Meyer V, Wu B, Ram AFJ. Aspergillus as a multi-purpose cell factory: current status and perspectives. Biotechnol Lett. 2011;33:469–76.
Article
CAS
PubMed
Google Scholar
Cairns TC, Nai C, Meyer V. How a fungus shapes biotechnology: 100 years of Aspergillus niger research. Fungal Biol Biotechnol. 2018;5:13.
Article
PubMed
PubMed Central
Google Scholar
Meyer V. Genetic engineering of filamentous fungi-progress, obstacles and future trends. Biotechnol Adv. 2008;26:177–85.
Article
CAS
PubMed
Google Scholar
Lubertozzi D, Keasling JD. Developing Aspergillus as a host for heterologous expression. Biotechnol Adv. 2009;27:53–75.
Article
CAS
PubMed
Google Scholar
Meyer V, Andersen MR, Brakhage AA, Braus GH, Caddick MX, Cairns TC, et al. Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper. Fungal Biol Biotechnol. 2016;3:6.
Article
PubMed
PubMed Central
Google Scholar
Nielsen JC, Grijseels S, Prigent S, Ji B, Dainat J, Nielsen KF, et al. Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium species. Nat Microbiol. 2017;2:17044.
Article
CAS
PubMed
Google Scholar
Weinhold M, Mast-Gerlach E, Meyer V. Vita activa in biotechnology: what we do with fungi and what fungi do with us. Fungal Biol Biotechnol. 2017;4:14.
Article
PubMed
PubMed Central
Google Scholar
Dang T, Süssmuth RD. Bioactive peptide natural products as lead structures for medicinal use. Acc Chem Res. 2017;50:1566–76.
Article
CAS
PubMed
Google Scholar
Richter L, Wanka F, Boecker S, Storm D, Kurt T, Vural Ö, et al. Engineering of Aspergillus niger for the production of secondary metabolites. Fungal Biol Biotechnol. 2014;1:4.
Article
PubMed
PubMed Central
Google Scholar
Meyer V, Wanka F, Van Gent J, Arentshorst M, Den Van, Hondel CAMJJ, Ram AFJ. Fungal gene expression on demand: an inducible, tunable, and metabolism-independent expression system for Aspergillus niger. Appl Environ Microbiol. 2011;77:2975–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schuetze T, Meyer V. Polycistronic gene expression in Aspergillus niger. Microb Cell Fact. 2017;16:162.
Article
PubMed
PubMed Central
Google Scholar
Boecker S, Grätz S, Kerwat D, Adam L, Schirmer D, Richter L, et al. Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides. Fungal Biol Biotechnol. 2018;5:4.
Article
PubMed
PubMed Central
Google Scholar
Zobel S, Boecker S, Kulke D, Heimbach D, Meyer V, Süssmuth RD. Reprogramming the biosynthesis of cyclodepsipeptide synthetases to obtain new enniatins and beauvericins. ChemBioChem. 2016;17:283–7.
Article
CAS
PubMed
Google Scholar
Steiniger C, Hoffmann S, Mainz A, Kaiser M, Voigt K, Meyer V, et al. Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering. Chem Sci. 2017;8:7834–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Langer ES. Single-use bioreactors get nod. Genet Eng Biotechnol News. 2012;32:16.
Article
Google Scholar
Jacquemart R, Vandersluis M, Zhao M, Sukhija K, Sidhu N, Stout J. A single-use strategy to enable manufacturing of affordable biologics. Comput Struct Biotechnol J. 2016;14:309–18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oosterhuis NM, Neubauer P, Junne S. Single-use bioreactors for microbial cultivation. Pharm. Bioprocess. 2013;1:167–77.
Article
Google Scholar
Eibl R, Löffelholz C, Eibl D. Single-use bioreactors-an overview. Single-use technology in biopharmaceutical manufacture. Hoboken: Wiley; 2011. p. 33–51.
Book
Google Scholar
Klöckner W, Diederichs S, Büchs J. Orbitally shaken single-use bioreactors. New York: Springer; 2013. p. 45–60.
Google Scholar
Eibl R, Kaiser S, Lombriser R, Eibl D. Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology. Appl Microbiol Biotechnol. 2010;86:41–9.
Article
CAS
PubMed
Google Scholar
Neubauer P, Cruz N, Glauche F, Junne S, Knepper A, Raven M. Consistent development of bioprocesses from microliter cultures to the industrial scale. Eng Life Sci. 2013;13:224–38.
Article
CAS
Google Scholar
Hillig F, Pilarek M, Junne S, Neubauer P. Cultivation of marine microorganism in single-use systems. Adv Biochem Eng Biotechnol. 2014;138:179–206.
CAS
PubMed
Google Scholar
Singh V. Disposable bioreactor for cell culture using wave-induced agitation. Cytotechnology. 1999;30:149–58.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lehmann N, Rischer H, Eibl D, Eibl R. Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation. Chem Ing Tech. 2013;85:197–201.
Article
CAS
Google Scholar
Eibl R, Werner S, Eibl D. Bag bioreactor based on wave-induced motion: characteristics and applications. Berlin: Springer; 2010. p. 55–87.
Google Scholar
Jonczyk P, Takenberg M, Hartwig S, Beutel S, Berger RG, Scheper T. Cultivation of shear stress sensitive microorganisms in disposable bag reactor systems. J Biotechnol. 2013;167:370–6.
Article
CAS
PubMed
Google Scholar
Junne S, Neubauer P. How scalable and suitable are single-use bioreactors? Curr Opin Biotechnol. 2018;53:240–7.
Article
CAS
PubMed
Google Scholar
Casas López JL, Sánchez Pérez JA, Fernández Sevilla JM, Rodríguez Porcel EM, Chisti Y. Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus. J Biotechnol. 2005;116:61–77.
Article
CAS
PubMed
Google Scholar
Kim JH, Lebeault JM, Reuss M. Comparative study on rheological properties of mycelial broth in filamentous and pelleted forms. Eur J Appl Microbiol Biotechnol. 1983;18:11–6.
Article
Google Scholar
Gibbs PA, Seviour RJ, Schmid F. Growth of filamentous fungi in submerged culture: problems and possible solutions. Crit Rev Biotechnol. 2000;20:17–48.
Article
CAS
PubMed
Google Scholar
Kaup B-A, Ehrich K, Pescheck M, Schrader J. Microparticle-enhanced cultivation of filamentous microorganisms: increased chloroperoxidase formation by Caldariomyces fumago as an example. Biotechnol Bioeng. 2008;99:491–8.
Article
CAS
PubMed
Google Scholar
Driouch H, Hänsch R, Wucherpfennig T, Krull R, Wittmann C. Improved enzyme production by bio-pellets of Aspergillus niger: targeted morphology engineering using titanate microparticles. Biotechnol Bioeng. 2012;109:462–71.
Article
CAS
PubMed
Google Scholar
Papagianni M, Mattey M. Morphological development of Aspergillus niger in submerged citric acid fermentation as a function of the spore inoculum level. Application of neural network and cluster analysis for characterization of mycelial morphology. Microb Cell Fact. 2006;5:3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wucherpfennig T, Lakowitz A, Krull R. Comprehension of viscous morphology—evaluation of fractal and conventional parameters for rheological characterization of Aspergillus niger culture broth. J Biotechnol. 2013;163:124–32.
Article
CAS
PubMed
Google Scholar
Jüsten P, Paul GC, Nienow AW, Thomas CR. Dependence of mycelial morphology on impeller type and agitation intensity. Biotechnol Bioeng. 1996;52:672–84.
Article
PubMed
Google Scholar
Wongwicharn A, McNeil B, Harvey LM. Effect of oxygen enrichment on morphology, growth, and heterologous protein production in chemostat cultures of Aspergillus niger B1-D. Biotechnol Bioeng. 1999;65:416–24.
Article
CAS
PubMed
Google Scholar
Das RK, Brar SK. Enhanced fumaric acid production from brewery wastewater and insight into the morphology of Rhizopus oryzae 1526. Appl Biochem Biotechnol. 2014;172:2974–88.
Article
CAS
PubMed
Google Scholar
Krijgsheld P, Bleichrodt R, van Veluw GJ, Wang F, Müller WH, Dijksterhuis J, et al. Development in Aspergillus. Stud Mycol. 2013;74:1–29.
Article
CAS
PubMed
Google Scholar
Amanullah A, Christensen LH, Hansen K, Nienow AW, Thomas CR. Dependence of morphology on agitation intensity in fed-batch cultures of Aspergillus oryzae and its implications for recombinant protein production. Biotechnol Bioeng. 2002;77:815–26.
Article
CAS
PubMed
Google Scholar
Wucherpfennig T, Kiep KA, Driouch H, Wittmann C, Krull R. Morphology and rheology in filamentous cultivations. Adv Appl Microbiol. 2010;72:89–136.
Article
CAS
PubMed
Google Scholar
Wucherpfennig T, Hestler T, Krull R. Morphology engineering—osmolality and its effect on Aspergillus niger morphology and productivity. Microb Cell Fact. 2010;10:58.
Article
Google Scholar
Driouch H, Sommer B, Wittmann C. Morphology engineering of Aspergillus niger for improved enzyme production. Biotechnol Bioeng. 2010;105:1058–68.
CAS
PubMed
Google Scholar
Driouch H, Roth A, Dersch P, Wittmann C. Filamentous fungi in good shape: microparticles for tailor-made fungal morphology and enhanced enzyme production. Bioeng Bugs. 2011;2:100–4.
Article
PubMed
Google Scholar
Sitanggang AB, Wu H-S, Wang SS, Ho Y-C. Effect of pellet size and stimulating factor on the glucosamine production using Aspergillus sp. BCRC 31742. Bioresour Technol. 2010;101:3595–601.
Article
CAS
PubMed
Google Scholar
Choy V, Patel N, Thibault J. Application of image analysis in the fungal fermentation of Trichoderma reesei RUT-C30. Biotechnol Prog. 2011;27:1544–53.
Article
CAS
PubMed
Google Scholar
Tepwong P, Giri A, Ohshima T. Effect of mycelial morphology on ergothioneine production during liquid fermentation of Lentinula edodes. Mycoscience. 2012;53:102–12.
Article
CAS
Google Scholar
Amanullah A, Blair R, Nienow AW, Thomas CR. Effects of agitation intensity on mycelial morphology and protein production in chemostat cultures of recombinant Aspergillus oryzae. Biotechnol Bioeng. 1999;62:434–46.
Article
CAS
PubMed
Google Scholar
Clark DS, Ito K, Horitsu H. Effect of manganese and other heavy metals on submerged citric acid fermentation of molasses. Biotechnol Bioeng. 1966;8:465–71.
Article
CAS
Google Scholar
Schügerl K, Wittler R, Lorenz T. The use of molds in pellet form. Trends Biotechnol. 1983;1:120–3.
Article
Google Scholar
Papagianni M. Fungal morphology and metabolite production in submerged mycelial processes. Biotechnol Adv. 2004;22:189–259.
Article
CAS
PubMed
Google Scholar
Pirt SJ, Callow DS. Continuous-flow culture of the filamentous mould Penicillium chrysogenum and the control of its morphology. Nature. 1959;184:307–10.
Article
CAS
PubMed
Google Scholar
Rocha-Valadez JA, Galindo E, Serrano-Carreón L. The influence of circulation frequency on fungal morphology: a case study considering Kolmogorov microscale in constant specific energy dissipation rate cultures of Trichoderma harzianum. J Biotechnol. 2007;130:394–401.
Article
CAS
PubMed
Google Scholar
Braun S, Vecht-Lifshitz SE. Mycelial morphology and metabolite production. Trends Biotechnol. 1991;9:63–8.
Article
Google Scholar
Metz B, Kossen NWF. The growth of molds in the form of pellets—a literature review. Biotechnol Bioeng. 1977;19:781–99.
Article
CAS
Google Scholar
Elmayergi H, Scharer JM, Moo-Young M. Effects of polymer additives on fermentation parameters in a culture of A. niger. Biotechnol Bioeng. 1973;15:845–59.
Article
CAS
Google Scholar
Ruohang W, Webb C. Effect of cell concentration on the rheology of glucoamylase fermentation broth. Biotechnol Tech. 1995;9:55–8.
Article
CAS
Google Scholar
Jørgensen TR, Goosen T, van den Hondel CA, Ram AF, Iversen JJ. Transcriptomic comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway. BMC Genomics. 2009;10:44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nitsche BM, Jørgensen TR, Akeroyd M, Meyer V, Ram AF. The carbon starvation response of Aspergillus niger during submerged cultivation: insights from the transcriptome and secretome. BMC Genomics. 2012;13:380.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hillig F. Impact of cultivation conditions and bioreactor design on docosahexaenoic acid production by a heterotrophic marine microalga. Technische Universität Berlin, Faculty III-Process Sciences; 2014.
Hillig F, Annemüller S, Chmielewska M, Pilarek M, Junne S, Neubauer P. Bioprocess development in single-use systems for heterotrophic marine microalgae. Chem Ing Tech. 2013;85:153–61.
Article
CAS
Google Scholar
Wang X, Kang Y, Luo C, Zhao T, Liu L, Jiang X, et al. Heteroresistance at the single-cell level: adapting to antibiotic stress through a population-based strategy and growth-controlled interphenotypic coordination. MBio. 2014;5:e00942.
PubMed
PubMed Central
Google Scholar
Nikolic N, Schreiber F, Dal Co A, Kiviet DJ, Bergmiller T, Littmann S, et al. Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations. PLoS Genet. 2017;13:e1007122.
Article
CAS
PubMed
PubMed Central
Google Scholar
Martins BM, Locke JC. Microbial individuality: how single-cell heterogeneity enables population level strategies. Curr Opin Microbiol. 2015;24:104–12.
Article
CAS
PubMed
Google Scholar
Jørgensen TR, Nitsche BM, Lamers GE, Arentshorst M, Van Den Hondel CA, Ram AF. Transcriptomic insights into the physiology of Aspergillus niger approaching a specific growth rate of zero. Appl Environ Microbiol. 2010;76:5344–55.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lemoine A, Maya Martίnez-Iturralde N, Spann R, Neubauer P, Junne S. Response of Corynebacterium glutamicum exposed to oscillating cultivation conditions in a two- and a novel three-compartment scale-down bioreactor. Biotechnol Bioeng. 2015;112:1220–31.
Article
CAS
PubMed
Google Scholar