Fig. 1From: Semi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compoundsDocking of ONDPA into the substrate binding pocket of iolS. A The spatial shape of the substrate binding pocket of WT, B illustration of the key residues at the small and large binding pockets. Residues in the large and small binding pockets are depicted in pink and slate, respectively. Orange: NADPH; green: catalytic D53, Y58, K84, and H125; yellow: ONDPABack to article page