Fig. 7
From: Improving the production of the micafungin precursor FR901379 in an industrial production strain
Improving FR901379 titer through combinatorial metabolic engineering and fed-batch fermentation. A Titers of FR901379, WF11899B, and WF11899C were quantified in MEFC09-JFH in shake-flask cultures. JFH: mutant strains MEFC09-JFH; J: mutant strain MEFC09-J; WT: C. empetri MEFC09. Statistical analysis was performed by using Student’s t test (**p < 0.01; ***p < 0.001). B Titers of FR901379 were quantified in the strains MEFC09, MEFC09-HF, and MEFC09-JFH cultivated in a 5 L bioreactor. C Titers of FR901379 were quantified in the strain MEFC09-JFH in fed-batch cultivation