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Table 1 Experimental design matrix describing illudin M production in response to timed pH change

From: Optimization of the production process for the anticancer lead compound illudin M: process development in stirred tank bioreactors

Subset

Trial

Factor 1 (x1)

Shift Time (h)

Factor 2 (x2) pH

Response

    

Illudin M (mg L−1)

    

Actual

Predicted

1

1

78.0

6.50

698

888

1

2

85.0

6.00

43

132

1

3

85.0

6.50

995

981

1

4

85.0

6.25

901

708

1

5

85.0

7.00

605

621

2

6

74.0

6.20

682

606

2

7

74.0

6.50

736

756

2

8

78.5

6.80

797

703

2

9

83.0

6.20

608

647

2

10

87.5

6.80

953

950

2

11

92.0

6.20

421

399

2

12

92.0

6.50

851

900