Table 2 Summary of basic characteristics of several commercial parallel fermentation systems

Characteristics

Contain 12 or 24 fully featured single-use mini bioreactors; Individual control for each bioreactor vessel; Integrated liquid feed individually per bioreactor; Real time culture monitoring

Contain 4 independently controlled bioreactors; Integrated liquid feed individually per bioreactor; Real time culture monitoring

Contain 6 independently controlled bioreactors; Integrated liquid feed individually per bioreactor; Real time culture monitoring

Working volume

100–250 mL

300 mL to 1 L

150 mL to 1 L

Application areas

Applicable for process development; Process optimization; Scale-down studies; Cell culture and microbial fermentation

Applicable for the process development of bacteria, yeast, mammalian cell cultures; Clone screening; DoE optimization

Applicable for the process development of microorganisms and mammalian cell cultures; Clone screening; DoE optimization

Reference

https://doi.org/10.1002/biot.201700766

https://doi.org/10.1007/s00253-022-11918-x

https://doi.org/10.3389/fbioe.2021.695306

Website of suppliers

https://www.sartorius-stedim-tap.com/tap/cell_culture/ambr_250.htm

http://www.bioyd.com/

https://www.infors-ht.com/en/bioreactors/bench-top-bioreactors/multifors2/

Name

BIOSTAT® Qplus multi-bioreactor system

BioXplorer 100/400

Dasgip parallel bioreactor system

Characteristics

Fully independent control of up to 12 expandable culture vessels; Specifically designed for early process development and multivariable process optimization; Offers a broad range of measurement and automation features

Parallel processing of 4 or 8 independent reactors; Integrated individual liquid and gas feeds with options for gas mixing; Real time culture monitoring

Fully independent control of up to 16 expandable culture vessels; All control systems can be accessed remotely by one or more remote operators simultaneously

Working volume

150 mL to 1 L

20 to 100 mL; 20 ml to 400 ml

1.3 to 4.3 L

Application areas

Applicable for microbial, mammalian, insect and plant cell growth studies; Clone screening; DoE optimization; Small-scale expression of recombinant proteins

Microbial fermentation; C1 Gas fermentation and cell culture; Process development, DoE optimization

Applicable for process development of bacteria, yeast, fungi, and mammalian cell cultures; DoE optimization

Reference

https://doi.org/10.1038/nmeth.f.340

https://doi.org/10.3389/fbioe.2021.695306

https://doi.org/10.1186/1472-6750-12-96

Website of suppliers

https://www.sartorius.com/en

https://helgroup.com/products/bioreactors/

http://www.dasgip.com