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Table 3 Consumption or production pattern of amino acids in complex media

From: Genome-scale metabolic network reconstruction and in silico flux analysis of the thermophilic bacterium Thermus thermophilus HB27

Amino acids

Supply from medium

Biosynthetic demand

Contribution

   

To others

From others

Remarks

Alanine

0.7399

0.355

0.3853

 

Surplus alanine contributes to glycine synthesis

Glycine

0.116

0.308

 

0.1918

Some are produced from alanine

Valine

0.224

0.109

0.1151

 

Excess valine is utilized in synthesis of anteiso-17:1 and anteiso-15:0 fatty acids

Leucine

1.427

0.244

1.1827

 

Excess leucine is utilized in iso-15:0 and iso-17:0 fatty acids synthesis

Isoleucine

0.5181

0.039

0.4794

 

Excess isoleucine is utilized in synthesis of anteiso fatty acid synthesis

Proline

-0.24

0.189

 

0.4291

Synthesized from glutamate

Methionine

0.015

0.015

  

Utilized from media as per biosynthetic demand

Serine

0.057

0.135

 

0.0785

Synthesized from glycine

Threonine

0.03

0.100

 

0.0699

Synthesized from aspartate

Phenylalanine

0.086

0.086

  

Utilized from media as per biosynthetic demand

Aspartate

-0.12

0.103

 

0.2232

Synthesized from oxaloacetate and glutamate

Cysteine

0.0087

0.009

  

Utilized from media as per biosynthetic demand

Glutamate

1.48

0.176

1.3041

 

Excess glutamate is utilized in several other amino acid synthesis

Arginine

-0.93

0.211

 

1.1409

Synthesized from aspartate

Asparagine

-0.023

0.103

 

0.1262

Synthesized from aspartate

Lysine

-0.141

0.087

 

0.2283

Synthesized from oxoglutarate

Glutamine

0

0.177

 

0.1771

Synthesized from glutamate

Histidine

0

0.024

 

0.0245

Synthetsized from PRPP

Tyrosine

-0.03204

0.069

 

0.1007

Synthesized from PEP, E4P

Tryptophan

-0.01116

0.043

 

0.0538

Synthesized from serine