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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling

Fig. 2

TLR4/MYD88 signaling pathway is involved in EV-induced inflammation in macrophages. (A + B) Levels of TLR4 and MYD88 mRNAs in PMA-treated THP-1 macrophages, pretreated or not pretreated with TAK242, and incubated for 12 h with EVs (30, 40, or 50 µg/mL) were measured with RT–qPCR. Statistical test: one-way ANOVA, *P < 0.05, **P < 0.01. (C + D) Levels of TLR4 and MYD88 mRNAs in HD11 macrophages incubated for 12 h with EVs (30 µg/mL) pretreated or not pretreated with TAK242 were measured with RT-qPCR. Statistical test: one-way ANOVA, *P < 0.05, **P < 0.01

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Microbial Cell Factories

ISSN: 1475-2859

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