Won Jang, Young-Gyun Park, Bong-Seong Koo and Hyeon-Cheol Lee

    Citation: Microbial Cell Factories 2017 16:224

    Published on:

  5. Content type: RESEARCH

    The ease of use of CRISPR-Cas9 reprogramming, its high efficacy, and its multiplexing capabilities have brought this technology at the forefront of genome editing techniques. Saccharomyces pastorianus is an aneup...

    Authors: Arthur R. Gorter de Vries, Philip A. de Groot, Marcel van den Broek and Jean-Marc G. Daran

    Citation: Microbial Cell Factories 2017 16:222

    Published on:

  6. Content type: RESEARCH

    Lactic acid bacteria are a family of “generally regarded as safe” organisms traditionally used for food fermentation. In recent years, they have started to emerge as potential chassis for heterologous protein ...

    Authors: Pei Yu Lim, Lee Ling Tan, Dave Siak-Wei Ow and Fong T. Wong

    Citation: Microbial Cell Factories 2017 16:221

    Published on:

  7. Content type: RESEARCH

    Escherichia coli (E. coli) is the most abundant expression host for recombinant proteins. The production efficiency is dependent on a multitude of parameters. Therefore, high-throughpu...

    Authors: Martina Mühlmann, Eva Forsten, Saskia Noack and Jochen Büchs

    Citation: Microbial Cell Factories 2017 16:220

    Published on:

  8. Content type: Research

    Although mycobacterial glycolipids are among the first-line molecules involved in host–pathogen interactions, their contribution in virulence remains incomplete. Mycobacterium marinum is a waterborne pathogen of ...

    Authors: Izabela Szulc-Kielbik, Jakub Pawelczyk, Michal Kielbik, Laurent Kremer, Jaroslaw Dziadek and Magdalena Klink

    Citation: Microbial Cell Factories 2017 16:217

    Published on:

  9. Content type: Research

    Bacteria have developed different mechanisms for the transformation of metalloid oxyanions to non-toxic chemical forms. A number of bacterial isolates so far obtained in axenic culture has shown the ability to...

    Authors: Emanuele Zonaro, Elena Piacenza, Alessandro Presentato, Francesca Monti, Rossana Dell’Anna, Silvia Lampis and Giovanni Vallini

    Citation: Microbial Cell Factories 2017 16:215

    Published on:

  10. Content type: RESEARCH

    Gene therapy has gained an increasing interest in its anti-tumor efficiency. However, numerous efforts are required to promote them to clinics. In this study, a novel and efficient delivery platform based on b...

    Authors: Qinglei Dai, Ruimin Long, Shibin Wang, Ranjith Kumar Kankala, Jiaojiao Wang, Wei Jiang and Yuangang Liu

    Citation: Microbial Cell Factories 2017 16:216

    Published on:

  11. Content type: RESEARCH

    Most endophytic bacteria in consortia, which provide robust and broad metabolic capacity, are attractive for applications in plant metabolic engineering. The aim of this study was to investigate the effects of...

    Authors: Yupei Liu, Lixiang Cao, Hongming Tan and Renduo Zhang

    Citation: Microbial Cell Factories 2017 16:214

    Published on:

  12. Content type: RESEARCH

    The Bacillus subtilis spore has long been used to display antigens and enzymes. Spore display can be accomplished by a recombinant and a non-recombinant approach, with the latter proved more efficient than the re...

    Authors: Rosanna Mattossovich, Roberta Iacono, Giuseppina Cangiano, Beatrice Cobucci-Ponzano, Rachele Isticato, Marco Moracci and Ezio Ricca

    Citation: Microbial Cell Factories 2017 16:218

    Published on:

  13. Content type: Research

    Optically pure d-lactic acid (≥ 99%) is an important precursor of polylactic acid. However, there are relatively few studies on d-lactic acid fermentation compared with the extensive investigation of l-lactic aci...

    Authors: Caili Zhang, Cheng Zhou, Nilnate Assavasirijinda, Bo Yu, Limin Wang and Yanhe Ma

    Citation: Microbial Cell Factories 2017 16:213

    Published on:

  14. Content type: Research

    Production directly from carbon dioxide by engineered cyanobacteria is one of the promising technologies for sustainable future. Previously, we have successfully achieved 1,3-propanediol (1,3-PDO) production u...

    Authors: Yasutaka Hirokawa, Shingo Matsuo, Hiroyuki Hamada, Fumio Matsuda and Taizo Hanai

    Citation: Microbial Cell Factories 2017 16:212

    Published on:

  15. Content type: Research

    Understanding the bioprocess limitations is critical for the efficient design of biocatalysts to facilitate process feasibility and improve process economics. In this study, a proline hydroxylation process wit...

    Authors: Kequan Chen, Yang Pang, Bowen Zhang, Jiao Feng, Sheng Xu, Xin Wang and Pingkai Ouyang

    Citation: Microbial Cell Factories 2017 16:210

    Published on:

  16. Content type: Research

    Monascus pigments are widely used in the food and pharmaceutical industries due to their safety to human health. Our previous study found that glucose concentration induced extracellul...

    Authors: Tao Huang, Hailing Tan, Fangju Lu, Gong Chen and Zhenqiang Wu

    Citation: Microbial Cell Factories 2017 16:208

    Published on:

  17. Content type: Research

    Trichoderma reesei is one of the most important fungi utilized for cellulase production. However, its cellulase system has been proven to be present in suboptimal ratio for deconstruct...

    Authors: Yuanchao Qian, Lixia Zhong, Jia Gao, Ningning Sun, Yifan Wang, Guoyong Sun, Yinbo Qu and Yaohua Zhong

    Citation: Microbial Cell Factories 2017 16:207

    Published on:

  18. Content type: Research

    d-Lactate is a valued chemical which can be produced by some bacteria including Klebsiella pneumoniae. However, only a few studies have focused on K. pneumoniae for d-lactate productio...

    Authors: Xinjun Feng, Liqun Jiang, Xiaojuan Han, Xiutao Liu, Zhiqiang Zhao, Huizhou Liu, Mo Xian and Guang Zhao

    Citation: Microbial Cell Factories 2017 16:209

    Published on:

  19. Content type: Research

    There is a need to replace petroleum-derived with sustainable feedstocks for chemical production. Certain biomass feedstocks can meet this need as abundant, diverse, and renewable resources. Specific ionic liq...

    Authors: Elsayed T. Mohamed, Shizeng Wang, Rebecca M. Lennen, Markus J. Herrgård, Blake A. Simmons, Steven W. Singer and Adam M. Feist

    Citation: Microbial Cell Factories 2017 16:204

    Published on:

  20. Content type: Research

    Xenocoumacin 1 (Xcn1) and Xenocoumacin 2 (Xcn2) are the main antimicrobial compounds produced by Xenorhabdus nematophila. Culture conditions, including pH, had remarkably distinct effects on the antimicrobial act...

    Authors: Shuqi Guo, Shujing Zhang, Xiangling Fang, Qi Liu, Jiangtao Gao, Muhammad Bilal, Yonghong Wang and Xing Zhang

    Citation: Microbial Cell Factories 2017 16:203

    Published on:

  21. Content type: Research

    Yeast transcription factors (TFs) involved in the regulation of multidrug resistance (MDR) were investigated in experiments with deletion mutants, transformants overexpressing synthetic genes encoding TFs, and...

    Authors: Guochao Wu, Zixiang Xu and Leif J. Jönsson

    Citation: Microbial Cell Factories 2017 16:199

    Published on:

  22. Content type: Research

    Viral protein expression in Escherichia coli (E. coli) is a powerful tool for structural/functional studies as well as for vaccine and diagnostics development. However, numerous factors such as codon bias, mRNA s...

    Authors: Nouredine Behloul, Wenjuan Wei, Sarra Baha, Zhenzhen Liu, Jiyue Wen and Jihong Meng

    Citation: Microbial Cell Factories 2017 16:200

    Published on:

  23. Content type: Commentary

    Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions. PEGylation has become a sophis...

    Authors: Yanying Xu, Yueyuan Shi, Jianzhong Zhou, Wei Yang, Lei Bai, Shilei Wang, Xin Jin, Qiangsi Niu, Ailong Huang and Deqiang Wang

    Citation: Microbial Cell Factories 2017 16:197

    Published on:

  24. Content type: Research

    Heat-stable antifungal factor (HSAF) is a polycyclic tetramate macrolactam secondary metabolite that exhibits broad-spectrum inhibitory activities against filamentous fungal pathogens. The native yield of this...

    Authors: Huiyong Xu, Ruping Wang, Yangyang Zhao, Zheng Qing Fu, Guoliang Qian and Fengquan Liu

    Citation: Microbial Cell Factories 2017 16:202

    Published on:

  25. Content type: Research

    In the present work we described the recombinant production and characterization of heterodimeric construction ZnT8-Arg-Trp325 fused to thioredoxin using a high-performance expression system such as Escherichia c...

    Authors: Natalia I. Faccinetti, Luciano L. Guerra, Adriana V. Sabljic, Silvina S. Bombicino, Bruno D. Rovitto, Ruben F. Iacono, Edgardo Poskus, Aldana Trabucchi and Silvina N. Valdez

    Citation: Microbial Cell Factories 2017 16:196

    Published on:

  26. Content type: Research

    Analyses of substrate and metabolites are often bottleneck activities in high-throughput screening of microbial bioprocesses. We have assessed Fourier transform infrared spectroscopy (FTIR), in combination wit...

    Authors: Gergely Kosa, Volha Shapaval, Achim Kohler and Boris Zimmermann

    Citation: Microbial Cell Factories 2017 16:195

    Published on:

  27. Content type: Research

    First generation bioethanol production utilizes the starch fraction of maize, which accounts for approximately 60% of the ash-free dry weight of the grain. Scale-up of this technology for fuels applications ha...

    Authors: Fang Liu, Weihua Wu, Mary B. Tran-Gyamfi, James D. Jaryenneh, Xun Zhuang and Ryan W. Davis

    Citation: Microbial Cell Factories 2017 16:192

    Published on:

  28. Content type: Research

    Tup1 is a general transcriptional repressor of diverse gene families coordinately controlled by glucose repression, mating type, and other mechanisms in Saccharomyces cerevisiae. Several functional domains of Tup...

    Authors: Xue Lin, Ai-Qun Yu, Cui-Ying Zhang, Li Pi, Xiao-Wen Bai and Dong-Guang Xiao

    Citation: Microbial Cell Factories 2017 16:194

    Published on:

  29. Content type: Research

    The present study compared the effects of soybean meal fermented by three different probiotics organisms with non-fermented soybean meal on growth performance, serum parameters, immune chemistry and intestinal...

    Authors: Jiajia Zhu, Mingxing Gao, Ruili Zhang, Zhuojian Sun, Chunmei Wang, Fenfang Yang, Tingting Huang, Shaoqi Qu, Li Zhao, Yuwen Li and Zhihui Hao

    Citation: Microbial Cell Factories 2017 16:191

    Published on:

  30. Content type: Research

    d-Tagatose 3-epimerase epimerizes d-fructose to yield d-psicose, which is a rare sugar that exists in small quantities in nature and is difficult to synthesize chemically. We aim to ex...

    Authors: Zhengliang Qi, Zhangliang Zhu, Jian-Wen Wang, Songtao Li, Qianqian Guo, Panpan Xu, Fuping Lu and Hui-Min Qin

    Citation: Microbial Cell Factories 2017 16:193

    Published on:

  31. Content type: Review

    Today, biofuels represent a hot topic in the context of petroleum and adjacent products decrease. As biofuels production increase, so does the production of their major byproduct, namely crude glycerol. The ef...

    Authors: Laura Mitrea, Monica Trif, Adriana-Florinela Cătoi and Dan-Cristian Vodnar

    Citation: Microbial Cell Factories 2017 16:190

    Published on:

  32. Content type: Technical Notes

    Multiplex control of metabolic pathway genes is essential for maximizing product titers and conversion yields of fuels, chemicals, and pharmaceuticals in metabolic engineering. To achieve this goal, artificial...

    Authors: Seong Keun Kim, Wonjae Seong, Gui Hwan Han, Dae-Hee Lee and Seung-Goo Lee

    Citation: Microbial Cell Factories 2017 16:188

    Published on:

  33. Content type: Research

    Shewanella baltica KB30 was isolated from seawater collected in Kandalaksha Bay, White Sea (Russia). This strain is known for its ability to grow on a pool of different substrates, inc...

    Authors: Juan Carlos Leyva-Díaz, José Manuel Poyatos, Paolo Barghini, Susanna Gorrasi and Massimiliano Fenice

    Citation: Microbial Cell Factories 2017 16:189

    Published on:

  34. Content type: Research

    Recombinant protein production and purification from Escherichia coli is often accompanied with expensive and complicated procedures, especially for therapeutic proteins. Here it was demonstrated that, by using a...

    Authors: Jinping Du and Bernd H. A. Rehm

    Citation: Microbial Cell Factories 2017 16:184

    Published on:

  35. Content type: Research

    The application of chemical dispersants as a response to marine oil spills is raising concerns related to their potential toxicity also towards microbes involved in oil biodegradation. Hence, oil spills occurr...

    Authors: Noura Raddadi, Lucia Giacomucci, Grazia Totaro and Fabio Fava

    Citation: Microbial Cell Factories 2017 16:186

    Published on:

  36. Content type: Research

    Medium chain length (C6–C12) α,ω-dicarboxylic acids (DCAs) and corresponding esters are important building blocks for the polymer industry. For DCAs of 12 carbon atoms and longer, a sustainable process based o...

    Authors: Youri M. van Nuland, Gerrit Eggink and Ruud A. Weusthuis

    Citation: Microbial Cell Factories 2017 16:185

    Published on:

  37. Content type: Research

    Cofactor engineering is involved in the modification of enzymes related to nicotinamide adenine dinucleotides (NADH and NAD+) metabolism, which results in a significantly altered spectrum of metabolic products. C...

    Authors: Liqiu Su, Yanbing Shen, Wenkai Zhang, Tian Gao, Zhihua Shang and Min Wang

    Citation: Microbial Cell Factories 2017 16:182

    Published on:

  38. Content type: Research

    Exogenous RNAs can specifically up-regulate or down-regulate gene expression after they enter into cells. Alu RNAs are the main constituent of human transcriptome and participate in gene expression regulation....

    Authors: Chao Liu, Yuehua Zhao, Shuxian Yin, Shufeng Liu, Huanling Zhang, Xiufang Wang and Zhanjun Lv

    Citation: Microbial Cell Factories 2017 16:183

    Published on:

  39. Content type: Technical Notes

    The widely established production of CH4 from renewable biomass in industrial scale anaerobic reactors may play a major role in the future energy supply. It relies on methanogenic archaea as key organisms which r...

    Authors: Johannes Lambrecht, Nicolas Cichocki, Thomas Hübschmann, Christin Koch, Hauke Harms and Susann Müller

    Citation: Microbial Cell Factories 2017 16:180

    Published on:

  40. Content type: Research

    3-Hydroxypropionic acid (3-HP) is an important platform chemical, serving as a precursor for a wide range of industrial applications such as the production of acrylic acid and 1,3-propanediol. Although Escherichi...

    Authors: Yi-Ming Yang, Wen-Jing Chen, Jing Yang, Yuan-Ming Zhou, Bo Hu, Min Zhang, Li-Ping Zhu, Guang-Yuan Wang and Song Yang

    Citation: Microbial Cell Factories 2017 16:179

    Published on:

  41. Content type: Research

    Multiple lignocellulose-derived inhibitors represent great challenges for bioethanol production from lignocellulosic materials. These inhibitors that are related to the levels of intracellular reactive oxidati...

    Authors: Jiaoqi Gao, Wenjie Yuan, Yimin Li, Fengwu Bai and Yu Jiang

    Citation: Microbial Cell Factories 2017 16:181

    Published on:

  42. Content type: Review

    Cutaneotrichosporon oleaginosus ATCC 20509, previously known as Trichosporon oleaginosus, Cryptococcus curvatus, Apiotrichum curvatum or Candida curvata D is an oleaginous yeast with seve...

    Authors: Felix Bracharz, Teun Beukhout, Norbert Mehlmer and Thomas Brück

    Citation: Microbial Cell Factories 2017 16:178

    Published on:

  43. Content type: Research

    Griseoviridin (GV) and viridogrisein (VG, also referred as etamycin), both biosynthesized by a distinct 105 kb biosynthetic gene cluster (BGC) in Streptomyces griseoviridis NRRL 2427, are a pair of synergistic st...

    Authors: Yunchang Xie, Junying Ma, Xiangjing Qin, Qinglian Li and Jianhua Ju

    Citation: Microbial Cell Factories 2017 16:177

    Published on:

2017 Journal Metrics