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Fig. 6 | Microbial Cell Factories

Fig. 6

From: Mining and characterization of the PKS–NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996

Fig. 6

Unrooted phylogenetic tree of NRPS R domains or proteins catalyzing Dieckmann cyclization during tetramates biosynthesis. NRPS R domains involved in fungal tetramates metabolic pathways; TrdC family cyclases involved in actinomycete-derived tetramates; TEs involved in bacterial polycyclic tetramic macrolactams (PTMs) biosynthesis; PyrD3, and ChlD3 involved in pyrrolidine-2,4-dione ring formation during pyrroindomycin and chlorothricin synthesis, respectively

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