Figure 1
From: Genome engineering for improved recombinant protein expression in Escherichia coli
Metabolic engineering strategies to enhance the flux through a pathway. The various strategies used to improve the flux from a cellular intermediate to the desired product is shown. This includes enhancing pathways leading to the formation of intermediates (shown in yellow) and pathways which are rate limiting (B to C). Additionally branched chain pathways and feed back controls need to be blocked.