Fig. 6From: Intestinal mucosal microbiota mediate amino acid metabolism involved in the gastrointestinal adaptability to cold and humid environmental stress in miceAmino acid metabolic functional annotation and intestinal community function network modeling of the altered microbiota. A Cluster analysis of KEGG secondary function. B KEGG secondary function difference analysis. C Amino acid metabolism pathway analysis of KO/KEGG and EC enzymes/MetaCyc. D The network modeling of microbiota and amino acid metabolic function. The microbiota interaction network based on microbiota species abundance and Spearmen’s correlation in all samples (R ≥ 0.7, FDR < 0.05). The core microbiota function network based on microbiota species abundance significance between cold and humid environmental stressed mice and normal control mice (Wilcoxon signed-rank test, FDR < 0.05) and Spearmen’s correlation in all samples (R ≥ 0.7, FDR < 0.05). The microbiota amino acid metabolic function network based on microbiota species abundance, KEGG pathway, MetaCyc pathway, and Spearmen’s correlation in all samples (R ≥ 0.7, FDR < 0.05). Circled, arrowed, and squared shapes are related to microbiota species, KEGG pathway, and MetaCyc pathway, respectively. Red and blue nodes are related to up-regulated and down-regulated abundance significance between cold and humid environmental stressed mice and normal control mice (Wilcoxon signed-rank test, FDR < 0.05), respectively; and gray circled nodes represent microbiota species with no difference. Based on R value of Spearmen correlation, the red and blue edges represent negative and positive correlation, respectively; and the width of the edge represents correlation coefficient; the greater the width, the stronger the correlationBack to article page