Fig. 7

Morphological analysis of PrPs inside IBs. Fresh and intact PrP^WT (a, b) and PrP^90–231 (c, d) IBs observed by negative staining and transmission electron microscopy display amyloid-like structures. Scale bars 0.5 μm (a), 0.2 μm (b), 0.2 μm (c, d). The arrows indicate single filaments; the asterisks mean unzipped filaments and the hash indicates the initial step of a protofibril formation