Skip to main content

Table 1 List of C1 reactions predicted by EMMA and their parallel reactions in E. coli iML1515

From: Towards creating an extended metabolic model (EMM) for E. coli using enzyme promiscuity prediction and metabolomics data

  EC number (gene) Reaction
Predicted
iML1515
2.4.2.10 (b3642)
3.2.2.10 (b2795)
Cytosine + 5-phospho-α-d-ribose-1-diphosphate  CMP + diphosphate
Cytosine + d-ribose-5-phosphate  CMP + H2O
Predicted
iML1515
1.1.1.79 (b1033)
1.1.1.95 (b2913)
2-Oxoglutarate + NADPH + H+ 2-hydroxyglutarate + NADP+
2-Oxoglutarate + NADH + H+ 2-hydroxyglutarate + NAD+
Predicted
KEGG
3.6.1.7 (b0968)
6.3.5.5 (b0032 or b0033)
Bicarbonate + orthophosphate  carboxyphosphate + H2O
Bicarbonate + ATP  carboxyphosphate + ADP
Predicted
iML1515
2.8.3.10 (b0615)
2.8.3.8 (b2221 and b2222 or b1694) or 2.8.3.9 (b2221 and b2222)
Acetoacetyl-CoA + citrate  acetoacetate + (3S)-citryl-CoA
Acetoacetyl-CoA + acetate  acetoacetate + acetyl-CoA
  1. Each of the predicted/iML1515 reaction pair occurs between the same substrate and product but utilize different co-substrate or cofactors