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Table 3 Comparison of the performances of the strains PHE01 and PHE07 for L-PHE production in fed-batch fermentation

From: Engineering of global transcription factor FruR to redirect the carbon flow in Escherichia coli for enhancing l-phenylalanine biosynthesis

Strains

OD610

GlcCa (g/L)

L-PHE (g/L)

qPHE (mg/g DCW/h)

Yield (g/g)

Vp (g/L/h)

PHE01

119.25 ± 1.42

342.27 ± 10.80

57.16 ± 1.16

24.45 ± 0.02

0.167 ± 0.001

1.02 ± 0.01

PHE07

106.75 ± 0.48

340.58 ± 11.20

70.50 ± 1.02

33.69 ± 0.13

0.207 ± 0.001

1.26 ± 0.01

  1. Fed-batch fermentations were performed in 50 L bioreactors at 37 ℃ and pH 6.8; the initial glucose concentration was 10 g/L; the initial inoculation volume ratio was 0.25. Results are given as means ± standard deviations
  2. aGlcC is the calculated cumulative consumption per reactor volume
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Microbial Cell Factories

ISSN: 1475-2859

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