Fig. 2

Fp-EVs attenuate DSS-induced colitis in mice. (A) Flow diagram illustrating the Fp-EV treatment schedule in DSS-induced mice (5–6 mice/group). (B) Changes in body weight among groups. (C) Changes in the disease activity index of the mice after the administration of 3% DSS. (D) Representative images of the colon. (E) Comparison of colon length among groups. (F) Representative H&E-stained colon sections. Magnification 200×. Scale bars represent 100 μm. (G) Histopathological scores among the different groups. Data are presented as the mean ± SD (n = 5–6). ** p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. DSS group. DSS: dextran sulfate sodium; Fp: Faecalibacterium prausnitzii