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  1. Bacillus subtilis is an important industrial workhorse applied in the production of many different commercially relevant proteins, especially enzymes. Virtually all of these proteins are secreted via the general ...

    Authors: Jolanda Neef, Cristina Bongiorni, Brian Schmidt, Vivianne J. Goosens and Jan Maarten van Dijl

    Citation: Microbial Cell Factories 2020 19:52

    Content type: Research

    Published on:

  2. Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, and in an effort to identify novel therapeutic target for this disease in recent years, human microbiota has attracted much inte...

    Authors: Liang Shen

    Citation: Microbial Cell Factories 2020 19:50

    Content type: Review

    Published on:

  3. The GRAS and oleaginous yeast Yarrowia lipolytica (Y. lipolytica) is an attractive cell factory for the production of chemicals and biofuels. The production of many natural products of commercial interest have be...

    Authors: Yanping Lu, Qingyu Yang, Zhanglin Lin and Xiaofeng Yang

    Citation: Microbial Cell Factories 2020 19:49

    Content type: Research

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  4. Escherichia coli is an important strain for l-threonine production. Genetic switch is a ubiquitous regulatory tool for gene expression in prokaryotic cells. To sense and regulate intracellular or extracellular ch...

    Authors: Lei Zhao, Ying Lu, Jun Yang, Yu Fang, Lifei Zhu, Zhixiang Ding, Chenhui Wang, Wenjian Ma, Xiaoqing Hu and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2020 19:46

    Content type: Research

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  5. Bacillus licheniformis 2709 is extensively applied as a host for the high-level production of heterologous proteins, but Bacillus cells often possess unfavorable wild-type properties, such as production of viscou...

    Authors: Cuixia Zhou, Huiying Zhou, Dengke Li, Huitu Zhang, Hongbin Wang and Fuping Lu

    Citation: Microbial Cell Factories 2020 19:45

    Content type: Research

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  6. Spore-forming bacteria of the Bacillus genus are widely used probiotics known to exert their beneficial effects also through the stimulation of the host immune response. The oral delivery of B. toyonensis spores ...

    Authors: Francisco Denis S. Santos, Arianna Mazzoli, Ana Raquel Maia, Anella Saggese, Rachele Isticato, Fabio Leite, Susanna Iossa, Ezio Ricca and Loredana Baccigalupi

    Citation: Microbial Cell Factories 2020 19:42

    Content type: Research

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  8. The efficiency of industrial fermentation process mainly depends on carbon yield, final titer and productivity. To improve the efficiency of l-lysine production from mixed sugar, we engineered carbohydrate metabo...

    Authors: Jian-Zhong Xu, Hao-Zhe Ruan, Hai-Bo Yu, Li-Ming Liu and Weiguo Zhang

    Citation: Microbial Cell Factories 2020 19:39

    Content type: Research

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  10. Porcine growth hormone (pGH) is a class of peptide hormones secreted from the pituitary gland, which can significantly improve growth and feed utilization of pigs. However, it is unstable and volatile in vitro...

    Authors: Jinbo Deng, Jiaoqing Li, Miaopeng Ma, Peijing Zhao, Feiping Ming, Zhipeng Lu, Juqing Shi, Qin Fan, Qianyi Liang, Junhao Jia, Jiayi Li, Shuxia Zhang and Linghua Zhang

    Citation: Microbial Cell Factories 2020 19:35

    Content type: Research

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  11. Steroid compounds with a 6,19-oxirane bridge possess interesting biological activities including anticonvulsant and analgesic properties, bacteriostatic activity against Gram-positive bacteria and selective an...

    Authors: Ewa Kozłowska, Agata Matera, Jordan Sycz, Anna Kancelista, Edyta Kostrzewa-Susłow and Tomasz Janeczko

    Citation: Microbial Cell Factories 2020 19:37

    Content type: Research

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  12. Biomass growth of Pencillium chrysogenum is characterised by a distinct pellet morphology consisting of compact hyphal agglomerates. Fungal pellets are advantageous in industrial process control due to rheologica...

    Authors: Lukas Veiter, Julian Kager and Christoph Herwig

    Citation: Microbial Cell Factories 2020 19:33

    Content type: Research

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  13. Bleomycin is a broad-spectrum glycopeptide antitumor antibiotic produced by Streptomyces verticillus. Clinically, the mixture of bleomycin A2 and bleomycin B2 is widely used in combination with other drugs for th...

    Authors: Hong Chen, Jiaqi Cui, Pan Wang, Xin Wang and Jianping Wen

    Citation: Microbial Cell Factories 2020 19:32

    Content type: Research

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  15. Lincomycin, produced by Streptomyces lincolnensis, is a lincosamide antibiotic and widely used for the treatment of the infective diseases caused by Gram-positive bacteria. The mechanisms of lincomycin biosynthes...

    Authors: Chun-Yan Lin, Ai-Ping Pang, Yue Zhang, Jianjun Qiao and Guang-Rong Zhao

    Citation: Microbial Cell Factories 2020 19:30

    Content type: Research

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  16. Avian coccidiosis posts a severe threat to poultry production. In addition to commercial attenuated vaccines, other strategies to combat coccidiosis are urgently needed. Lactobacillus plantarum has been frequentl...

    Authors: Qiong Liu, Yanlong Jiang, Wentao Yang, Yongshi Liu, Chunwei Shi, Jing Liu, Xing Gao, Haibin Huang, Tianming Niu, Guilian Yang and Chunfeng Wang

    Citation: Microbial Cell Factories 2020 19:28

    Content type: Research

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  17. Saccharopolyspora pogona is a prominent industrial strain due to its production of butenyl-spinosyn, a high-quality insecticide against a broad spectrum of insect pests. TetR family proteins are diverse in a trem...

    Authors: Haocheng He, Shuangqin Yuan, Jinjuan Hu, Jianming Chen, Jie Rang, Jianli Tang, Zhudong Liu, Ziyuan Xia, Xuezhi Ding, Shengbiao Hu and Liqiu Xia

    Citation: Microbial Cell Factories 2020 19:27

    Content type: Research

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  18. Caffeic acid is industrially recognized for its antioxidant activity and therefore its potential to be used as an anti-inflammatory, anticancer, antiviral, antidiabetic and antidepressive agent. It is traditio...

    Authors: Kristina Haslinger and Kristala L. J. Prather

    Citation: Microbial Cell Factories 2020 19:26

    Content type: Research

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  19. pWB980 derived from pUB110 is a promising expression vector in Bacillus for its high copy number and high stability. However, the low transformation rate of recombinant plasmids to the wild cells limited the appl...

    Authors: XingYa Zhao, JianYong Xu, Ming Tan, Jie Zhen, WenJu Shu, ShiBin Yang, YanHe Ma, HongChen Zheng and Hui Song

    Citation: Microbial Cell Factories 2020 19:25

    Content type: Research

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  20. Rhodosporidium toruloides has emerged as a promising host for the production of bioproducts from lignocellulose, in part due to its ability to grow on lignocellulosic feedstocks, tolerate growth inhibitors, and c...

    Authors: Gina M. Geiselman, Xun Zhuang, James Kirby, Mary B. Tran-Gyamfi, Jan-Philip Prahl, Eric R. Sundstrom, Yuqian Gao, Nathalie Munoz Munoz, Carrie D. Nicora, Derek M. Clay, Gabriella Papa, Kristin E. Burnum-Johnson, Jon K. Magnuson, Deepti Tanjore, Jeffrey M. Skerker and John M. Gladden

    Citation: Microbial Cell Factories 2020 19:24

    Content type: Research

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  21. The gut microbiota can significantly affect the function of the intestinal barrier. Some intestinal probiotics (such as Lactobacillus, Bifidobacteria, a few Escherichia coli strains, and a new generation of probi...

    Authors: Qing Liu, Zhiming Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai and Wei Chen

    Citation: Microbial Cell Factories 2020 19:23

    Content type: Review

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  22. Yarrowia lipolytica is an oleaginous yeast that can be genetically engineered to produce lipid and non-lipid biochemicals from a variety of feedstocks. Metabolic engineering of this organism usually requires gene...

    Authors: Maureen Hamilton, Andrew L. Consiglio, Kyle MacEwen, A. Joe Shaw and Vasiliki Tsakraklides

    Citation: Microbial Cell Factories 2020 19:22

    Content type: Research

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  23. (+)-Nootkatone is a highly valued sesquiterpenoid compound, exhibiting a typical grapefruit aroma and various desired biological activities for use as aromatics and pharmaceuticals. The high commercial demand ...

    Authors: Xiangfeng Meng, Hui Liu, Wenqiang Xu, Weixin Zhang, Zheng Wang and Weifeng Liu

    Citation: Microbial Cell Factories 2020 19:21

    Content type: Research

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  24. Steviol glycosides such as stevioside have attracted the attention of the food and beverage industry. Recently, efforts were made to produce these natural sweeteners in microorganisms using metabolic engineeri...

    Authors: Jun Ho Moon, Kunjoong Lee, Jun Ho Lee and Pyung Cheon Lee

    Citation: Microbial Cell Factories 2020 19:20

    Content type: Research

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  25. A possible future shortage of feed protein will force mankind to explore alternative protein sources that can replace conventional soymeal or fishmeal. Several large industrial organic side-streams could poten...

    Authors: David Lapeña, Gergely Kosa, Line D. Hansen, Liv T. Mydland, Volkmar Passoth, Svein J. Horn and Vincent G. H. Eijsink

    Citation: Microbial Cell Factories 2020 19:19

    Content type: Research

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  26. Amphotericin B (AmB) is widely used against fungal infection and produced mainly by Streptomyces nodosus. Various intracellular metabolites of S. nodosus were identified during AmB fermentation, and the key compo...

    Authors: Bo Zhang, Yi-Teng Zhou, Sheng-Xian Jiang, Yu-Han Zhang, Kai Huang, Zhi-Qiang Liu and Yu-Guo Zheng

    Citation: Microbial Cell Factories 2020 19:18

    Content type: Research

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  27. Citric acid, a commodity product of industrial biotechnology, is produced by fermentation of the filamentous fungus Aspergillus niger. A requirement for high-yield citric acid production is keeping the concentrat...

    Authors: Balázs Fejes, Jean-Paul Ouedraogo, Erzsébet Fekete, Erzsébet Sándor, Michel Flipphi, Áron Soós, Ákos P. Molnár, Béla Kovács, Christian P. Kubicek, Adrian Tsang and Levente Karaffa

    Citation: Microbial Cell Factories 2020 19:17

    Content type: Research

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  28. Cell-based experimentation in microfluidic droplets is becoming increasingly popular among biotechnologists and microbiologists, since inherent characteristics of droplets allow high throughput at low cost and...

    Authors: Miguel Tovar, Lisa Mahler, Stefanie Buchheim, Martin Roth and Miriam A. Rosenbaum

    Citation: Microbial Cell Factories 2020 19:16

    Content type: Technical notes

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  29. Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmac...

    Authors: Nikolaj L. Hansen, Karel Miettinen, Yong Zhao, Codruta Ignea, Aggeliki Andreadelli, Morten H. Raadam, Antonios M. Makris, Birger L. Møller, Dan Stærk, Søren Bak and Sotirios C. Kampranis

    Citation: Microbial Cell Factories 2020 19:15

    Content type: Research

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  30. Today there is an increasing demand for high yielding robust and cost efficient biotechnological production processes. Although cells in these processes originate from isogenic cultures, heterogeneity induced ...

    Authors: Anna-Lena Heins, Jan Reyelt, Marlen Schmidt, Harald Kranz and Dirk Weuster-Botz

    Citation: Microbial Cell Factories 2020 19:14

    Content type: Research

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  31. Androstenedione (AD) is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of AD is mainly the degradation of the phytostero...

    Authors: Yang Zhang, Xiuling Zhou, Xuemei Wang, Lu Wang, Menglei Xia, Jianmei Luo, Yanbing Shen and Min Wang

    Citation: Microbial Cell Factories 2020 19:13

    Content type: Research

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  32. The ureolytic bacterium Sporosarcina pasteurii is well-known for its capability of microbially induced calcite precipitation (MICP), representing a great potential in constructional engineering and material appli...

    Authors: Liang Ma, Ai-Ping Pang, Yongsheng Luo, Xiaolin Lu and Fengming Lin

    Citation: Microbial Cell Factories 2020 19:12

    Content type: Research

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  33. In recent years, the industrial workhorse Corynebacterium glutamicum has gained increasing interest as a host organism for the secretory production of heterologous proteins. Generally, the yield of a target prote...

    Authors: Sarah Jurischka, Astrid Bida, Doris Dohmen-Olma, Britta Kleine, Janko Potzkei, Stephan Binder, Georg Schaumann, Patrick J. Bakkes and Roland Freudl

    Citation: Microbial Cell Factories 2020 19:11

    Content type: Research

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  34. The use of microorganisms in the biosynthesis of zinc oxide nanoparticles (ZnO NPs) has recently emerged as an alternative to chemical and physical methods due to its low-cost and eco-friendly method. Several ...

    Authors: Hidayat Mohd Yusof, Rosfarizan Mohamad, Uswatun Hasanah Zaidan and Nor’Aini Abdul Rahman

    Citation: Microbial Cell Factories 2020 19:10

    Content type: Research

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  35. Aerobic growth provides benefits in biomass yield and stress tolerance of Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus). Catabolite control protein A (CcpA) is a master regulator involved in the aer...

    Authors: Guofang Zhang, Libo Liu and Chun Li

    Citation: Microbial Cell Factories 2020 19:9

    Content type: Research

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  36. The authors of this article [1] wish to draw the readers’ attention to their closely related paper, published in RSC Advances [2] which should have been cited in this article. The authors regret that there is ...

    Authors: Hailin Chen, Meijie Li, Changqing Liu, Haibo Zhang, Mo Xian and Huizhou Liu

    Citation: Microbial Cell Factories 2020 19:8

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2018 17:65

  37. Therapeutic glycoproteins have occupied an extremely important position in the market of biopharmaceuticals. N-Glycosylation of protein drugs facilitates them to maintain optimal conformations and affect their st...

    Authors: Shengjun Wang, Yongheng Rong, Yaoguang Wang, Decai Kong, Peng George Wang, Min Chen and Yun Kong

    Citation: Microbial Cell Factories 2020 19:7

    Content type: Research

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  38. 1,3-propanediol (1,3-PDO) is the most widely studied value-added product that can be produced by feeding glycerol to bacteria, including Lactobacillus sp. However, previous research reported that L. reuteri only ...

    Authors: Jung-Hyun Ju, Dexin Wang, Sun-Yeon Heo, Min-Soo Kim, Jeong-Woo Seo, Young-Min Kim, Dae-Hyuk Kim, Soon-Ah Kang, Chul-Ho Kim and Baek-Rock Oh

    Citation: Microbial Cell Factories 2020 19:6

    Content type: Research

    Published on:

  39. Heterologous expression of secondary metabolite gene clusters is used to achieve increased production of desired compounds, activate cryptic gene clusters, manipulate clusters from genetically unamenable strai...

    Authors: Yousra Ahmed, Yuriy Rebets, Marta Rodríguez Estévez, Josef Zapp, Maksym Myronovskyi and Andriy Luzhetskyy

    Citation: Microbial Cell Factories 2020 19:5

    Content type: Research

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  40. Swep is an excellent carbamate herbicide that kills weeds by interfering with metabolic processes and inhibiting cell division at the growth point. Due to the large amount of use, swep residues in soil and wat...

    Authors: Long Zhang, Ping Hang, Xiyi Zhou, Chen Dai, Ziyi He and Jiandong Jiang

    Citation: Microbial Cell Factories 2020 19:4

    Content type: Research

    Published on:

  41. Using an established CRISPR-Cas mediated genome editing technique for streptomycetes, we explored the combinatorial biosynthesis potential of the auroramycin biosynthetic gene cluster in Streptomyces roseosporous...

    Authors: Wan Lin Yeo, Elena Heng, Lee Ling Tan, Yi Wee Lim, Kuan Chieh Ching, De-Juin Tsai, Yi Wun Jhang, Tsai-Ling Lauderdale, Kak-Shan Shia, Huimin Zhao, Ee Lui Ang, Mingzi M. Zhang, Yee Hwee Lim and Fong T. Wong

    Citation: Microbial Cell Factories 2020 19:3

    Content type: Research

    Published on:

  42. l-ornithine is a valuable amino acid with a wide range of applications in the pharmaceutical and food industries. However, the production of l-ornithine by fermentation cannot compete with other methods, because ...

    Authors: Yan Jiang, Ming-Zhu Huang, Xue-Lan Chen and Bin Zhang

    Citation: Microbial Cell Factories 2020 19:2

    Content type: Research

    Published on:

  43. The author’s middle name is missed out in the original publication of the article [1]. The correct coauthor’s name is Tobias J. Erb.

    Authors: Daniel Moog, Johanna Schmitt, Jana Senger, Jan Zarzycki, Karl-Heinz Rexer, Uwe Linne, Tobias J. Erb and Uwe G. Maier

    Citation: Microbial Cell Factories 2020 19:1

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2019 18:171

  44. Following publication of the original article [1], the authors have noted that the standard curve in Additional file 1: Figure S7 is incorrect.

    Authors: Maren Wehrs, Jan-Philip Prahl, Jadie Moon, Yuchen Li, Deepti Tanjore, Jay D. Keasling, Todd Pray and Aindrila Mukhopadhyay

    Citation: Microbial Cell Factories 2019 18:218

    Content type: Correction

    Published on:

    The original article was published in Microbial Cell Factories 2018 17:193

  45. Diacetyl provides the buttery aroma in products such as butter and margarine. It can be made via a harsh set of chemical reactions from sugarcane bagasse, however, in dairy products it is normally formed spont...

    Authors: Robin Dorau, Lin Chen, Jianming Liu, Peter Ruhdal Jensen and Christian Solem

    Citation: Microbial Cell Factories 2019 18:217

    Content type: Research

    Published on:

  46. This study reveals that it is possible to secrete truncated versions of outer membrane cytochromes into the culture supernatant and that these proteins can provide a basis for the export of heterologously prod...

    Authors: Helge M. Dietrich, Miriam Edel, Thea Bursac, Manfred Meier, Katrin Sturm-Richter and Johannes Gescher

    Citation: Microbial Cell Factories 2019 18:216

    Content type: Research

    Published on:

  47. Serratia marcescens, a Gram-negative nosocomial pathogen secretes a 50 kDa multi-domain zinc metalloprotease called serratiopeptidase. Broad substrate specificity of serratiopeptidase makes it suitable for deterg...

    Authors: Vishal Srivastava, Shivam Mishra and Tapan K. Chaudhuri

    Citation: Microbial Cell Factories 2019 18:215

    Content type: Research

    Published on:

  48. Increased inclusion of plant proteins in aquafeeds has become a common practice due to the high cost and limited supply of fish meal but generally leads to inferior growth performance and health problems of fi...

    Authors: Chaoqun Li, Beili Zhang, Xin Wang, Xionge Pi, Xuan Wang, Huihui Zhou, Kangsen Mai and Gen He

    Citation: Microbial Cell Factories 2019 18:214

    Content type: Research

    Published on:

  49. Ustilago cynodontis ranks among the relatively unknown itaconate production organisms. In comparison to the well-known and established organisms like Aspergillus terreus and Ustilago maydis, genetic engineering a...

    Authors: Hamed Hosseinpour Tehrani, Katharina Saur, Apilaasha Tharmasothirajan, Lars M. Blank and Nick Wierckx

    Citation: Microbial Cell Factories 2019 18:213

    Content type: Research

    Published on:

  50. Histamine is a key mediator of the anti-inflammatory activity conferred by the probiotic organism Lactobacillus reuteri ATCC PTA 6475 in animal models of colitis and colorectal cancer. In L. reuteri, histamine sy...

    Authors: Anne E. Hall, Melinda A. Engevik, Numan Oezguen, Anthony Haag and James Versalovic

    Citation: Microbial Cell Factories 2019 18:212

    Content type: Research

    Published on:

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