Table 4 Percentage of tolerance genes in each dataset regulated by transcription factors identified as tolerance determinants
Gene/ORF | Description of the encoded protein function | Susceptibility level and percentage of tolerance genes present in each dataset that are regulated by TFs also identified as tolerance determinants | ||
|---|---|---|---|---|
C2 | C4 | C8 | ||
CBF1 | Transcription factor associated with kinetochore proteins; required for chromosome segregation |  + /76.6 |  + /78.0 |  + /76.9 |
DAL81 | Transcription factor acting as a positive regulator of genes involved multiple nitrogen degradation pathways |  + /4.5 |  + /4.7 |  + /4.7 |
GCR2 | Transcriptional activator of genes involved in glycolysis |  + /15.8 |  + /15.4 |  + /16.3 |
MGA2 | Transcription factor involved in regulation of OLE1 transcription |  + /16.8 |  + / 14.2 |  + /12.4 |
ROX1 | Transcription factor repressing hypoxic genes in aerobic conditions | 0 |  + /15.6 | 0 |
RPH1 | Transcription factor involved in the repression of autophagy-related genes in nutrient-replete conditions | 0 | 0 | 29.4 |
RPN4 | Transcription factor that activates the transcription of proteasome encoding genes being regulated by the 26S proteasome in a negative feedback control mechanism |  + /83.2 |  + /86.0 |  + /85.7 |
SFP1 | Transcription factor that regulates ribosomal protein and biogenesis genes; also involved in the regulation of the response to nutrients and stress, G2/M transition during mitotic cell cycle and DNA-damage response and modulates cell size | 0 | 49.3 | 0 |
STP1 | Transcription factor that activates transcription of amino acid permease genes and may have a role in tRNA processing |  + /13.4 |  + /11.8 |  + /11.2 |
UME6 | Transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping |  + /15.3 |  + /16.6 |  + /15.5 |