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Table 1 Upregulated gene functions in multiple conditions

From: Genome-wide Escherichia coli stress response and improved tolerance towards industrially relevant chemicals

 

Gene, protein or function

No. of genes

Chemicalsa

But

Byr

Diol

Furf

Ace

Ita

Lev

Suc

Deca

Ger

Ser

Thre

Anaerobic respiration

Hydrogenase 1

6

x

x

 

x

x

x

x

x

    

Hydrogenase 3

9

x

x

 

x

        

Hydrogenase 4

11

x

x

 

x

x

x

 

x

    

Nitric oxide reductase

3

x

x

 

x

 

x

x

x

    

Nitrate reductase 2

5

x

x

x

x

x

 

x

x

   

x

Glycerol dehydrogenase

3

x

x

 

x

x

 

x

x

   

x

Lactate dehydrogenase

2

x

x

x

x

x

 

x

 

x

   

Fumarate dehydrogenase

4

x

x

x

x

x

x

x

x

   

x

Fermentation

Pyruvate formate lyase

3

x

x

x

x

        

Acetate (pta, ackA)

2

x

 

x

 

x

x

 

x

  

x

x

Alcohol dehydrogenase

2

x

x

x

x

x

x

x

x

   

x

Lactate dehydrogenase

1

x

x

x

x

x

      

x

Electron transport chain

NADH dehydrogenase I

13

x

x

 

x

        

NADH dehydrogenase II

1

x

x

 

x

       

x

Cytochrome d

2

x

x

x

x

x

     

x

x

Menaquinol biosynthesis

6

x

x

  

x

x

x

x

    

Ubiquinol biosynthesis

8

x

x

 

x

        

Acid resistance

Acid fitness island

12

 

x

  

x

 

x

 

x

  

x

Glutamate decarb. (gadAB)

2

 

x

x

 

x

x

x

 

x

x

 

x

Antiporters (gadC, adiC, cadA)

3

x

x

x

x

x

x

x

     

Cyclopropane fatty acid (cfa)

1

x

x

x

x

x

x

x

x

x

x

 

x

Oxidative stress

sodC, katE

2

x

x

x

x

x

x

x

x

    

Carbon metabolism

Pentose phosphate pathway

8

x

x

x

x

x

  

x

    

Glycolysis

11

x

x

x

x

x

       

Ethanolamine

Metabolism (eut)

12

x

x

x

x

        

Thiamine

Biosynthesis

6

x

x

x

x

 

x

x

x

   

x

Membrane

Colanic acid synthesis

20

x

xb

 

xb

x

x

 

x

    

Iron sulphur cluster

Isc

4

x

x

x

x

x

 

x

  

x

x

x

Suf

6

 

x

x

 

x

x

x

x

x

   

Potassium

Transporter (kdp)

5

x

x

 

x

x

x

 

x

x

x

  

Quorum sensing autoinducer

Synthesis

2

x

x

x

x

x

x

x

x

 

x

 

x

Transport

4

x

x

x

x

x

 

x

     

Sigma factors

rpoS

1

x

x

x

x

x

x

x

x

x

x

 

x

rpoE

1

x

x

x

x

x

x

 

x

   

x

rpoH

1

x

x

x

x

   

x

x

x

 

x

rpoD

1

x

x

x

x

x

      

x

rpoN

1

x

x

x

x

        
  1. aAn x denotes that half or more of the genes within a functional categories are differentially expressed
  2. bFor butyrolactone and furfural 7 and 9, respectively, out of 20 genes are significant
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Microbial Cell Factories

ISSN: 1475-2859

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