Table 1 Modification of AHAS for BCAAs production
From: Metabolic engineering of Corynebacterium glutamicum for producing branched chain amino acids
Host | Mutation sites of AHAS | Titer of BCAAs (shake flask) (g/L) | Substrate | References |
|---|---|---|---|---|
C. glutamicum ATCC13032 | G20D/I21D/I22F | l-Valine: 15.2 | Glucose | [27] |
C. glutamicum A-1 | Truncating 53 amino acids from ilvN C-terminus | l-Valine: 11.2 | Glucose | [35] |
C. glutamicum ATCC14067 | A42V/A89V | l-Valine: 10.1 | Glucose | [34] |
C. glutamicum KCCM11201P | W503Q/T96S | l-Valine: 3.40 | Glucose | [36] |
C. glutamicum KCCM11662P | W503Q | l-Leucine: 3.40 | Glucose | [36] |