Fig. 4

Fp-EVs alleviate acute colon injury and apoptosis of epithelial cells in the colon in DSS-induced colitis mice (3–4 mice/group). (A) Representative images of colon sections for MPO immunohistochemical analysis. Magnification 200×. Scale bars represent 100 μm. (B) Quantification of the number of MPO-positive cells among the different groups. (C) Tunel assay. Magnification 100×, 200×. Scale bars represent 50 μm. (D) Quantification of Tunel + cells (%). Data are presented as the mean ± SD (n = 3–4). *p < 0.05, ** p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. DSS group. MPO: myeloperoxidase; TUNEL: Transferase-mediated deoxyuridine triphosphate-biotin nick end labelling