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Fig. 4 | Microbial Cell Factories

Fig. 4

From: Refactoring the architecture of a polyketide gene cluster enhances docosahexaenoic acid production in Yarrowia lipolytica through improved expression and genetic stability

Fig. 4

Impact of the genetic architecture of heterologous PUFA clusters on the production of docosahexaenoic acid (DHA) in recombinant Y. lipolytica. The strains differed in the genetic architecture of the DHA cluster as follows: TEF Af4 (A), U4 TEF INT Af4 (B), U4 minLEU2 Af4 (C), U4 minLEU2INT Af4 (D), U4 minLEU2 S Af4 (E), and U4 minLEU2 INT S Af4 (F).  They were cultivated in glycerol-based minimal medium. The time point of glycerol depletion is indicated by a dotted line. The different genetic cluster layouts are shown in Fig. 3. NFA = native fatty acids. n = 3

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Microbial Cell Factories

ISSN: 1475-2859

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