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Table 2 Evaluation of cytotoxicity of purified pyocyanin from PsC05 and PsE02 isolates

From: Molecular and biological characterization of pyocyanin from clinical and environmental Pseudomonas aeruginosa

 

In vitro Cytotoxicity (IC50 µg/ml) *

HePG2

HCT-116

Hela

MCF-7

PC3

WI38

WISH

DOX**

4.50 ± 0.2

5.23 ± 0.3

5.57 ± 0.4

4.17 ± 0.2

8.87 ± 0.6

6.72 ± 0.5

3.34 ± 0.2

PsE02

61.71 ± 3.4

53.06 ± 3.1

74.13 ± 3.9

37.29 ± 2.2

63.21 ± 3.3

85.47 ± 4.1

> 100

PsC05

46.45 ± 2.7

32.34 ± 2.1

39.27 ± 2.3

28.85 ± 1.9

41.31 ± 2.3

92.23 ± 4.5

> 100

  1. * IC50 (µg/ml): 1–10 (very strong), 11–20 (strong), 21–50 (moderate), 51–100 (weak), and above 100 (non-cytotoxic)
  2. ** DOX: Doxorubicin