Scheme 1From: Semi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compoundsAsymmetric reduction of 2-oxo-N, 2-diphenyl-acetamide (ONDPA) into (S)- and (R)- N-phenyl-2-hydroxy-2-phenylacetamide (NPHPA) by iolS variants and the related drugs with NPHPA as a key intermediateBack to article page