Fig. 2

Examples of protein structural models as reported in the A3D Yeast database. Visualization of A3D predicted aggregation propensity ranges from blue (more solubilizing) to red (more aggregation-prone). A3D Yeast database provides the per-residue local confidence score (pDDLT), a metric that has been shown to inversely correlate with protein disorder [29]. Recent analysis suggests pDDLT scores < 70 usually correspond to unstructured in isolation. Examples of the A3D Yeast database output for (a) a globular protein, (b) a membrane protein and (c) a disordered protein are shown