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Correction to: Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies

Correction to: Microb Cell Fact (2020) 19:159 https://doi.org/10.1186/s12934-020-01418-w

Following publication of the original article [1], the authors have flagged that an incorrect version of Fig. 4b has been published.

Fig. 4
figure4

a The CRM A production titer on different media (Additional file 1: Table S1); 1–7 represent the Medium 1–Medium 7 (Additional file 1: Table S1); N1 represents the Medium N1 and N2 represents the Medium N2 (Additional file 1: Table S2); b Pareto chart displays the standardized effects of each variable and indicates three most significant factors of medium N2 for improving the CRM A production titer. The bars of the diagram that go beyond the vertical dashed line (95% confidence level) correspond to the statistically significant standardized effects

In the published version, the vertical dashed line is incorrectly positioned and the dummy variables are erroneously omitted from the y-axis.

To correct the version provided in the published article, please find (the corrected version of) Fig. 4b in this correction.

The authors apologize for any inconvenience caused.

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  1. 1.

    Xie Y, Chen J, Wang B, Chen T, Chen J, Zhang Y, Liu X, Chen Q. Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies. Microb Cell Fact. 2020;19(1):159. https://doi.org/10.1186/s12934-020-01418-w.

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Correspondence to Xiaoying Liu or Qi Chen.

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Supplementary information

Additional file 1: Table S1.

Genome features of Actinoalloteichus sp. AHMU CJ021; Table S2. Number of genes associated with the general COG functional categories; Table S3. The biosynthetic gene clusters of secondary metabolites in Actinoalloteichus sp. AHMU CJ021 analyzed by antiSMASH 5.0; Table S4. Deduced functions of the open reading frames (ORFs) indicated in Fig. 2; Table S5. Fermentation media used for caerulomycin A (CRM A) production; Table S6. The mutants obtained from ribosome engineering experiments; Table S7. The CRM A production comparison of three camE-expressing mutants; Table S8. 1H NMR and 13C NMR spectral data of CRM A in DMSO-d6; Table S9. The comparison of selected mutants generated from UV mutagenesis; Table S10. CRM A production titer of optimal mutant XC-11GUR; Table S11. The dose of all factors in medium N2 by using Plackett-Burman Design; Table S12. Screening of significant variables for CRM A production in Medium N2 by using Plackett-Burman Design; Table S13. The effects of all factors of Medium N2 for CRM A production by using Plackett-Burman Design; Table S14. The dose of important factors in response surface analysis; Table S15. The design of experiments and response of CRM A production; Table S16. The primers used in identification of gentamycin-resistant mutant; Table S17. The primers used in gene expression analysis; Fig. S1. Phylogenetic tree of Actinoalloteichus sp. AHMU CJ021; Fig. S2. HR-ESI-MS spectrum of CRM A; Fig. S3. 1H NMR spectrum of CRM A in DMSO-d6; Fig. S4. 13C NMR spectrum of CRM A in DMSO-d6; Fig. S5. CRM A production comparison of different generations of mutants; Fig. S6. The quantitative HPLC standard curves.

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Xie, Y., Chen, J., Wang, B. et al. Correction to: Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies. Microb Cell Fact 19, 177 (2020). https://doi.org/10.1186/s12934-020-01429-7

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