Table 3 Valorization of CO2 into valuable chemicals by engineered C. necator H16
Target product | Pathway used | Titer (mg/L) | Reference |
|---|---|---|---|
Resveratrol | Phenylpropanoid pathway | 1.9 | This study |
Lycopene | Isopentenyl pyrophosphate (IPP) and dimethylallyl diphosphate (DMAPP)-dependent pathway | 1.7 | [13] |
1,3-butanediol | 3-hydroxybutyraldehyde-CoA-(3HB-CoA) and pyruvate-dependent pathway | 2,970 | [15] |
Isopropanol | Acetoacetyl-CoA based pathway | 250 | [1] |
Humulene* | Mevalonate pathway and humulene synthase | 10.8 | [10] |
Methyl ketone | TesA thioesterase dependent pathway | 50–180 | [12] |
Alkene | Acyl-ACP reductase (AAR) and alde- hyde deformylating oxygenase (ADO) | 4.4 | [9] |
Trehalose | Expression of transport proteins for secretion | 470 | [11] |
Glucose | Blocking the glucose catabolic pathway via deletion of glk | 250 | [47] |