Table 6 Genes involved in the ATPase complex assembly
Gene/ORF | Description of the encoded protein function | Susceptibility | ||
|---|---|---|---|---|
C2 | C4 | C8 | ||
ATP10 (1,2) | Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase | 0 | + | + |
ATP11 (1,2) | Molecular chaperone. Atp11p is required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase | 0 | + | + |
ATP12 (2) | Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase. Atp12p is required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase | + | + | 0 |
ATP22 (1) | Specific translational activator for the mitochondrial ATP6 mRNA | 0 | 0 | + + |
ATP23(1,2) | Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p. Also, Atp23p has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex | 0 | + | + |
ATP25 (1, 2) | Protein that associates with mitochondrial ribosome. Atp25p is required for the stability of Oli1p (Atp9p) mRNA | + | + | + |
OXA1 (1,2) | Mitochondrial inner membrane insertase. Oxa1p mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane and plays a role in the insertion of carrier proteins into the inner membrane. Also, Oxa1p acts as a voltage-gated ion channel, activated by substrate peptides | + | + | + |
PFK2 (1) | Beta subunit of heterooctameric phosphofructokinase, involved in glycolysis | + + | + + | + + |
PKR1(1) | V-ATPase assembly factor. Pkr1p functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0) | 0 | 0 | + |
VMA21 (1) | Integral membrane protein required for V-ATPase function. Vma21p is not an actual component of the vacuolar H+-ATPase (V-ATPase) complex.) | 0 | + | + |
VPH2(1) | Integral membrane protein required for V-H+-ATPase function. Vph2p is involved in the assembly of V-H+-ATPase | + | + | + |