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Figure 1 | Microbial Cell Factories

Figure 1

From: Increased isobutanol production in Saccharomyces cerevisiae by eliminating competing pathways and resolving cofactor imbalance

Figure 1

Metabolic maps of the metabolically engineered Saccharomyces cerevisiae strains constructed in this study. (a) BSW4 strain expressing two genes related to the Ehrlich pathway (kivd and ADH6). (b) BSW191 strain expressing genes related to the Ehrlich pathway (kivd and ADH6), mitochondrial valine biosynthetic pathway (ILV2), artificial valine biosynthetic pathway in the cytosol (ILV2c, ILV5c, and ILV3c), and transhydrogenase-like shunt (PYC2, MDH2, and sMAE1). Black lines indicate the overexpressed or constructed reactions in these strains. Dotted lines represent translocation between mitochondria and cytosol. Pyr, pyruvate; 2-KIV, 2-ketoisovalerate.

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Microbial Cell Factories

ISSN: 1475-2859

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