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  1. Immobilization is an appropriate tool to ease the handling and recycling of enzymes in biocatalytic processes and to increase their stability. Most of the established immobilization methods require case-to-cas...

    Authors: V. D. Jäger, R. Kloss, A. Grünberger, S. Seide, D. Hahn, T. Karmainski, M. Piqueray, J. Embruch, S. Longerich, U. Mackfeld, K.-E. Jaeger, W. Wiechert, M. Pohl and U. Krauss

    Citation: Microbial Cell Factories 2019 18:33

    Content type: RESEARCH

    Published on:

  2. Isobutanol, a C4 branched-chain higher alcohol, is regarded as an attractive next-generation transport fuel. Metabolic engineering for efficient isobutanol production has been achieved in many studies. BmoR, a...

    Authors: Huan Yu, Ning Wang, Wenbo Huo, Yuhong Zhang, Wei Zhang, Yu Yang, Zhenya Chen and Yi-Xin Huo

    Citation: Microbial Cell Factories 2019 18:30

    Content type: RESEARCH

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  3. Citric acid is the world’s largest consumed organic acid and is widely used in beverage, food and pharmaceutical industries. Aspergillus niger is the main industrial workhorse for citric acid production. Since th...

    Authors: Zhenyu Tong, Xiaomei Zheng, Yi Tong, Yong-Cheng Shi and Jibin Sun

    Citation: Microbial Cell Factories 2019 18:28

    Content type: Review

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  4. l-Alanyl-l-glutamine (Ala-Gln) represents the great application potential in clinic due to the unique physicochemical properties. A new approach was developed to synthesize Ala-Gln by recombinant Escherichia coli

    Authors: Yi-Min Li, Jiao-Qi Gao, Xu-Ze Pei, Cong Du, Chao Fan, Wen-Jie Yuan and Feng-Wu Bai

    Citation: Microbial Cell Factories 2019 18:27

    Content type: RESEARCH

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  5. Escherichia coli W3110 and a group of six isogenic derivatives, each displaying distinct specific rates of glucose consumption were characterized to determine levels of GFP production and population heterogeneity...

    Authors: Juan Carlos Fragoso-Jiménez, Jonathan Baert, Thai Minh Nguyen, Wenzheng Liu, Hosni Sassi, Frédéric Goormaghtigh, Laurence Van Melderen, Paul Gaytán, Georgina Hernández-Chávez, Alfredo Martinez, Frank Delvigne and Guillermo Gosset

    Citation: Microbial Cell Factories 2019 18:26

    Content type: RESEARCH

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  6. Phosphoketolases (Xfpk) are a non-native group of enzymes in yeast, which can be expressed in combination with other metabolic enzymes to positively influence the yield of acetyl-CoA derived products by reduci...

    Authors: Alexandra Bergman, John Hellgren, Thomas Moritz, Verena Siewers, Jens Nielsen and Yun Chen

    Citation: Microbial Cell Factories 2019 18:25

    Content type: RESEARCH

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  7. Lignocellulosic biomass is one of the most abundant materials for biochemicals production. However, efficient co-utilization of glucose and xylose from the lignocellulosic biomass is a challenge due to the glu...

    Authors: Yan Hua, Jichao Wang, Yelin Zhu, Biao Zhang, Xin Kong, Wenjie Li, Dongmei Wang and Jiong Hong

    Citation: Microbial Cell Factories 2019 18:24

    Content type: RESEARCH

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  8. Terpenes are industrially relevant natural compounds the biosynthesis of which relies on two well-established—mevalonic acid (MVA) and methyl erythritol phosphate (MEP)-pathways. Both pathways are widely distr...

    Authors: Juan Rico, Katia Duquesne, Jean-Louis Petit, Aline Mariage, Ekaterina Darii, Frédéric Peruch, Véronique de Berardinis and Gilles Iacazio

    Citation: Microbial Cell Factories 2019 18:23

    Content type: RESEARCH

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  10. Infectious bursal disease (IBD) is an acute contagious immunosuppressive disease which lead to acute bursal injury and immune dysfunction in poultry. It has caused heavy economic losses in the commercial poult...

    Authors: Wenqian Wang, Yuxin Song, Linlin Liu, Yuan Zhang, Tingting Wang, Wang Zhang, Kai Li, Xiaole Qi, Yulong Gao, Li Gao, Changjun Liu, Yanping Zhang, Yongqiang Wang, Qing Pan, Gaoming He, Xiaomei Wang…

    Citation: Microbial Cell Factories 2019 18:21

    Content type: RESEARCH

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  11. Long-chain free fatty acids (FFAs) are a type of backbone molecule that can react with alcohol to produce biodiesels. Various microorganisms have become potent producers of FFAs. Efforts have focused on increa...

    Authors: Xiaomeng Tong, Eun Kyoung Oh, Byeong-ha Lee and Jeong K. Lee

    Citation: Microbial Cell Factories 2019 18:20

    Content type: RESEARCH

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  12. The Twin-arginine translocation (Tat) pathway of Escherichia coli has great potential for the export of biopharmaceuticals to the periplasm due to its ability to transport folded proteins, and its proofreading me...

    Authors: Isabel Guerrero Montero, Katarzyna Magdalena Dolata, Rabea Schlüter, Gilles Malherbe, Susanne Sievers, Daniela Zühlke, Thomas Sura, Emma Dave, Katharina Riedel and Colin Robinson

    Citation: Microbial Cell Factories 2019 18:19

    Content type: RESEARCH

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  14. Recombinant human Fibroblast growth factor 21 (rhFGF21) is an endocrine hormone that has profound effects on treatment of metabolic diseases. However, rhFGF21 is prone to form inclusion body when expressed in ...

    Authors: Dandan Li, Gang Fu, Ran Tu, Zhaoxia Jin and Dawei Zhang

    Citation: Microbial Cell Factories 2019 18:17

    Content type: RESEARCH

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  15. Streptomyces chattanoogensis L10 is the industrial producer of natamycin and has been proved a highly efficient host for diverse natural products. It has an enormous potential to be developed as a versatile cell ...

    Authors: Qing-Ting Bu, Pin Yu, Jue Wang, Zi-Yue Li, Xin-Ai Chen, Xu-Ming Mao and Yong-Quan Li

    Citation: Microbial Cell Factories 2019 18:16

    Content type: RESEARCH

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  16. Electrochemical energy is a key factor of biosynthesis, and is necessary for the reduction or assimilation of substrates such as CO2. Previous microbial electrosynthesis (MES) research mainly utilized naturally e...

    Authors: Zaiqiang Wu, Junsong Wang, Jun Liu, Yan Wang, Changhao Bi and Xueli Zhang

    Citation: Microbial Cell Factories 2019 18:15

    Content type: RESEARCH

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  17. Research on filamentous fungi emphasized the remarkable redundancy in genes encoding hydrolytic enzymes, the similarities but also the large differences in their expression, especially through the role of the ...

    Authors: Agustina Llanos, Sébastien Déjean, Virginie Neugnot-Roux, Jean M. François and Jean-Luc Parrou

    Citation: Microbial Cell Factories 2019 18:14

    Content type: RESEARCH

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  18. Alternaria sp. MG1, an endophytic fungus isolated from grape, is a native producer of resveratrol, which has important application potential. However, the metabolic characteristics and physiological behavior of M...

    Authors: Yao Lu, Chao Ye, Jinxin Che, Xiaoguang Xu, Dongyan Shao, Chunmei Jiang, Yanlin Liu and Junling Shi

    Citation: Microbial Cell Factories 2019 18:13

    Content type: RESEARCH

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  19. Styrene monooxygenase (SMO) catalyzes the first step of aromatic alkene degradation yielding the corresponding epoxides. Because of its broad spectrum of substrates, the enzyme harbors a great potential for an...

    Authors: Chunlin Tan, Xian Zhang, Zhijing Zhu, Meijuan Xu, Taowei Yang, Tolbert Osire, Shangtian Yang and Zhiming Rao

    Citation: Microbial Cell Factories 2019 18:12

    Content type: RESEARCH

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  20. Pichia pastoris (syn. Komagataella phaffii) is one of the most highly utilized eukaryotic expression systems for the production of heterologous glycoproteins, being able to perform both N- and O-mannosylation. In...

    Authors: Giroshi Bando-Campos, Daniel Juárez-López, Sergio A. Román-González, Antonia I. Castillo-Rodal, Clarita Olvera, Yolanda López-Vidal, Roberto Arreguín-Espinosa, Clara Espitia, Mauricio A. Trujillo-Roldán and Norma A. Valdez-Cruz

    Citation: Microbial Cell Factories 2019 18:11

    Content type: RESEARCH

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  21. Many valuable biopharmaceutical and biotechnological proteins have been produced in Escherichia coli, however these proteins are almost exclusively localised in the cytoplasm or periplasm. This presents challenge...

    Authors: Charlotte A. Green, Nitin S. Kamble, Elizabeth K. Court, Owain J. Bryant, Matthew G. Hicks, Christopher Lennon, Gillian M. Fraser, Phillip C. Wright and Graham P. Stafford

    Citation: Microbial Cell Factories 2019 18:10

    Content type: RESEARCH

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  22. Cellulase is the one of the largest contributors to the high production costs of the lignocellulose-based biorefineries. As the most widely used cellulase producer, Trichoderma reesei has two weaknesses, deficien...

    Authors: Hao Fang, Runze Zhao, Chaofeng Li and Chen Zhao

    Citation: Microbial Cell Factories 2019 18:9

    Content type: RESEARCH

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  23. In vivo protein formation is a crucial part of cellular life. The process needs to adapt to growth conditions and is exploited for the production of technical and pharmaceutical proteins in microbes such as Esche...

    Authors: Alexander Nieß, Martin Siemann-Herzberg and Ralf Takors

    Citation: Microbial Cell Factories 2019 18:8

    Content type: RESEARCH

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  24. Multi-monocistronic and multi-variate vectors were designed, built, and tested for the improved production of cyanidin 3-O-glucoside (C3G) in Escherichia coli BL21 (DE3). The synthetic bio-parts were designed in ...

    Authors: Biplav Shrestha, Ramesh Prasad Pandey, Sumangala Darsandhari, Prakash Parajuli and Jae Kyung Sohng

    Citation: Microbial Cell Factories 2019 18:7

    Content type: RESEARCH

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  25. The shortage of food based feedstocks has been one of the stumbling blocks in industrial biomanufacturing. The acetone bioproduction from the traditional acetone–butanol–ethanol fermentation is limited by the ...

    Authors: Hao Yang, Bing Huang, Ningyu Lai, Yang Gu, Zhimin Li, Qin Ye and Hui Wu

    Citation: Microbial Cell Factories 2019 18:6

    Content type: RESEARCH

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  26. The production of therapeutically active single chain variable fragment (scFv) antibody is still challenging in E. coli due to the aggregation propensity of recombinant protein into inclusion bodies (IBs). Howeve...

    Authors: Animesh Sarker, Abhishek Singh Rathore and Rinkoo Devi Gupta

    Citation: Microbial Cell Factories 2019 18:5

    Content type: RESEARCH

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  27. As an essential platform chemical mostly used for rubber synthesis, isoprene is produced in industry through chemical methods, derived from petroleum. As an alternative, bio-production of isoprene has attracte...

    Authors: Meijie Li, Hailin Chen, Changqing Liu, Jing Guo, Xin Xu, Haibo Zhang, Rui Nian and Mo Xian

    Citation: Microbial Cell Factories 2019 18:4

    Content type: RESEARCH

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  28. Genome-scale metabolic models (GEMs) allow predicting metabolic phenotypes from limited data on uptake and secretion fluxes by defining the space of all the feasible solutions and excluding physio-chemically a...

    Authors: Ilaria Massaiu, Lorenzo Pasotti, Nikolaus Sonnenschein, Erlinda Rama, Matteo Cavaletti, Paolo Magni, Cinzia Calvio and Markus J. Herrgård

    Citation: Microbial Cell Factories 2019 18:3

    Content type: RESEARCH

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  29. Biosurfactants are surface-active agents produced by microorganisms that have higher efficiency and stability, lower toxicity and higher biocompatibility and biodegradability than chemical surfactants. Despite...

    Authors: Hélvia W. C. Araújo, Rosileide F. S. Andrade, Dayana Montero-Rodríguez, Daylin Rubio-Ribeaux, Carlos A. Alves da Silva and Galba M. Campos-Takaki

    Citation: Microbial Cell Factories 2019 18:2

    Content type: Review

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  30. Glucosamine-6-phosphate N-acetyltransferase (GNA1) is the key enzyme that causes overproduction of N-acetylglucosamine in Bacillus subtilis. Previously, we increased GlcNAc production by promoting the expression ...

    Authors: Wenlong Ma, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du and Long Liu

    Citation: Microbial Cell Factories 2019 18:1

    Content type: RESEARCH

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  31. The catabolite control protein A (CcpA) is a master regulator of many important cellular processes in Gram-positive bacteria. In Lactobacillus plantarum, CcpA directly or indirectly controls the transcription of ...

    Authors: Yanqing Lu, Sichao Song, Huaixiang Tian, Haiyan Yu, Jianxin Zhao and Chen Chen

    Citation: Microbial Cell Factories 2018 17:201

    Content type: RESEARCH

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  32. Corynebacterium glutamicum is a well-known producer of various l-amino acids in industry. During the fermenting process, C. glutamicum unavoidably encounters oxidative stress due to a specific reactive oxygen spe...

    Authors: Meiru Si, Tao Su, Can Chen, Jinfeng Liu, Zhijin Gong, Chengchuan Che, GuiZhi Li and Ge Yang

    Citation: Microbial Cell Factories 2018 17:200

    Content type: RESEARCH

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  33. The secretion of recombinant disulfide-bond containing proteins into the periplasm of Gram-negative bacterial hosts, such as E. coli, has many advantages that can facilitate product isolation, quality and activit...

    Authors: Luminita Gabriela Horga, Samantha Halliwell, Tania Selas Castiñeiras, Chris Wyre, Cristina F. R. O. Matos, Daniela S. Yovcheva, Ross Kent, Rosa Morra, Steven G. Williams, Daniel C. Smith and Neil Dixon

    Citation: Microbial Cell Factories 2018 17:199

    Content type: RESEARCH

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  34. The Gram-positive Streptomyces lividans TK24 is an attractive host for heterologous protein production because of its high capability to secrete proteins—which favors correct folding and facilitates downstream pr...

    Authors: Wouter Daniels, Jeroen Bouvin, Tobias Busche, Christian Rückert, Kenneth Simoens, Spyridoula Karamanou, Lieve Van Mellaert, Ólafur H. Friðjónsson, Bart Nicolai, Anastassios Economou, Jörn Kalinowski, Jozef Anné and Kristel Bernaerts

    Citation: Microbial Cell Factories 2018 17:198

    Content type: RESEARCH

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  35. Although interactions between microorganisms involved in biogas production are largely uncharted, it is commonly accepted that methanogenic Archaea are essential for the process. Methanogens thrive in various env...

    Authors: Adam Pyzik, Martyna Ciezkowska, Pawel S. Krawczyk, Adam Sobczak, Lukasz Drewniak, Andrzej Dziembowski and Leszek Lipinski

    Citation: Microbial Cell Factories 2018 17:197

    Content type: RESEARCH

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  36. Gram-negative bacteria are attractive hosts for recombinant protein production because they are fast growing, easy to manipulate, and genetically stable in large cultures. However, the utility of these microbe...

    Authors: Lisa Ann Burdette, Samuel Alexander Leach, Han Teng Wong and Danielle Tullman-Ercek

    Citation: Microbial Cell Factories 2018 17:196

    Content type: Review

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  37. Scaling up of bioprocesses represents a crucial step in the industrial production of biologicals. However, our knowledge about the impact of scale-up on the organism’s physiology and function is still incomple...

    Authors: Juan C. Aon, Ricardo C. Tecson and Vakhtang Loladze

    Citation: Microbial Cell Factories 2018 17:195

    Content type: RESEARCH

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  38. Butadiene is a platform chemical used as an industrial feedstock for the manufacture of automobile tires, synthetic resins, latex and engineering plastics. Currently, butadiene is predominantly synthesized as ...

    Authors: Jing Yang, Chang-Tai Zhang, Xiao-Jie Yuan, Min Zhang, Xu-Hua Mo, Ling-Ling Tan, Li-Ping Zhu, Wen-Jing Chen, Ming-Dong Yao, Bo Hu and Song Yang

    Citation: Microbial Cell Factories 2018 17:194

    Content type: RESEARCH

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  39. Beyond pathway engineering, the metabolic state of the production host is critical in maintaining the efficiency of cellular production. The biotechnologically important yeast Saccharomyces cerevisiae adjusts its...

    Authors: Maren Wehrs, Jan-Philip Prahl, Jadie Moon, Yuchen Li, Deepti Tanjore, Jay D. Keasling, Todd Pray and Aindrila Mukhopadhyay

    Citation: Microbial Cell Factories 2018 17:193

    Content type: RESEARCH

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    The Correction to this article has been published in Microbial Cell Factories 2019 18:218

  40. Chemical industries are constantly in search of an expeditious and environmentally benign method for producing chiral synthons. Ketoreductases have been used as catalysts for enantioselective conversion of des...

    Authors: Saiful F. Haq, Anirudh P. Shanbhag, Subbulakshmi Karthikeyan, Imran Hassan, Kannan Thanukrishnan, Abhishek Ashok, Sunilkumar Sukumaran, S. Ramaswamy, Nagakumar Bharatham, Santanu Datta, Shalaka Samant and Nainesh Katagihallimath

    Citation: Microbial Cell Factories 2018 17:192

    Content type: RESEARCH

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  41. Bacterial expression and purification of recombinant proteins under homogeneous active form is often challenging. Fusion to highly soluble carrier proteins such as Maltose Binding Protein (MBP) often improves ...

    Authors: Anna Bonhoure, Auguste Demenge, Camille Kostmann, Leticia San José, Eva De la Cal, Pilar Armisen, Yves Nominé and Gilles Travé

    Citation: Microbial Cell Factories 2018 17:191

    Content type: RESEARCH

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  42. Efficient microbial production of chemicals is often hindered by the cytotoxicity of the products or by the pathogenicity of the host strains. Hence 2,3-butanediol, an important drop-in chemical, is an interes...

    Authors: Anna Maria Erian, Martin Gibisch and Stefan Pflügl

    Citation: Microbial Cell Factories 2018 17:190

    Content type: RESEARCH

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  43. In Streptomyces, understanding the switch from primary to secondary metabolism is important for maximizing the production of secondary metabolites such as antibiotics, as well as for optimizing recombinant glycop...

    Authors: Ramsés A. Gamboa-Suasnavart, Norma A. Valdez-Cruz, Gerardo Gaytan-Ortega, Greta I. Reynoso-Cereceda, Daniel Cabrera-Santos, Lorena López-Griego, Wolf Klöckner, Jochen Büchs and Mauricio A. Trujillo-Roldán

    Citation: Microbial Cell Factories 2018 17:189

    Content type: RESEARCH

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  44. d-Psicose 3-epimerase (DPEase) catalyzes the isomerization of d-fructose to the rare sugar d-psicose, which may help prevent obesity, reduce blood sugar and blood fat, and inhibit intra-abdominal fat accumulation...

    Authors: Lingqia Su, Fan Sun, Zhanzhi Liu, Kang Zhang and Jing Wu

    Citation: Microbial Cell Factories 2018 17:188

    Content type: RESEARCH

    Published on:

  45. We previously engineered Bacillus subtilis to express an antigen of interest fused to TasA in a biofilm. B. subtilis has several properties such as sporulation, biofilm formation and probiotic ability that were u...

    Authors: Cédric M. Vogt, Monika Hilbe, Mathias Ackermann, Claudio Aguilar and Catherine Eichwald

    Citation: Microbial Cell Factories 2018 17:187

    Content type: RESEARCH

    Published on:

  46. The chloroplast of eukaryotic microalgae such as Chlamydomonas reinhardtii is a potential platform for metabolic engineering and the production of recombinant proteins. In industrial biotechnology, inducible expr...

    Authors: Rosanna Young and Saul Purton

    Citation: Microbial Cell Factories 2018 17:186

    Content type: RESEARCH

    Published on:

  47. Promoters are commonly used to regulate the expression of specific target genes or operons. Although a series of promoters have been developed in Corynebacterium glutamicum, more precise and unique expression pat...

    Authors: Yuechao Ma, Yi Cui, Lihong Du, Xiaoqian Liu, Xixian Xie and Ning Chen

    Citation: Microbial Cell Factories 2018 17:185

    Content type: RESEARCH

    Published on:

  48. The viral or host systems for a gene expression assume repeatability of the process and high quality of the protein product. Since level and fidelity of transcription primarily determines the overall efficienc...

    Authors: Dawid Koscielniak, Ewa Wons, Karolina Wilkowska and Marian Sektas

    Citation: Microbial Cell Factories 2018 17:184

    Content type: RESEARCH

    Published on:

  49. The methylotrophic yeast Pichia pastoris is a common host for the production of recombinant proteins. However, hypermannosylation hinders the use of recombinant proteins from yeast in most biopharmaceutical appli...

    Authors: Alexander Pekarsky, Lukas Veiter, Vignesh Rajamanickam, Christoph Herwig, Clemens Grünwald-Gruber, Friedrich Altmann and Oliver Spadiut

    Citation: Microbial Cell Factories 2018 17:183

    Content type: RESEARCH

    Published on:

  50. The glutamate decarboxylase (GAD) system of Lactobacillus brevis involves two isoforms of GAD, GadA and GadB, which catalyze the conversion of L-glutamate to γ-aminobutyric acid (GABA) in a proton-consuming react...

    Authors: Changjiang Lyu, Weirui Zhao, Chunlong Peng, Sheng Hu, Hui Fang, Yujiao Hua, Shanjing Yao, Jun Huang and Lehe Mei

    Citation: Microbial Cell Factories 2018 17:180

    Content type: RESEARCH

    Published on:

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