Figure 1

Central metabolic reactions of strain JM101 growing on glycerol as the sole carbon source and relative gene transcription values as compared to the same strain grown on glucose. Metabolites abbreviations: Gly, glycerol, Gly3P glycerol-3-phosphate; G, glucose; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6P, fructose-1,6-biphosphate; DHAP, dihydroxyacetone phosphate; G3P, glyceraldehyde 3-phosphate; G1,3P, 1,3-bisphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phophoglycerate; PEP, phosphoenolpyruvate; PYR, pyruvate; 6PGLN, 6-phosphoglucono-δ-lactone; 6PGNT, 6-phophogluconate; Ru5P, ribulose-5-phosphate; R5P, ribose-5-phosphate; Xu5P, xylulose-5-phosphate; S7P, seudoheptulose-7-phosphate; E4P, erythrose-4-phosphate; Ac-CoA, acetyl coenzyme A; Ac-P, acetyl phosphate; A-AMP, acetyl-AMP; CIT, citrate; ICT, isocitrate; GOX, glyoxylate; α-KG, α-ketoglutarate; SUC-CoA, succinyl-coenzyme A; SUC, succinate; FUM, fumarate; MAL, malate; OAA, oxaloacetate; KDPGNT, 2-keto-3-deoxy-D-gluconate-6-phosphate; PRPP, 5-phospho-D-ribosyl-α-1-pyrophosphate; DAHP, 3-deoxy-D-arabino-heptulosonate-7-phosphate; SHK, shikimate; CHO, chorismate; ANT, anthranilate; TRP, L-tryptophan. Genes in red: overexpressed. Genes in green: underexpressed. Genes in black: no change.