Fig. 1
From: Bacterial synthesis of N-hydroxycinnamoyl phenethylamines and tyramines
A schematic pathway for the synthesis of N-(p-coumaroyl) phenethylamine and N-(p-coumaroyl) tyramine in Escherichia coli. ppsA phosphoenolpyruvate synthetase, tktA transketolase, tyrR phenylalanine DNA-binding transcription repressor, aroG deoxyphosphoheptonate aldolase, tyrA prephenate dehydrogenase, pheA prephenate dehydratase, tyrB phenylalanine aminotransferase, TAL tyrosine amino lyase, 4CL 4-coumaroyl-CoA ligase, TDC tyrosine decarboxylase, PDC phenylalanine decarboxylase, THT tyramine N-hydroxycinnamoyl transferase, SHT phenethylamine N-hydroxycinnamoyl transferase. Tyrosine inhibits tyrR and tyrA while phenylalanine inhibits pheA. PDC, TDC, TAL, SHT, and THT were introduced into E. coli to synthesize N-(p-coumaroyl) phenethylamine and N-(p-coumaroyl) tyramine