Fig. 5From: The extracellular polysaccharide inhibit porcine epidemic diarrhea virus with extract and gene editing LacticaseibacillusThe EPS was the functional component of EPS from lacticaseibacillus to the antiviral infection of PEDV with the STAT3 in the cell nucleus, which robust the mRNA transcription of anti-inflammatory and anti-viral genes, such as IL-10 and IFN-λ. The B indicated that the EPS did not specifically stimulate the IL-10 single pathways, and enhance the expression STAT3 with the PEDV infection. The C explained the higher expression of STAT3 with the EPS stimulation with the PEDV infection comparing with other groups in the IPEC-J2. The EPS from the lacticaseibacillus stimulate the STAT3 in the cell nucleus, which specifically robust the mRNA transcription and expression of anti-viral genes with IFN-λ in the FBack to article page