Fig. 1From: Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125Scheme of the CDKL5 isoform 1 structural architecture and position of pathological mutations analyzed in this study. The grey box indicates the folded kinase domain harboring an ATP binding region a Serine/threonine (S/T) kinase active site and an autophosphorylation region. The remaining C-terminal extremity of the protein is predicted to be disorderedBack to article page