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  1. Content type: RESEARCH

    The morphology of yeast cells changes during budding, depending on the growth rate and cultivation conditions. A photo-optical microscope was adapted and used to observe such morphological changes of individua...

    Authors: Anna-Maria Marbà-Ardébol, Jörn Emmerich, Michael Muthig, Peter Neubauer and Stefan Junne

    Citation: Microbial Cell Factories 2018 17:73

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  2. Content type: RESEARCH

    The angelic acid moiety represents an essential modification in many biologically active products. These products are commonly known as angelates and several studies have demonstrated their therapeutic benefit...

    Authors: Roberta Callari, David Fischer, Harald Heider and Nora Weber

    Citation: Microbial Cell Factories 2018 17:72

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  3. Content type: RESEARCH

    Steroid compounds are very interesting substrates for biotransformation due to their high biological activity and a high number of inactivated carbons which make chemical modification difficult. Microbial tran...

    Authors: Ewa Kozłowska, Natalia Hoc, Jordan Sycz, Monika Urbaniak, Monika Dymarska, Jakub Grzeszczuk, Edyta Kostrzewa-Susłow, Łukasz Stępień, Elżbieta Pląskowska and Tomasz Janeczko

    Citation: Microbial Cell Factories 2018 17:71

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  4. Content type: RESEARCH

    Screening in the fed-batch operation mode is essential for biological cultivations facing challenges as oxygen limitation, osmotic inhibition, catabolite repression, substrate inhibition or overflow metabolism...

    Authors: P. Philip, D. Kern, J. Goldmanns, F. Seiler, A. Schulte, T. Habicher and J. Büchs

    Citation: Microbial Cell Factories 2018 17:69

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  5. Content type: RESEARCH

    Actinobacteria from freshwater habitats have been explored less than from other habitats in the search for compounds of pharmaceutical value. This study highlighted the abundance of actinobacteria from freshwa...

    Authors: Zothanpuia, Ajit Kumar Passari, Vincent Vineeth Leo, Preeti Chandra, Brijesh Kumar, Chandra Nayak, Abeer Hashem, Elsayed Fathi Abd_Allah, Abdulaziz A. Alqarawi and Bhim Pratap Singh

    Citation: Microbial Cell Factories 2018 17:68

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    The Correction to this article has been published in Microbial Cell Factories 2018 17:86

  6. Content type: RESEARCH

    Lignocellulosic ethanol could offer a sustainable source to meet the increasing worldwide demand for fuel. However, efficient and simultaneous metabolism of all types of sugars in lignocellulosic hydrolysates ...

    Authors: Jinfeng Sun, Kangming Tian, Jie Wang, Zixing Dong, Xiaoguang Liu, Kugenthiren Permaul, Suren Singh, Bernard A. Prior and Zhengxiang Wang

    Citation: Microbial Cell Factories 2018 17:66

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  7. Content type: RESEARCH

    Lycopene is a terpenoid pigment that has diverse applications in the food and medicine industries. A prospective approach for lycopene production is by metabolic engineering in microbial hosts, such as Escherichi...

    Authors: Hailin Chen, Meijie Li, Changqing Liu, Haibo Zhang, Mo Xian and Huizhou Liu

    Citation: Microbial Cell Factories 2018 17:65

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  8. Content type: RESEARCH

    Aureobasidium pullulans is a yeast-like fungus that can ferment xylose to generate high-value-added products, such as pullulan, heavy oil, and melanin. The combinatorial expression of two xylose reductase (XR) ge...

    Authors: Jian Guo, Siyao Huang, Yefu Chen, Xuewu Guo and Dongguang Xiao

    Citation: Microbial Cell Factories 2018 17:64

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  9. Content type: RESEARCH

    Extensive modification of genome is an efficient manner to regulate the metabolic network for producing target metabolites or non-native products using Corynebacterium glutamicum as a cell factory. Genome editing...

    Authors: Bo Wang, Qitiao Hu, Yu Zhang, Ruilin Shi, Xin Chai, Zhe Liu, Xiuling Shang, Yun Zhang and Tingyi Wen

    Citation: Microbial Cell Factories 2018 17:63

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  10. Content type: RESEARCH

    The oleaginous yeast Yarrowia lipolytica is a promising microbial cell factory due to their biochemical characteristics and native capacity to accumulate lipid-based chemicals. To create heterogenous biosynthesis...

    Authors: Jin-lai Zhang, Yang-Zi Peng, Duo Liu, Hong Liu, Ying-Xiu Cao, Bing-Zhi Li, Chun Li and Ying-Jin Yuan

    Citation: Microbial Cell Factories 2018 17:62

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  11. Content type: RESEARCH

    Type III polyketide synthases (PKSs) are simple homodimer ketosynthases that distribute across plants, fungi, and bacteria, catalyzing formation of pyrone- and resorcinol-types aromatic polyketides with variou...

    Authors: Lukuan Hou, Huiming Huang, Huayue Li, Shuyao Wang, Jianhua Ju and Wenli Li

    Citation: Microbial Cell Factories 2018 17:61

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  12. Content type: RESEARCH

    2-phenylethanol (2-PE) is an important aromatic compound with a lovely rose-like scent. Saccharomyces cerevisiae is a desirable microbe for 2-PE production but its natural yield is not high, and one or two crucia...

    Authors: Zhaoyue Wang, Mingyue Jiang, Xuena Guo, Zhaozheng Liu and Xiuping He

    Citation: Microbial Cell Factories 2018 17:60

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  13. Content type: RESEARCH

    Saccharomyces cerevisiae, engineered for l-lactic acid production from glucose and xylose, is a promising production host for lignocellulose-to-lactic acid processes. However, the two principal engineering strate...

    Authors: Vera Novy, Bernd Brunner and Bernd Nidetzky

    Citation: Microbial Cell Factories 2018 17:59

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  14. Content type: RESEARCH

    Saccharomyces cerevisiae is widely studied for production of biofuels and biochemicals. To improve production efficiency under industrially relevant conditions, coordinated expression of multiple genes by manipul...

    Authors: Liang Xiong, Yu Zeng, Rui-Qi Tang, Hal S. Alper, Feng-Wu Bai and Xin-Qing Zhao

    Citation: Microbial Cell Factories 2018 17:58

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  15. Content type: RESEARCH

    AmbLOXe is a lipoxygenase, which is up-regulated during limb-redevelopment in the Mexican axolotl, Ambystoma mexicanum, an animal with remarkable regeneration capacity. Previous studies have shown that mammalian ...

    Authors: Anne Stamm, Sarah Strauß, Peter Vogt, Thomas Scheper and Iliyana Pepelanova

    Citation: Microbial Cell Factories 2018 17:57

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  16. Content type: RESEARCH

    Klebsiella pneumoniae is a promising industrial species for bioproduction of bulk chemicals such as 1,3-propanediol, 2,3-butanediol and 3-hydroxypropionic acid (3-HP). However, lactic acid is a troublesome by-pro...

    Authors: Jingxuan Wang, Peng Zhao, Ying Li, Lida Xu and Pingfang Tian

    Citation: Microbial Cell Factories 2018 17:56

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  17. Content type: RESEARCH

    The production of recombinant proteins with proper conformation, appropriate post-translational modifications in an easily scalable and cost-effective system is challenging. Lactococcus lactis has recently been i...

    Authors: Susheel K. Singh, Régis Wendpayangde Tiendrebeogo, Bishwanath Kumar Chourasia, Ikhlaq Hussain Kana, Subhash Singh and Michael Theisen

    Citation: Microbial Cell Factories 2018 17:55

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  18. Content type: RESEARCH

    Microalgal metabolic engineering holds great promise for the overproduction of a wide range of commercial bioproducts. It demands simultaneous manipulation of multiple metabolic nodes. However, high-efficiency...

    Authors: Li-Gong Zou, Jia-Wen Chen, Dan-Lin Zheng, Srinivasan Balamurugan, Da-Wei Li, Wei-Dong Yang, Jie-Sheng Liu and Hong-Ye Li

    Citation: Microbial Cell Factories 2018 17:54

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  19. Content type: RESEARCH

    Growth conditions that bring about stress on Phaffia rhodozyma cells encourage the synthesis of astaxanthin, an antioxidant carotenoid, which protects cells against oxidative damage. Using P. rhodozyma cultures p...

    Authors: Anahí Martínez-Cárdenas, Cipriano Chávez-Cabrera, Jazmín M. Vasquez-Bahena and Luis B. Flores-Cotera

    Citation: Microbial Cell Factories 2018 17:53

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  20. Content type: RESEARCH

    Thermostable lipases from microbial sources have been substantially overexpressed in E. coli, however, these enzymes are often produced with low-level enzymatic activity and mainly in the form of inclusion bodies...

    Authors: Weiqing Zhang, Jing Lu, Shuwen Zhang, Lu Liu, Xiaoyang Pang and Jiaping Lv

    Citation: Microbial Cell Factories 2018 17:50

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  21. Content type: Review

    Torulene and torularhodin represent the group of carotenoids and are synthesized by yeasts and fungi. The most important producers of these two compounds include yeasts of Rhodotorula and Sporobolomyces genera. T...

    Authors: Anna M. Kot, Stanisław Błażejak, Iwona Gientka, Marek Kieliszek and Joanna Bryś

    Citation: Microbial Cell Factories 2018 17:49

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  22. Content type: RESEARCH

    The unicellular cyanobacterium Synechocystis sp. PCC 6803 has been widely used as a photoautotrophic host for synthetic biology studies. However, as a green chassis to capture CO2 for biotechnological application...

    Authors: Deng Liu and Himadri B. Pakrasi

    Citation: Microbial Cell Factories 2018 17:48

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  23. Content type: RESEARCH

    Chitinases are ubiquitous enzymes that have gained a recent biotechnological attention due to their ability to transform biological waste from chitin into valued chito-oligomers with wide agricultural, industr...

    Authors: Peter Elias Kidibule, Paloma Santos-Moriano, Elena Jiménez-Ortega, Mercedes Ramírez-Escudero, M. Carmen Limón, Miguel Remacha, Francisco José Plou, Julia Sanz-Aparicio and María Fernández-Lobato

    Citation: Microbial Cell Factories 2018 17:47

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  24. Content type: RESEARCH

    Hydroxycinnamoyl anthranilates, also known as avenanthramides (avns), are a group of phenolic alkaloids with anti-inflammatory, antioxidant, anti-itch, anti-irritant, and antiatherogenic activities. Some avena...

    Authors: Su Jin Lee, Geun Young Sim, Hyunook Kang, Won Seok Yeo, Bong-Gyu Kim and Joong-Hoon Ahn

    Citation: Microbial Cell Factories 2018 17:46

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  25. Content type: RESEARCH

    In industries lipolytic reactions occur in insensitive conditions such as high temperature thus novel stout esterases with unique properties are attracts to the industrial application. Protein engineering is t...

    Authors: Haofeng Gao, Chanjuan Li, Ramesh Bandikari, Ziduo Liu, Nan Hu and Qiang Yong

    Citation: Microbial Cell Factories 2018 17:45

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  26. Content type: RESEARCH

    Biodegradation of hydrocarbons in Antarctic soil has been reported to be achieved through the utilisation of indigenous cold-adapted microorganisms. Although numerous bacteria isolated from hydrocarbon-contami...

    Authors: Syahir Habib, Siti Aqlima Ahmad, Wan Lutfi Wan Johari, Mohd Yunus Abd Shukor, Siti Aisyah Alias, Khalilah Abdul Khalil and Nur Adeela Yasid

    Citation: Microbial Cell Factories 2018 17:44

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  27. Content type: RESEARCH

    Members of the genus Streptomyces are Gram-positive bacteria that are used as important cell factories to produce secondary metabolites and secrete heterologous proteins. They possess some of the largest bacteria...

    Authors: Konstantinos C. Tsolis, Evridiki-Pandora Tsare, Georgia Orfanoudaki, Tobias Busche, Katerina Kanaki, Reshmi Ramakrishnan, Frederic Rousseau, Joost Schymkowitz, Christian Rückert, Jörn Kalinowski, Jozef Anné, Spyridoula Karamanou, Maria I. Klapa and Anastassios Economou

    Citation: Microbial Cell Factories 2018 17:43

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  28. Content type: RESEARCH

    In the l-histidine (His) biosynthetic pathway of Escherichia coli, the first key enzyme, ATP-phosphoribosyltransferase (ATP-PRT, HisG), is subject to different types of inhibition. Eliminating the feedback inhibi...

    Authors: Evgeniya A. Malykh, Ivan A. Butov, Anna B. Ravcheeva, Alexander A. Krylov, Sergey V. Mashko and Nataliya V. Stoynova

    Citation: Microbial Cell Factories 2018 17:42

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  29. Content type: Research

    The soil bacterium Pseudomonas putida KT2440 is a “generally recognized as safe”-certified strain with robust property and versatile metabolism. Thus, it is an ideal candidate for synthetic biology, biodegradatio...

    Authors: Jun Sun, Qingzhuo Wang, Yu Jiang, Zhiqiang Wen, Lirong Yang, Jianping Wu and Sheng Yang

    Citation: Microbial Cell Factories 2018 17:41

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  30. Content type: RESEARCH

    Rhamnolipids are the most extensively studied biosurfactants and has been successfully used in various areas from bioremediation to industrial fields. Rhamnolipids structural composition decide their physicoch...

    Authors: Feng Zhao, Rongjiu Shi, Fang Ma, Siqin Han and Ying Zhang

    Citation: Microbial Cell Factories 2018 17:39

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  31. Content type: RESEARCH

    To produce 1-propanol as a potential biofuel, metabolic engineering of microorganisms, such as E. coli, has been studied. However, 1-propanol production using metabolically engineered Saccharomyces cerevisiae, wh...

    Authors: Yuya Nishimura, Terumi Matsui, Jun Ishii and Akihiko Kondo

    Citation: Microbial Cell Factories 2018 17:38

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  32. Content type: RESEARCH

    The market for recombinant proteins is on the rise, and Gram-positive strains are widely exploited for this purpose. Bacillus subtilis is a profitable host for protein production thanks to its ability to secrete ...

    Authors: Roberto Ferro, Maja Rennig, Cristina Hernández-Rollán, Daniel O. Daley and Morten H. H. Nørholm

    Citation: Microbial Cell Factories 2018 17:37

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  33. Content type: Review

    Microalgae have recently attracted considerable interest worldwide, due to their extensive application potential in the renewable energy, biopharmaceutical, and nutraceutical industries. Microalgae are renewab...

    Authors: Muhammad Imran Khan, Jin Hyuk Shin and Jong Deog Kim

    Citation: Microbial Cell Factories 2018 17:36

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  34. Content type: RESEARCH

    Phenolic compounds generated in hydrolysis of lignocellulosic materials are major limiting factors for biological production of solvents by Clostridia, but it lacks the attention on the study of adaptation or res...

    Authors: Jun Liu, Qinlu Lin, Xueying Chai, Yunchuan Luo and Ting Guo

    Citation: Microbial Cell Factories 2018 17:35

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  35. Content type: RESEARCH

    Photosynthetic cyanobacteria have been studied as potential host organisms for direct solar-driven production of different carbon-based chemicals from CO2 and water, as part of the development of sustainable futu...

    Authors: Kati Thiel, Edita Mulaku, Hariharan Dandapani, Csaba Nagy, Eva-Mari Aro and Pauli Kallio

    Citation: Microbial Cell Factories 2018 17:34

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  36. Content type: RESEARCH

    Tannases are tannin-degrading enzymes that have been described in fungi and bacteria as an adaptative mechanism to overcome the stress conditions associated with the presence of these phenolic compounds.

    Authors: Julen Tomás-Cortázar, Laura Plaza-Vinuesa, Blanca de las Rivas, José Luis Lavín, Diego Barriales, Leticia Abecia, José Miguel Mancheño, Ana M. Aransay, Rosario Muñoz, Juan Anguita and Héctor Rodríguez

    Citation: Microbial Cell Factories 2018 17:33

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  37. Content type: Review

    Pioneered exactly 20 years ago, yeast surface display (YSD) continues to take a major role in protein engineering among the high-throughput display methodologies that have been developed to date. The classical...

    Authors: Doreen Könning and Harald Kolmar

    Citation: Microbial Cell Factories 2018 17:32

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  38. Content type: RESEARCH

    Syringolin, synthesized by a mixed non-ribosomal peptide synthetase/polyketide synthetase in Pseudomonas syringae pv. syringae (Pss) B728a, is a novel eukaryotic proteasome inhibitor. Meanwhile, directly modifyin...

    Authors: Fan Huang, Jianli Tang, Lian He, Xuezhi Ding, Shaoya Huang, Youming Zhang, Yunjun Sun and Liqiu Xia

    Citation: Microbial Cell Factories 2018 17:31

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  39. Content type: RESEARCH

    Chinese Nong-flavor (NF) liquor is continuously and stably produced by solid-state fermentation technology for 1000 years, resulting in enrichment of special microbial community and enzymes system in its start...

    Authors: Zhuolin Yi, Yang Fang, Kaize He, Dayu Liu, Huibo Luo, Dong Zhao, Hui He, Yanling Jin and Hai Zhao

    Citation: Microbial Cell Factories 2018 17:30

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  40. Content type: RESEARCH

    The direct link between inflammatory bowel diseases and colorectal cancer is well documented. Previous studies have reported that some lactic acid bacterial strains could inhibit colon cancer progression howev...

    Authors: Nehal M. El-Deeb, Abdelrahman M. Yassin, Lamiaa A. Al-Madboly and Amr El-Hawiet

    Citation: Microbial Cell Factories 2018 17:29

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  41. Content type: RESEARCH

    The deep-sea-derived microbe Streptomyces koyangensis SCSIO 5802 produces neoabyssomicins A–B (12) and abyssomicins 2 (3) and 4 (4). Neoabyssomicin A (1) augments human immunodeficiency virus-1 (HIV-1) replicati...

    Authors: Jiajia Tu, Siting Li, Jiang Chen, Yongxiang Song, Shaobin Fu, Jianhua Ju and Qinglian Li

    Citation: Microbial Cell Factories 2018 17:28

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  42. Content type: RESEARCH

    Inorganic polyphosphate bodies (PPB) have recently been linked to a variety of functions in mammalian cells. To improve the yield of PPB from Synechococcus sp. PCC 7002 and characterize its form, in this study, a...

    Authors: Fengzheng Gao, Haohao Wu, Mingyong Zeng, Min Huang and Guangxin Feng

    Citation: Microbial Cell Factories 2018 17:27

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  43. Content type: RESEARCH

    Genome sequencing revealed that Streptomyces sp. can dedicate up to ~ 10% of their genomes for the biosynthesis of bioactive secondary metabolites. However, the majority of these biosynthetic gene clusters are on...

    Authors: Dimitris Kallifidas, Guangde Jiang, Yousong Ding and Hendrik Luesch

    Citation: Microbial Cell Factories 2018 17:25

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  44. Content type: RESEARCH

    Dengue is listed as a neglected tropical disease by the Center for Disease Control and Preservation, as there are insufficient integrated surveillance strategies, no effective treatment, and limited licensed v...

    Authors: Jyotiranjan Bal, Nguyen Ngoc Luong, Jisang Park, Ki-Duk Song, Yong-Suk Jang and Dae-Hyuk Kim

    Citation: Microbial Cell Factories 2018 17:24

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