From: Recombinant vaccines in 2022: a perspective from the cell factory
 | Pathogen | Antigen | Names | Year of 1st Approval (FDA/EMA) | Production system | Formulation |
---|---|---|---|---|---|---|
Human | Hepatitis B virus | Hepatitis B Surface antigen (HBsAg) | Engerix-B, Heplisav-B, Pediarix, HBVaxPRO, Recombivax, Twinrix, Vaxelis, Heplisav-B | 1986 | Yeast (S. cerevisiae) Yeast (H. Polymorpha) | VLPs |
 | Papillomavirus | L1 capsid protein | Gardasil, Gardasil 9 Cervarix | 2006 2009 | Yeast (S. cerevisiae) Insect cells-BVES | VLPs Adjuvanted |
 | Hepatitis E virus | ORF2 protein | Hecolin | 2012* | E. coli | VLPs |
 | Influenza A & B virus | Hemagglutinin (HA) | Flublok, Flublok RIV4, Supemtek | 2013 | Insect cells-BVES | NPs No adjuvant |
 | Neisseria meningitidis serogrup B | 2 fHbp variants | Trumenba | 2014 | E. coli | No adjuvant |
 | Malaria | HBsAg + RTS chimera | Mosquirix | 2015 | Yeast (S. cerevisiae) | VLPs |
 | Varicella Zoster virus | Truncated gE | Shingrix | 2017 | CHO cells | Adjuvanted |
 | SARS-CoV-2 | Spike (S) protein | Nuvaxovid | 2021 | Insect cells-BVES | NPs |
 | SARS-CoV-2 | Spike protein | Covifenz | 2022** | Plant (Nicothiana benthamiana) | VLPs |
Swine | A. pleuropneumoniae | ApxII, TbpB, CysL, Om1A proteins | Pleurostar APP | n.s | n.s | Â |
 | Classical Swine Fever virus | E2 protein | Porcilis Pesti, Bayovac CSF E2 | 2000 Withdrawn | Insect cells-BVES | Subunit Adjuvanted |
 | Porcine Circovirus Type 2 | ORF-2 protein | Ingelvac CircoFLEX, Porcilis PCV, Circogard, Circumvent PCV | 2008 | Insect cells-BVES | Fom VLPs Adjuvanted |
 | Porcine parvovirus (PPV) | PPV 27a VP2 | Reprocyc ParvoFLEX | 2019 | Insect cells-BVEs | VLPs Adjuvanted |
Canine | Borrelia burgdorferi | OspA & C chimeric OspA | Vanguard crLyme, Recombitek Lyme | n.s | E. coli | No adjuvant |
 | Leishmania | A2 different species | Leish-Tec | 2004 | n.s | Adjuvanted |
 | Leishmania | Chimeric Protein Q | Letifend | 2016 | E. coli | No adjuvant |
Poultry | Newcastle disease virus | Hemagglutinin-neuraminidase | Approved by USDA, not commercialized | 2006 | Plants (tobacco suspension cells) | Â |
Feline | Feline leukemia virus | P45 env. antigen | Leucogen Nobivac LeuFel | 2009 | E. coli | Subunit Adjuvanted |
Equine | Streptococcus equi | CCE, mEq84, IdeE | Strangvac | 2021 | E. coli | Adjuvanted |