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Table 2 CCD matrix and corresponding response values

From: Improved fed-batch processes with Wickerhamomyces anomalus WC 1501 for the production of d-arabitol from pure glycerol

Run order

Point type

A

B

C

D

Arabitol (g/L)

Yield (g/g)

1

Factorial

+ 1

− 1

− 1

+ 1

3.4

0.070

2

Axial

0

+ α

0

0

20.1

0.253

3

Axial

− α

0

0

0

1.8

0.077

4

Center

0

0

0

0

16.2

0.220

5

Axial

0

0

0

− α

15.6

0.196

6

Factorial

+ 1

+ 1

− 1

+ 1

18.9

0.204

7

Factorial

− 1

− 1

+ 1

+ 1

6.6

0.134

8

Axial

0

0

0

4.5

0.079

9

Center

0

0

0

0

17.4

0.212

10

Factorial

− 1

+ 1

− 1

− 1

7.3

0.147

11

Axial

0

0

− α

0

19.2

0.250

12

Factorial

− 1

+ 1

+ 1

− 1

12.4

0.244

13

Center

0

0

0

0

19.0

0.236

14

Factorial

+ 1

+ 1

+ 1

− 1

24.0

0.293

15

Factorial

+ 1

− 1

+ 1

− 1

10.2

0.177

16

Factorial

+ 1

− 1

+ 1

+ 1

14.7

0.251

17

Axial

0

0

+ α

0

20.4

0.246

18

Factorial

− 1

− 1

− 1

− 1

6.4

0.137

19

Factorial

− 1

+ 1

+ 1

+ 1

11.7

0.205

20

Center

0

0

0

0

19.0

0.228

21

Factorial

+ 1

+ 1

− 1

− 1

21.0

0.199

22

Factorial

− 1

− 1

− 1

+ 1

5.9

0.121

23

Axial

+ α

0

0

0

8.6

0.189

24

Factorial

+ 1

− 1

− 1

− 1

1.9

0.068

25

Center

0

0

0

0

16.0

0.221

26

Factorial

− 1

− 1

+ 1

− 1

12.0

0.253

27

Axial

0

0

0

+ α

20.0

0.230

28

Factorial

+ 1

− 1

+ 1

+ 1

28.0

0.291

29

Factorial

− 1

+ 1

− 1

+ 1

6.6

0.140

30

Center

0

0

0

0

18.3

0.240

  1. Response values are those registered at the time point when glycerol was depleted or, at the latest, after 140 h of fermentation.