Strategies for improving the production of bio-based vanillin

Liu, Ying; Sun, Lichao; Huo, Yi-Xin; Guo, Shuyuan

doi:10.1186/s12934-023-02144-9

Microbial Cell Factories

Table 1 Summary of vanillin production from different feedstocks

From: Strategies for improving the production of bio-based vanillin

Substrate	Microorganisms	Scale	Titer	Yield	Productivity	References
Ferulic acid	B. subtilis B7-S	Bioreactor	379 mg/L	0.63 g/g ferulic acid	/	[55]
	P. fluorescens BF13-1p4 with pBB1	Bioreactor	1.28 g/L	84.1% (molar yield)	/	[15]
	Streptomyces sp. V-1	Bioreactor	19.20 g/L	0.43 g/g ferulic acid	/	[16]
	E. coli DH5α with pTAHEF	Bioreactor	1.12 g/L	0.78 g/g ferulic acid	/	[58]
	E. coli NTG-VR1	Flask	2.90 g/L	0.29 g/g ferulic acid	/	[29]
	E. coli JM109-FE-F	Bioreactor	2.28 g/L	75.0% (molar yield)	0.126 g/L/h	[43]
	E. coli DH5α (ΔicdA) with pTAHEF-gltA	Bioreactor	5.14 g/L	86.6% (molar yield)	/	[38]
	E. coli VA1 with pETDuet-fcs-ech	Bioreactor	/	86.7% (molar yield)	1.10 g/L/h	[49]
	Amycolatopsis sp. ATCC 39,116	Bioreactor	7.76 g/L	0.69 g/g ferulic acid	0.46 g/L/h	[56]
	Amycolatopsis sp. ATCC 39,116	Flask	9.18 g/L	96.1% (molar yield)	/	[59]
	Amycolatopsis sp. ATCC 39,116 Δvdh::permE::echfcs* with utilization of resin	Bioreactor	22.30 g/L	/	/	[60]
	Streptomyces V1	Flask	9.09 g/L	95.2% (molar yield)	/	[59]
Eugenol	Bacillus safensis SMS 1003	Bioreactor	120 mg/L	26.0% (molar yield)	/	[14]
	P. resinovorans SPR1	Bioreactor	240 mg/L	10.0% (molar yield)	/	[22]
	Pseudomonas sp. HRvdhΩKm	Bioreactor	441 mg/L	44.6% (molar yield)	/	[25]
Isoeugenol	B. pumilus S-1	Bioreactor	3.75 g/L	40.5% (molar yield)	/	[18]
	Pseudomonas sp. ISPC2	Bioreactor	1.15 g/L	12.4% (molar yield)	/	[19]
	Psychrobacter sp. CSW4	Bioreactor	1.28 g/L	/	/	[61]
	Candida galli PG06	Bioreactor	1.12 g/L	25.7% (molar yield)	/	[20]
	Trichosporon asahii MP24	Bioreactor	2.40 g/L	52.5% (molar yield)	/	[21]
	Bacillus fusiformis CGMCCl347	Bioreactor	3.25 g/L	/	/	[44]
	Bacillus fusiformis CGMCC1347 with utilization of HD-8 resin	Bioreactor	8.10 g/L	0.29 g/g Isoeugenol	/	[62]
	Bacillus fusiformis CGMCC1347 with utilization of HD-8resin after 6 times reuse of immobilized cells	Bioreactor	39.26 g/L	/	/	[63]
	E. coli BL21(DE3) with pET-21a-iem	Bioreactor	/	0.76 g/g Isoeugenol	115 g/L/d	[46]
Glucose	S. cerevisiae VAN286	Bioreactor	65 mg/L	/	/	[28]
	S. pombe VAN294	Bioreactor	45 mg/L	/	/	[28]
	E. coli K-12 MG1655	Bioreactor	119 mg/L	/	/	[34]
	C. glutamicum PV-IYΔ0324	Flask	0.31 g/L	/	/	[32]
	E. coli BL21(DE3) VT-4	Bioreactor	19.3 mg/L	1.93 mg/g Glucose	/	[37]

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ISSN: 1475-2859

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